| Alpha9alpha10 knockout mice show altered physiological and behavioral responses to signals in masking noise. | Alpha9alpha10 knockout mice show altered physiological and behavioral responses to signals in masking noise.
Mondul JA, Burke K, Morley B, Lauer AM., Free PMC Article | 06/27/2024 |
| Expression of Chrna9 is regulated by Tbx3 in undifferentiated pluripotent stem cells. | Expression of Chrna9 is regulated by Tbx3 in undifferentiated pluripotent stem cells.
Yazawa T, Imamichi Y, Kitano T, Islam MS, Khan MRI, Takahashi S, Sekiguchi T, Suzuki N, Umezawa A, Uwada J., Free PMC Article | 02/4/2023 |
| Efferent feedback controls bilateral auditory spontaneous activity. | Efferent feedback controls bilateral auditory spontaneous activity.
Wang Y, Sanghvi M, Gribizis A, Zhang Y, Song L, Morley B, Barson DG, Santos-Sacchi J, Navaratnam D, Crair M., Free PMC Article | 05/8/2021 |
| Characterization of HA-tagged alpha9 and alpha10 nAChRs in the mouse cochlea. | Characterization of HA-tagged α9 and α10 nAChRs in the mouse cochlea.
Vyas P, Wood MB, Zhang Y, Goldring AC, Chakir FZ, Fuchs PA, Hiel H., Free PMC Article | 05/1/2021 |
| Attenuation in Nicotinic Acetylcholine Receptor alpha9 and alpha10 Subunit Double Knock-Out Mice of Experimental Autoimmune Encephalomyelitis. | Attenuation in Nicotinic Acetylcholine Receptor α9 and α10 Subunit Double Knock-Out Mice of Experimental Autoimmune Encephalomyelitis.
Liu Q, Li M, Whiteaker P, Shi FD, Morley BJ, Lukas RJ., Free PMC Article | 09/26/2020 |
| nAChR containing the alpha9 subunit might be involved in the homeostasis of osteocytes and therefore in bone mass regulation. | Deletion of nicotinic acetylcholine receptor alpha9 in mice resulted in altered bone structure.
Baumann L, Kauschke V, Vikman A, Dürselen L, Krasteva-Christ G, Kampschulte M, Heiss C, Yee KT, Vetter DE, Lips KS., Free PMC Article | 02/22/2020 |
| A point mutation in the hair cell's Chrna9 leads to increased gating of the receptor and greatly elongates IPSCs. | A Gain-of-Function Mutation in the α9 Nicotinic Acetylcholine Receptor Alters Medial Olivocochlear Efferent Short-Term Synaptic Plasticity.
Wedemeyer C, Vattino LG, Moglie MJ, Ballestero J, Maison SF, Di Guilmi MN, Taranda J, Liberman MC, Fuchs PA, Katz E, Elgoyhen AB., Free PMC Article | 10/5/2019 |
| Chrna9 is critical for efferent modulation of mammalian type II vestibular hair cells. Type II hair cells from alpha9-/- mice, fail to respond to ACh at all. | ACh-induced hyperpolarization and decreased resistance in mammalian type II vestibular hair cells.
Poppi LA, Tabatabaee H, Drury HR, Jobling P, Callister RJ, Migliaccio AA, Jordan PM, Holt JC, Rabbitt RD, Lim R, Brichta AM., Free PMC Article | 03/16/2019 |
| we developed RgIA4, a peptide that exhibits high potency for both human and rodent a9a10 nAChRs, and was at least 1,000-fold more selective for a9a10 nAChRs vs. all other molecular targets tested, including opioid and GABAB receptors | Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain.
Romero HK, Christensen SB, Di Cesare Mannelli L, Gajewiak J, Ramachandra R, Elmslie KS, Vetter DE, Ghelardini C, Iadonato SP, Mercado JL, Olivera BM, McIntosh JM., Free PMC Article | 04/14/2018 |
| This study demonstrated that Alpha-9 nicotinic acetylcholine receptors mediate hypothermic responses elicited by provocative motion in mice. | Alpha-9 nicotinic acetylcholine receptors mediate hypothermic responses elicited by provocative motion in mice.
Tu L, Poppi L, Rudd J, Cresswell ET, Smith DW, Brichta A, Nalivaiko E. | 03/3/2018 |
| In this study present study have shown that loss of alpha9-nAChRs also affects vestibulo-ocular reflex compensation, suggesting that the mice efferent vestibular system plays an important role in vestibular plasticity. | The mammalian efferent vestibular system plays a crucial role in vestibulo-ocular reflex compensation after unilateral labyrinthectomy.
Hübner PP, Khan SI, Migliaccio AA., Free PMC Article | 09/23/2017 |
| the present study, we show that alpha9-nAChR KO mice, which lack cholinergic transmission between medial (MOC) and lateral (LOC) olivocochlear neurons located in the brainstem. | Selective Attention to Visual Stimuli Using Auditory Distractors Is Altered in Alpha-9 Nicotinic Receptor Subunit Knock-Out Mice.
