| S100A6 drives lymphatic metastasis of liver cancer via activation of the RAGE/NF-kB/VEGF-D pathway. | S100A6 drives lymphatic metastasis of liver cancer via activation of the RAGE/NF-kB/VEGF-D pathway.
Chen T, Ruan Y, Ji L, Cai J, Tong M, Xue Y, Zhao H, Cai X, Xu J. | 03/26/2024 |
| Vascular endothelial growth factor-D plasma levels in fluid overload and cardiac function evaluation of elderly patients with cardiovascular disease. | Vascular endothelial growth factor-D plasma levels in fluid overload and cardiac function evaluation of elderly patients with cardiovascular disease.
Li J, Li XL, Liu FH, Yu YF, Du Y., Free PMC Article | 11/27/2023 |
| Vascular Endothelial Growth Factor-D (VEGF-D): An Angiogenesis Bypass in Malignant Tumors. | Vascular Endothelial Growth Factor-D (VEGF-D): An Angiogenesis Bypass in Malignant Tumors.
Bokhari SMZ, Hamar P., Free PMC Article | 09/18/2023 |
| Vascular endothelial growth factor-D plasma levels and VEGFD genetic variants are independently associated with outcomes in patients with cardiovascular disease. | Vascular endothelial growth factor-D plasma levels and VEGFD genetic variants are independently associated with outcomes in patients with cardiovascular disease.
Davidsson P, Eketjäll S, Eriksson N, Walentinsson A, Becker RC, Cavallin A, Bogstedt A, Collén A, Held C, James S, Siegbahn A, Stewart R, Storey RF, White H, Wallentin L. | 09/12/2023 |
| Serum VEGF-D level is correlated with renal dysfunction and proteinuria in patients with diabetic chronic kidney disease. | Serum VEGF-D level is correlated with renal dysfunction and proteinuria in patients with diabetic chronic kidney disease.
Nguyen TTU, Kim H, Chae YJ, Jung JH, Kim W., Free PMC Article | 04/16/2022 |
| VEGF-D-mediated signaling in tendon cells is involved in degenerative processes. | VEGF-D-mediated signaling in tendon cells is involved in degenerative processes.
Tempfer H, Spitzer G, Lehner C, Wagner A, Gehwolf R, Fierlbeck J, Weissenbacher N, Jessen M, Heindl LM, Traweger A. | 02/19/2022 |
| circEHBP1 promotes lymphangiogenesis and lymphatic metastasis of bladder cancer via miR-130a-3p/TGFbetaR1/VEGF-D signaling. | circEHBP1 promotes lymphangiogenesis and lymphatic metastasis of bladder cancer via miR-130a-3p/TGFβR1/VEGF-D signaling.
Zhu J, Luo Y, Zhao Y, Kong Y, Zheng H, Li Y, Gao B, Ai L, Huang H, Huang J, Li Z, Chen C., Free PMC Article | 12/4/2021 |
| Methacholine reactivity in lymphangioleiomyomatosis is inversely related to FEV1 and VEGF-D. | Methacholine reactivity in lymphangioleiomyomatosis is inversely related to FEV(1) and VEGF-D.
Cassandro R, Elia D, Caminati A, Pacheco-Rodriguez G, Stylianou M, Moss J, Harari S. | 08/21/2021 |
| Vascular endothelial growth factor D is a biomarker of fluid overload in haemodialysis patients. | Vascular endothelial growth factor D is a biomarker of fluid overload in haemodialysis patients.
von Moos S, Segerer S, Davenport A, Sadoune M, Gerritsen K, Pottecher J, Ruschitzka F, Mebazaa A, Arrigo M, Cippà PE. | 05/22/2021 |
| A multi-institutional phase 2 trial of regorafenib in refractory advanced biliary tract cancer. | A multi-institutional phase 2 trial of regorafenib in refractory advanced biliary tract cancer.
