| Upregulation of FHL1, SPNS3, and MPZL2 predicts poor prognosis in pediatric acute myeloid leukemia patients with FLT3-ITD mutation. | Upregulation of FHL1, SPNS3, and MPZL2 predicts poor prognosis in pediatric acute myeloid leukemia patients with FLT3-ITD mutation.
Eshibona N, Giwa A, Rossouw SC, Gamieldien J, Christoffels A, Bendou H. | 08/27/2022 |
| PCBP2 promotes the development of glioma by regulating FHL3/TGF-beta/Smad signaling pathway. | PCBP2 promotes the development of glioma by regulating FHL3/TGF-β/Smad signaling pathway.
Mao J, Sun Z, Cui Y, Du N, Guo H, Wei J, Hao Z, Zheng L., Free PMC Article | 02/6/2021 |
| these findings highlight the role of FHL3 as a stemness-suppressor in regulation of the Smad2/3-SOX4-SOX2 axis in glioma | FHL3 links cell growth and self-renewal by modulating SOX4 in glioma.
Han W, Hu P, Wu F, Wang S, Hu Y, Li S, Jiang T, Qiang B, Peng X., Free PMC Article | 07/11/2020 |
| the present study established a link between Ang and FHL3 proteins and identifies a new pathway for regulating astrocytoma progression. | Angiogenin promotes U87MG cell proliferation by activating NF-κB signaling pathway and downregulating its binding partner FHL3.
Xia W, Fu W, Cai X, Wang M, Chen H, Xing W, Wang Y, Zou M, Xu T, Xu D., Free PMC Article | 01/16/2016 |
| These findings suggest that functional interactions between FHL3 and MT-1X may provide some clues to the mechanisms of FHL3-regulated cell proliferation. | Identification and characterization of MT-1X as a novel FHL3-binding partner.
Cai X, Wang J, Huang X, Fu W, Xia W, Zou M, Wang Y, Wang J, Xu D., Free PMC Article | 06/20/2015 |
| PCBP2 could bind to FHL3 mRNA 3'UTR-A and inhibited the expression of FHL3 in T98G glioms cells | Ribotrap analysis of proteins associated with FHL3 3'untranslated region in glioma cells.
Han W, Xia Q, Yin B, Peng XZ. | 08/30/2014 |
| FHL3 enhances Tax1-mediated activation of the Human T-cell leukemia virus type 1 long terminal repeat (LTR) without affecting basal activity and regulates NF-kappaB activation by Tax1 in a cell-specific manner. | The four and a half LIM family members are novel interactants of the human T-cell leukemia virus type 1 Tax oncoprotein.
McCabe Á, Hashimoto K, Hall WW, Sheehy N., Free PMC Article | 08/31/2013 |
| findings suggest that the interaction between Ang and FHL3 may provide some clues to the mechanisms of Ang-regulated cell growth and apoptosis | Identification and characterization of FHL3 as a novel angiogenin-binding partner.
Xia W, Fu W, Cai L, Kong H, Cai X, Liu J, Wang Y, Zou M, Xu D. | 09/1/2012 |
| FHL3 suppressed anchorage-dependent and -independent growth of human breast cancer cells. | Downregulation and antiproliferative role of FHL3 in breast cancer.
Niu C, Yan Z, Cheng L, Zhu J, Zhang H, Xu X, Lin J, Ye Q. | 07/14/2012 |
| FHL3 does not bind to HIF-1alpha or p300, indicating that it regulates transactivation by a novel molecular mechanism. | Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1.
Hubbi ME, Gilkes DM, Baek JH, Semenza GL., Free PMC Article | 04/28/2012 |
| the second zinc finger motif in LIM4 was responsible for the auto-activation of FHL3. | Identification of the transactivation domain of the human FHL3.
Huang X, Wang JF, Xia WR, Zou MJ, Cai X, Xu DG. | 08/2/2010 |
| Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway. | Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway.
Ding L, Wang Z, Yan J, Yang X, Liu A, Qiu W, Zhu J, Han J, Zhang H, Lin J, Cheng L, Qin X, Niu C, Yuan B, Wang X, Zhu C, Zhou Y, Li J, Song H, Huang C, Ye Q., Free PMC Article | 01/21/2010 |
| FHL2 and FHL3, respectively, are colocalized with alpha(7)beta(1) integrin receptor at the periphery of Z-discs, suggesting a role in mechanical stabilization of muscle cells | The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor.
Samson T, Smyth N, Janetzky S, Wendler O, Müller JM, Schüle R, von der Mark H, von der Mark K, Wixler V. | 01/21/2010 |
| MZF-1 and FHL3 formed a complex of high molecular mass with some additional proteins in the nucleus. Transcriptional repression of FcepsilonRI by MZF-1 required FHL3. | FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF-1.
Takahashi K, Matsumoto C, Ra C., Free PMC Article | 01/21/2010 |
| FHL3 association with MyoD may contribute to the regulation of MyoD-dependent transcription of muscle genes and thereby myogenesis | FHL3 binds MyoD and negatively regulates myotube formation.
Cottle DL, McGrath MJ, Cowling BS, Coghill ID, Brown S, Mitchell CA. | 01/21/2010 |
| Data show that FHL3 (human four-and-a-half LIM-only protein 3) interacts with human phosphatase CDC25B in the cell nucleus. | LIM-only protein FHL3 interacts with CDC25B2 phosphatase.
Mils V, Lee SM, Joly W, Hang EW, Baldin V, Waye MM, Ducommun B, Tsui SK. | 01/21/2010 |