| Melatonin Protects Against Mitochondrial Dyshomeostasis and Ovarian Damage Caused by Chronic Unpredictable Mild Stress Through the eIF2alpha-AFT4 Signaling Pathway in Mice. | Melatonin Protects Against Mitochondrial Dyshomeostasis and Ovarian Damage Caused by Chronic Unpredictable Mild Stress Through the eIF2α-AFT4 Signaling Pathway in Mice.
Ding SM, Shi LG, Xing F, Cui SS, Cheng HR, Liu Y, Ji DM, Liang D, Cao YX, Liu YJ. | 10/8/2024 |
| Impact of eIF2alpha phosphorylation on the translational landscape of mouse embryonic stem cells. | Impact of eIF2α phosphorylation on the translational landscape of mouse embryonic stem cells.
Amiri M, Kiniry SJ, Possemato AP, Mahmood N, Basiri T, Dufour CR, Tabatabaei N, Deng Q, Bellucci MA, Harwalkar K, Stokes MP, Giguère V, Kaufman RJ, Yamanaka Y, Baranov PV, Tahmasebi S, Sonenberg N., Free PMC Article | 02/5/2024 |
| ALKBH5 protects against stroke by reducing endoplasmic reticulum stress-dependent inflammation injury via the STAT5/PERK/EIF2alpha/CHOP signaling pathway in an m[6]A-YTHDF1-dependent manner. | ALKBH5 protects against stroke by reducing endoplasmic reticulum stress-dependent inflammation injury via the STAT5/PERK/EIF2α/CHOP signaling pathway in an m(6)A-YTHDF1-dependent manner.
Liu C, Chen H, Tao X, Li C, Li A, Wu W. | 01/4/2024 |
| Activation of BZW1 by CEBPB in macrophages promotes eIF2alpha phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice. | Activation of BZW1 by CEBPB in macrophages promotes eIF2α phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice.
Qi H, Zheng Z, Liu Q., Free PMC Article | 11/18/2023 |
| Bridging Energy Need and Feeding Behavior: The Impact of eIF2alpha Phosphorylation in AgRP Neurons. | Bridging Energy Need and Feeding Behavior: The Impact of eIF2α Phosphorylation in AgRP Neurons.
Kim KK, Lee TH, Park BS, Kang D, Kim DH, Jeong B, Kim JW, Yang HR, Kim HR, Jin S, Back SH, Park JW, Kim JG, Lee BJ. | 09/26/2023 |
| Oxidized phospholipids facilitate calcific aortic valve disease by elevating ATF4 through the PERK/eIF2alpha axis. | Oxidized phospholipids facilitate calcific aortic valve disease by elevating ATF4 through the PERK/eIF2α axis.
Zhu X, Yang L, Han X, Huang C, Huang G, Wei T, Shu L, Xu J., Free PMC Article | 08/7/2023 |
| Iron overload induces apoptosis of osteoblast cells via eliciting ER stress-mediated mitochondrial dysfunction and p-eIF2alpha/ATF4/CHOP pathway in vitro. | Iron overload induces apoptosis of osteoblast cells via eliciting ER stress-mediated mitochondrial dysfunction and p-eIF2α/ATF4/CHOP pathway in vitro.
Che J, Lv H, Yang J, Zhao B, Zhou S, Yu T, Shang P. | 04/9/2022 |
| eIF2alphaP is a nodal point of mTORC1 signaling, which can determine the susceptibility of TSC2-deficient cells to oxidative insults and their efficacy in tumor formation in mice maintained on antioxidant diet. | Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells.
Krishnamoorthy J, Tenkerian C, Gupta J, Ghaddar N, Wang S, Darini C, Staschke KA, Ghosh A, Gandin V, Topisirovic I, Kristof AS, Hatzoglou M, Simos G, Koromilas AE., Free PMC Article | 04/11/2020 |
| phosphorylation of eIF2alpha was mediated via protein kinase R (PKR), but further investigation revealed that PKR activation, phosphorylation of eIF2alpha, and translational arrest were uncoupled during viral infection | Mouse Norovirus Infection Arrests Host Cell Translation Uncoupled from the Stress Granule-PKR-eIF2α Axis.
