| Inhibition of KDM2/7 Promotes Notochordal Differentiation of hiPSCs. | Inhibition of KDM2/7 Promotes Notochordal Differentiation of hiPSCs.
Diaz-Hernandez ME, Murakami K, Murata S, Khan NM, Shenoy SPV, Henke K, Yamada H, Drissi H., Free PMC Article | 11/7/2024 |
| Hepatitis B virus core protein stabilizes RANGAP1 to upregulate KDM2A and facilitate hepatocarcinogenesis. | Hepatitis B virus core protein stabilizes RANGAP1 to upregulate KDM2A and facilitate hepatocarcinogenesis.
You HJ, Ma LH, Wang X, Wang YX, Zhang HY, Bao ES, Zhong YJ, Liu XY, Kong DL, Zheng KY, Kong FY, Tang RX. | 06/11/2024 |
| Biological Functions of the KDM2 Family of Histone Demethylases. | Biological Functions of the KDM2 Family of Histone Demethylases.
Andricovich J, Tzatsos A. | 11/1/2023 |
| Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma. | Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma.
Chen C, Shin JH, Fang Z, Brennan K, Horowitz NB, Pfaff KL, Welsh EL, Rodig SJ, Gevaert O, Gozani O, Uppaluri R, Sunwoo JB., Free PMC Article | 08/20/2023 |
| Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance. | Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance.
Li F, Wang Y, Hwang I, Jang JY, Xu L, Deng Z, Yu EY, Cai Y, Wu C, Han Z, Huang YH, Huang X, Zhang L, Yao J, Lue NF, Lieberman PM, Ying H, Paik J, Zheng H., Free PMC Article | 04/4/2023 |
| Stabilization of nuclear beta-catenin by inhibiting KDM2A mediates cerebral ischemic tolerance. | Stabilization of nuclear β-catenin by inhibiting KDM2A mediates cerebral ischemic tolerance.
Zuo Y, Zhan L, Wen H, Xue J, Tan Y, Sun W, Xu E. | 02/11/2023 |
| Histone demethylase KDM2A suppresses EGF-TSPAN8 pathway to inhibit breast cancer cell migration and invasion in vitro. | Histone demethylase KDM2A suppresses EGF-TSPAN8 pathway to inhibit breast cancer cell migration and invasion in vitro.
Zhang H, Tu Y, Huang B, Xiao J, Xiao J, Wang J, Pei Y, Yang R, Feng J, Li J, Zhang X. | 10/15/2022 |
| KDM2A plays a dual role in regulating the expression of malignancy-related genes in esophageal squamous cell carcinoma. | KDM2A plays a dual role in regulating the expression of malignancy-related genes in esophageal squamous cell carcinoma.
Wang J, Zhang ZY, Jiang J, Tang L, Wang XY, Wang Z, Yang XL, Yu XL, Huang CC, Chen F, Wan HS, Ye SJ. | 08/27/2022 |
| NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition. | NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition.
Drosos Y, Myers JA, Xu B, Mathias KM, Beane EC, Radko-Juettner S, Mobley RJ, Larsen ME, Piccioni F, Ma X, Low J, Hansen BS, Peters ST, Bhanu NV, Dhanda SK, Chen T, Upadhyaya SA, Pruett-Miller SM, Root DE, Garcia BA, Partridge JF, Roberts CWM., Free PMC Article | 07/23/2022 |
| Histone H3K36me2 demethylase KDM2A promotes bladder cancer progression through epigenetically silencing RARRES3. | Histone H3K36me2 demethylase KDM2A promotes bladder cancer progression through epigenetically silencing RARRES3.
Lu B, Wei J, Zhou H, Chen J, Li Y, Ye L, Zhao W, Wu S., Free PMC Article | 06/18/2022 |
| Up-regulation of miR-663a inhibits the cancer stem cell-like properties of glioma via repressing the KDM2A-mediated TGF-beta/SMAD signaling pathway. | Up-regulation of miR-663a inhibits the cancer stem cell-like properties of glioma via repressing the KDM2A-mediated TGF-β/SMAD signaling pathway.
Wang L, Lang B, Zhou Y, Ma J, Hu K., Free PMC Article | 04/16/2022 |
| Nuclear receptor binding SET domain protein 1 promotes epithelial-mesenchymal transition in paclitaxel-resistant breast cancer cells via regulating nuclear factor kappa B and F-box and leucine-rich repeat protein 11. | Nuclear receptor binding SET domain protein 1 promotes epithelial-mesenchymal transition in paclitaxel-resistant breast cancer cells via regulating nuclear factor kappa B and F-box and leucine-rich repeat protein 11.
