| MSRB2 Ameliorates H2O2-induced Chondrocyte Oxidative Stress and Suppresses Apoptosis in Osteoarthritis. | MSRB2 Ameliorates H(2)O(2)-induced Chondrocyte Oxidative Stress and Suppresses Apoptosis in Osteoarthritis.
Huang K, Fu W, Wang A, Du G, Tang H, Yin L, Yin Z, Gao W. | 10/25/2024 |
| Release of the enzyme MsrB2 from damaged mitochondria, initiating autophagosome formation, represents a novel regulatory mechanism for oxidative stress-induced mitophagy. | Mitochondrial MsrB2 serves as a switch and transducer for mitophagy.
Lee SH, Lee S, Du J, Jain K, Ding M, Kadado AJ, Atteya G, Jaji Z, Tyagi T, Kim WH, Herzog RI, Patel A, Ionescu CN, Martin KA, Hwa J., Free PMC Article | 05/9/2020 |
| the role for mitochondrial MSRB2 in Alzheimer's disease pathology is indispensible. | Mitochondrial methionine sulfoxide reductase B2 links oxidative stress to Alzheimer's disease-like pathology.
Xiang XJ, Song L, Deng XJ, Tang Y, Min Z, Luo B, Wen QX, Li KY, Chen J, Ma YL, Zhu BL, Yan Z, Chen GJ. | 03/7/2020 |
| this study we have identified, for the first time, compounds structurally related to the natural products fusaricidins that markedly activate recombinant bovine and human MsrA and human MsrB. | Identification of activators of methionine sulfoxide reductases A and B.
Cudic P, Joshi N, Sagher D, Williams BT, Stawikowski MJ, Weissbach H., Free PMC Article | 05/28/2016 |
| Silencing the expression of the main Msr elements-MsrA, MsrB1, or MsrB2 exacerbates sensitivity toward oxidative stress. | Proteome alteration in oxidative stress-sensitive methionine sulfoxide reductase-silenced HEK293 cells.
Ugarte N, Ladouce R, Radjei S, Gareil M, Friguet B, Petropoulos I. | 07/25/2015 |
| the mitochondrial methionine-R-sulfoxide reductase B2 (MSRB2) is a specific interaction partner of LG72. | Identification of the mitochondrial MSRB2 as a binding partner of LG72.
Otte DM, Raskó T, Wang M, Dreiseidler M, Drews E, Schrage H, Wojtalla A, Höhfeld J, Wanker E, Zimmer A. | 06/20/2015 |
| Data show that glutaredoxin acts as a reductant for methionine sulfoxide reductases A and B (MsrA and MsrB) with or without resolving cysteine. | Glutaredoxin serves as a reductant for methionine sulfoxide reductases with or without resolving cysteine.
Kim HY. | 11/3/2012 |
| MSR enzymes are differentially expressed in human skin. | Differential expression of the antioxidant repair enzyme methionine sulfoxide reductase (MSRA and MSRB) in human skin.
Taungjaruwinai WM, Bhawan J, Keady M, Thiele JJ. | 01/21/2010 |
| almost absent catalase and methionine sulfoxide reductase A and B protein expression in human gray/white scalp hair shafts in association with a functional loss of methionine sulfoxide repair in the entire gray hair follicle | Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair.
Wood JM, Decker H, Hartmann H, Chavan B, Rokos H, Spencer JD, Hasse S, Thornton MJ, Shalbaf M, Paus R, Schallreuter KU. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (4) articlesGenetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.
Starr JM, Shiels PG, Harris SE, Pattie A, Pearce MS, Relton CL, Deary IJ. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
Harris SE, Fox H, Wright AF, Hayward C, Starr JM, Whalley LJ, Deary IJ. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A. | 11/19/2008 |
| upon oxidative stress, the overexpression of methionine sulfoxide reductase B2 leads to the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role | Overexpression of mitochondrial methionine sulfoxide reductase B2 protects leukemia cells from oxidative stress-induced cell death and protein damage.
Cabreiro F, Picot CR, Perichon M, Castel J, Friguet B, Petropoulos I. | 01/21/2010 |
| Methionine sulfoxide reductases A and B are seriously affected by hydrogen peroxide accumulation in acute vitiligo. | Methionine sulfoxide reductases A and B are deactivated by hydrogen peroxide (H2O2) in the epidermis of patients with vitiligo.
Schallreuter KU, Rübsam K, Gibbons NC, Maitland DJ, Chavan B, Zothner C, Rokos H, Wood JM. | 01/21/2010 |
| hMSRB2 expression was weak in brain, but strong in heart, skeletal muscle, and smooth muscle-containing organs (digestive system, bladder), lung and aorta, while hMSRB1 displayed a higher expression in liver and kidney | A second human methionine sulfoxide reductase (hMSRB2) reducing methionine-R-sulfoxide displays a tissue expression pattern distinct from hMSRB1.
Hansel A, Jung S, Hoshi T, Heinemann SH. | 01/21/2010 |
| showed the expression and function of both sulfoxide reductases together with thioredoxin reductase in the cytosol as well as in the nucleus of epidermal melanocytes which are especially sensitive to reactive oxygen | Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus.
Schallreuter KU, Rübsam K, Chavan B, Zothner C, Gillbro JM, Spencer JD, Wood JM. | 01/21/2010 |
| MSRB is down-regulated during cell aging. | The peptide methionine sulfoxide reductases, MsrA and MsrB (hCBS-1), are downregulated during replicative senescence of human WI-38 fibroblasts.
Picot CR, Perichon M, Cintrat JC, Friguet B, Petropoulos I. | 01/21/2010 |
| CBS1, a methionine sulfoxide reductase of type B, is most abundant in muscle tissues, especially in the heart and thereby shows an expression pattern different to the human methionine sulfoxide reductase A | Activity, tissue distribution and site-directed mutagenesis of a human peptide methionine sulfoxide reductase of type B: hCBS1.
Jung S, Hansel A, Kasperczyk H, Hoshi T, Heinemann SH. | 01/21/2010 |