Kim RD, Sanoff HK, Poklepovic AS, Soares H, Kim J, Lyu J, Liu Y, Nixon AB, Kim DW., Free PMC Article | 05/22/2021 |
| Distinct Characteristics of VEGF-D and VEGF-C to Predict Mortality in Patients With Suspected or Known Coronary Artery Disease. | Distinct Characteristics of VEGF-D and VEGF-C to Predict Mortality in Patients With Suspected or Known Coronary Artery Disease.
Wada H, Suzuki M, Matsuda M, Ajiro Y, Shinozaki T, Sakagami S, Yonezawa K, Shimizu M, Funada J, Takenaka T, Morita Y, Nakamura T, Fujimoto K, Matsubara H, Kato T, Unoki T, Takagi D, Wada K, Wada M, Iguchi M, Masunaga N, Ishii M, Yamakage H, Kusakabe T, Yasoda A, Shimatsu A, Kotani K, Satoh-Asahara N, Abe M, Akao M, Hasegawa K, ANOX Study Investigators., Free PMC Article | 03/13/2021 |
| Elevated plasma tyrosine kinases VEGF-D and HER4 in heart failure patients decrease after heart transplantation in association with improved haemodynamics. | Elevated plasma tyrosine kinases VEGF-D and HER4 in heart failure patients decrease after heart transplantation in association with improved haemodynamics.
Ahmed S, Ahmed A, Säleby J, Bouzina H, Lundgren J, Rådegran G., Free PMC Article | 12/12/2020 |
| SIRT2 modulates VEGFD-associated lymphangiogenesis by deacetylating EPAS1 in human head and neck cancer. | SIRT2 modulates VEGFD-associated lymphangiogenesis by deacetylating EPAS1 in human head and neck cancer.
Hu A, Yang LY, Liang J, Lu D, Zhang JL, Cao FF, Fu JY, Dai WJ, Zhang JF. | 12/5/2020 |
| No correlation was detected between VEGF-C and VEGF-D immunoexpression in relation to lymphatic tumor density and endothelial lymphatic proliferation. | Analyses of VEGFC/VEGF-D expressions, density and endothelial lymphatic proliferation in salivary gland neoplasms.
Barroso KMA, De Andrade Santos PP, da Silva LP, Nonaka CFW, Craveiro Sarmento AS, Pereira Pinto L, Souza LB. | 07/25/2020 |
| Here the authors describe a novel, unique VEGF-C form in the human reproductive system produced via cleavage by kallikrein-related peptidase 3 (KLK3), aka prostate-specific antigen (PSA). Using mass spectrometric analysis of the isolated VEGF-C-cleaving activity from human saliva, we identified cathepsin D as a protease that can activate VEGF-C as well as VEGF-D. | KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D.
Jha SK, Rauniyar K, Chronowska E, Mattonet K, Maina EW, Koistinen H, Stenman UH, Alitalo K, Jeltsch M., Free PMC Article | 02/22/2020 |
| VEGF-D is weakly associated with lung function impairment and strongly associated with lymphatic involvement in lymphangioleiomyomatosis. | Concentration of Serum Vascular Endothelial Growth Factor (VEGF-D) and Its Correlation with Functional and Clinical Parameters in Patients with Lymphangioleiomyomatosis from a Brazilian Reference Center.
Amaral AF, de Oliveira MR, Dias OM, Arimura FE, Freitas CSG, Acencio MMP, de Alvarenga VA, Kairalla RA, Carvalho CRR, Baldi BG, Tuberous Sclerosis, Lymphangioleiomyomatosis and Angiomyolipoma Study Group, Universidade de Sao Paulo, Brazil. | 02/1/2020 |
| Pre-treatment with the recombinant HMGB1 (rHMGB1) markedly abolished curcumin-reduced VEGF-D expression. | Curcumin inhibits the lymphangiogenesis of gastric cancer cells by inhibiton of HMGB1/VEGF-D signaling.