Chen Y, Tang W, Zhu X, Zhang L, Zhu Y, Xiao H, Xu J, Fang Y, Li X, Tang C, Shi J., Free PMC Article | 02/19/2022 |
| Expression pattern and regulatory effect of lysine-specific demethylase 2A gene in clear cell renal cell carcinoma. | Expression pattern and regulatory effect of lysine-specific demethylase 2A gene in clear cell renal cell carcinoma.
Wang J, Li T, Li X, Zhang Y, Wang X., Free PMC Article | 01/1/2022 |
| Combined expression levels of KDM2A and KDM2B correlate with nucleolar size and prognosis in primary breast carcinomas. | Combined expression levels of KDM2A and KDM2B correlate with nucleolar size and prognosis in primary breast carcinomas.
De Nicola I, Guerrieri AN, Penzo M, Ceccarelli C, De Leo A, Trerè D, Montanaro L. | 10/2/2021 |
| Production of ROS by Gallic Acid Activates KDM2A to Reduce rRNA Transcription. | Production of ROS by Gallic Acid Activates KDM2A to Reduce rRNA Transcription.
Tanaka Y, Obinata H, Konishi A, Yamagiwa N, Tsuneoka M., Free PMC Article | 07/3/2021 |
| LncRNA LINC01278 accelerates colorectal cancer progression via miR-134-5p/KDM2A axis. | LncRNA LINC01278 accelerates colorectal cancer progression via miR-134-5p/KDM2A axis.
Xi C, Ye NY, Wang YB. | 06/26/2021 |
| Lysine demethylase 2A expression in cancer-associated fibroblasts promotes breast tumour growth. | Lysine demethylase 2A expression in cancer-associated fibroblasts promotes breast tumour growth.
Chen JY, Li CF, Lai YS, Hung WC., Free PMC Article | 04/17/2021 |
| Lysine-specific demethylase 2A enhances binding of various nuclear factors to CpG-rich genomic DNAs by action of its CXXC-PHD domain. | Lysine-specific demethylase 2A enhances binding of various nuclear factors to CpG-rich genomic DNAs by action of its CXXC-PHD domain.
Iuchi S, Paulo JA., Free PMC Article | 10/10/2020 |
| p300 Acetylates JHDM1A to inhibit osteosarcoma carcinogenesis | p300 Acetylates JHDM1A to inhibit osteosarcoma carcinogenesis.
Wang Y, Sun B, Zhang Q, Dong H, Zhang J. | 12/14/2019 |
| MicroRNA3666 suppresses the growth and migration of glioblastoma cells by targeting KDM2A. | MicroRNA‑3666 suppresses the growth and migration of glioblastoma cells by targeting KDM2A.
Shou T, Yang H, Lv J, Liu D, Sun X., Free PMC Article | 05/25/2019 |
| these findings suggested that KDM2A might be a key regulator of cell proliferation and cell cycle via impacting TGF-beta signaling pathway. | Knockdown of KDM2A inhibits proliferation associated with TGF-β expression in HEK293T cell.
Xu WH, Liang DY, Wang Q, Shen J, Liu QH, Peng YB. | 05/18/2019 |
| KDM2B is crucial for glioblastoma maintenance, with it's inhibition causing loss of glioblastoma stem-like cells survival, genomic stability, and chemoresistance. | Targeting glioma stem-like cell survival and chemoresistance through inhibition of lysine-specific histone demethylase KDM2B.
Staberg M, Rasmussen RD, Michaelsen SR, Pedersen H, Jensen KE, Villingshøj M, Skjoth-Rasmussen J, Brennum J, Vitting-Seerup K, Poulsen HS, Hamerlik P., Free PMC Article | 02/23/2019 |
| Study data revealed that KDM2A functions as a tumor oncogene, and the downregulation of KDM2A expression regulates Epithelialmesenchymal transition and epithelial ovarian cancer progression. | Lysine demethylase 2A promotes the progression of ovarian cancer by regulating the PI3K pathway and reversing epithelial‑mesenchymal transition.
Lu DH, Yang J, Gao LK, Min J, Tang JM, Hu M, Li Y, Li ST, Chen J, Hong L., Free PMC Article | 02/2/2019 |
| KDM2A-SF forms distinct nuclear heterochromatic bodies in an HP1a dependent manner | A demethylation deficient isoform of the lysine demethylase KDM2A interacts with pericentromeric heterochromatin in an HP1a-dependent manner.
Lađinović D, Novotná J, Jakšová S, Raška I, Vacík T., Free PMC Article | 02/17/2018 |
| Authors conclude that KDM2A functions as an oncogene in breast cancer by upregulating JAG1 to promote stemness, chemoresistance and angiogenesis. | Lysine demethylase 2A promotes stemness and angiogenesis of breast cancer by upregulating Jagged1.
Chen JY, Li CF, Chu PY, Lai YS, Chen CH, Jiang SS, Hou MF, Hung WC., Free PMC Article | 01/20/2018 |