| Cholesterol uptake in the intestine is regulated by the LASP1-AKT-NPC1L1 signaling pathway. | Cholesterol uptake in the intestine is regulated by the LASP1-AKT-NPC1L1 signaling pathway.
Butt E, Günder T, Stürzebecher P, Kowalski I, Schneider P, Buschmann N, Schäfer S, Bender A, Hermanns HM, Zernecke A. | 06/15/2024 |
| Bile acids-mediated intracellular cholesterol transport promotes intestinal cholesterol absorption and NPC1L1 recycling. | Bile acids-mediated intracellular cholesterol transport promotes intestinal cholesterol absorption and NPC1L1 recycling.
Xiao J, Dong LW, Liu S, Meng FH, Xie C, Lu XY, Zhang WJ, Luo J, Song BL., Free PMC Article | 10/24/2023 |
| NPC1L1 Deficiency Suppresses Ileal Fibroblast Growth Factor 15 Expression and Increases Bile Acid Pool Size in High-Fat-Diet-Fed Mice. | NPC1L1 Deficiency Suppresses Ileal Fibroblast Growth Factor 15 Expression and Increases Bile Acid Pool Size in High-Fat-Diet-Fed Mice.
Jia L, Ma Y, Haywood J, Jiang L, Xue B, Shi H, Dawson PA, Yu L., Free PMC Article | 01/22/2022 |
| NPC1L1-dependent transport of 27-alkyne cholesterol in intestinal epithelial cells. | NPC1L1-dependent transport of 27-alkyne cholesterol in intestinal epithelial cells.
Ticho AL, Calzadilla N, Malhotra P, Lee H, Anbazhagan AN, Saksena S, Dudeja PK, Lee D, Gill RK, Alrefai WA., Free PMC Article | 07/31/2021 |
| NPC1L1 Facilitates Sphingomyelin Absorption and Regulates Diet-Induced Production of VLDL/LDL-associated S1P. | NPC1L1 Facilitates Sphingomyelin Absorption and Regulates Diet-Induced Production of VLDL/LDL-associated S1P.
Yamanashi Y, Takada T, Yamamoto H, Suzuki H., Free PMC Article | 04/3/2021 |
| Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins. | Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins.
Saha P, Shumate JL, Caldwell JG, Elghobashi-Meinhardt N, Lu A, Zhang L, Olsson NE, Elias JE, Pfeffer SR., Free PMC Article | 03/20/2021 |
| Hepatic NPC1L1 overexpression attenuates alcoholic autophagy in mice. | Hepatic NPC1L1 overexpression attenuates alcoholic autophagy in mice.
Wang Y, Yang P, Zhang B, Ding Y, Lei S, Hou Y, Guan X, Li Q., Free PMC Article | 02/8/2020 |
| Results revealed that hepatic NPC1L1 exacerbates diet-induced dyslipidemia and atherosclerosis when intestinal NPC1L1 is functional. | Hepatic Expression of Niemann-Pick C1-Like 1, a Cholesterol Reabsorber from Bile, Exacerbates Western Diet-Induced Atherosclerosis in LDL Receptor Mutant Mice.
Yamamoto H, Yamanashi Y, Takada T, Mu S, Tanaka Y, Komine T, Suzuki H. | 12/14/2019 |
| TGIF1 represses Niemann-Pick C1 like 1 (Npc1l1) promoter activity in intestines, lowering intestinal cholesterol absorption. | Overexpression of transforming growth factor β induced factor homeobox 1 represses NPC1L1 and lowers markers of intestinal cholesterol absorption.
Parini P, Melhuish TA, Wotton D, Larsson L, Ahmed O, Eriksson M, Pramfalk C. | 10/26/2019 |
| The present study demonstrated that OPN deficiency reduced intestinal absorption of cholesterol by suppressing the expression of NPC1L1, thus protecting mice from cholesterol gallstone formation. | Osteopontin deficiency protects mice from cholesterol gallstone formation by reducing expression of intestinal NPC1L1.
Lin J, Shao WQ, Chen QZ, Zhu WW, Lu L, Jia HL, Chen JH., Free PMC Article | 05/12/2018 |
| Decreased mRNA levels of HNF4alpha and SREBP2 in mice could be involved in the reduction in NPC1L1 expression. | Impact of a high-cholesterol diet on expression levels of Niemann-Pick C1-like 1 and intestinal transporters in rats and mice.
Kawase A, Araki Y, Ueda Y, Nakazaki S, Iwaki M. | 03/25/2017 |
| NPC1L1 knockout protects against colitis-associated tumorigenesis. | NPC1L1 knockout protects against colitis-associated tumorigenesis in mice.
