| Deregulated 14-3-3zeta and methionine adenosyltransferase alpha1 interplay promotes liver cancer tumorigenesis in mice and humans. | Deregulated 14-3-3ζ and methionine adenosyltransferase α1 interplay promotes liver cancer tumorigenesis in mice and humans.
Lu L, Zhang J, Fan W, Li Y, Wang J, Li TWH, Barbier-Torres L, Mato JM, Liu T, Seki E, Matsuda M, Tomasi ML, Bhowmick NA, Yang H, Lu SC., Free PMC Article | 08/28/2024 |
| 14-3-3zeta suppresses RANKL signaling by destabilizing TRAF6. | 14-3-3ζ suppresses RANKL signaling by destabilizing TRAF6.
Ayyasamy R, Fan S, Czernik P, Lecka-Czernik B, Chattopadhyay S, Chakravarti R., Free PMC Article | 07/29/2024 |
| IgE receptor of mast cells signals mediator release and inflammation via adaptor protein 14-3-3zeta. | IgE receptor of mast cells signals mediator release and inflammation via adaptor protein 14-3-3ζ.
Yip KH, Chao J, Coolen C, Pant H, Kral A, Smith W, Schwarz Q, Grimbaldeston MA, Pitson S, Lopez AF, Woodcock J, Tumes DJ. | 10/26/2023 |
| High-throughput functional screen identifies YWHAZ as a key regulator of pancreatic cancer metastasis. | High-throughput functional screen identifies YWHAZ as a key regulator of pancreatic cancer metastasis.
Cao F, Jiang Y, Chang L, Du H, Chang D, Pan C, Huang X, Yu D, Zhang M, Fan Y, Bian X, Li K., Free PMC Article | 09/9/2023 |
| 14-3-3zeta inhibits maladaptive repair in renal tubules by regulating YAP and reduces renal interstitial fibrosis. | 14-3-3ζ inhibits maladaptive repair in renal tubules by regulating YAP and reduces renal interstitial fibrosis.
Wang TT, Wu LL, Wu J, Zhang LS, Shen WJ, Zhao YH, Liu JN, Fu B, Wang X, Li QG, Bai XY, Wang LQ, Chen XM., Free PMC Article | 06/15/2023 |
| YBX1 regulates the survival of chronic myeloid leukemia stem cells by modulating m[6]A-mediated YWHAZ stability. | YBX1 regulates the survival of chronic myeloid leukemia stem cells by modulating m(6)A-mediated YWHAZ stability.
Chai J, Wang Q, Qiu Q, Han G, Chen Y, Li W, Zhang H. | 04/14/2023 |
| 14-3-3zeta Constrains insulin secretion by regulating mitochondrial function in pancreatic beta cells. | 14-3-3ζ Constrains insulin secretion by regulating mitochondrial function in pancreatic β cells.
Mugabo Y, Zhao C, Tan JJ, Ghosh A, Campbell SA, Fadzeyeva E, Paré F, Pan SS, Galipeau M, Ast J, Broichhagen J, Hodson DJ, Mulvihill EE, Petropoulos S, Lim GE., Free PMC Article | 05/7/2022 |
| Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3zeta protein and represses lung cancer metastasis. | Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3ζ protein and represses lung cancer metastasis.
Chen Z, Zheng L, Chen Y, Liu X, Kawakami M, Mustachio LM, Roszik J, Ferry-Galow KV, Parchment RE, Liu X, Andresson T, Duncan G, Kurie JM, Rodriguez-Canales J, Liu X, Dmitrovsky E., Free PMC Article | 04/16/2022 |
| 14-3-3zeta mediates an alternative, non-thermogenic mechanism in male mice to reduce heat loss and improve cold tolerance. | 14-3-3ζ mediates an alternative, non-thermogenic mechanism in male mice to reduce heat loss and improve cold tolerance.
Diallo K, Dussault S, Noll C, Lopez AF, Rivard A, Carpentier AC, Lim GE., Free PMC Article | 08/21/2021 |
| Reducing 14-3-3zeta expression influences adipocyte maturity and impairs function. | Reducing 14-3-3ζ expression influences adipocyte maturity and impairs function.
Oppong AK, Diallo K, Robillard Frayne I, Des Rosiers C, Lim GE. | 10/31/2020 |
| It has been proposed that MsrA-dependent 14-3-3 zeta ubiquitination affects the regulation of alpha synuclein degradation and dopamine synthesis in the brain. | Methionine sulfoxide reductase A (MsrA) mediates the ubiquitination of 14-3-3 protein isotypes in brain.
Deng Y, Jiang B, Rankin CL, Toyo-Oka K, Richter ML, Maupin-Furlow JA, Moskovitz J., Free PMC Article | 09/28/2019 |
| DEX can increase IOP in mouse eyes and concurrently downregulate 14-3-3 zeta protein expression in mouse TM | Expression of 14-3-3 Zeta Protein in Dexamethasone-Treated Mice and Human TM-1 Cells.
Liu Q, Ye Y, Lin X, Yang Y, Wu K, Yu M. | 01/20/2018 |
| These results demonstrate that miR-146a enhances class switch and secretion of IgE in B cells by upregulating 14-3-3sigma expression, and suggest that miR-146a may be a potential target for asthma therapy. | MicroRNA-146a promotes IgE class switch in B cells via upregulating 14-3-3σ expression.
