| MGRN1 depletion promotes intercellular adhesion in melanoma by upregulation of E-cadherin and inhibition of CDC42. | MGRN1 depletion promotes intercellular adhesion in melanoma by upregulation of E-cadherin and inhibition of CDC42.
Cerdido S, Abrisqueta M, Sánchez-Beltrán J, Lambertos A, Castejón-Griñán M, Muñoz C, Olivares C, García-Borrón JC, Jiménez-Cervantes C, Herraiz C. | 12/21/2023 |
| Mahogunin Ring Finger 1 regulates pigmentation by controlling the pH of melanosomes in melanocytes and melanoma cells. | Mahogunin Ring Finger 1 regulates pigmentation by controlling the pH of melanosomes in melanocytes and melanoma cells.
Sirés-Campos J, Lambertos A, Delevoye C, Raposo G, Bennett DC, Sviderskaya E, Jiménez-Cervantes C, Olivares C, García-Borrón JC., Free PMC Article | 01/22/2022 |
| epletion of MGRN1 activity may hamper physiologically important processes like mitochondrial movement in neuronal processes and intracellular transport of ligands through the endosomal pathway thereby contributing to the pathogenesis of neurodegeneration in certain types of prion diseases | MGRN1-mediated ubiquitination of α-tubulin regulates microtubule dynamics and intracellular transport.
Mukherjee R, Majumder P, Chakrabarti O. | 07/28/2018 |
| In a heterologous expression system, MC1R-dependent Arrestins B ubiquitination was enhanced by overexpression of MGRN1 and was impaired by siRNA-mediated MGRN1 knockdown thus pointing to MGRN1 as the responsible E3-ligase. | Human melanocortin 1 receptor-mediated ubiquitination of nonvisual arrestins. Role of Mahogunin Ring Finger 1 E3 ligase.
Abrisqueta M, Olivares C, Herraiz C, Castejón-Griñán M, Sirés-Campos J, García-Borrón JC, Jiménez-Cervantes C. | 04/7/2018 |
| Hypomethylation of CpG sites in RPTOR, MGRN1 and RAPSN in blood is associated with breast cancer. | DNA methylation array analysis identifies breast cancer associated RPTOR, MGRN1 and RAPSN hypomethylation in peripheral blood DNA.
Tang Q, Holland-Letz T, Slynko A, Cuk K, Marme F, Schott S, Heil J, Qu B, Golatta M, Bewerunge-Hudler M, Sutter C, Surowy H, Wappenschmidt B, Schmutzler R, Hoth M, Bugert P, Bartram CR, Sohn C, Schneeweiss A, Yang R, Burwinkel B., Free PMC Article | 02/10/2018 |
| Regulation of Mfn1 by MGRN1 and the proteasome modulates mitochondrial fusion. | Regulation of Mitofusin1 by Mahogunin Ring Finger-1 and the proteasome modulates mitochondrial fusion.
Mukherjee R, Chakrabarti O. | 10/7/2017 |
| With aging, the neuroprotective e3 ligase MGRN1 relocates from the cytosol to the nucleus of neurons, where it associates with chromatin and potentiates the cellular response to proteotoxic stress. This nuclear shift is due to a proteasome impairment dependent increase of a monoubiquitinated form of MGRN1. | Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival.
Benvegnù S, Mateo MI, Palomer E, Jurado-Arjona J, Dotti CG. | 09/9/2017 |
| Catalytic inactivation of MGRN1 results in elevated levels of GP78 and a consequential increase in the initiation of mitophagy. | Ubiquitin-mediated regulation of the E3 ligase GP78 by MGRN1 in trans affects mitochondrial homeostasis.
Mukherjee R, Chakrabarti O. | 12/17/2016 |
| Mahogunin-mediated alpha-tubulin ubiquitination via noncanonical K6 linkage regulates microtubule stability and mitotic spindle orientation. | Mahogunin-mediated α-tubulin ubiquitination via noncanonical K6 linkage regulates microtubule stability and mitotic spindle orientation.
Srivastava D, Chakrabarti O., Free PMC Article | 10/25/2014 |
| data suggest that MGRN1 selectively targets misfolded proteins for degradation and may exhibit viable therapeutic potential for the treatment of spongiform neurodegeneration | Mahogunin ring finger-1 (MGRN1) suppresses chaperone-associated misfolded protein aggregation and toxicity.
Chhangani D, Mishra A., Free PMC Article | 10/19/2013 |
| It therefore seems probable that the role of MGRN1 in the adrenal relates to the trafficking and/or degradation of the melanocortin 2 receptor. | The E3 ubiquitin ligase Mahogunin ubiquitinates the melanocortin 2 receptor.
Cooray SN, Guasti L, Clark AJ. | 12/10/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Study shows that both (Ctm)PrP and cyPrP can interact with and disrupt the function of Mahogunin (Mgrn), a cytosolic ubiquitin ligase whose loss causes spongiform neurodegeneration. | Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration.
Chakrabarti O, Hegde RS., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Pigmentation-related genes and their implication in malignant melanoma susceptibility.
Fernandez LP, Milne RL, Pita G, Floristan U, Sendagorta E, Feito M, Avilés JA, Martin-Gonzalez M, Lázaro P, Benítez J, Ribas G. | 04/8/2009 |
| a role for Mahogunin in a proteasome-independent ubiquitylation pathway: TSG101 is a specific Mahogunin substrate | Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking.
Kim BY, Olzmann JA, Barsh GS, Chin LS, Li L., Free PMC Article | 01/21/2010 |