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    FGF13 fibroblast growth factor 13 [ Homo sapiens (human) ]

    Gene ID: 2258, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    FGF13 enhances the function of TRPV1 by stabilizing microtubules and regulates acute and chronic itch.

    FGF13 enhances the function of TRPV1 by stabilizing microtubules and regulates acute and chronic itch.
    Dong ZS, Zhang XR, Xue DZ, Liu JH, Yi F, Zhang YY, Xian FY, Qiao RY, Liu BY, Zhang HL, Wang C.

    07/3/2024
    A Heterozygous Variant of FGF13 Caused X-Linked Developmental and Epileptic Encephalopathy 90 in a Chinese Family.

    A Heterozygous Variant of FGF13 Caused X-Linked Developmental and Epileptic Encephalopathy 90 in a Chinese Family.
    Cheng H, Miao P, Wang Y, Guo Y, Gao L, Lou Y, Yang F, Liang M, Feng J.

    03/21/2024
    The inhibitory role of microRNA-141-3p in human cutaneous melanoma growth and metastasis through the fibroblast growth factor 13-mediated mitogen-activated protein kinase axis.

    The inhibitory role of microRNA-141-3p in human cutaneous melanoma growth and metastasis through the fibroblast growth factor 13-mediated mitogen-activated protein kinase axis.
    Yang H, Zhou J, Li D, Zhou S, Dai X, Du X, Mao H, Wang B.

    11/1/2023
    FGF13A interacts with NPM1 and UBF and inhibits the invasion of bladder cancer cells.

    FGF13A interacts with NPM1 and UBF and inhibits the invasion of bladder cancer cells.
    Han D, Guan L, Zhang Y, Yang H, Si L, Jia T, Wu Y, Lv K, Song T, Yang G.

    09/18/2023
    FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches.

    FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches.
    Li R, Xue K, Li J.

    01/21/2023
    Further evidence of affected females with a heterozygous variant in FGF13 causing X-linked developmental and epileptic encephalopathy 90.

    Further evidence of affected females with a heterozygous variant in FGF13 causing X-linked developmental and epileptic encephalopathy 90.
    Narayanan DL, Majethia P, Shrikiran A, Siddiqui S, Dalal A, Shukla A., Free PMC Article

    03/12/2022
    Increased expression of fibroblast growth factor 13 in cortical lesions of the focal cortical dysplasia.

    Increased expression of fibroblast growth factor 13 in cortical lesions of the focal cortical dysplasia.
    Wu K, Yue J, Shen K, He J, Zhu G, Liu S, Zhang C, Yang H.

    01/8/2022
    FGF13 enhances resistance to platinum drugs by regulating hCTR1 and ATP7A via a microtubule-stabilizing effect.

    FGF13 enhances resistance to platinum drugs by regulating hCTR1 and ATP7A via a microtubule-stabilizing effect.
    Yu H, Wang H, Qie A, Wang J, Liu Y, Gu G, Yang J, Zhang H, Pan W, Tian Z, Wang C., Free PMC Article

    11/27/2021
    FGF13 interaction with SHCBP1 activates AKT-GSK3alpha/beta signaling and promotes the proliferation of A549 cells.

    FGF13 interaction with SHCBP1 activates AKT-GSK3α/β signaling and promotes the proliferation of A549 cells.
    Lu H, Yin M, Wang L, Cheng J, Cheng W, An H, Zhang T., Free PMC Article

    10/23/2021
    5'-UTR SNP of FGF13 causes translational defect and intellectual disability.

    5'-UTR SNP of FGF13 causes translational defect and intellectual disability.
    Pan X, Zhao J, Zhou Z, Chen J, Yang Z, Wu Y, Bai M, Jiao Y, Yang Y, Hu X, Cheng T, Lu Q, Wang B, Li CL, Lu YJ, Diao L, Zhong YQ, Pan J, Zhu J, Xiao HS, Qiu ZL, Li J, Wang Z, Hui J, Bao L, Zhang X., Free PMC Article

    09/25/2021
    Expression and cellular distribution of FGF13 in cortical tubers of the tuberous sclerosis complex.

    Expression and cellular distribution of FGF13 in cortical tubers of the tuberous sclerosis complex.
    Wu K, Yue J, Shen K, He J, Zhu G, Liu S, Yang H, Zhang CQ.

    06/5/2021
    FGF10 and FGF13 genetic variation and tooth-size discrepancies.

    FGF10 and FGF13 genetic variation and tooth-size discrepancies.
    Marañón-Vásquez GA, Vieira AR, Dos Santos LV, Cunha AS, Weiss SG, Araujo MTS, Bolognese AM, Scariot R, Küchler EC, Stuani MBS., Free PMC Article

    05/15/2021
    lncRNA LINC00963 downregulation regulates colorectal cancer tumorigenesis and progression via the miR10b/FGF13 axis.

    lncRNA LINC00963 downregulation regulates colorectal cancer tumorigenesis and progression via the miR‑10b/FGF13 axis.
    Wu Y, Cong L, Chen W, Wang X, Qiu F., Free PMC Article

    05/8/2021
    FGF13 promotes metastasis of triple-negative breast cancer.

    FGF13 promotes metastasis of triple-negative breast cancer.
    Johnstone CN, Pattison AD, Harrison PF, Powell DR, Lock P, Ernst M, Anderson RL, Beilharz TH.

    03/27/2021
    Missense variants in the N-terminal domain of the A isoform of FHF2/FGF13 cause an X-linked developmental and epileptic encephalopathy.