Li F, Huang Y, Huang YY, Kuang YS, Wei YJ, Xiang L, Zhang XJ, Jia ZC, Jiang S, Li JY, Wan Y. | 12/2/2017 |
| When taken together these findings demonstrate novel roles of 14-3-3zeta in the regulation of glucose homeostasis and suggest that modulating 14-3-3zeta levels in intestinal L cells may have beneficial metabolic effects through GLP-1-dependent mechanisms. | Ywhaz/14-3-3ζ Deletion Improves Glucose Tolerance Through a GLP-1-Dependent Mechanism.
Lim GE, Piske M, Lulo JE, Ramshaw HS, Lopez AF, Johnson JD. | 06/10/2017 |
| The data obtained from the 14-3-3epsilon/14-3-3zeta/Wnt1-Cre mice strongly indicate the importance of 14-3-3 proteins in the development of melanocyte lineages. | Deficiency of 14-3-3ε and 14-3-3ζ by the Wnt1 promoter-driven Cre recombinase results in pigmentation defects.
Cornell B, Toyo-oka K., Free PMC Article | 12/17/2016 |
| Results indicate that HuR induces 14-3-3zeta translation via interaction with its 3' UTR and that 14-3-3zeta is necessary for stimulation of intestinal epithelial cell migration after wounding. | Posttranscriptional regulation of 14-3-3ζ by RNA-binding protein HuR modulating intestinal epithelial restitution after wounding.
Hansraj NZ, Xiao L, Wu J, Chen G, Turner DJ, Wang JY, Rao JN., Free PMC Article | 09/24/2016 |
| PKCdelta-mediated phosphorylation of 14-3-3zeta contributes to the nuclear retention of FOXO1, even when FOXO1 is phosphorylated as under non-stress conditions | Protein kinase Cδ regulates nuclear export of FOXO1 through phosphorylation of the chaperone 14-3-3ζ.
Gerst F, Kaiser G, Panse M, Sartorius T, Pujol A, Hennige AM, Machicao F, Lammers R, Bosch F, Häring HU, Ullrich S. | 08/27/2016 |
| analysis of phosphorylation-dependent interactions of AQP2 with 14-3-3theta; and -zeta | Regulation of the Water Channel Aquaporin-2 via 14-3-3θ and -ζ.
Moeller HB, Slengerik-Hansen J, Aroankins T, Assentoft M, MacAulay N, Moestrup SK, Bhalla V, Fenton RA., Free PMC Article | 06/28/2016 |
| 14-3-3zeta deficient mice in the BALB/c background display behavioral and anatomical defects associated with Schizophrenia-like disorder. | 14-3-3ζ deficient mice in the BALB/c background display behavioural and anatomical defects associated with neurodevelopmental disorders.
Xu X, Jaehne EJ, Greenberg Z, McCarthy P, Saleh E, Parish CL, Camera D, Heng J, Haas M, Baune BT, Ratnayake U, van den Buuse M, Lopez AF, Ramshaw HS, Schwarz Q., Free PMC Article | 05/28/2016 |
| Ywhaz coordinates adipogenesis in visceral fat. | 14-3-3ζ coordinates adipogenesis of visceral fat.
Lim GE, Albrecht T, Piske M, Sarai K, Lee JTC, Ramshaw HS, Sinha S, Guthridge MA, Acker-Palmer A, Lopez AF, Clee SM, Nislow C, Johnson JD., Free PMC Article | 04/16/2016 |
| An essential role for 14-3-3 zeta in the regulation of macropinocytosis in macrophages upon cytokine stimulation through modulation of the localization of coronin 1. | Cytokine-induced macropinocytosis in macrophages is regulated by 14-3-3ζ through its interaction with serine-phosphorylated coronin 1.
BoseDasgupta S, Moes S, Jenoe P, Pieters J. | 06/20/2015 |
| In the majority of NAFLD treatment groups and time points the most stable gene was YWHAZ. | The housekeeping gene YWHAZ remains stable in a model of developmentally primed non-alcoholic fatty liver disease.
Bruce KD, Sihota KK, Byrne CD, Cagampang FR. | 09/6/2014 |
| By preventing the inactivation of cofilin, metabolic stress-induced degradation of 14-3-3zeta promotes the conversion of blood monocytes into a hypermigratory, proatherogenic phenotype. | Redox regulation of 14-3-3ζ controls monocyte migration.
Kim HS, Ullevig SL, Nguyen HN, Vanegas D, Asmis R., Free PMC Article | 08/30/2014 |
| 14-3-3zeta KO mice displayed enhanced locomotor hyperactivity induced by the dopamine (DA) releaser amphetamine. Consistent with 14-3-3zeta having a role in DA signalling, we found increased levels of DA in the striatum of 14-3-3zeta KO mice. | Locomotor hyperactivity in 14-3-3ζ KO mice is associated with dopamine transporter dysfunction.
Ramshaw H, Xu X, Jaehne EJ, McCarthy P, Greenberg Z, Saleh E, McClure B, Woodcock J, Kabbara S, Wiszniak S, Wang TY, Parish C, van den Buuse M, Baune BT, Lopez A, Schwarz Q., Free PMC Article | 06/7/2014 |
| The activated serine/threonine kinase Akt/protein kinase B phosphorylated BTK on two sites prior to 14-3-3 zeta binding. | Dual phosphorylation of Btk by Akt/protein kinase b provides docking for 14-3-3ζ, regulates shuttling, and attenuates both tonic and induced signaling in B cells.
Mohammad DK, Nore BF, Hussain A, Gustafsson MO, Mohamed AJ, Smith CI., Free PMC Article | 10/26/2013 |