| The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms. | The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms.
Bui DLH, Roach A, Li J, Bandekar SJ, Orput E, Raghavan R, Araç D, Sando RC., Free PMC Article | 10/11/2023 |
| ADGRL3 genomic variation implicated in neurogenesis and ADHD links functional effects to the incretin polypeptide GIP. | ADGRL3 genomic variation implicated in neurogenesis and ADHD links functional effects to the incretin polypeptide GIP.
Vidal OM, Vélez JI, Arcos-Burgos M., Free PMC Article | 10/15/2022 |
| Driver mutations in ADGRL3 are involved in the evolution of ependymoma. | Driver mutations in ADGRL3 are involved in the evolution of ependymoma.
Wang J, Xi SY, Zhao Q, Xia YF, Yang QY, Cai HP, Wang F, Zhao YY, Hu HJ, Yu ZH, Chen FR, Xu PF, Xu RZ, Wang J, Zhang J, Ke C, Zhang XH, Lin FH, Guo CC, Lv YC, Li C, Xie HT, Cui Q, Wu HM, Liu YH, Li Z, Su HK, Zeng J, Han F, Li ZJ, Sai K, Chen ZP. | 09/3/2022 |
| Thwarting of Lphn3 Functions in Cell Motility and Signaling by Cancer-Related GAIN Domain Somatic Mutations. | Thwarting of Lphn3 Functions in Cell Motility and Signaling by Cancer-Related GAIN Domain Somatic Mutations.
Avila-Zozaya M, Rodríguez-Hernández B, Monterrubio-Ledezma F, Cisneros B, Boucard AA., Free PMC Article | 07/2/2022 |
| Convergent selective signaling impairment exposes the pathogenicity of latrophilin-3 missense variants linked to inheritable ADHD susceptibility. | Convergent selective signaling impairment exposes the pathogenicity of latrophilin-3 missense variants linked to inheritable ADHD susceptibility.
Moreno-Salinas AL, Holleran BJ, Ojeda-Muñiz EY, Correoso-Braña KG, Ribalta-Mena S, Ovando-Zambrano JC, Leduc R, Boucard AA., Free PMC Article | 06/11/2022 |
| Machine Learning Prediction of ADHD Severity: Association and Linkage to ADGRL3, DRD4, and SNAP25. | Machine Learning Prediction of ADHD Severity: Association and Linkage to ADGRL3, DRD4, and SNAP25.
Cervantes-Henríquez ML, Acosta-López JE, Martinez AF, Arcos-Burgos M, Puentes-Rozo PJ, Vélez JI. | 03/26/2022 |
| Adhesion G protein-coupled receptor L3 gene variants: Statistically significant association observed in the male Indo-caucasoid Attention deficit hyperactivity disorder probands. | Adhesion G protein-coupled receptor L3 gene variants: Statistically significant association observed in the male Indo-caucasoid Attention deficit hyperactivity disorder probands.
Chatterjee M, Saha S, Shom S, Sinha S, Mukhopadhyay K. | 02/5/2022 |
| CDH13 and LPHN3 Gene Polymorphisms in Attention-Deficit/Hyperactivity Disorder: Their Relation to Clinical Characteristics. | CDH13 and LPHN3 Gene Polymorphisms in Attention-Deficit/Hyperactivity Disorder: Their Relation to Clinical Characteristics.
Özaslan A, Güney E, Ergün MA, Okur İ, Yapar D. | 10/9/2021 |
| Brain structural and functional substrates of ADGRL3 (latrophilin 3) haplotype in attention-deficit/hyperactivity disorder. | Brain structural and functional substrates of ADGRL3 (latrophilin 3) haplotype in attention-deficit/hyperactivity disorder.
Moreno-Alcázar A, Ramos-Quiroga JA, Ribases M, Sánchez-Mora C, Palomar G, Bosch R, Salavert J, Fortea L, Monté-Rubio GC, Canales-Rodríguez EJ, Milham MP, Castellanos FX, Casas M, Pomarol-Clotet E, Radua J., Free PMC Article | 09/25/2021 |
| Expression of the adult ADHD-associated gene ADGRL3 is dysregulated by risk variants and environmental risk factors. | Expression of the adult ADHD-associated gene ADGRL3 is dysregulated by risk variants and environmental risk factors.
McNeill RV, Palladino VS, Brunkhorst-Kanaan N, Grimm O, Reif A, Kittel-Schneider S. | 08/21/2021 |
| Tissue Expression Of LPHN3 in Breast Cancer: An Immunohistochemistry Method. | Tissue Expression Of LPHN3 in Breast Cancer: An Immunohistochemistry Method.
Kotepui KU, Kotepui M, Piwkham D, Songsri A, Charoenkijkajorn L, Kongnok T, Chanil Y., Free PMC Article | 08/7/2021 |
| G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3. | G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3.
Mathiasen S, Palmisano T, Perry NA, Stoveken HM, Vizurraga A, McEwen DP, Okashah N, Langenhan T, Inoue A, Lambert NA, Tall GG, Javitch JA., Free PMC Article | 01/23/2021 |
| ADGRL3 rs6551665 as a Common Vulnerability Factor Underlying Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder. | ADGRL3 rs6551665 as a Common Vulnerability Factor Underlying Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder.
Kappel DB, Schuch JB, Rovaris DL, da Silva BS, Müller D, Breda V, Teche SP, S Riesgo R, Schüler-Faccini L, Rohde LA, Grevet EH, Bau CHD. | 10/3/2020 |
| LPHN3 gene has a significant effect on the attention-deficit/hyperactivity disorder in a Chinese population. | LPHN3 gene variations and susceptibility to ADHD in Chinese Han population: a two-stage case-control association study and gene-environment interactions.
