| Regulation of fractone heparan sulfate composition in young and aged subventricular zone neurogenic niches. | Regulation of fractone heparan sulfate composition in young and aged subventricular zone neurogenic niches.
Kerever A, Nagahara F, Keino-Masu K, Masu M, van Kuppevelt TH, Vivès RR, Arikawa-Hirasawa E. | 03/19/2022 |
| Sulf-1 might play a critical role from development to maintenance of intervertebral disc homeostasis by regulating collagen expression | Role of heparan sulfate 6-0 endosulfatases in intervertebral disc homeostasis.
Otsuki S, Alvarez-Garcia O, Lotz MK, Neo M., Free PMC Article | 02/22/2020 |
| Loss of SULF1 expression is associated with corticospinal tract defect. | Desulfation of Heparan Sulfate by Sulf1 and Sulf2 Is Required for Corticospinal Tract Formation.
Okada T, Keino-Masu K, Nagamine S, Kametani F, Ohto T, Hasegawa M, van Kuppevelt TH, Kunita S, Takahashi S, Masu M., Free PMC Article | 07/20/2019 |
| Shh signaling requires the coordinated activity of Sulf1 and Sulf2 in order to reach that threshold in the mouse ventral spinal cord | Sulfatase 2 Modulates Fate Change from Motor Neurons to Oligodendrocyte Precursor Cells through Coordinated Regulation of Shh Signaling with Sulfatase 1.
Jiang W, Ishino Y, Hashimoto H, Keino-Masu K, Masu M, Uchimura K, Kadomatsu K, Yoshimura T, Ikenaka K. | 05/26/2018 |
| our findings show that Sulf-1 is an important tumor suppressor gene in hepatocellular carcinoma (HCC), and its over expression downregulates Msln and results in a decrease in HCC cell proliferation, migration, invasion, and lymphatic metastasis. | Overexpression of sulfatase-1 in murine hepatocarcinoma Hca-F cell line downregulates mesothelin and leads to reduction in lymphatic metastasis, both in vitro and in vivo.
Mahmoud S, Ibrahim M, Hago A, Huang Y, Wei Y, Zhang J, Zhang Q, Xiao Y, Wang J, Adam M, Guo Y, Wang L, Zhou S, Xin B, Xuan W, Tang J., Free PMC Article | 03/3/2018 |
| Sulf1 and Sulf2 play indispensable roles to maintain glomerular integrity and protective roles in diabetic nephropathy, probably by growth factor modulation. | Heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, regulate glomerular integrity by modulating growth factor signaling.
Takashima Y, Keino-Masu K, Yashiro H, Hara S, Suzuki T, van Kuppevelt TH, Masu M, Nagata M. | 07/30/2016 |
| Expression of the heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, in the avian and mammalian inner ear suggests a role for sulfation during inner ear development. | Expression of the heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, in the avian and mammalian inner ear suggests a role for sulfation during inner ear development.
Freeman SD, Keino-Masu K, Masu M, Ladher RK. | 07/25/2015 |
| Our study proposes a novel role of SULF1 in hepatocellular carcinoma tumor progression through augmentation of the TGF-beta pathway, thus defining SULF1 as a potential biomarker for tumor progression and a novel target for drug development for HCC. | Activation of the transforming growth factor-β/SMAD transcriptional pathway underlies a novel tumor-promoting role of sulfatase 1 in hepatocellular carcinoma.
Dhanasekaran R, Nakamura I, Hu C, Chen G, Oseini AM, Seven ES, Miamen AG, Moser CD, Zhou W, van Kuppevelt TH, van Deursen JM, Mounajjed T, Fernandez-Zapico ME, Roberts LR., Free PMC Article | 06/6/2015 |
| It is proposed that Sulf1, Sulf2 and ErbB1 are involved in the inhibition of neurite outgrowth and may regulate structural plasticity and regeneration in the nervous system. | Sulf1 and Sulf2 expression in the nervous system and its role in limiting neurite outgrowth in vitro.
Joy MT, Vrbova G, Dhoot GK, Anderson PN. | 02/14/2015 |
| Sulf1/, but not Sulf2/, mice, exhibited a marked delay in healing of corneal epithelial wounds. | The SULFs, extracellular sulfatases for heparan sulfate, promote the migration of corneal epithelial cells during wound repair.
Maltseva I, Chan M, Kalus I, Dierks T, Rosen SD., Free PMC Article | 05/3/2014 |
| Distinct expression patterns of Sulf1 and Hs6st1 spatially regulate heparan sulfate sulfation during prostate development. | Distinct expression patterns of Sulf1 and Hs6st1 spatially regulate heparan sulfate sulfation during prostate development.
Buresh-Stiemke RA, Malinowski RL, Keil KP, Vezina CM, Oosterhof A, Van Kuppevelt TH, Marker PC., Free PMC Article | 05/4/2013 |
| Our study provides additional insights into the temporal control of Olig2 progenitor cell fate change by the identification of Sulf1 as an extracellular timing signal in the ventral spinal cord. | Sulfatase 1 promotes the motor neuron-to-oligodendrocyte fate switch by activating Shh signaling in Olig2 progenitors of the embryonic ventral spinal cord.
