| Interaction between the mitochondrial adaptor MIRO and the motor adaptor TRAK. | Interaction between the mitochondrial adaptor MIRO and the motor adaptor TRAK.
Baltrusaitis EE, Ravitch EE, Fenton AR, Perez TA, Holzbaur ELF, Dominguez R., Free PMC Article | 01/3/2024 |
| Recurrent TRAK1::RAF1 Fusions in pediatric low-grade gliomas. | Recurrent TRAK1::RAF1 Fusions in pediatric low-grade gliomas.
Benhamida JK, Harmsen HJ, Ma D, William CM, Li BK, Villafania L, Sukhadia P, Mullaney KA, Dewan MC, Vakiani E, Karajannis MA, Snuderl M, Zagzag D, Ladanyi M, Rosenblum MK, Bale TA., Free PMC Article | 08/31/2023 |
| TRAK1-Mediated Abnormality of Mitochondrial Fission Increases Seizure Susceptibility in Temporal Lobe Epilepsy. | TRAK1-Mediated Abnormality of Mitochondrial Fission Increases Seizure Susceptibility in Temporal Lobe Epilepsy.
Wu H, Liu Y, Li H, Du C, Li K, Dong S, Meng Q, Zhang H. | 10/16/2021 |
| Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments. | Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments.
Henrichs V, Grycova L, Barinka C, Nahacka Z, Neuzil J, Diez S, Rohlena J, Braun M, Lansky Z., Free PMC Article | 08/29/2020 |
| The findings uncover a novel function of Trak1 as a regulator of mitochondrial fusion and provide evidence linking dysregulated mitochondrial dynamics to hypertonia pathogenesis. | Hypertonia-linked protein Trak1 functions with mitofusins to promote mitochondrial tethering and fusion.
Lee CA, Chin LS, Li L., Free PMC Article | 06/15/2019 |
| Data show that the ADP-ribosylation factor 6 (Arf6)-trafficking kinesin protein 1 (trak1) promote the anterograde trafficking of mitochondria. | Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe.
Onodera Y, Nam JM, Horikawa M, Shirato H, Sabe H., Free PMC Article | 12/22/2018 |
| This study confirms the role of TRAK1 in mitochondrial dynamics and constitutes the first report of this gene in association with a severe neurodevelopmental disorder. | Deleterious variants in TRAK1 disrupt mitochondrial movement and cause fatal encephalopathy.
Barel O, Malicdan MCV, Ben-Zeev B, Kandel J, Pri-Chen H, Stephen J, Castro IG, Metz J, Atawa O, Moshkovitz S, Ganelin E, Barshack I, Polak-Charcon S, Nass D, Marek-Yagel D, Amariglio N, Shalva N, Vilboux T, Ferreira C, Pode-Shakked B, Heimer G, Hoffmann C, Yardeni T, Nissenkorn A, Avivi C, Eyal E, Kol N, Glick Saar E, Wallace DC, Gahl WA, Rechavi G, Schrader M, Eckmann DM, Anikster Y., Free PMC Article | 06/3/2017 |
| This study showed that the TRAK1 was prevalently localized in axons of hippocampal and cortical neurons. | Localization of the kinesin adaptor proteins trafficking kinesin proteins 1 and 2 in primary cultures of hippocampal pyramidal and cortical neurons.
Loss O, Stephenson FA. | 02/6/2016 |
| Data suggest that vitamin D receptor target genes (TRAK1; DUSP10, dual specificity phosphatase 10; NRIP1, nuclear receptor interacting protein 1; THBD, thrombomodulin) can be used as markers for individual's response to vitamin D3 supplements. | Changes in vitamin D target gene expression in adipose tissue monitor the vitamin D response of human individuals.
Ryynänen J, Neme A, Tuomainen TP, Virtanen JK, Voutilainen S, Nurmi T, de Mello VD, Uusitupa M, Carlberg C. | 06/6/2015 |
| By mapping and mutating four key sites of GlcNAc addition in hMilton1 (hMilton1Qmut), study demonstrated that Milton is the key and essential substrate through which OGT inhibits mitochondrial motility. | Glucose regulates mitochondrial motility via Milton modification by O-GlcNAc transferase.
Pekkurnaz G, Trinidad JC, Wang X, Kong D, Schwarz TL., Free PMC Article | 09/20/2014 |
| Details of a robust association of DISC1 with mitochondrial transport complexes containing TRAK1 and Miro1. | DISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial trafficking.
Ogawa F, Malavasi EL, Crummie DK, Eykelenboom JE, Soares DC, Mackie S, Porteous DJ, Millar JK., Free PMC Article | 09/13/2014 |
| The results of this study established a key role for mammalian TRAK1 proteins in axonal and dendritic targeting of mitochondria. | TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites.
van Spronsen M, Mikhaylova M, Lipka J, Schlager MA, van den Heuvel DJ, Kuijpers M, Wulf PS, Keijzer N, Demmers J, Kapitein LC, Jaarsma D, Gerritsen HC, Akhmanova A, Hoogenraad CC. | 04/13/2013 |
| MGb2-Ag/TRAK1 may play an important role in the development of colorectal cancer (CRC) and may be a valuable prognostic indicator of CRC. | Elevated expression of MGb2-Ag/TRAK1 is correlated with poor prognosis in patients with colorectal cancer.
An Y, Zhou Y, Ren G, Tian Q, Lu Y, Li H, Li K, Su T, Xu B, Chen S, Wang T, Zhang X, Nie Y, Wang X, Zhao Q. | 02/11/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| TRAK1/MGb2-Ag is a promising diagnostic marker for gastric cancer and may help to detect signet-ring cell carcinoma and mucinous adenocarcinoma | Identification of TRAK1 (Trafficking protein, kinesin-binding 1) as MGb2-Ag: a novel cancer biomarker.
Zhang F, Ren G, Lu Y, Jin B, Wang J, Chen X, Liu Z, Li K, Nie Y, Wang X, Fan D. | 01/21/2010 |
| Data show that Trak1 interacts with hepatocyte-growth-factor-regulated tyrosine kinase substrate (Hrs), an essential component of the endosomal sorting and trafficking machinery. | Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking.
Webber E, Li L, Chin LS., Free PMC Article | 01/21/2010 |
| GRIF-1 and OIP106 have roles in protein and/or organelle transport in excitable cells in a manner analogous to glutamate receptor-interacting-protein 1 | GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin.
Brickley K, Smith MJ, Beck M, Stephenson FA. | 01/21/2010 |