| [1]H, [15]N, and [13]C resonance assignments of the SH3-like tandem domain of human KIN protein. | (1)H, (15)N, and (13)C resonance assignments of the SH3-like tandem domain of human KIN protein.
de Lourenço IO, Seixas FAV, Fernandez MA, Almeida FCL, Fossey MA, de Souza FP, Caruso ÍP. | 08/27/2024 |
| KIN17 functions in DNA damage repair and chemosensitivity by modulating RAD51 in hepatocellular carcinoma. | KIN17 functions in DNA damage repair and chemosensitivity by modulating RAD51 in hepatocellular carcinoma.
Huang X, Dai Z, Zeng B, Xiao X, Zahid KR, Lin X, Liu T, Zeng T. | 08/23/2024 |
| KIN17 promotes cell migration and invasion through stimulating the TGF-beta/Smad2 pathway in hepatocellular carcinoma. | KIN17 promotes cell migration and invasion through stimulating the TGF-β/Smad2 pathway in hepatocellular carcinoma.
Dai Z, Huang Q, Huang X, Zhu C, Zahid KR, Liu T, Li Q, Wu C, Peng M, Xiao X, Raza U, Yu N, Zeng T. | 02/28/2023 |
| KIN17 promotes tumor metastasis by activating EMT signaling in luminal-A breast cancer. | KIN17 promotes tumor metastasis by activating EMT signaling in luminal-A breast cancer.
Huang Q, Zahid KR, Chen J, Pang X, Zhong M, Huang H, Pan W, Yin J, Raza U, Zeng J, Zhu X, Zeng T., Free PMC Article | 12/18/2021 |
| Interactome Analysis of KIN (Kin17) Shows New Functions of This Protein. | Interactome Analysis of KIN (Kin17) Shows New Functions of This Protein.
Gaspar VP, Ramos AC, Cloutier P, Pattaro Junior JR, Duarte Junior FF, Bouchard A, Seixas FAV, Coulombe B, Fernandez MA., Free PMC Article | 10/2/2021 |
| Kin17 facilitates thyroid cancer cell proliferation, migration, and invasion by activating p38 MAPK signaling pathway. | Kin17 facilitates thyroid cancer cell proliferation, migration, and invasion by activating p38 MAPK signaling pathway.
Jiang QG, Xiong CF, Lv YX. | 07/24/2021 |
| characterization and molecular phylogeny of human KIN protein | Biophysical characterization and molecular phylogeny of human KIN protein.
Pattaro Júnior JR, Caruso ÍP, de Lima Neto QA, Duarte Junior FF, Dos Santos Rando F, Gerhardt ECM, Fernandez MA, Seixas FAV. | 02/1/2020 |
| Findings demonstrate that kin17 is closely related to the cell proliferation and invasion of cervical cancer. | Elevated Expression of Kin17 in Cervical Cancer and Its Association With Cancer Cell Proliferation and Invasion.
Zhang Y, Gao H, Gao X, Huang S, Wu K, Yu X, Yuan K, Zeng T. | 01/13/2018 |
| overexpression of KIN rendered colorectal cancer cells enriching cancer stem cell (CSC) markers and CSC phenotype, and silencing KIN reduced CSC markers and CSC phenotype. | KIN enhances stem cell-like properties to promote chemoresistance in colorectal carcinoma.
Yu M, Zhang Z, Yu H, Xue C, Yuan K, Miao M, Shi H. | 07/12/2014 |
| Trimethylated at Lys-135 by METTL22 | A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.
Cloutier P, Lavallée-Adam M, Faubert D, Blanchette M, Coulombe B., Free PMC Article | 03/7/2013 |
| up-regulation of kin17 is strongly associated with cellular proliferation, DNA replication, DNA damage response and breast cancer development | Up-regulation of kin17 is essential for proliferation of breast cancer.
Zeng T, Gao H, Yu P, He H, Ouyang X, Deng L, Zhang Y., Free PMC Article | 01/28/2012 |
| Observational study of gene-disease association. (HuGE Navigator) | A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A., Free PMC Article | 12/2/2009 |
| Thus, human KIN17 region 51-160 might rather be involved in protein-protein interaction through its conserved surface centered on the 3(10)-helix. | Solution structure of the region 51-160 of human KIN17 reveals an atypical winged helix domain.
Carlier L, Couprie J, le Maire A, Guilhaudis L, Milazzo-Segalas I, Courçon M, Moutiez M, Gondry M, Davoust D, Gilquin B, Zinn-Justin S., Free PMC Article | 01/21/2010 |
| Analysis of KIN17 structure complexed with tungstate shows structural variability within the domain | A tandem of SH3-like domains participates in RNA binding in KIN17, a human protein activated in response to genotoxics.
le Maire A, Schiltz M, Stura EA, Pinon-Lataillade G, Couprie J, Moutiez M, Gondry M, Angulo JF, Zinn-Justin S. | 01/21/2010 |
| Kin17 protein strongly associates in vivo with DNA fragments containing replication origins in both human HeLa and monkey CV-1 cells. | The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins.
Miccoli L, Frouin I, Novac O, Di Paola D, Harper F, Zannis-Hadjopoulos M, Maga G, Biard DS, Angulo JF., Free PMC Article | 01/21/2010 |
| results indicate the presence of functional XPA and XPC proteins is essential for the up-regulation of the KIN17 gene after UVC irradiation; also show that the integrity of global genome repair is required to trigger KIN17 gene expression | Global genome repair is required to activate KIN17, a UVC-responsive gene involved in DNA replication.
Masson C, Menaa F, Pinon-Lataillade G, Frobert Y, Chevillard S, Radicella JP, Sarasin A, Angulo JF., Free PMC Article | 01/21/2010 |
| KIN17 protein may be a component of the DNA replication machinery that participates in the cellular response to unrepaired DSBs, and an impaired KIN17 pathway leads to an increased sensitivity to ionizing radiation. | Depletion of KIN17, a human DNA replication protein, increases the radiosensitivity of RKO cells.
Despras E, Miccoli L, Créminon C, Rouillard D, Angulo JF, Biard DS. | 01/21/2010 |
| The overexpression of human kin17 protein in vivo and the introduction of increased amounts of human kin17 protein in an in vitro assay reduced T-antigen-dependent DNA replication. | Human kin17 protein directly interacts with the simian virus 40 large T antigen and inhibits DNA replication.
Miccoli L, Biard DS, Créminon C, Angulo JF. | 01/21/2010 |
| C-terminal domain of human KIN17 has a basic pI, heavy-atom derivatives were obtained by soaking crystals with negatively charged ions such as tungstate & iodine. Replacement of LiCl by KI in cryosolution allowed determination of phases from iodide ions. | Crystallization and halide phasing of the C-terminal domain of human KIN17.
le Maire A, Schiltz M, Braud S, Gondry M, Charbonnier JB, Zinn-Justin S, Stura E., Free PMC Article | 01/21/2010 |
| A chromatin-associated protein conserved during evolution and overproduced in certain human tumor cell lines, which is involved in DNA replication. | Participation of kin17 protein in replication factories and in other DNA transactions mediated by high molecular weight nuclear complexes.
Biard DS, Miccoli L, Despras E, Harper F, Pichard E, Créminon C, Angulo JF. | 01/21/2010 |
| ionizing radiation triggers chromatin complex formation in human cells | Ionizing radiation triggers chromatin-bound kin17 complex formation in human cells.
Biard DS, Miccoli L, Despras E, Frobert Y, Creminon C, Angulo JF. | 01/21/2010 |