| Nuclear receptor coactivator 6 is a critical regulator of NLRP3 inflammasome activation and gouty arthritis. | Nuclear receptor coactivator 6 is a critical regulator of NLRP3 inflammasome activation and gouty arthritis.
Lee KG, Hong BK, Lee S, Lee N, Kim SW, Kim D, Kim WU., Free PMC Article | 03/1/2024 |
| Multiomics analyses and machine learning of nuclear receptor coactivator 6 reveal its essential role in hepatocellular carcinoma. | Multiomics analyses and machine learning of nuclear receptor coactivator 6 reveal its essential role in hepatocellular carcinoma.
Fang Y, Xu Y, Liao W, Ji T, Yu L, Li L, Pan M, Yang D., Free PMC Article | 01/11/2023 |
| Nuclear receptor coactivator-6 is essential for the morphological change of human uterine stromal cell decidualization via regulating actin fiber reorganization. | Nuclear receptor coactivator-6 is essential for the morphological change of human uterine stromal cell decidualization via regulating actin fiber reorganization.
Watanabe N, Kawagoe J, Sugiyama A, Takehara I, Ohta T, Nagase S. | 04/30/2022 |
| Application of WES Towards Molecular Investigation of Congenital Cataracts: Identification of Novel Alleles and Genes in a Hospital-Based Cohort of South India. | Application of WES Towards Molecular Investigation of Congenital Cataracts: Identification of Novel Alleles and Genes in a Hospital-Based Cohort of South India.
Kandaswamy DK, Prakash MVS, Graw J, Koller S, Magyar I, Tiwari A, Berger W, Santhiya ST., Free PMC Article | 03/20/2021 |
| Nuclear receptor coactivator 6 promotes HTR-8/SVneo cell invasion and migration by activating NF-kappaB-mediated MMP9 transcription. | Nuclear receptor coactivator 6 promotes HTR-8/SVneo cell invasion and migration by activating NF-κB-mediated MMP9 transcription.
Wu L, Zhao KQ, Wang W, Cui LN, Hu LL, Jiang XX, Shuai J, Sun YP., Free PMC Article | 12/26/2020 |
| NCOA6 associates with the GREB1 promoter and enhancer in an E2-independent manner and that NCOA6 knockout reduces chromatin looping, enhancer-promoter interactions, and basal GREB1 expression in the absence of estradiol. | The transcriptional co-activator NCOA6 promotes estrogen-induced GREB1 transcription by recruiting ERα and enhancing enhancer-promoter interactions.
Tong Z, Liu Y, Yu X, Martinez JD, Xu J., Free PMC Article | 06/27/2020 |
| The retinoid x receptor does not interact with the NR box-1 of ASC-2, but functions as an allosteric activator of LXR binding to NR box-2 of ASC-2. | RXR heterodimerization allosterically activates LXR binding to the second NR box of activating signal co-integrator-2.
Son YL, Park OG, Kim GS, Lee JW, Lee YC. | 03/22/2012 |
| diverse physiological function of NCOA6 may be mediated by multiple isoforms expressed in different tissues and localized in different subcellular compartments | Identification and characterization of the alternatively spliced nuclear receptor coactivator-6 isoforms.
Li Q, Xu J., Free PMC Article | 08/27/2011 |
| NCOA6 is responsible for the synergistic activation of CYP2C9 by HNF4alpha and pregnane X receptor and NCOA6 differentially regulates CYP2C9 and CYP3A4 gene expression though both the genes are regulated by the same nuclear receptors. | NCOA6 differentially regulates the expression of the CYP2C9 and CYP3A4 genes.
Surapureddi S, Rana R, Goldstein JA., Free PMC Article | 08/20/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| ASCOM-MLL3 and ASCOM-MLL4 play redundant but essential roles in FXR transactivation via their histone 3 lysine 4 trimethylation activity. | ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.
Kim DH, Lee J, Lee B, Lee JW., Free PMC Article | 01/21/2010 |
| AIB3 contributes to the maintenance of beta-cell function in nondiabetic children and regulates gene expression in INS-1 cells. | The nuclear receptor coactivator AIB3 is a modulator of HOMA beta-cell function in nondiabetic children.
Burghardt H, López-Bermejo A, Baumgartner B, Ibáñez L, Vendrell J, Ricart W, Palacín M, Fernández-Real JM, Zorzano A, Burghardt H, López-Bermejo A, Baumgartner B, Ibáñez L, Vendrell J, Ricart W, Palacín M, Fernández-Real JM, Zorzano A. | 01/21/2010 |
| Promoter analysis showed that PRIP acted through serum-responsive factor to regulate FOS gene expression. | PRIP promotes tumor formation through enhancing serum-responsive factor-mediated FOS expression.
