| [The Regulatory Effect of RNA m[6] A Methylation Modification on KDM4B Gene Expression in t (8;21) AML Cells by MeRIP-qPCR]. | [The Regulatory Effect of RNA m(6) A Methylation Modification on KDM4B Gene Expression in t (8;21) AML Cells by MeRIP-qPCR].
Li YQ, Shao YL, Li MY, Wang LL, Gao XN. | 05/17/2024 |
| KDM4B down-regulation facilitated breast cancer cell stemness via PHGDH upregulation in H3K36me3-dependent manner. | KDM4B down-regulation facilitated breast cancer cell stemness via PHGDH upregulation in H3K36me3-dependent manner.
Wang XY, Li HM, Xia R, Li X, Zhang X, Jin TZ, Zhang HS. | 04/17/2024 |
| Histone demethylase KDM4B accelerates the progression of glioblastoma via the epigenetic regulation of MYC stability. | Histone demethylase KDM4B accelerates the progression of glioblastoma via the epigenetic regulation of MYC stability.
Wang Z, Cai H, Li Z, Sun W, Zhao E, Cui H., Free PMC Article | 12/20/2023 |
| HIF1alpha-mediated transactivation of WTAP promotes AML cell proliferation via m[6]A-dependent stabilization of KDM4B mRNA. | HIF1α-mediated transactivation of WTAP promotes AML cell proliferation via m(6)A-dependent stabilization of KDM4B mRNA.
Shao YL, Li YQ, Li MY, Wang LL, Zhou HS, Liu DH, Yu L, Lin J, Gao XN. | 06/13/2023 |
| Histone demethylase KDM4B contributes to advanced clear cell renal carcinoma and association with copy number variations and cell cycle progression. | Histone demethylase KDM4B contributes to advanced clear cell renal carcinoma and association with copy number variations and cell cycle progression.
Tang H, Guan Y, Yuan Z, Guo T, Tan X, Fan Y, Zhang E, Wang X., Free PMC Article | 03/28/2023 |
| Histone H3K9 demethylase JMJD2B/KDM4B promotes osteogenic differentiation of bone marrow-derived mesenchymal stem cells by regulating H3K9me2 on RUNX2. | Histone H3K9 demethylase JMJD2B/KDM4B promotes osteogenic differentiation of bone marrow-derived mesenchymal stem cells by regulating H3K9me2 on RUNX2.
Kang P, Wu Z, Huang Y, Luo Z, Huo S, Chen Q., Free PMC Article | 02/13/2023 |
| KDM4B, a potential prognostic biomarker revealed by large-scale public databases and clinical samples in uterine corpus endometrial carcinoma. | KDM4B, a potential prognostic biomarker revealed by large-scale public databases and clinical samples in uterine corpus endometrial carcinoma.
Zhang M, Liu Y, Hou S, Wang Y, Wang C, Yin Y, Chen X. | 07/16/2022 |
| Loss of KDM4B impairs osteogenic differentiation of OMSCs and promotes oral bone aging. | Loss of KDM4B impairs osteogenic differentiation of OMSCs and promotes oral bone aging.
Deng P, Chang I, Wang J, Badreldin AA, Li X, Yu B, Wang CY., Free PMC Article | 05/14/2022 |
| KDM4B Overexpression Promotes the Growth, Migration, and Invasion of Rheumatoid Arthritis Fibroblast-Like Synoviocytes by Activating STAT3 Pathway. | KDM4B Overexpression Promotes the Growth, Migration, and Invasion of Rheumatoid Arthritis Fibroblast-Like Synoviocytes by Activating STAT3 Pathway.
Zhang X, Nan H, Guo J, Liu J., Free PMC Article | 01/22/2022 |
| IL-13 Augments Histone Demethylase JMJD2B/KDM4B Expression Levels, Activity, and Nuclear Translocation in Airway Fibroblasts in Asthma. | IL-13 Augments Histone Demethylase JMJD2B/KDM4B Expression Levels, Activity, and Nuclear Translocation in Airway Fibroblasts in Asthma.
Bajbouj K, Hachim MY, Ramakrishnan RK, Fazel H, Mustafa J, Alzaghari S, Eladl M, Shafarin J, Olivenstein R, Hamid Q., Free PMC Article | 11/6/2021 |
| Targeting KDM4B that coactivates c-Myc-regulated metabolism to suppress tumor growth in castration-resistant prostate cancer. | Targeting KDM4B that coactivates c-Myc-regulated metabolism to suppress tumor growth in castration-resistant prostate cancer.
Wu MJ, Chen CJ, Lin TY, Liu YY, Tseng LL, Cheng ML, Chuu CP, Tsai HK, Kuo WL, Kung HJ, Wang WC., Free PMC Article | 08/28/2021 |
| JMJD2B-induced amino acid alterations enhance the survival of colorectal cancer cells under glucose-deprivation via autophagy. | JMJD2B-induced amino acid alterations enhance the survival of colorectal cancer cells under glucose-deprivation via autophagy.
Tan J, Wang HL, Yang J, Liu QQ, Li CM, Wang YQ, Fu LN, Gao QY, Chen YX, Fang JY., Free PMC Article | 08/7/2021 |
| Association of JMJD2B and Hypoxia-Inducible Factor 1 Expressions with Poor Prognosis in Osteosarcoma. | Association of JMJD2B and Hypoxia-Inducible Factor 1 Expressions with Poor Prognosis in Osteosarcoma.