    Missense variants in the N-terminal domain of the A isoform of FHF2/FGF13 cause an X-linked developmental and epileptic encephalopathy.
    Fry AE, Marra C, Derrick AV, Pickrell WO, Higgins AT, Te Water Naude J, McClatchey MA, Davies SJ, Metcalfe KA, Tan HJ, Mohanraj R, Avula S, Williams D, Brady LI, Mesterman R, Tarnopolsky MA, Zhang Y, Yang Y, Wang X, Genomics England Research Consortium, Rees MI, Goldfarb M, Chung SK., Free PMC Article

    02/6/2021
    The knockdown of FGF13 was able to mimic the inhibitory effects of miR-10b on the progression of colorectal cancer (CRC) cells.

    MiR-10b suppresses the growth and metastasis of colorectal cancer cell by targeting FGF13.
    Song JJ, Li W.

    08/15/2020
    Genetic polymorphisms in FGF3, FGF10, and FGF13 genes were associated with temporomandibular disorders in a population with dentofacial deformities

    Polymorphisms in FGF3, FGF10, and FGF13 May Contribute to the Presence of Temporomandibular Disorders in Patients Who Required Orthognathic Surgery.
    Carpio Horta K, Weiss SG, Miranda K, Sebastiani AM, Costa DJD, Matsumoto MAN, Marañón-Vásquez GA, Vieira AR, Scariot R, Küchler EC.

    11/30/2019
    High FGF13 expression is associated with glioma cell invasion.

    Fibroblast growth factor 13 regulates glioma cell invasion and is important for bevacizumab-induced glioma invasion.
    Otani Y, Ichikawa T, Kurozumi K, Inoue S, Ishida J, Oka T, Shimizu T, Tomita Y, Hattori Y, Uneda A, Matsumoto Y, Michiue H, Date I.

    03/16/2019
    The present study reported the presence of FGF13 in the follicular fluid of women undergoing IVF/ICSI. Moreover, the relationships between FF-FGF13 and FF-TT, ovarian morphology and oocyte developmental competence imply that FF-FGF13 might be involved in the pathophysiological process of polycystic ovary syndrome.

    Intrafollicular fibroblast growth factor 13 in polycystic ovary syndrome: relationship with androgen levels and oocyte developmental competence.
    Liu Y, Li S, Tao T, Li X, Zhu Q, Liao Y, Ma J, Sun Y, Liu W., Free PMC Article

    12/29/2018
    Autism-related protein MeCP2 regulates FGF13 expression and emotional behaviors

    Autism-related protein MeCP2 regulates FGF13 expression and emotional behaviors.
    Yuan B, Cheng TL, Yang K, Zhang X, Qiu Z.

    12/22/2018
    FGF13 was downregulated in human placentae with early-onset preeclampsia. FGF13 played an important role in maintaining placental trophoblast permeability via the modulation of E-cadherin.

    Decreased expression of fibroblast growth factor 13 in early-onset preeclampsia is associated with the increased trophoblast permeability.
    Yue X, Sun Y, Zhong M, Ma Y, Wei Y, Sun F, Xiao L, Liu M, Chen J, Lai Y, Yan C, Huang L, Yu Y.

    12/22/2018
    We propose that, in cells in which activated oncogenes drive excessive protein synthesis, FGF13 may favor survival by maintaining translation rates at a level compatible with the protein quality-control capacity of the cell. Thus, FGF13 may serve as an enabler, allowing cancer cells to evade proteostasis stress triggered by oncogene activation.

    Regulatory module involving FGF13, miR-504, and p53 regulates ribosomal biogenesis and supports cancer cell survival.
    Bublik DR, Bursać S, Sheffer M, Oršolić I, Shalit T, Tarcic O, Kotler E, Mouhadeb O, Hoffman Y, Fuchs G, Levin Y, Volarević S, Oren M., Free PMC Article

    04/14/2018
    Study screened the coding and splice site regions of the FGF13 gene in a sample of 45 unrelated probands where genetic epilepsy with febrile seizures plus segregated in an X-linked pattern; subsequently identified a de novo FGF13 missense variant in an additional patient with febrile seizures and facial edema. Results suggest that FGF13 is not a common cause of genetic epilepsy with febrile seizures plus.

    Is FGF13 a major contributor to genetic epilepsy with febrile seizures plus?
    Rigbye KA, van Hasselt PM, Burgess R, Damiano JA, Mullen SA, Petrovski S, Puranam RS, van Gassen KL, Gecz J, Scheffer IE, McNamara JO, Berkovic SF, Hildebrand MS.

    01/6/2018
    identified two novel native phosphorylation sites in the C terminus of NaV1.5 that impair FGF13-dependent regulation of channel inactivation and may contribute to CaMKIIdeltac-dependent arrhythmogenic disorders in failing hearts.

    C-terminal phosphorylation of Na(V)1.5 impairs FGF13-dependent regulation of channel inactivation.
    Burel S, Coyan FC, Lorenzini M, Meyer MR, Lichti CF, Brown JH, Loussouarn G, Charpentier F, Nerbonne JM, Townsend RR, Maier LS, Marionneau C., Free PMC Article

    10/28/2017
    These data showed the diversity of the roles of the FGF13 N-termini in NaV1.5 channel modulation and suggested the importance of isoform-specific regulation

    FGF13 modulates the gating properties of the cardiac sodium channel Na(v)1.5 in an isoform-specific manner.
    Yang J, Wang Z, Sinden DS, Wang X, Shan B, Yu X, Zhang H, Pitt GS, Wang C., Free PMC Article

    10/14/2017
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