| Carbonic anhydrase 14 protects the liver against the cytotoxicity of bile acids in a biliary bicarbonate umbrella-related manner. | Carbonic anhydrase 14 protects the liver against the cytotoxicity of bile acids in a biliary bicarbonate umbrella-related manner.
Qian J, Shen Q, Zhang T, Chen J, Chen L, Dong Y, Yan R, Chen Z. | 11/19/2022 |
| Loss of luminal carbonic anhydrase XIV results in decreased biliary bicarbonate output, liver fibrosis, and cholangiocyte proliferation in mice. | Loss of luminal carbonic anhydrase XIV results in decreased biliary bicarbonate output, liver fibrosis, and cholangiocyte proliferation in mice.
Zhou Z, Qian J, Kini A, Riederer B, Römermann D, Gros G, Seidler U., Free PMC Article | 04/23/2022 |
| During inner ear development, transcripts of four cytosolic isozymes (Car1, Car2, Car3, and Car13), two membrane-bound isozymes (Car12 and Car14), and two CA-related proteins (Car8 and Car11) were expressed at higher levels than other isozymes. | A systematic survey of carbonic anhydrase mRNA expression during mammalian inner ear development.
Wu L, Sagong B, Choi JY, Kim UK, Bok J. | 08/10/2013 |
| CAXIV functionally interacts with AE3, forming an extracellular membrane protein complex involved in the regulation of bicarbonate metabolism and pHi in the heart. | Carbonic anhydrase XIV in the normal and hypertrophic myocardium.
Vargas LA, Alvarez BV. | 07/14/2012 |
| Association of AE3 and CAXIV may represent a mechanism to enhance disposal of waste CO(2) and to balance pH in excitable tissues. | Bicarbonate homeostasis in excitable tissues: role of AE3 Cl-/HCO3- exchanger and carbonic anhydrase XIV interaction.
Casey JR, Sly WS, Shah GN, Alvarez BV., Free PMC Article | 01/21/2010 |
| CA XIV (along with carbonic anhydrase 4) plays an important role in the regulation of intracellular pH in hippocampus, via facilitation of anion exchanger AE3-mediated chloride-bicarbonate antiporter HCO3 exchange. | Carbonic anhydrases CA4 and CA14 both enhance AE3-mediated Cl--HCO3- exchange in hippocampal neurons.
Svichar N, Waheed A, Sly WS, Hennings JC, Hübner CA, Chesler M., Free PMC Article | 01/21/2010 |
| CA XIV is expressed in sarcoplasmic reticulum and sarcolemma of skeletal muscle. | Carbonic anhydrase XIV in skeletal muscle: subcellular localization and function from wild-type and knockout mice.
Wetzel P, Scheibe RJ, Hellmann B, Hallerdei J, Shah GN, Waheed A, Gros G, Sly WS. | 01/21/2010 |
| The presence of CA XIV in the hepatocyte plasma membrane places it at a strategic site to control pH regulation and ion transport between the hepatocytes, sinusoids and bile canaliculi. | The plasma membrane carbonic anhydrase in murine hepatocytes identified as isozyme XIV.
Parkkila S, Kivelä AJ, Kaunisto K, Parkkila AK, Hakkola J, Rajaniemi H, Waheed A, Sly WS., Free PMC Article | 01/21/2010 |
| studies on hippocampal slices on these KO mice showed that either CA can mediate buffering after synaptic transmission in hippocampal slices in the absence of the other, but that eliminating both is as effective in blocking the buffering seen in WT mice | Carbonic anhydrase IV and XIV knockout mice: roles of the respective carbonic anhydrases in buffering the extracellular space in brain.
Shah GN, Ulmasov B, Waheed A, Becker T, Makani S, Svichar N, Chesler M, Sly WS., Free PMC Article | 01/21/2010 |
| carbonic anhydrase XIV has a role in selective inhibition of membrane-associated isozymes | Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV: implications for selective inhibition of membrane-associated isozymes.
Whittington DA, Grubb JH, Waheed A, Shah GN, Sly WS, Christianson DW. | 01/21/2010 |
| CA XIV, which regulates extracellular pH and pCO(2), plays an important part in producing a normal retinal light response. | Carbonic anhydrase XIV deficiency produces a functional defect in the retinal light response.
Ogilvie JM, Ohlemiller KK, Shah GN, Ulmasov B, Becker TA, Waheed A, Hennig AK, Lukasiewicz PD, Sly WS., Free PMC Article | 01/21/2010 |