Zhu YT, Hu L, Qi C, Zhu YJ., Free PMC Article | 01/21/2010 |
| The coactivator NCOA6 mediates the mechanism of the synergistic activation of the CYP2C9 gene by CAR and HNF4alpha. | Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome P-450 2C9 by the constitutive androstane receptor and hepatic nuclear factor-4alpha.
Surapureddi S, Rana R, Reddy JK, Goldstein JA., Free PMC Article | 01/21/2010 |
| interaction between RAP250, Smad2, and Smad3 constitutes an important bridging mechanism linking LXR and TGF-beta signaling pathways. | RAP250 is a coactivator in the transforming growth factor beta signaling pathway that interacts with Smad2 and Smad3.
Antonson P, Jakobsson T, Almlöf T, Guldevall K, Steffensen KR, Gustafsson JA. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesAssociation of a common AGO1 variant with lung cancer risk: a two-stage case-control study.
Kim JS, Choi YY, Jin G, Kang HG, Choi JE, Jeon HS, Lee WK, Kim DS, Kim CH, Kim YJ, Son JW, Jung TH, Park JY. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, van 't Slot R, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM. The nuclear receptor coactivator AIB3 is a modulator of HOMA beta-cell function in nondiabetic children.
Burghardt H, López-Bermejo A, Baumgartner B, Ibáñez L, Vendrell J, Ricart W, Palacín M, Fernández-Real JM, Zorzano A, Burghardt H, López-Bermejo A, Baumgartner B, Ibáñez L, Vendrell J, Ricart W, Palacín M, Fernández-Real JM, Zorzano A. | 05/21/2008 |
| ASC-2 is a bona fide coactivator of the xenobiotic nuclear receptor CAR and mediate the specific xenobiotic response by CAR in vivo. | Characterization of activating signal cointegrator-2 as a novel transcriptional coactivator of the xenobiotic nuclear receptor constitutive androstane receptor.
Choi E, Lee S, Yeom SY, Kim GH, Lee JW, Kim SW. | 01/21/2010 |
| we show that ASC-2 belongs to a steady-state complex of approximately 2 MDa (ASC-2 complex [ASCOM]) in HeLa nuclei. ASCOM contains retinoblastoma-binding protein RBQ-3, alpha/beta-tubulins, and trithorax group proteins ALR-1, ALR-2, HALR, and ASH2. | Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.
Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW., Free PMC Article | 01/21/2010 |
| interacts with and stimulates its associated DNA-dependent protein kinase | Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase.
Ko L, Chin WW, Ko L, Chin WW. | 01/21/2010 |
| ASC-2 appears to contain at least three distinct nuclear receptor interaction domains; also, Rb and ASC-2 have roles in androgen receptor transactivation | Interactions between activating signal cointegrator-2 and the tumor suppressor retinoblastoma in androgen receptor transactivation.
Goo YH, Na SY, Zhang H, Xu J, Hong S, Cheong J, Lee SK, Lee JW. | 01/21/2010 |
| ASC-2 is a physiologically important transcriptional coactivator of LXRs and demonstrate its pivotal role in the liver lipid metabolism | Activating signal cointegrator 2 required for liver lipid metabolism mediated by liver X receptors in mice.
Kim SW, Park K, Kwak E, Choi E, Lee S, Ham J, Kang H, Kim JM, Hwang SY, Kong YY, Lee K, Lee JW., Free PMC Article | 01/21/2010 |
| ASC-2 has a role in inducing target gene transcription during granulocytic differentiation through binding to ATF2 | Activation and interaction of ATF2 with the coactivator ASC-2 are responsive for granulocytic differentiation by retinoic acid.
Hong S, Choi HM, Park MJ, Kim YH, Choi YH, Kim HH, Choi YH, Cheong J. | 01/21/2010 |
| results suggest that ASC-2 is a novel coactivator for HSF1 and heat shock stress may contribute to the strong active transcription complex through sequential recruitment of HSF1 and ASC-2. | Coactivator ASC-2 mediates heat shock factor 1-mediated transactivation dependent on heat shock.
Hong S, Kim SH, Heo MA, Choi YH, Park MJ, Yoo MA, Kim HD, Kang HS, Cheong J. | 01/21/2010 |
| The activation of DNA-PK in the absence of DNA ends by the coactivator TRBP suggests a novel mechanism of coactivator-stimulated DNA-PK phosphorylation in transcriptional regulation. | Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase.
Ko L, Chin WW, Ko L, Chin WW. | 11/10/2005 |