He J, Shin H, Wei X, Kadegowda AK, Chen R, Xie SK., Free PMC Article | 01/2/2016 |
| demonstrate that Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter, plays a central role in intestinal VK uptake and modulates the anticoagulant effect of warfarin. In | NPC1L1 is a key regulator of intestinal vitamin K absorption and a modulator of warfarin therapy.
Takada T, Yamanashi Y, Konishi K, Yamamoto T, Toyoda Y, Masuo Y, Yamamoto H, Suzuki H. | 11/21/2015 |
| NPC1L1 may suppress gluconeogenesis by inhibition of FoxO1 pathways. | Hepatic NPC1L1 overexpression ameliorates glucose metabolism in diabetic mice via suppression of gluconeogenesis.
Kurano M, Hara M, Satoh H, Tsukamoto K. | 05/23/2015 |
| DNA methylation in the promoter region of the NPC1L1 gene appears to be a major mechanism underlying differential expression of NPC1L1 along the length of the gastrointestinal tract. | Epigenetic modulation of intestinal cholesterol transporter Niemann-Pick C1-like 1 (NPC1L1) gene expression by DNA methylation.
Malhotra P, Soni V, Kumar A, Anbazhagan AN, Dudeja A, Saksena S, Gill RK, Dudeja PK, Alrefai WA., Free PMC Article | 12/20/2014 |
| cholesterol and tocopherol uptakes share common pathways in cell culture models, but display different in vivo absorption patterns associated with distinct contributions of SR-BI and NPC1L1 | Respective contributions of intestinal Niemann-Pick C1-like 1 and scavenger receptor class B type I to cholesterol and tocopherol uptake: in vivo v. in vitro studies.
Reboul E, Soayfane Z, Goncalves A, Cantiello M, Bott R, Nauze M, Tercé F, Collet X, Coméra C. | 05/31/2014 |
| The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1. | The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1.
Li PS, Fu ZY, Zhang YY, Zhang JH, Xu CQ, Ma YT, Li BL, Song BL. | 03/22/2014 |
| Glucose appears to directly modulate NPC1L1 expression via transcriptional mechanisms and the involvement of phosphatase-dependent pathways. | D-Glucose modulates intestinal Niemann-Pick C1-like 1 (NPC1L1) gene expression via transcriptional regulation.
Malhotra P, Boddy CS, Soni V, Saksena S, Dudeja PK, Gill RK, Alrefai WA., Free PMC Article | 03/9/2013 |
| hepatitis c virus entry factor | Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor.
Sainz B Jr, Barretto N, Martin DN, Hiraga N, Imamura M, Hussain S, Marsh KA, Yu X, Chayama K, Alrefai WA, Uprichard SL., Free PMC Article | 03/31/2012 |
| the mechanism of cholesterol sensing by NPC1L1 and proposes a mechanism for selective cholesterol absorption | The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake.
Zhang JH, Ge L, Qi W, Zhang L, Miao HH, Li BL, Yang M, Song BL., Free PMC Article | 01/28/2012 |
| Cdc42 controls the cholesterol-regulated transport and localization of NPC1L1, and plays a role in cholesterol absorption. | The small GTPase Cdc42 interacts with Niemann-Pick C1-like 1 (NPC1L1) and controls its movement from endocytic recycling compartment to plasma membrane in a cholesterol-dependent manner.
Xie C, Li N, Chen ZJ, Li BL, Song BL., Free PMC Article | 12/17/2011 |
| These findings demonstrated a direct role of hepatic NPC1L1 in regulating biliary cholesterol excretion and hepatic/blood cholesterol levels, and unequivocally established hepatic NPC1L1 as a target of ezetimibe. | Ezetimibe restores biliary cholesterol excretion in mice expressing Niemann-Pick C1-Like 1 only in liver.
Tang W, Jia L, Ma Y, Xie P, Haywood J, Dawson PA, Li J, Yu L., Free PMC Article | 11/12/2011 |
| The results of this study indicated a general presynaptic functional impairment in the NPC1(-/-) neurons and such defects were not dependent of glial cells. | Presynaptic impairment in Niemann-Pick C1-deficient neurons: not dependent on presence of glial cells.
Xu S, Chen X, Wei X, Liu G, Wang Q. | 08/27/2011 |
| flotillins have a role in NPC1L1-mediated cholesterol uptake and NPC1L1-flotillins-postive cholesterol-enriched membrane microdomains are involved in the mechanism for efficient cholesterol absorption | Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake.
Ge L, Qi W, Wang LJ, Miao HH, Qu YX, Li BL, Song BL., Free PMC Article | 02/26/2011 |
| NBD-cholesterol absorption proceeds through an NPC1L1-independent and ezetimibe-insensitive sterol absorption mechanism. | Use of NBD-cholesterol to identify a minor but NPC1L1-independent cholesterol absorption pathway in mouse intestine.
Adams MR, Konaniah E, Cash JG, Hui DY., Free PMC Article | 02/5/2011 |