Fritzlar S, Aktepe TE, Chao YW, Kenney ND, McAllaster MR, Wilen CB, White PA, Mackenzie JM., Free PMC Article | 02/15/2020 |
| CReP deletion activates a linear signaling pathway involving eIF2alpha phosphorylation, ATF4 translation, and FGF21 induction, which promotes increased energy expenditure, and subsequently improved obesity-related metabolic parameters. | Preemptive Activation of the Integrated Stress Response Protects Mice From Diet-Induced Obesity and Insulin Resistance by Fibroblast Growth Factor 21 Induction.
Xu X, Krumm C, So JS, Bare CJ, Holman C, Gromada J, Cohen DE, Lee AH., Free PMC Article | 03/23/2019 |
| The data show that activating transcription factor 4 is not required, but eukaryotic initiation factor 2 alpha phosphorylation is necessary to prevent mTORC1 activation during amino acid stress. | Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver.
Nikonorova IA, Mirek ET, Signore CC, Goudie MP, Wek RC, Anthony TG., Free PMC Article | 01/12/2019 |
| HRD1 prevents apoptosis in renal tubular epithelial cells by mediating eIF-2a ubiquitylation and degradation. | HRD1 prevents apoptosis in renal tubular epithelial cells by mediating eIF2α ubiquitylation and degradation.
Huang Y, Sun Y, Cao Y, Sun H, Li M, You H, Su D, Li Y, Liang X., Free PMC Article | 07/28/2018 |
| ER stress is induced early in EAE and that modulation of ER stress by inhibition of eIF2alpha-CHOP and activation of XBP-1 in RGC specifically, protects RGC somata and axons and preserves visual function. | Neuroprotection by eIF2α-CHOP inhibition and XBP-1 activation in EAE/optic neuritiss.
Huang H, Miao L, Liang F, Liu X, Xu L, Teng X, Wang Q, Ridder WH 3rd, Shindler KS, Sun Y, Hu Y., Free PMC Article | 04/7/2018 |
| alpha-asarone abrogated 7beta-hydroxycholesterol-triggered eIF2alpha-CHOP activation, and enhanced macrophage beclin1 dependent autophagy. | α-Asarone blocks 7β-hydroxycholesterol-exposed macrophage injury through blocking elF2α phosphorylation and prompting beclin-1-dependent autophagy.
Park SH, Kang MK, Choi YJ, Kim YH, Antika LD, Kim DY, Lee EJ, Lim SS, Kang YH., Free PMC Article | 03/3/2018 |
| In response to endoplasmic reticulum stress, activation of PERK coordinates the integrated stress response by phosphorylating eIF2alpha, which is then quickly dephosphorylated by the GADD34 complex. Data imply dual role of the ISR in promoting and inhibiting medulloblastoma tumorigenesis. | Dual role of the integrated stress response in medulloblastoma tumorigenesis.
Stone S, Ho Y, Li X, Jamison S, Harding HP, Ron D, Lin W., Free PMC Article | 02/10/2018 |
| stress granule formation is a downstream event of eIF2alpha phosphorylation that may not directly protect cells from apoptosis, at least in spermatocytes of seminiferous tubules in early stages. | Importance of eIF2α phosphorylation as a protective mechanism against heat stress in mouse male germ cells.
Yoon J, Park K, Hwang DS, Rhee K. | 12/23/2017 |
| results further extended the understanding of Heme-regulated eIF2alpha kinase on the regulation of non-erythroid lineages and might provide new aspects for preventing and treating Cd-induced detrimental effects | A protective role of Heme-regulated eIF2α kinase in cadmium-induced liver and kidney injuries.
