| Rab18 maintains homeostasis of subcutaneous adipose tissue to prevent obesity-induced metabolic disorders. | Rab18 maintains homeostasis of subcutaneous adipose tissue to prevent obesity-induced metabolic disorders.
Liu J, Li L, Xu D, Li Y, Chen T, Liu Y, Bao Y, Wang Y, Yang L, Li P, Xu L. | 10/25/2024 |
| 2'3'-cGAMP interactome identifies 2'3'-cGAMP/Rab18/FosB signaling in cell migration control independent of innate immunity. | 2'3'-cGAMP interactome identifies 2'3'-cGAMP/Rab18/FosB signaling in cell migration control independent of innate immunity.
Deng Y, Hahn Q, Yu L, Zhu Z, Boyer JA, Wang J, Kong D, Carey LM, Hepperla AJ, Simon JM, Temple B, Zhang Z, Zhang Y, Santos C, Frank JE, Herring LE, Wang X, Dokholyan NV, Campbell SL, Baldwin AS, Damania B, Zhang Q, Liu P., Free PMC Article | 10/23/2024 |
| Rab18 Drift in Lipid Droplet and Endoplasmic Reticulum Interactions of Adipocytes under Obesogenic Conditions. | Rab18 Drift in Lipid Droplet and Endoplasmic Reticulum Interactions of Adipocytes under Obesogenic Conditions.
López-Alcalá J, Soler-Vázquez MC, Tercero-Alcázar C, Sánchez-Ceinos J, Guzmán-Ruiz R, Malagón MM, Gordon A., Free PMC Article | 01/9/2024 |
| Rab18 interacted with V-set and immunoglobulin domain-containing 4 (VSIG4) to involve in the apoptosis of glioma and the sensitivity to temozolomide. | Rab18 interacted with V-set and immunoglobulin domain-containing 4 (VSIG4) to involve in the apoptosis of glioma and the sensitivity to temozolomide.
Yang K, Wang Z., Free PMC Article | 12/4/2021 |
| Micro and Martsolf syndromes in 34 new patients: Refining the phenotypic spectrum and further molecular insights. | Micro and Martsolf syndromes in 34 new patients: Refining the phenotypic spectrum and further molecular insights.
Abdel-Hamid MS, Abdel-Ghafar SF, Ismail SR, Desouky LM, Issa MY, Effat LK, Zaki MS. | 08/21/2021 |
| The Warburg Micro Syndrome-associated Rab3GAP-Rab18 module promotes autolysosome maturation through the Vps34 Complex I. | The Warburg Micro Syndrome-associated Rab3GAP-Rab18 module promotes autolysosome maturation through the Vps34 Complex I.
Takáts S, Lévay L, Boda A, Tóth S, Simon-Vecsei Z, Rubics A, Varga Á, Lippai M, Lőrincz P, Glatz G, Juhász G. | 06/19/2021 |
| Rab18 regulates focal adhesion dynamics by interacting with kinectin-1 at the endoplasmic reticulum. | Rab18 regulates focal adhesion dynamics by interacting with kinectin-1 at the endoplasmic reticulum.
Guadagno NA, Margiotta A, Bjørnestad SA, Haugen LH, Kjos I, Xu X, Hu X, Bakke O, Margadant F, Progida C., Free PMC Article | 03/20/2021 |
| Rab18 plays a role upstream of the cytosolic lipolytic enzyme adipose triglyceride lipase (ATGL) and that recruitment of ATGL by Rab18 is mediated by elements of the Arf/GBF1 machinery. We find that Arf4-GFP is accumulated on the subset of lipid droplets associated with Rab18. | Rab18 regulates lipolysis via Arf/GBF1 and adipose triglyceride lipase.
Dejgaard SY, Presley JF. | 07/18/2020 |
| The study elucidates a role for RAB18 in autophagy and regulation of proteostasis in human stellate cells. | RAB18 modulates autophagy in human stellate cells.
BasuRay S. | 07/11/2020 |
| Studies suggest that rab GTP-binding protein Rab18 (Rab18) functions related to organelle tethering and to autophagy [Review]. | Rab18: new insights into the function of an essential protein.
Dejgaard SY, Presley JF., Free PMC Article | 06/1/2019 |
| Rab18 is not a general, necessary component of the protein machinery involved in lipid droplet biogenesis or turnover. | Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells.
Jayson CBK, Arlt H, Fischer AW, Lai ZW, Farese RV Jr, Walther TC., Free PMC Article | 05/4/2019 |
| The authors found that the previously documented interaction between TRAPPII and COPI was also required for the recruitment of Rab18 to the lipid droplet. | COPI-TRAPPII activates Rab18 and regulates its lipid droplet association.
Li C, Luo X, Zhao S, Siu GK, Liang Y, Chan HC, Satoh A, Yu SS., Free PMC Article | 07/15/2017 |
| RAB18 modulates macroautophagy and proteostasis, and is dependent on activity of RAB3GAP1 and RAB3GAP2. | The RAB GTPase RAB18 modulates macroautophagy and proteostasis.