Terreros G, Jorratt P, Aedo C, Elgoyhen AB, Delano PH., Free PMC Article | 07/22/2017 |
| Auditory cortex microstimulation produces an enhancement of contralateral noise suppression of auditory brainstem responses in WT mice but not in Chrna9 KO mice. | The Corticofugal Effects of Auditory Cortex Microstimulation on Auditory Nerve and Superior Olivary Complex Responses Are Mediated via Alpha-9 Nicotinic Receptor Subunit.
Aedo C, Terreros G, León A, Delano PH., Free PMC Article | 07/8/2017 |
| alpha9-nAChR KO mice showed normal responses to acute noxious thermal and mechanical stimuli, and developed normal chronic cold and mechanical allodynia in inflammatory and nerve injury pain models. | α9-nicotinic acetylcholine receptors contribute to the maintenance of chronic mechanical hyperalgesia, but not thermal or mechanical allodynia.
Mohammadi S, Christie MJ., Free PMC Article | 03/21/2015 |
| This study demonstrate that blocking efferent cholinergic neurotransmission to developing hair cells in mice that lack the alpha9 subunit of nicotinic acetylcholine receptors (alpha9 KO mice) altered the temporal fine structure of spontaneous activity. | The precise temporal pattern of prehearing spontaneous activity is necessary for tonotopic map refinement.
Clause A, Kim G, Sonntag M, Weisz CJ, Vetter DE, Rűbsamen R, Kandler K., Free PMC Article | 07/19/2014 |
| beta2*- and alpha9*-nAChRs, in addition to alpha7-nAChRs, have different roles in endogenous and nicotine-dependent modulation of immune functions and could be exploited as therapeutic targets to modulate inflammation and autoimmunity. | Differential modulation of EAE by α9*- and β2*-nicotinic acetylcholine receptors.
Simard AR, Gan Y, St-Pierre S, Kousari A, Patel V, Whiteaker P, Morley BJ, Lukas RJ, Shi FD., Free PMC Article | 08/31/2013 |
| Data indicate a change in the GABAergic system upon loss of alpha9 nicotinic receptor subunit within the cochlea. | Lack of nAChR activity depresses cochlear maturation and up-regulates GABA system components: temporal profiling of gene expression in alpha9 null mice.
Turcan S, Slonim DK, Vetter DE., Free PMC Article | 10/4/2010 |
| Inhibition of N-type Ca(2+) channel channels by Vc1.1 and RgIA conotoxins is not mediated by the expression of alpha9 nAChRs in dorsal root ganglia neurons. | Analgesic α-conotoxins Vc1.1 and RgIA inhibit N-type calcium channels in sensory neurons of α9 nicotinic receptor knockout mice.
Callaghan B, Adams DJ. | 07/12/2010 |
| In nAChR alpha9 null mice there is premature, effusive innervation to the synaptic pole of outer hair cells coinciding with delayed expression of cell adhesion proteins.Collapse of ectopic innervation coincides with age-related hyperexpression pattern. | Activity of nAChRs containing alpha9 subunits modulates synapse stabilization via bidirectional signaling programs.
Murthy V, Taranda J, Elgoyhen AB, Vetter DE., Free PMC Article | 01/21/2010 |
| Relative to their wild-type littermates, Chrna9(L9'T/L9'T) mice showed less permanent hearing loss following exposure to intense noise. Thus, a point mutation designed to alter alpha9alpha10 receptor gating has provided an animal model. | A point mutation in the hair cell nicotinic cholinergic receptor prolongs cochlear inhibition and enhances noise protection.
Taranda J, Maison SF, Ballestero JA, Katz E, Savino J, Vetter DE, Boulter J, Liberman MC, Fuchs PA, Elgoyhen AB., Free PMC Article | 01/21/2010 |
| Alpha9 was observed exclusively in the umbrella cells. | Expression of muscarinic and nicotinic acetylcholine receptors in the mouse urothelium.
Zarghooni S, Wunsch J, Bodenbenner M, Brüggmann D, Grando SA, Schwantes U, Wess J, Kummer W, Lips KS. | 01/21/2010 |
| Efferent protection from acoustic injury is mediated via alpha9 nicotinic acetylcholine receptors on outer hair cells. | Efferent protection from acoustic injury is mediated via alpha9 nicotinic acetylcholine receptors on outer hair cells.
Maison SF, Luebke AE, Liberman MC, Zuo J., Free PMC Article | 01/21/2010 |
| description of the role of alpha9 nAChR subunit in the development of the olivocochlear system and efferent function | Role of alpha9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation.
Vetter DE, Liberman MC, Mann J, Barhanin J, Boulter J, Brown MC, Saffiote-Kolman J, Heinemann SF, Elgoyhen AB. | 11/8/2006 |