Liu X, Zhang Q, Zhao Y, Xun J, Wu H, Feng H., Free PMC Article | 08/7/2021 |
| Inhibition of microRNA-27b-3p relieves osteoarthritis pain via regulation of KDM4B-dependent DLX5. | Inhibition of microRNA-27b-3p relieves osteoarthritis pain via regulation of KDM4B-dependent DLX5.
Zhang G, Zhou Y, Su M, Yang X, Zeng B. | 07/31/2021 |
| Histone H3K9 Demethylase JMJD2B Plays a Role in LXRalpha-Dependent Lipogenesis. | Histone H3K9 Demethylase JMJD2B Plays a Role in LXRα-Dependent Lipogenesis.
Kim JH, Jung DY, Kim HR, Jung MH., Free PMC Article | 03/20/2021 |
| Heterozygous Variants in KDM4B Lead to Global Developmental Delay and Neuroanatomical Defects. | Heterozygous Variants in KDM4B Lead to Global Developmental Delay and Neuroanatomical Defects.
Duncan AR, Vitobello A, Collins SC, Vancollie VE, Lelliott CJ, Rodan L, Shi J, Seman AR, Agolini E, Novelli A, Prontera P, Guillen Sacoto MJ, Santiago-Sim T, Trimouille A, Goizet C, Nizon M, Bruel AL, Philippe C, Grant PE, Wojcik MH, Stoler J, Genetti CA, van Dooren MF, Maas SM, Alders M, Faivre L, Sorlin A, Yoon G, Yalcin B, Agrawal PB., Free PMC Article | 01/16/2021 |
| Tudor domain of histone demethylase KDM4B is a reader of H4K20me3. | Tudor domain of histone demethylase KDM4B is a reader of H4K20me3.
Xiang Y, Guo J, Li F, Xiong J. | 01/9/2021 |
| Upregulated KDM4B promotes prostate cancer cell proliferation by activating autophagy. | Upregulated KDM4B promotes prostate cancer cell proliferation by activating autophagy.
Sha J, Han Q, Chi C, Zhu Y, Pan J, Dong B, Huang Y, Xia W, Xue W. | 12/19/2020 |
| Targeting the KDM4B-AR-c-Myc axis promotes sensitivity to androgen receptor-targeted therapy in advanced prostate cancer. | Targeting the KDM4B-AR-c-Myc axis promotes sensitivity to androgen receptor-targeted therapy in advanced prostate cancer.
Tang DE, Dai Y, He JX, Lin LW, Leng QX, Geng XY, Fu DX, Jiang HW, Xu SH. | 12/19/2020 |
| Silencing of JMJD2B reduced TGF-beta2-induced expression of mesenchymal genes, prevented the alterations in endothelial morphology and impaired endothelial barrier function. | The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition.
Glaser SF, Heumüller AW, Tombor L, Hofmann P, Muhly-Reinholz M, Fischer A, Günther S, Kokot KE, Hassel D, Kumar S, Jo H, Boon RA, Abplanalp W, John D, Boeckel JN, Dimmeler S., Free PMC Article | 07/18/2020 |
| Results showed that KDM4B promoted glucose uptake and ATP production by regulating the expression of GLUT1 via the AKT signaling pathway through the combination with TRAF6. KDM4B was overexpressed in colorectal (CRC) tissues and associated with a poor survival rate in CRC patients. Collectively, KDM4B was shown to play an important role in promoting CRC progression by enhancing glucose metabolism. | KDM4B facilitates colorectal cancer growth and glucose metabolism by stimulating TRAF6-mediated AKT activation.
Li H, Lan J, Wang G, Guo K, Han C, Li X, Hu J, Cao Z, Luo X., Free PMC Article | 06/6/2020 |
| This study defines KDM4B-regulated alternative splicing as a pivotal mechanism for generating AR-V7 and a contributing factor for castration-resistant prostate cancer, providing insight for mechanistic targeting of castration-resistant prostate cancer. | Histone lysine demethylase KDM4B regulates the alternative splicing of the androgen receptor in response to androgen deprivation.
Duan L, Chen Z, Lu J, Liang Y, Wang M, Roggero CM, Zhang QJ, Gao J, Fang Y, Cao J, Lu J, Zhao H, Dang A, Pong RC, Hernandez E, Chang CM, Hoang DT, Ahn JM, Xiao G, Wang RT, Yu KJ, Kapur P, Rizo J, Hsieh JT, Luo J, Liu ZP., Free PMC Article | 05/16/2020 |
| activation of the DLX5/KDM4B signaling pathway might serve as an intrinsic mechanism that promotes tissue regeneration mediated by dental-derived mesenchymal stem cells. | Distal-less homeobox 5 promotes the osteo-/dentinogenic differentiation potential of stem cells from apical papilla by activating histone demethylase KDM4B through a positive feedback mechanism.
Yang H, Fan J, Cao Y, Gao R, Fan Z. | 05/9/2020 |
| These results reveal a novel function of KDM4B in controlling the JNK/c-Jun-induced IL-8-IL-8R axis in gastric cancer, and offer a new strategy in cancer therapy. | KDM4B is a coactivator of c-Jun and involved in gastric carcinogenesis.
Wu MC, Cheng HH, Yeh TS, Li YC, Chen TJ, Sit WY, Chuu CP, Kung HJ, Chien S, Wang WC., Free PMC Article | 04/11/2020 |
| JMJD2B knockdown or inhibition increased H3K9/K36me3 levels, decreased ATG gene expression and autophagy, and sensitized MDM2-nonamplified cells to apoptosis. | The histone demethylase JMJD2B is critical for p53-mediated autophagy and survival in Nutlin-treated cancer cells.
Duan L, Perez RE, Lai X, Chen L, Maki CG., Free PMC Article | 02/29/2020 |