| Ovarian Tumor Domain-Containing 7B Attenuates Pathological Cardiac Hypertrophy by Inhibiting Ubiquitination and Degradation of Kruppel-Like Factor 4. | Ovarian Tumor Domain-Containing 7B Attenuates Pathological Cardiac Hypertrophy by Inhibiting Ubiquitination and Degradation of Krüppel-Like Factor 4.
Du BB, Zhang JL, Kong LY, Shi HT, Zhang DH, Wang X, Yang CL, Li PC, Yao R, Liang C, Wu LM, Huang Z., Free PMC Article | 01/3/2024 |
| The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2. | The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2.
Harit K, Bhattacharjee R, Matuschewski K, Becker J, Kalinke U, Schlüter D, Nishanth G., Free PMC Article | 08/1/2023 |
| Cezanne is a critical regulator of pathological arterial remodelling by targeting beta-catenin signalling. | Cezanne is a critical regulator of pathological arterial remodelling by targeting β-catenin signalling.
An W, Luong LA, Bowden NP, Yang M, Wu W, Zhou X, Liu C, Niu K, Luo J, Zhang C, Sun X, Poston R, Zhang L, Evans PC, Xiao Q., Free PMC Article | 03/5/2022 |
| OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis. | OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis.
Gong Z, Li A, Ding J, Li Q, Zhang L, Li Y, Meng Z, Chen F, Huang J, Zhou D, Hu R, Ye J, Liu W, You H., Free PMC Article | 01/22/2022 |
| Downregulation of miR-146a-5p Inhibits Choroidal Neovascularization via the NF-kappaB Signaling Pathway by Targeting OTUD7B. | Downregulation of miR-146a-5p Inhibits Choroidal Neovascularization via the NF-κB Signaling Pathway by Targeting OTUD7B.
Li L, Lai K, Gong Y, Huang C, Xu F, Li Y, Jin C. | 10/16/2021 |
| The Clock-Controlled lncRNA-AK028245 Participates in the Immune Response via Immune Response Factors OTUD7B and A20. | The Clock-Controlled lncRNA-AK028245 Participates in the Immune Response via Immune Response Factors OTUD7B and A20.
Qi F, Jiang Z, Hou W, Peng B, Cheng S, Zhang X, Luo Z, Dai Z, Wang Y, Liu Y, Wang Y, Wang Z. | 09/18/2021 |
| Cezanne may be a novel antioncogene that has a pivotal role in the invasion of hepatocellular carcinoma. | Cezanne predicts progression and adjuvant TACE response in hepatocellular carcinoma.
Wang JH, Zhong XP, Zhang YF, Wu XL, Li SH, Jian PE, Ling YH, Shi M, Chen MS, Wei W, Guo RP., Free PMC Article | 06/9/2018 |
| TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling | TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling.
Wang B, Jie Z, Joo D, Ordureau A, Liu P, Gan W, Guo J, Zhang J, North BJ, Dai X, Cheng X, Bian X, Zhang L, Harper JW, Sun SC, Wei W., Free PMC Article | 09/9/2017 |
| These findings establish Otud7b as a positive regulator of T cell receptor-proximal signaling and T cell activation, highlighting the importance of deubiquitination in regulating Zap70 function. | Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination.
Hu H, Wang H, Xiao Y, Jin J, Chang JH, Zou Q, Xie X, Cheng X, Sun SC., Free PMC Article | 07/30/2016 |
| Inflammatory responses to ischemia are controlled by a balance between ubiquitination and deubiquitination, and Cezanne is a key regulator of this process. | Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.
Luong le A, Fragiadaki M, Smith J, Boyle J, Lutz J, Dean JL, Harten S, Ashcroft M, Walmsley SR, Haskard DO, Maxwell PH, Walczak H, Pusey C, Evans PC., Free PMC Article | 08/31/2013 |
| findings establish OTUD7B as a crucial regulator of signal-induced non-canonical NF-kappaB activation and indicate a mechanism of immune regulation that involves OTUD7B-mediated deubiquitination and stabilization of TRAF3 | OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3.
Hu H, Brittain GC, Chang JH, Puebla-Osorio N, Jin J, Zal A, Xiao Y, Cheng X, Chang M, Fu YX, Zal T, Zhu C, Sun SC., Free PMC Article | 03/16/2013 |
| DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB. | DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB.
McNally RS, Davis BK, Clements CM, Accavitti-Loper MA, Mak TW, Ting JP., Free PMC Article | 03/26/2011 |