| KCNQ5 Controls Perivascular Adipose Tissue-Mediated Vasodilation. | KCNQ5 Controls Perivascular Adipose Tissue-Mediated Vasodilation.
Tsvetkov D, Schleifenbaum J, Wang Y, Kassmann M, Polovitskaya MM, Ali M, Schütze S, Rothe M, Luft FC, Jentsch TJ, Gollasch M. | 02/21/2024 |
| KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3. | KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3.
Soh H, Springer K, Doci K, Balsbaugh JL, Tzingounis AV., Free PMC Article | 05/7/2022 |
| KCNQ5 controls excitability and function of hippocampal networks through modulation of synaptic inhibition. | KCNQ5 K(+) channels control hippocampal synaptic inhibition and fast network oscillations.
Fidzinski P, Korotkova T, Heidenreich M, Maier N, Schuetze S, Kobler O, Zuschratter W, Schmitz D, Ponomarenko A, Jentsch TJ. | 02/6/2016 |
| analysis of the vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models | Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models.
Spitzmaul G, Tolosa L, Winkelman BH, Heidenreich M, Frens MA, Chabbert C, de Zeeuw CI, Jentsch TJ., Free PMC Article | 06/1/2013 |
| Data show that in early pregnant mouse myometrium, the relative abundance of mRNA expression was KCNQ3 > KCNQ4 > KCNQ5 > KCNQ1 > KCNQ2. | The contribution of Kv7 channels to pregnant mouse and human myometrial contractility.
McCallum LA, Pierce SL, England SK, Greenwood IA, Tribe RM., Free PMC Article | 07/23/2011 |
| Kcnq5(dn/dn) mice are viable and have normal brain morphology. However, in the CA3 area of hippocampus, a region that highly expresses KCNQ5 channels, the medium and slow afterhyperpolarization currents are significantly reduced. | The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus.
Tzingounis AV, Heidenreich M, Kharkovets T, Spitzmaul G, Jensen HS, Nicoll RA, Jentsch TJ., Free PMC Article | 07/5/2010 |
| K(v)7.4 and K(v)7.5 are expressed in different regions of the murine gastrointestinal tract and blockers of K(v)7 channels augment inherent contractile activity. | Molecular and functional characterization of Kv7 K+ channel in murine gastrointestinal smooth muscles.
Jepps TA, Greenwood IA, Moffatt JD, Sanders KM, Ohya S., Free PMC Article | 01/21/2010 |
| Results provide support for KCNQ4- or KCNQ5-encoded channels having an important functional impact in the vasculature. | Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currents.
Yeung S, Schwake M, Pucovský V, Greenwood Ia., Free PMC Article | 01/21/2010 |
| These data represent an exhaustive characterisation of a truncated KCNQ5 splice variant that may contribute to the native XE991-sensitive channel in murine vasculature. | Expression profile and characterisation of a truncated KCNQ5 splice variant.
Yeung SY, Lange W, Schwake M, Greenwood IA. | 01/21/2010 |
| Murine blood vessels exhibit a distinctive expression profile of KCNQ1, KCNQ4, and KCNQ5, with 'neuronal' KCNQ4 dominating | Molecular expression and pharmacological identification of a role for K(v)7 channels in murine vascular reactivity.
Yeung SY, Pucovský V, Moffatt JD, Saldanha L, Schwake M, Ohya S, Greenwood IA., Free PMC Article | 01/21/2010 |
| Data show that murine KCNQ5 channels are tightly regulated by changes in extracellular Zn2+, pH, and tonicity, thus adding to the complex regulation of these channels. | The KCNQ5 potassium channel from mouse: a broadly expressed M-current like potassium channel modulated by zinc, pH, and volume changes.
Jensen HS, Callø K, Jespersen T, Jensen BS, Olesen SP. | 01/21/2010 |