| Tyrosine-phosphorylated DNER sensitizes insulin signaling in hepatic gluconeogenesis by inducing proteasomal degradation of TRB3. | Tyrosine-phosphorylated DNER sensitizes insulin signaling in hepatic gluconeogenesis by inducing proteasomal degradation of TRB3.
Li J, Huang Y, Yang X, Cai Y, Wang Y, Dai W, Jiang L, Wang C, Wen Z., Free PMC Article | 05/6/2024 |
| Role of Delta/Notch-like EGF-related receptor in blood glucose homeostasis. | Role of Delta/Notch-like EGF-related receptor in blood glucose homeostasis.
Ruiz-Otero N, Kuruvilla R., Free PMC Article | 06/12/2023 |
| BET Protein Inhibition Regulates Macrophage Chromatin Accessibility and Microbiota-Dependent Colitis. | BET Protein Inhibition Regulates Macrophage Chromatin Accessibility and Microbiota-Dependent Colitis.
Hoffner O'Connor M, Berglind A, Kennedy Ng MM, Keith BP, Lynch ZJ, Schaner MR, Steinbach EC, Herzog J, Trad OK, Jeck WR, Arthur JC, Simon JM, Sartor RB, Furey TS, Sheikh SZ., Free PMC Article | 04/23/2022 |
| Tadalafil enhances the therapeutic efficacy of BET inhibitors in hepatocellular carcinoma through activating Hippo pathway. | Tadalafil enhances the therapeutic efficacy of BET inhibitors in hepatocellular carcinoma through activating Hippo pathway.
Kong D, Jiang Y, Miao X, Wu Z, Liu H, Gong W. | 01/1/2022 |
| this study shows that BET inhibition modifies melanoma infiltrating T cells and enhances response to PD-L1 blockade | BET Inhibition Modifies Melanoma Infiltrating T Cells and Enhances Response to PD-L1 Blockade.
Nikbakht N, Tiago M, Erkes DA, Chervoneva I, Aplin AE., Free PMC Article | 05/30/2020 |
| DNER is a novel protein induced in COPD patients and 6months CS-exposed mice that regulates IFNgamma secretion via non-canonical Notch in pro-inflammatory recruited macrophages. | The Notch ligand DNER regulates macrophage IFNγ release in chronic obstructive pulmonary disease.
Ballester-López C, Conlon TM, Ertüz Z, Greiffo FR, Irmler M, Verleden SE, Beckers J, Fernandez IE, Eickelberg O, Yildirim AÖ., Free PMC Article | 11/30/2019 |
| Overall, these studies show that BET proteins may have a critical role in asthma pathogenesis by altering type 17 inflammation. | Bromodomain and Extra-Terminal Protein Inhibition Attenuates Neutrophil-dominant Allergic Airway Disease.
Manni ML, Mandalapu S, Salmeron A, Lora JM, Kolls JK, Alcorn JF., Free PMC Article | 11/10/2018 |
| This study showed that the DNER is present in ganglion and amacrine cells on P1, also labeling the horizontal cells by P10. Developing AII amacrine cells exhibit accumulating DNER labeling at the dendritic stalk, labeling that becomes progressively conspicuous by P10, as it is in maturity. | DNER and NFIA are expressed by developing and mature AII amacrine cells in the mouse retina.
Keeley PW, Reese BE., Free PMC Article | 07/28/2018 |
| the present study demonstrated that DNER was expressed in SGNs and appeared to be involved in the mechanisms underlying neuronal polarity and neuritogenesis, via a Notchdependent signaling pathway. | DNER modulates the length, polarity and synaptogenesis of spiral ganglion neurons via the Notch signaling pathway.
Du J, Wang X, Zhang X, Zhang X, Jiang H., Free PMC Article | 07/28/2018 |
| DNER plays a redundant role with other Notch ligands in cochlear development | Delta/notch-like EGF-related receptor (DNER) is expressed in hair cells and neurons in the developing and adult mouse inner ear.
Hartman BH, Nelson BR, Reh TA, Bermingham-McDonogh O., Free PMC Article | 07/26/2010 |
| These observations suggest that pleiotrophin-PTPzeta signaling controls subcellular localization of DNER and thereby regulates neuritogenesis. | Receptor type protein tyrosine phosphatase zeta-pleiotrophin signaling controls endocytic trafficking of DNER that regulates neuritogenesis.
Fukazawa N, Yokoyama S, Eiraku M, Kengaku M, Maeda N., Free PMC Article | 01/21/2010 |
| expression in developing and mature central nervous system | Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons.
Eiraku M, Hirata Y, Takeshima H, Hirano T, Kengaku M. | 01/21/2010 |
| DNER mediates neuron-glia interaction and promotes morphological differentiation of Bergmann glia through Deltex-dependent Notch signaling. | DNER acts as a neuron-specific Notch ligand during Bergmann glial development.
Eiraku M, Tohgo A, Ono K, Kaneko M, Fujishima K, Hirano T, Kengaku M. | 01/21/2010 |