Da W, Zhang J, Zhang R, Zhu J., Free PMC Article | 01/25/2020 |
| The expressions of VEGF receptors and their ligands significantly differed between malignant ovarian tumors and paired distant metastases. VEGF-A, VEGF-D, and VEGFR1 protein expressions seem to be higher in distant metastases than in the primary high grade serous ovarian cancer lesions. | Expression profiles of VEGF-A, VEGF-D and VEGFR1 are higher in distant metastases than in matched primary high grade epithelial ovarian cancer.
Sopo M, Anttila M, Hämäläinen K, Kivelä A, Ylä-Herttuala S, Kosma VM, Keski-Nisula L, Sallinen H., Free PMC Article | 11/30/2019 |
| Data indicate that the detection of vascular endothelial growth factor-D (VEGF-D) levels in bronchoalveolar lavage fluid (BALF) is a valuable diagnostic tool for lung squamous carcinoma. | Vascular Endothelial Growth Factor-D (VEGF-D) is Elevated in Bronchoalveolar Lavage Fluid of Patients with Lung Squamous Carcinoma.
Lv D, Tan L, Zhang Q, Ma H, Zhang Y, Zhang Q, Yu Y, Chen Z, Ding Q, Deng Z. | 11/30/2019 |
| The RAISE biomarker program identified VEGF-D as a potential predictive biomarker for ramucirumab efficacy in second-line metastatic colorectal cancer treatment | Analysis of angiogenesis biomarkers for ramucirumab efficacy in patients with metastatic colorectal cancer from RAISE, a global, randomized, double-blind, phase III study.
Tabernero J, Hozak RR, Yoshino T, Cohn AL, Obermannova R, Bodoky G, Garcia-Carbonero R, Ciuleanu TE, Portnoy DC, Prausová J, Muro K, Siegel RW, Konrad RJ, Ouyang H, Melemed SA, Ferry D, Nasroulah F, Van Cutsem E., Free PMC Article | 04/13/2019 |
| SPARC expression was inversely associated with the degree of malignancy and it had a negative correlation with VEGF-C and VEGF-D expression. Results suggest SPARC might function as a tumor suppressor inhibiting angiogenesis and lymphangiogenesis in ovarian cancer by reducing the expression of VEGF-C and VEGF-D. | SPARC suppresses lymph node metastasis by regulating the expression of VEGFs in ovarian carcinoma.
Peng F, Zhong Y, Liu Y, Zhang Y, Xie Y, Lu Y, Zhang X, Li D. | 07/28/2018 |
| Serum VEGF-D levels were significantly increased in definite lymphangioleiomyomatosis (LAM) patients compared with healthy controls. Serum VEGF-D levels were significantly increased in definite LAM patients who had chylothorax compared with those without chylothorax. | Diagnostic and Treatment Monitoring Potential of Serum Vascular Endothelial Growth Factor-D in Lymphangioleiomyomatosis.
Mou Y, Ye L, Wang J, Yee MS, Song YL, Zhu L, Jin ML. | 07/14/2018 |
| no difference in the levels of VEGF-A, VEGF-C, and VEGF-D in pre-eclampsia compared to normotensive pregnant women stratified by HIV status | Effect of vascular endothelial growth factors A, C, and D in HIV-associated pre-eclampsia.
Shange GP, Moodley J, Naicker T. | 04/14/2018 |
| CXCR4, CCR7, VEGF-C and VEGF-D expression might have synergistic effects on the lymph node metastasis in patients with cervical cancer. | Association of CXCR4, CCR7, VEGF-C and VEGF-D expression with lymph node metastasis in patients with cervical cancer.
Dai Y, Tong R, Guo H, Yu T, Wang C. | 03/17/2018 |
| VEGF-D-induced changes in serine/threonine kinase mTOR shuttling between the cytosol and nucleus and its increased phosphorylation at Ser-2448, lead us to the conclusion that the observed shift in redox balance is regulated via mTOR kinase signalling. | Vascular endothelial growth factor-D modulates oxidant-antioxidant balance of human vascular endothelial cells.
Papiewska-Pająk I, Balcerczyk A, Stec-Martyna E, Koziołkiewicz W, Boncela J., Free PMC Article | 02/24/2018 |