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    MCF2L MCF.2 cell line derived transforming sequence like [ Homo sapiens (human) ]

    Gene ID: 23263, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    LncRNA MCF2L-AS1 aggravates the malignant development of colorectal cancer via targeting miR-105-5p/RAB22A axis.

    LncRNA MCF2L-AS1 aggravates the malignant development of colorectal cancer via targeting miR-105-5p/RAB22A axis.
    Kong W, Li H, Xie L, Cui G, Gu W, Zhang H, Ma W, Zhou Y., Free PMC Article

    10/23/2021
    miR-140-3p exhibits repressive functions on preosteoblast viability and differentiation by downregulating MCF2L in osteoporosis.

    miR-140-3p exhibits repressive functions on preosteoblast viability and differentiation by downregulating MCF2L in osteoporosis.
    Mao JH, Sui YX, Ao S, Wang Y, Liu Y, Leng H.

    10/3/2020
    When compared to the gemcitabine-sensitive cells, the gemcitabine-resistant cells had a higher level of MCF2L expression, suggesting that MCF2L plays an important role in gemcitabine resistance

    Establishment of a human primary pancreatic cancer mouse model to examine and investigate gemcitabine resistance.
    Zhang YJ, Wen CL, Qin YX, Tang XM, Shi MM, Shen BY, Fang Y., Free PMC Article

    07/21/2018
    A rare variant in MCF2L has been identified using exclusion linkage in a pedigree with premature atherosclerosis.

    A rare variant in MCF2L identified using exclusion linkage in a pedigree with premature atherosclerosis.
    Maiwald S, Motazacker MM, van Capelleveen JC, Sivapalaratnam S, van der Wal AC, van der Loos C, Kastelein JJ, Ouwehand WH, Hovingh GK, Trip MD, van Buul JD, Dallinga-Thie GM., Free PMC Article

    09/24/2016
    MCF2L is subject to a cis-acting eQTL in synovial membrane that correlates with the OA association signal. This signal contains several functional SNPs that could account for the susceptibility and which therefore merit further investigation

    Expression analysis of the osteoarthritis genetic susceptibility locus mapping to an intron of the MCF2L gene and marked by the polymorphism rs11842874.
    Shepherd C, Skelton AJ, Rushton MD, Reynard LN, Loughlin J., Free PMC Article

    03/5/2016
    In conclusion, we find that GDF5, but not COG5 or MCF2L, influence the extent of radiographic damage in knee osteoarthritis

    Genetic contribution to radiographic severity in osteoarthritis of the knee.
    Valdes AM, Doherty S, Muir KR, Zhang W, Maciewicz RA, Wheeler M, Arden N, Cooper C, Doherty M., Free PMC Article

    10/20/2012
    A single nucleotide polymorphism in MCF2L is associated with osteoarthritis.

    A variant in MCF2L is associated with osteoarthritis.
    Day-Williams AG, Southam L, Panoutsopoulou K, Rayner NW, Esko T, Estrada K, Helgadottir HT, Hofman A, Ingvarsson T, Jonsson H, Keis A, Kerkhof HJ, Thorleifsson G, Arden NK, Carr A, Chapman K, Deloukas P, Loughlin J, McCaskie A, Ollier WE, Ralston SH, Spector TD, Wallis GA, Wilkinson JM, Aslam N, Birell F, Carluke I, Joseph J, Rai A, Reed M, Walker K, arcOGEN Consortium, Doherty SA, Jonsdottir I, Maciewicz RA, Muir KR, Metspalu A, Rivadeneira F, Stefansson K, Styrkarsdottir U, Uitterlinden AG, van Meurs JB, Zhang W, Valdes AM, Doherty M, Zeggini E., Free PMC Article

    11/26/2011
    Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

    Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article

    06/30/2010
    Observational study of gene-disease association. (HuGE Navigator)

    Mutation of ARHGAP9 in patients with coronary spastic angina.
    Takefuji M, Asano H, Mori K, Amano M, Kato K, Watanabe T, Morita Y, Katsumi A, Itoh T, Takenawa T, Hirashiki A, Izawa H, Nagata K, Hirayama H, Takatsu F, Naoe T, Yokota M, Kaibuchi K.

    01/20/2010
    the guanine nucleotide exchange factor Ost has a role in negative regulation of receptor endocytosis by the small GTPase Rac1

    Role of the guanine nucleotide exchange factor Ost in negative regulation of receptor endocytosis by the small GTPase Rac1.
    Ieguchi K, Ueda S, Kataoka T, Satoh T.

    01/21/2010
    Dbs is activated by Rac1 at the pleckstrin homology domain

    Pleckstrin homology domain-mediated activation of the rho-specific guanine nucleotide exchange factor Dbs by Rac1.
    Cheng L, Mahon GM, Kostenko EV, Whitehead IP.

    01/21/2010
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