Wang L, Zhang S, Wang Z, Xu M, Yuan L, Cui J, Liu S. | 11/18/2017 |
| Data, including data from studies using cells from knockout mice, suggest that gasotransmitter H(2)S up-regulates eIF2a phosphorylation by inhibiting PPP1CA via persulfidation, which in turn leads to transient suppression of global translation and activation of Atf4 expression. (eIF2a = eukaryotic initiation factor-2alpha; PPP1CA = protein phosphatase 1 catalytic subunit alpha; Atf4 = activating transcription factor 4) | Hydrogen sulfide modulates eukaryotic translation initiation factor 2α (eIF2α) phosphorylation status in the integrated stress-response pathway.
Yadav V, Gao XH, Willard B, Hatzoglou M, Banerjee R, Kabil O., Free PMC Article | 08/26/2017 |
| Results mechanistically link multiple forms of dystonia and put forth a new overall cellular mechanism for dystonia pathogenesis, impairment of eIF2alpha signaling, a pathway known for its roles in cellular stress responses and synaptic plasticity. | Functional Genomic Analyses of Mendelian and Sporadic Disease Identify Impaired eIF2α Signaling as a Generalizable Mechanism for Dystonia.
Rittiner JE, Caffall ZF, Hernández-Martinez R, Sanderson SM, Pearson JL, Tsukayama KK, Liu AY, Xiao C, Tracy S, Shipman MK, Hickey P, Johnson J, Scott B, Stacy M, Saunders-Pullman R, Bressman S, Simonyan K, Sharma N, Ozelius LJ, Cirulli ET, Calakos N., Free PMC Article | 07/29/2017 |
| The eIF2A knock out mice strain is viable and to date displays no apparent phenotype. | The eIF2A knockout mouse.
Golovko A, Kojukhov A, Guan BJ, Morpurgo B, Merrick WC, Mazumder B, Hatzoglou M, Komar AA., Free PMC Article | 06/24/2017 |
| The role of dietary zinc in the expression of proteins involved in the endoplasmic reticulum stress response is reported. | Dietary Zinc Regulates Apoptosis through the Phosphorylated Eukaryotic Initiation Factor 2α/Activating Transcription Factor-4/C/EBP-Homologous Protein Pathway during Pharmacologically Induced Endoplasmic Reticulum Stress in Livers of Mice.
Kim MH, Aydemir TB, Cousins RJ., Free PMC Article | 06/3/2017 |
| Thus, during addiction, cocaine hijacks translational control by p-eIF2alpha, initiating synaptic potentiation and addiction-related behaviors. | Translational control by eIF2α phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine.
Huang W, Placzek AN, Viana Di Prisco G, Khatiwada S, Sidrauski C, Krnjević K, Walter P, Dani JA, Costa-Mattioli M., Free PMC Article | 12/17/2016 |
| in mouse skeletal muscle stem cells, general repression of translation, mediated by the phosphorylation of translation initiation factor eIF2alpha at serine 51 (P-eIF2alpha), is required to maintain the quiescent state | Phosphorylation of eIF2α Is a Translational Control Mechanism Regulating Muscle Stem Cell Quiescence and Self-Renewal.
Zismanov V, Chichkov V, Colangelo V, Jamet S, Wang S, Syme A, Koromilas AE, Crist C. | 10/22/2016 |
| Skeletal muscle-specific eukaryotic translation initiation factor 2alpha phosphorylation controls amino acid metabolism and fibroblast growth factor 21-mediated non-cell-autonomous energy metabolism. | Skeletal muscle-specific eukaryotic translation initiation factor 2α phosphorylation controls amino acid metabolism and fibroblast growth factor 21-mediated non-cell-autonomous energy metabolism.
Miyake M, Nomura A, Ogura A, Takehana K, Kitahara Y, Takahara K, Tsugawa K, Miyamoto C, Miura N, Sato R, Kurahashi K, Harding HP, Oyadomari M, Ron D, Oyadomari S., Free PMC Article | 06/28/2016 |
| These experiments connect embryonic stem cell growth factors to eIF2alpha phosphorylation. | Embryonic Stem Cell Growth Factors Regulate eIF2α Phosphorylation.
Friend K, Brooks HA, Propson NE, Thomson JA, Kimble J., Free PMC Article | 06/4/2016 |