Feldmann A, Bekbulat F, Huesmann H, Ulbrich S, Tatzelt J, Behl C, Kern A. | 06/3/2017 |
| findings suggest that RAB18 rs3765133 polymorphism affects the development of specific brain regions, particularly the cerebellum, in healthy people. | The association of RAB18 gene polymorphism (rs3765133) with cerebellar volume in healthy adults.
Cheng CY, Yang AC, Huang CC, Liu ME, Liou YJ, Wu JC, Tsai SJ, Lin CP, Hong CJ. | 02/18/2017 |
| RAB18 is the direct target of miR-455-5p in gastric cancer. | MiR-455-5p acts as a novel tumor suppressor in gastric cancer by down-regulating RAB18.
Liu J, Zhang J, Li Y, Wang L, Sui B, Dai D. | 02/18/2017 |
| Warburg Micro syndrome is caused by RAB18 deficiency. | Warburg Micro syndrome is caused by RAB18 deficiency or dysregulation.
Handley MT, Carpanini SM, Mali GR, Sidjanin DJ, Aligianis IA, Jackson IJ, FitzPatrick DR., Free PMC Article | 03/5/2016 |
| These results suggest that Rab18 has an important role in viral assembly through the trafficking of the hepatitis C virus core protein to lipid droplets. | Rab18 is required for viral assembly of hepatitis C virus through trafficking of the core protein to lipid droplets.
Dansako H, Hiramoto H, Ikeda M, Wakita T, Kato N. | 10/4/2014 |
| High RAB18 expression is associated with glioma. | miR-200b as a prognostic factor targets multiple members of RAB family in glioma.
Liu Q, Tang H, Liu X, Liao Y, Li H, Zhao Z, Yuan X, Jiang W. | 10/4/2014 |
| Rab18-mediated membrane trafficking of FASN and NS3 facilitates dengue virus replication. | Rab18 facilitates dengue virus infection by targeting fatty acid synthase to sites of viral replication.
Tang WC, Lin RJ, Liao CL, Lin YL., Free PMC Article | 10/4/2014 |
| Rab18 and a Rab18 GEF complex of Rab3GAP1 and Rab3GAP2 have roles in the endoplasmic reticulum structure | Rab18 and a Rab18 GEF complex are required for normal ER structure.
Gerondopoulos A, Bastos RN, Yoshimura S, Anderson R, Carpanini S, Aligianis I, Handley MT, Barr FA., Free PMC Article | 08/9/2014 |
| Rab18 interacts with the HCV nonstructural protein NS5A. | Rab18 binds to hepatitis C virus NS5A and promotes interaction between sites of viral replication and lipid droplets.
Salloum S, Wang H, Ferguson C, Parton RG, Tai AW., Free PMC Article | 03/22/2014 |
| One-hundred and forty-four Micro and nine Martsolf families were investigated, identifying mutations in RAB3GAP1 in 41% of cases, mutations in RAB3GAP2 in 7% of cases, and mutations in RAB18 in 5% of cases | Mutation spectrum in RAB3GAP1, RAB3GAP2, and RAB18 and genotype-phenotype correlations in warburg micro syndrome and Martsolf syndrome.
Handley MT, Morris-Rosendahl DJ, Brown S, Macdonald F, Hardy C, Bem D, Carpanini SM, Borck G, Martorell L, Izzi C, Faravelli F, Accorsi P, Pinelli L, Basel-Vanagaite L, Peretz G, Abdel-Salam GM, Zaki MS, Jansen A, Mowat D, Glass I, Stewart H, Mancini G, Lederer D, Roscioli T, Giuliano F, Plomp AS, Rolfs A, Graham JM, Seemanova E, Poo P, García-Cazorla A, Edery P, Jackson IJ, Maher ER, Aligianis IA. | 10/19/2013 |
| Hepatitis B virus X protein enhances proliferation of hepatoma cells through Rab18. | Hepatitis B virus X protein upregulates oncogene Rab18 to result in the dysregulation of lipogenesis and proliferation of hepatoma cells.
You X, Liu F, Zhang T, Li Y, Ye L, Zhang X. | 09/7/2013 |
| Micro syndrome has been associated with causative mutations in three disease genes: RAB3GAP1, RAB3GAP2 and RAB18. Martsolf syndrome has been associated with a mutation in RAB3GAP2. [Review] | RAB3GAP1, RAB3GAP2 and RAB18: disease genes in Micro and Martsolf syndromes.
Handley MT, Aligianis IA. | 05/11/2013 |
| performed autozygosity mapping in five consanguineous families with Warburg micro syndrome without RAB3GAP1/2 mutations and identified loss-of-function mutations in RAB18 | Loss-of-function mutations in RAB18 cause Warburg micro syndrome.
Bem D, Yoshimura S, Nunes-Bastos R, Bond FC, Kurian MA, Rahman F, Handley MT, Hadzhiev Y, Masood I, Straatman-Iwanowska AA, Cullinane AR, McNeill A, Pasha SS, Kirby GA, Foster K, Ahmed Z, Morton JE, Williams D, Graham JM, Dobyns WB, Burglen L, Ainsworth JR, Gissen P, Müller F, Maher ER, Barr FA, Aligianis IA., Free PMC Article | 06/18/2011 |