Huang X, Zhang Q, Gu X, Hou Y, Wang M, Chen X, Wu J. | 08/17/2019 |
| Study identified ADGRL3 as a risk gene for substance use disorder. | ADGRL3 (LPHN3) variants predict substance use disorder.
Arcos-Burgos M, Vélez JI, Martinez AF, Ribasés M, Ramos-Quiroga JA, Sánchez-Mora C, Richarte V, Roncero C, Cormand B, Fernández-Castillo N, Casas M, Lopera F, Pineda DA, Palacio JD, Acosta-López JE, Cervantes-Henriquez ML, Sánchez-Rojas MG, Puentes-Rozo PJ, Molina BSG, MTA Cooperative Group, Boden MT, Wallis D, Lidbury B, Newman S, Easteal S, Swanson J, Patel H, Volkow N, Acosta MT, Castellanos FX, de Leon J, Mastronardi CA, Muenke M., Free PMC Article | 06/15/2019 |
| An ultraconserved brain-specific enhancer within LPHN3 is associated with ADHD susceptibility. | An Ultraconserved Brain-Specific Enhancer Within ADGRL3 (LPHN3) Underpins Attention-Deficit/Hyperactivity Disorder Susceptibility.
Martinez AF, Abe Y, Hong S, Molyneux K, Yarnell D, Löhr H, Driever W, Acosta MT, Arcos-Burgos M, Muenke M., Free PMC Article | 07/22/2017 |
| Associations between LPHN1 and LPHN3 polymorphisms and severity of bronchial hyper-responsiveness in asthmatics were conducted; however, no associations were found. | Latrophilin receptors: novel bronchodilator targets in asthma.
Faiz A, Donovan C, Nieuwenhuis MA, van den Berge M, Postma DS, Yao S, Park CY, Hirsch R, Fredberg JJ, Tjin G, Halayko AJ, Rempel KL, Ward JP, Lee T, Bossé Y, Nickle DC, Obeidat M, Vonk JM, Black JL, Oliver BG, Krishnan R, McParland B, Bourke JE, Burgess JK., Free PMC Article | 06/24/2017 |
| Results suggest that UNC5 and LPHN3 can simultaneously bind to FLRT3, forming a trimeric complex, and that FLRT3 may form transsynaptic complexes with both LPHN3 and UNC5. | Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion.
Lu YC, Nazarko OV, Sando R 3rd, Salzman GS, Li NS, Südhof TC, Araç D., Free PMC Article | 07/2/2016 |
| LPHN3 confers ADHD susceptibility, and moderates methylphenidate treatment response in children and adolescents with ADHD. | LPHN3 and attention-deficit/hyperactivity disorder: a susceptibility and pharmacogenetic study.
Bruxel EM, Salatino-Oliveira A, Akutagava-Martins GC, Tovo-Rodrigues L, Genro JP, Zeni CP, Polanczyk GV, Chazan R, Schmitz M, Arcos-Burgos M, Rohde LA, Hutz MH. | 03/26/2016 |
| Study examined the association between the LPHN3 rs6551665 A/G polymorphism and Attention deficit hyperactivity disorder (ADHD) in Korea; samples used in the study consisted of 150 ADHD children and 322 controls; ADHD children appeared to have a surplus of GG genotype, studies with larger sample sizes needed. | Association of LPHN3 rs6551665 A/G polymorphism with attention deficit and hyperactivity disorder in Korean children.
Hwang IW, Lim MH, Kwon HJ, Jin HJ. | 08/1/2015 |
| genetic association studies in Germany: Data suggest that, within a sample of patients with attention deficit disorder hyperactivity, SNPs in LPHN3 gene impacts behavioral and neurophysiological measures of cognitive response control. | Influence of a latrophilin 3 (LPHN3) risk haplotype on event-related potential measures of cognitive response control in attention-deficit hyperactivity disorder (ADHD).
Fallgatter AJ, Ehlis AC, Dresler T, Reif A, Jacob CP, Arcos-Burgos M, Muenke M, Lesch KP., Free PMC Article | 12/28/2013 |
| Increased LPHN3 mRNA expression levels correlated with axillary-node metastasis in breast cancer. | Quantitative real-time RT-PCR of ITGA7, SVEP1, TNS1, LPHN3, SEMA3G, KLB and MMP13 mRNA expression in breast cancer.
Kotepui M, Thawornkuno C, Chavalitshewinkoon-Petmitr P, Punyarit P, Petmitr S. | 07/6/2013 |
| The influence of LPHN3 genotype on attention deficit-hyperactivity disorder (ADHD) and addiction is mediated through alterations in transgenic monoamine signaling. | Initial characterization of mice null for Lphn3, a gene implicated in ADHD and addiction.
Wallis D, Hill DS, Mendez IA, Abbott LC, Finnell RH, Wellman PJ, Setlow B. | 04/13/2013 |
| A two-locus genetic interaction between LPHN3 and 11q predicts ADHD severity and long-term outcome. | A two-locus genetic interaction between LPHN3 and 11q predicts ADHD severity and long-term outcome.
Acosta MT, Vélez JI, Bustamante ML, Balog JZ, Arcos-Burgos M, Muenke M., Free PMC Article | 04/6/2013 |
| This study identifying loci for aADHD and led to the identification of LPHN3 as novel genes associated with ADHD across the lifespan. | The genetics of attention deficit/hyperactivity disorder in adults, a review.
Franke B, Faraone SV, Asherson P, Buitelaar J, Bau CH, Ramos-Quiroga JA, Mick E, Grevet EH, Johansson S, Haavik J, Lesch KP, Cormand B, Reif A, International Multicentre persistent ADHD CollaboraTion., Free PMC Article | 03/2/2013 |