| A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network. | A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network.
Broman MT, Nadadur RD, Perez-Cervantes C, Burnicka-Turek O, Lazarevic S, Gams A, Laforest B, Steimle JD, Iddir S, Wang Z, Smith L, Mazurek SR, Olivey HE, Zhou P, Gadek M, Shen KM, Khan Z, Theisen JWM, Yang XH, Ikegami K, Efimov IR, Pu WT, Weber CR, McNally EM, Svensson EC, Moskowitz IP., | 04/16/2024 |
| The integrity of the FOG-2 LXCXE pRb-binding motif is required for small intestine homeostasis. | The integrity of the FOG-2 LXCXE pRb-binding motif is required for small intestine homeostasis.
Goupille O, Kadri Z, Langelé A, Luccantoni S, Badoual C, Leboulch P, Chrétien S. | 08/13/2020 |
| Fog2Rb-/Rb- mice are resistant to obesity and present abnormal WAT/BAT conversion. | The LXCXE Retinoblastoma Protein-Binding Motif of FOG-2 Regulates Adipogenesis.
Goupille O, Penglong T, Kadri Z, Granger-Locatelli M, Denis R, Luquet S, Badoual C, Fucharoen S, Maouche-Chrétien L, Leboulch P, Chrétien S. | 07/21/2018 |
| identified key controls over corticothalamic projection neurons (CThPN) development and identify Fog2 as a critical control over CThPN diversity | Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity.
Galazo MJ, Emsley JG, Macklis JD., Free PMC Article | 08/26/2017 |
| FOG2 liver-specific knockout mice they exhibit enhanced insulin sensitivity and elevated hepatic TG accumulation, which were also reversed by Ad-PPARalpha. The results demonstrate a novel function of hepatic FOG2 in insulin sensitivity and lipid metabolism through PPARalpha. | A Novel Function of Hepatic FOG2 in Insulin Sensitivity and Lipid Metabolism Through PPARα.
Guo Y, Yu J, Deng J, Liu B, Xiao Y, Li K, Xiao F, Yuan F, Liu Y, Chen S, Guo F. | 06/10/2017 |
| Hypoxia-induced microRNA-429 promotes differentiation of osteoblastic cells by mediating ZFPM2 expression. | Hypoxia-Induced MicroRNA-429 Promotes Differentiation of MC3T3-E1 Osteoblastic Cells by Mediating ZFPM2 Expression.
Huang J, Peng J, Cao G, Lu S, Liu L, Li Z, Zhou M, Feng M, Shen H. | 02/4/2017 |
| MicroRNA-200c Promotes Suppressive Potential of Myeloid-Derived Suppressor Cells by Modulating PTEN and FOG2 Expression | MicroRNA-200c Promotes Suppressive Potential of Myeloid-Derived Suppressor Cells by Modulating PTEN and FOG2 Expression.
Mei S, Xin J, Liu Y, Zhang Y, Liang X, Su X, Yan H, Huang Y, Yang R., Free PMC Article | 05/14/2016 |
| Results indicate that FOG-2/NuRD interaction is required for cardiomyocyte proliferation. | FOG-2 mediated recruitment of the NuRD complex regulates cardiomyocyte proliferation during heart development.
Garnatz AS, Gao Z, Broman M, Martens S, Earley JU, Svensson EC., Free PMC Article | 12/20/2014 |
| ATOH8, GATA4, and FOG2 associate in a single complex | The transcription factor Atonal homolog 8 regulates Gata4 and Friend of Gata-2 during vertebrate development.
Rawnsley DR, Xiao J, Lee JS, Liu X, Mericko-Ishizuka P, Kumar V, He J, Basu A, Lu M, Lynn FC, Pack M, Gasa R, Kahn ML., Free PMC Article | 11/16/2013 |
| regulation of ovarian differentiation is dependent upon GATA4 but not FOG2 | The transcription factor GATA4 is required for follicular development and normal ovarian function.
Efimenko E, Padua MB, Manuylov NL, Fox SC, Morse DA, Tevosian SG., Free PMC Article | 11/2/2013 |
| data suggest a new mechanism for TGF-beta-induced Akt activation through FOG2 down-regulation by miR-200b/c, which can lead to glomerular mesangial hypertrophy in the progression of diabetic nephropathy | FOG2 protein down-regulation by transforming growth factor-β1-induced microRNA-200b/c leads to Akt kinase activation and glomerular mesangial hypertrophy related to diabetic nephropathy.
Park JT, Kato M, Yuan H, Castro N, Lanting L, Wang M, Natarajan R., Free PMC Article | 10/26/2013 |
| a new dynamics in which GATA-4 may alter the activity of FOG-2 by influencing its SUMOylation status | SUMOylation regulates the transcriptional repression activity of FOG-2 and its association with GATA-4.