Touahri Y, Escalas N, Benazeraf B, Cochard P, Danesin C, Soula C., Free PMC Article | 03/2/2013 |
| Sulf1 and Sulf2 differentially contribute to the generation of organ-specific sulfation patterns of heparan sulfate. | Organ-specific sulfation patterns of heparan sulfate generated by extracellular sulfatases Sulf1 and Sulf2 in mice.
Nagamine S, Tamba M, Ishimine H, Araki K, Shiomi K, Okada T, Ohto T, Kunita S, Takahashi S, Wismans RG, van Kuppevelt TH, Masu M, Keino-Masu K., Free PMC Article | 06/16/2012 |
| Sulf-1 and Sulf-2 are essential regulators of GDNF signaling in the SSC niche and direct downstream targets of Sertoli cell-specific transcriptional factor Wilm's tumor 1. | Expression regulation and function of heparan sulfate 6-O-endosulfatases in the spermatogonial stem cell niche.
Langsdorf A, Schumacher V, Shi X, Tran T, Zaia J, Jain S, Taglienti M, Kreidberg JA, Fine A, Ai X., Free PMC Article | 06/4/2011 |
| reduction in protein levels promotes satellite cell proliferation | Sulf1A and HGF regulate satellite-cell growth.
Gill R, Hitchins L, Fletcher F, Dhoot GK., Free PMC Article | 09/27/2010 |
| These results reveal that Sulf1 and Sulf2 fulfil non-redundant functions in vivo in the development and maintenance of the murine nervous system. | Differential involvement of the extracellular 6-O-endosulfatases Sulf1 and Sulf2 in brain development and neuronal and behavioural plasticity.
Kalus I, Salmen B, Viebahn C, von Figura K, Schmitz D, D'Hooge R, Dierks T., Free PMC Article | 07/26/2010 |
| The data identify sulfatase 1 as an inhibitor of prostatic branching morphogenesis and growth factor signaling that is down-regulated as part of the normal response to androgen action in the male urogenital sinus. | Sulfatase 1 is an inhibitor of ductal morphogenesis with sexually dimorphic expression in the urogenital sinus.
Buresh RA, Kuslak SL, Rusch MA, Vezina CM, Selleck SB, Marker PC., Free PMC Article | 07/12/2010 |
| results show that Sulf1 and Sulf2 play overlapping yet critical roles in mouse development and are redundant and essential for neonatal survival | Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survival.
Holst CR, Bou-Reslan H, Gore BB, Wong K, Grant D, Chalasani S, Carano RA, Frantz GD, Tessier-Lavigne M, Bolon B, French DM, Ashkenazi A., Free PMC Article | 05/3/2010 |
| Sulf1 and Sulf2 are two heparan sulfate 6-O-endosulfatases that regulate the activity of multiple growth factors, such as fibroblast growth factor and Wnt, and are essential for mammalian development and survival | Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling.
Lamanna WC, Frese MA, Balleininger M, Dierks T. | 01/21/2010 |
| Sulf1 is a TGF-beta1-responsive gene both in vitro and in vivo and may function as a negative regulator of TGF-beta1-induced fibrogenesis | Transforming growth factor-beta1 induces heparan sulfate 6-O-endosulfatase 1 expression in vitro and in vivo.
Yue X, Li X, Nguyen HT, Chin DR, Sullivan DE, Lasky JA., Free PMC Article | 01/21/2010 |
| Redundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 in fine-tuning rather than regulating the development of skeletal structures. | Redundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 during skeletal development.
Ratzka A, Kalus I, Moser M, Dierks T, Mundlos S, Vortkamp A. | 01/21/2010 |
| Results establish Sulfs 1 and 2 as essential regulators of heparan sulfate-dependent growth factor signaling in the adult muscle stem cell niche. | Sulfs are regulators of growth factor signaling for satellite cell differentiation and muscle regeneration.
Langsdorf A, Do AT, Kusche-Gullberg M, Emerson CP Jr, Ai X. | 01/21/2010 |
| SULF1 is expressed in GDNF-expressing esophageal muscle and SULF2 in innervating neurons, establishing their direct functions in esophageal innervation. | SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation.
Ai X, Kitazawa T, Do AT, Kusche-Gullberg M, Labosky PA, Emerson CP Jr. | 01/21/2010 |
| Sulf2 may have roles in several tissues but that there is compensation by and/or redundancy with Sulf1. | Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase gene, Sulf2.
Lum DH, Tan J, Rosen SD, Werb Z., Free PMC Article | 01/21/2010 |
| Sulfs are extracellular endosulfatases with strong potential for modulating the interactions of heparan sulfate proteoglycans in the extracellular microenvironment | Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans.
Morimoto-Tomita M, Uchimura K, Werb Z, Hemmerich S, Rosen SD., Free PMC Article | 01/21/2010 |