| Peroxisome proliferator-activated receptor gamma coactivator 1alpha regulates downstream of tyrosine kinase-7 (Dok-7) expression important for neuromuscular junction formation. | Peroxisome proliferator-activated receptor γ coactivator 1α regulates downstream of tyrosine kinase-7 (Dok-7) expression important for neuromuscular junction formation.
Sugimoto T, Sakamaki C, Kimura T, Eguchi T, Miura S, Kamei Y., Free PMC Article | 02/1/2024 |
| DOK7 Promotes NMJ Regeneration After Nerve Injury. | DOK7 Promotes NMJ Regeneration After Nerve Injury.
Kosco ED, Jing H, Chen P, Xiong WC, Samuels IS, Mei L. | 02/14/2023 |
| Mechanism of disease and therapeutic rescue of Dok7 congenital myasthenia. | Mechanism of disease and therapeutic rescue of Dok7 congenital myasthenia.
Oury J, Zhang W, Leloup N, Koide A, Corrado AD, Ketavarapu G, Hattori T, Koide S, Burden SJ., Free PMC Article | 10/9/2021 |
| Effect of salbutamol on neuromuscular junction function and structure in a mouse model of DOK7 congenital myasthenia. | Effect of salbutamol on neuromuscular junction function and structure in a mouse model of DOK7 congenital myasthenia.
Webster RG, Vanhaesebrouck AE, Maxwell SE, Cossins JA, Liu W, Ueta R, Yamanashi Y, Beeson DMW., Free PMC Article | 08/21/2021 |
| APC2(CDH1) negatively regulates agrin signaling by promoting the ubiquitination and proteolytic degradation of DOK7. | APC2(CDH1) negatively regulates agrin signaling by promoting the ubiquitination and proteolytic degradation of DOK7.
Chen A, Bai L, Zhong K, Shu X, Wang A, Xiao Y, Zhang K, Shen C. | 03/13/2021 |
| AAV9-DOK7 gene therapy reduces disease severity in Smn(2B/-) SMA model mice. | AAV9-DOK7 gene therapy reduces disease severity in Smn(2B/-) SMA model mice.
Kaifer KA, Villalón E, Smith CE, Simon ME, Marquez J, Hopkins AE, Morcos TI, Lorson CL., Free PMC Article | 02/27/2021 |
| Identification of the downstream molecules of agrin/Dok-7 signaling in muscle. | Identification of the downstream molecules of agrin/Dok-7 signaling in muscle.
Wang B, Li Y, Sui M, Qi Q, Wang T, Liu D, Zhou M, Zheng Y, Zhu LQ, Zhang B. | 01/23/2021 |
| Overexpression of Dok-7 in skeletal muscle enhances neuromuscular transmission with structural alterations of neuromuscular junctions: Implications in robustness of neuromuscular transmission. | Overexpression of Dok-7 in skeletal muscle enhances neuromuscular transmission with structural alterations of neuromuscular junctions: Implications in robustness of neuromuscular transmission.
Eguchi T, Tezuka T, Fukudome T, Watanabe Y, Sagara H, Yamanashi Y. | 09/19/2020 |
| The Dok-7's C-terminal region plays a key, but not fully essential, role in MuSK activation and NMJ formation. | The carboxyl-terminal region of Dok-7 plays a key, but not essential, role in activation of muscle-specific receptor kinase MuSK and neuromuscular synapse formation.
Ueta R, Tezuka T, Izawa Y, Miyoshi S, Nagatoishi S, Tsumoto K, Yamanashi Y. | 05/20/2017 |
| These results demonstrate that correct, physiological levels of dok-7 expression are required for the postnatal maintenance of neuromuscular junctions. | Postnatal knockdown of dok-7 gene expression in mice causes structural defects in neuromuscular synapses and myasthenic pathology.
Eguchi T, Tezuka T, Miyoshi S, Yamanashi Y. | 01/14/2017 |
| Protein kinase CK2 interacts at the neuromuscular synapse with Rapsyn, Rac1, 14-3-3gamma, and Dok-7 proteins and phosphorylates the latter two. | Protein kinase CK2 interacts at the neuromuscular synapse with Rapsyn, Rac1, 14-3-3γ, and Dok-7 proteins and phosphorylates the latter two.
Herrmann D, Straubinger M, Hashemolhosseini S., Free PMC Article | 12/5/2015 |
| Sp1 plays a crucial role in the regulation of the dok-7 gene. | The transcription factor Sp1 plays a crucial role in dok-7 gene expression.
Hamuro J, Hishida Y, Higuchi O, Yamanashi Y. | 07/30/2011 |
| Data show a critical role for Crk and Crk-L downstream from Dok-7 in presynaptic and postsynaptic differentiation. | Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L.
Hallock PT, Xu CF, Park TJ, Neubert TA, Curran T, Burden SJ., Free PMC Article | 02/12/2011 |
| The crystal structure of the Dok7 PH-PTB domains in complex with a phosphopeptide representing the Dok7-binding site on MuSK, is presented. | The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization.
Bergamin E, Hallock PT, Burden SJ, Hubbard SR., Free PMC Article | 08/2/2010 |
| the COOH-terminal NES and Src homology 2 target motifs play key roles in Dok-7/MuSK signaling for neuromuscular synaptogenesis. | Mutations causing DOK7 congenital myasthenia ablate functional motifs in Dok-7.
Hamuro J, Higuchi O, Okada K, Ueno M, Iemura S, Natsume T, Spearman H, Beeson D, Yamanashi Y. | 01/21/2010 |
| Dok-7 is essential for neuromuscular synaptogenesis through its interaction with MuSK | The muscle protein Dok-7 is essential for neuromuscular synaptogenesis.
Okada K, Inoue A, Okada M, Murata Y, Kakuta S, Jigami T, Kubo S, Shiraishi H, Eguchi K, Motomura M, Akiyama T, Iwakura Y, Higuchi O, Yamanashi Y. | 01/21/2010 |