Perdomo J, Jiang XM, Carter DR, Khachigian LM, Chong BH., Free PMC Article | 05/25/2013 |
| gonadal loss of Fog2 resulted in an early partial block in male pathway and sex reversal | Conditional ablation of Gata4 and Fog2 genes in mice reveals their distinct roles in mammalian sexual differentiation.
Manuylov NL, Zhou B, Ma Q, Fox SC, Pu WT, Tevosian SG., Free PMC Article | 07/2/2011 |
| Data show that cardiac expression of slow skeletal troponin T (Tnnt1) strictly depends on the physical interaction between GATA4-FOG2 in the myocardium of both atria and ventricles. | Cardiac expression of Tnnt1 requires the GATA4-FOG2 transcription complex.
Manuylov NL, Tevosian SG., Free PMC Article | 01/21/2010 |
| FOG2 regulates adult heart function and coronary angiogenesis | Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart.
Zhou B, Ma Q, Kong SW, Hu Y, Campbell PH, McGowan FX, Ackerman KG, Wu B, Zhou B, Tevosian SG, Pu WT., Free PMC Article | 01/21/2010 |
| Control of ovarian development by the GATA4-FOG2 complex presents a novel insight into the cross-talk between transcriptional regulation and extracellular signaling that occurs in ovarian development | Ovarian development in mice requires the GATA4-FOG2 transcription complex.
Manuylov NL, Smagulova FO, Leach L, Tevosian SG. | 01/21/2010 |
| SERCA2 is an important target of FOG-2 and that increased FOG-2 expression may contribute to a decline in cardiac function in end-stage heart failure by impaired T3 signaling | Increased FOG-2 in failing myocardium disrupts thyroid hormone-dependent SERCA2 gene transcription.
Rouf R, Greytak S, Wooten EC, Wu J, Boltax J, Picard M, Svensson EC, Dillmann WH, Patten RD, Huggins GS., Free PMC Article | 01/21/2010 |
| the Lhx9 gene represents the first direct target of the GATA4/FOG2 repressor complex in cardiac development. | GATA4/FOG2 transcriptional complex regulates Lhx9 gene expression in murine heart development.
Smagulova FO, Manuylov NL, Leach LL, Tevosian SG., Free PMC Article | 01/21/2010 |
| Fog2 transcription factors are haploinsufficient for testis determination in mice | Correct dosage of Fog2 and Gata4 transcription factors is critical for fetal testis development in mice.
Bouma GJ, Washburn LL, Albrecht KH, Eicher EM., Free PMC Article | 01/21/2010 |
| implicates FOG2 in the maintenance of epithelial cell differentiation in the mammary gland and in performing a protective role in breast cancer | Fog2 excision in mice leads to premature mammary gland involution and reduced Esr1 gene expression.
Manuylov NL, Smagulova FO, Tevosian SG. | 01/21/2010 |
| FOG2 is a limiting factor in the formation of a functional GATA4/FOG2 transcription complex that is required for Sox9 expression during gonadogenesis. | The regulation of Sox9 gene expression by the GATA4/FOG2 transcriptional complex in dominant XX sex reversal mouse models.
Manuylov NL, Fujiwara Y, Adameyko II, Poulat F, Tevosian SG., Free PMC Article | 01/21/2010 |
| FOG-2 null mouse embryos had thin compact myocardium, higher EDP and E/A ratio, smaller -dP/dt, and decreased sucking pressure than wild littermates, indicating that decreased ventricular diastolic function might be the main cause of embryonic lethality | Developmental changes in ventricular diastolic function correlate with changes in ventricular myoarchitecture in normal mouse embryos.
Ishiwata T, Nakazawa M, Pu WT, Tevosian SG, Izumo S. | 01/21/2010 |
| A Fog2-Gata4 interaction is critical for the development of normal pulmonary lobar structure, and this phenotype is not influenced by the additional loss of Gata6 interaction. | Gata4 is necessary for normal pulmonary lobar development.
Ackerman KG, Wang J, Luo L, Fujiwara Y, Orkin SH, Beier DR., Free PMC Article | 01/21/2010 |
| FOG-2, in addition to GATA-4, has a role in early gonadal development and sexual differentiation, and FOG-1 at later fetal stages, while GATA-1 executes its action postnatally | Developmental expression and spermatogenic stage specificity of transcription factors GATA-1 and GATA-4 and their cofactors FOG-1 and FOG-2 in the mouse testis.
Ketola I, Anttonen M, Vaskivuo T, Tapanainen JS, Toppari J, Heikinheimo M. | 01/21/2010 |
| Results suggest that FOG-2 repressive activity may be modulated by the generation of isoforms of FOG-2 lacking the FOG repression motif. | An alternative transcript of the FOG-2 gene encodes a FOG-2 isoform lacking the FOG repression motif.
Dale RM, Remo BF, Svensson EC., Free PMC Article | 01/21/2010 |