| Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure. | Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure.
Funato Y, Yamazaki D, Okuzaki D, Yamamoto N, Miki H., Free PMC Article | 07/10/2021 |
| increased urinary UMOD secretion in low-magnesium states reduces TRPM6 endocytosis and thereby up-regulates TRPM6 cell-surface abundance to defend against further urinary magn | Uromodulin regulates renal magnesium homeostasis through the ion channel transient receptor potential melastatin 6 (TRPM6).
Nie M, Bal MS, Liu J, Yang Z, Rivera C, Wu XR, Hoenderop JGJ, Bindels RJM, Marciano DK, Wolf MTF., Free PMC Article | 03/23/2019 |
| mTRPM6 and mTRPM7 contribute differentially to key functional characteristics of mTRPM6/7 complexes thereby functionally defining a new type of channel that remains active in the presence of physiological concentrations of [Mg2+]i and [Mg.ATP]i. | TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg(2+) and Mg·ATP.
Ferioli S, Zierler S, Zaißerer J, Schredelseker J, Gudermann T, Chubanov V., Free PMC Article | 03/16/2019 |
| Hence, maintenance of organismal Mg(2+) balance by TRPM6 is crucial for prenatal development and survival to adulthood. | Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival.
Chubanov V, Ferioli S, Wisnowsky A, Simmons DG, Leitzinger C, Einer C, Jonas W, Shymkiv Y, Bartsch H, Braun A, Akdogan B, Mittermeier L, Sytik L, Torben F, Jurinovic V, van der Vorst EP, Weber C, Yildirim ÖA, Sotlar K, Schürmann A, Zierler S, Zischka H, Ryazanov AG, Gudermann T., Free PMC Article | 10/21/2017 |
| TRPM6 mRNA increased during the last 4 days of pregnancy, coinciding with fetal bone mineralization in mice. TRPM6 mRNA and protein was localized in the trophoblasts in labyrinth where the maternal-fetal Ca(2+) transport occurs. In patch-clamp recordings, we observed TRPM6/TRPM7-like currents in mouse trophoblasts after starting fetal bone mineralization but not before mineralization. | Expression of the TRPM6 in mouse placental trophoblasts; potential role in maternal-fetal calcium transport.
Suzuki Y, Watanabe M, Saito CT, Tominaga M., Free PMC Article | 05/13/2017 |
| in a model of inherited hypomagnesemia, TRPM6 and TRPM7, but not paracellin-1, are downregulated | Dysregulation of renal transient receptor potential melastatin 6/7 but not paracellin-1 in aldosterone-induced hypertension and kidney damage in a model of hereditary hypomagnesemia.
Yogi A, Callera GE, O'Connor SE, He Y, Correa JW, Tostes RC, Mazur A, Touyz RM. | 10/15/2011 |
| TRPM6 deletion is embryonic lethal in mice; Heterozygous deletion of TRPM6 results in a mild hypomagnesemia | Transient receptor potential melastatin 6 knockout mice are lethal whereas heterozygous deletion results in mild hypomagnesemia.
Woudenberg-Vrenken TE, Sukinta A, van der Kemp AW, Bindels RJ, Hoenderop JG. | 05/7/2011 |
| consistently reduced expression of TRPM6 mRNA may play a role in the pathogenesis of hypomagnesemia in C57BL/6 asthmatic mice. | Decreased renal mRNA expression of TRPM6 is associated with hypomagnesemia in C57BL/6 asthmatic mice.
Jiang SP, Wu YM, Guo SE, Lv ZQ. | 02/26/2011 |
| MsrB1 recovers TRPM6 channel activity by reducing the oxidation of Met(1755) and could, thereby, function as a modulator of TRPM6 during oxidative stress. | Methionine sulfoxide reductase B1 (MsrB1) recovers TRPM6 channel activity during oxidative stress.
Cao G, Lee KP, van der Wijst J, de Graaf M, van der Kemp A, Bindels RJ, Hoenderop JG., Free PMC Article | 10/4/2010 |
| Trpm6(-/-) mice almost never survived to weaning and show neural tube defects. | Mice defective in Trpm6 show embryonic mortality and neural tube defects.
Walder RY, Yang B, Stokes JB, Kirby PA, Cao X, Shi P, Searby CC, Husted RF, Sheffield VC., Free PMC Article | 02/8/2010 |
| Modulation of TRPM6 and Na(+)/Mg(2+) exchange in mammary epithelial cells in response to variations of magnesium availability. | Modulation of TRPM6 and Na(+)/Mg(2+) exchange in mammary epithelial cells in response to variations of magnesium availability.
Wolf FI, Trapani V, Simonacci M, Mastrototaro L, Cittadini A, Schweigel M. | 01/21/2010 |
| REA operates as a negative feedback modulator of TRPM6 in the regulation of active Mg(2+) (re)absorption and provides new insight into the molecular mechanism of renal transepithelial Mg(2+) transport. | Regulation of the epithelial Mg2+ channel TRPM6 by estrogen and the associated repressor protein of estrogen receptor activity (REA).
Cao G, van der Wijst J, van der Kemp A, van Zeeland F, Bindels RJ, Hoenderop JG., Free PMC Article | 01/21/2010 |
| In C57BL/6J mice, dietary Mg(2+)-restriction results in increased Mg(2+) (re)absorption, which is correlated with increased TRPM6 expression. | Relationship between low magnesium status and TRPM6 expression in the kidney and large intestine.
Rondón LJ, Groenestege WM, Rayssiguier Y, Mazur A. | 01/21/2010 |