| GLIS3 expression in the thyroid gland in relation to TSH signaling and regulation of gene expression. | GLIS3 expression in the thyroid gland in relation to TSH signaling and regulation of gene expression.
Kang HS, Grimm SA, Liao XH, Jetten AM., Free PMC Article | 02/29/2024 |
| GLIS3: A Critical Transcription Factor in Islet beta-Cell Generation. | GLIS3: A Critical Transcription Factor in Islet β-Cell Generation.
Scoville DW, Jetten AM., Free PMC Article | 01/22/2022 |
| Identification of a novel lncRNA (G3R1) regulated by GLIS3 in pancreatic beta-cells. | Identification of a novel lncRNA (G3R1) regulated by GLIS3 in pancreatic β-cells.
Scoville DW, Gruzdev A, Jetten AM., Free PMC Article | 04/13/2021 |
| an unexpected role for GLIS3 in the development of male germ cells | Loss of Glis3 causes dysregulation of retrotransposon silencing and germ cell demise in fetal mouse testis.
Ungewitter EK, Rotgers E, Kang HS, Lichti-Kaiser K, Li L, Grimm SA, Jetten AM, Yao HH., Free PMC Article | 10/19/2019 |
| study identifies GLIS3 as a key regulator of TSH/TSHR-mediated thyroid hormone biosynthesis and proliferation of thyroid follicular cells and uncovers a mechanism by which GLIS3 deficiency causes neonatal hypothyroidism and prevents goiter development. | GLIS3 is indispensable for TSH/TSHR-dependent thyroid hormone biosynthesis and follicular cell proliferation.
Kang HS, Kumar D, Liao G, Lichti-Kaiser K, Gerrish K, Liao XH, Refetoff S, Jothi R, Jetten AM., Free PMC Article | 03/2/2019 |
| The observations suggest that GLIS3 promotes the gonocyte-to- spermatogonial stem cells transition and is a critical regulator of the dynamics of early postnatal spermatogenesis. | Transcription Factor GLIS3: A New and Critical Regulator of Postnatal Stages of Mouse Spermatogenesis.
Kang HS, Chen LY, Lichti-Kaiser K, Liao G, Gerrish K, Bortner CD, Yao HH, Eddy EM, Jetten AM., Free PMC Article | 01/27/2018 |
| Study demonstrates that Glis3 protein exhibits a temporal and cell type-specific pattern of expression during embryonic and neonatal pancreas development that is consistent with a regulatory role for Glis3 in promoting endocrine progenitor generation, regulating insulin and Ppy expression in beta and Ppy expression in beta and PP cells, respectively, and duct morphogenesis. | The Spatiotemporal Pattern of Glis3 Expression Indicates a Regulatory Function in Bipotent and Endocrine Progenitors during Early Pancreatic Development and in Beta, PP and Ductal Cells.
Kang HS, Takeda Y, Jeon K, Jetten AM., Free PMC Article | 07/29/2017 |
| Glis3 plays a pivotal role in the transcriptional regulation of insulin. | The Krüppel-like protein Gli-similar 3 (Glis3) functions as a key regulator of insulin transcription.
ZeRuth GT, Takeda Y, Jetten AM., Free PMC Article | 04/26/2014 |
| beta cell-specific inactivation of Glis3 in adult mice downregulates insulin expression, leading to hyperglycaemia and subsequently enhanced beta cell apoptosis | Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults.
Yang Y, Chang BH, Chan L., Free PMC Article | 06/8/2013 |
| The results indicate that GLIS3 controls fetal islet differentiation via direct transactivation of Neurog3, a perturbation | The Krüppel-like zinc finger protein GLIS3 transactivates neurogenin 3 for proper fetal pancreatic islet differentiation in mice.
Yang Y, Chang BH, Yechoor V, Chen W, Li L, Tsai MJ, Chan L., Free PMC Article | 04/28/2012 |
| Glis3 interacts with Suppressor of Fused (SUFU) | Modulation of the transactivation function and stability of Krüppel-like zinc finger protein Gli-similar 3 (Glis3) by Suppressor of Fused.
ZeRuth GT, Yang XP, Jetten AM., Free PMC Article | 09/3/2011 |
| Data show that Glis3 plays a role in cell lineage specification, particularly in the development of pancreatic beta cells, and also regulates insulin gene expression. | Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression.
Kang HS, Kim YS, ZeRuth G, Beak JY, Gerrish K, Kilic G, Sosa-Pineda B, Jensen J, Pierreux CE, Lemaigre FP, Foley J, Jetten AM., Free PMC Article | 01/21/2010 |
| Glis3(-/-) mice had increases in the blood sugar level in the first days after birth, attributed to a decrease in Insulin mRNA level in the pancreas caused by impaired islet development and the subsequent impairment of Insulin-producing cell formation. | A murine model of neonatal diabetes mellitus in Glis3-deficient mice.
Watanabe N, Hiramatsu K, Miyamoto R, Yasuda K, Suzuki N, Oshima N, Kiyonari H, Shiba D, Nishio S, Mochizuki T, Yokoyama T, Maruyama S, Matsuo S, Wakamatsu Y, Hashimoto H. | 01/21/2010 |
| Data show that dysfunction of Glis3 leads to the development of cystic renal disease, and suggest that localization to the primary cilium and interaction with Wwtr1 are key elements of the Glis3 signaling pathway. | Glis3 is associated with primary cilia and Wwtr1/TAZ and implicated in polycystic kidney disease.
Kang HS, Beak JY, Kim YS, Herbert R, Jetten AM., Free PMC Article | 01/21/2010 |
| The transcription factor, GLIS3, has both repressor and activation functions. | GLIS3, a novel member of the GLIS subfamily of Krüppel-like zinc finger proteins with repressor and activation functions.
Kim YS, Nakanishi G, Lewandoski M, Jetten AM., Free PMC Article | 01/21/2010 |