| A GITRL-mTORC1-GM-CSF Positive Loop Promotes Pathogenic Th17 Response in Primary Sjogren Syndrome. | A GITRL-mTORC1-GM-CSF Positive Loop Promotes Pathogenic Th17 Response in Primary Sjögren Syndrome.
Gan Y, Zhou H, Guo Y, Huang B, Liu H, Wang Z, Li Z, Zhao X, Zhu H, Han Q, Ye H, He J, Wang Q, Li Z, Sun X. | 08/31/2024 |
| GITRL impairs hepatocyte repopulation by liver progenitor cells to aggravate inflammation and fibrosis by GITR[+]CD8[+] T lymphocytes in CDE Mice. | GITRL impairs hepatocyte repopulation by liver progenitor cells to aggravate inflammation and fibrosis by GITR(+)CD8(+) T lymphocytes in CDE Mice.
Li L, He Y, Liu K, Liu L, Shan S, Liu H, Ren J, Sun S, Wang M, Jia J, Wang P., Free PMC Article | 02/14/2024 |
| GITRL impairs the immunosuppressive function of MDSCs via PTEN-mediated signaling pathway in experimental Sjogren syndrome. | GITRL impairs the immunosuppressive function of MDSCs via PTEN-mediated signaling pathway in experimental Sjögren syndrome.
Tian J, Zhang B, Yuan Q, Sun X, Peng N, Zhu B, Liu C, Wang X, Han M, Cao M, Xiao F, Wang S, Rui K, Lu L. | 11/19/2022 |
| GITRL on dendritic cells aggravates house dust mite-induced airway inflammation and airway hyperresponsiveness by modulating CD4(+) T cell differentiation. | GITRL on dendritic cells aggravates house dust mite-induced airway inflammation and airway hyperresponsiveness by modulating CD4(+) T cell differentiation.
Wang Y, Liao K, Liu B, Niu C, Zou W, Yang L, Wang T, Tian D, Luo Z, Dai J, Li Q, Liu E, Gong C, Fu Z, Li Y, Ding F., Free PMC Article | 10/30/2021 |
| Blockade of GITRL/GITR signaling pathway attenuates house dust mite-induced allergic asthma in mice through inhibition of MAPKs and NF-kappaB signaling. | Blockade of GITRL/GITR signaling pathway attenuates house dust mite-induced allergic asthma in mice through inhibition of MAPKs and NF-κB signaling.
Wang Y, Liu B, Niu C, Zou W, Yang L, Wang T, Tian D, Luo Z, Dai J, Li Q, Liu E, Gong C, Fu Z, Ding F. | 10/2/2021 |
| Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions. | Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions.
Wang F, Chau B, West SM, Kimberlin CR, Cao F, Schwarz F, Aguilar B, Han M, Morishige W, Bee C, Dollinger G, Rajpal A, Strop P., Free PMC Article | 03/13/2021 |
| our studies have demonstrated a critical role of GITRL in modulating the suppressive function of myeloid-derived suppressor cells | Increased GITRL Impairs the Function of Myeloid-Derived Suppressor Cells and Exacerbates Primary Sjögren Syndrome.
Tian J, Rui K, Hong Y, Wang X, Xiao F, Lin X, Ma J, Guo H, Xu H, Ma K, Xu D, Liu D, Zhao Y, Lu L, Wang S. | 01/11/2020 |
| this study shows that GITRL on inflammatory antigen presenting cells in the lung parenchyma provides signal 4 for T-cell accumulation and tissue-resident memory T-cell formation | GITRL on inflammatory antigen presenting cells in the lung parenchyma provides signal 4 for T-cell accumulation and tissue-resident memory T-cell formation.
Chu KL, Batista NV, Wang KC, Zhou AC, Watts TH. | 06/29/2019 |
| the upregulation of IFN-beta in DCs induces the up-regulation of coinhibitory molecules B7H1 and GITRL, which cause an impaired activation of naive Ag-specific T cells | Increased antigen presentation but impaired T cells priming after upregulation of interferon-beta induced by lipopolysaccharides is mediated by upregulation of B7H1 and GITRL.
Wang F, Wang YY, Li J, You X, Qiu XH, Wang YN, Gao FG., Free PMC Article | 11/14/2015 |
| GITRL expressed on macrophages drives cytokine release and T cell activation, resulting in neuropathic pain via GITR-dependent actions. The GITRL-GITR pathway might represent a novel target for the treatment of neuropathic pain. | Macrophage-T cell interactions mediate neuropathic pain through the glucocorticoid-induced tumor necrosis factor ligand system.
Kobayashi Y, Kiguchi N, Fukazawa Y, Saika F, Maeda T, Kishioka S., Free PMC Article | 08/1/2015 |
| Down-regulation of GITRL enhances CD8 T cell responses to chronic lymphocytic choriomeningitis virus. | Anti-GITR agonist therapy intrinsically enhances CD8 T cell responses to chronic lymphocytic choriomeningitis virus (LCMV), thereby circumventing LCMV-induced downregulation of costimulatory GITR ligand on APC.
Clouthier DL, Zhou AC, Watts TH. | 02/28/2015 |
| Sjogren's syndrome-like autoimmune sialadenitis in MRL-Faslpr mice is associated with expression of glucocorticoid-induced TNF receptor-related protein (GITR) ligand and 4-1BB ligand. | Sjögren's syndrome-like autoimmune sialadenitis in MRL-Faslpr mice is associated with expression of glucocorticoid-induced TNF receptor-related protein (GITR) ligand and 4-1BB ligand.
Saito K, Mori S, Date F, Ono M. | 11/30/2013 |
| GITRL triggering in endothelial cells increases leukocyte adhesion and transmigration. | Glucocorticoid-induced tumor necrosis factor receptor family-related ligand triggering upregulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 and promotes leukocyte adhesion.
Lacal PM, Petrillo MG, Ruffini F, Muzi A, Bianchini R, Ronchetti S, Migliorati G, Riccardi C, Graziani G, Nocentini G. | 11/30/2013 |
| The B7H1 and GITRL molecules may play an important role in TGF-beta-induced Treg expansion of lung cancer microenvironment. | TGF-β of lung cancer microenvironment upregulates B7H1 and GITRL expression in dendritic cells and is associated with regulatory T cell generation.
Ni XY, Sui HX, Liu Y, Ke SZ, Wang YN, Gao FG. | 01/26/2013 |
| results demonstrate that enhanced GITR/GITRL interactions have a pleiotropic role on the regulation of T-cell responses | Enhanced GITR/GITRL interactions augment IL-27 expression and induce IL-10-producing Tr-1 like cells.
Carrier Y, Whitters MJ, Miyashiro JS, LaBranche TP, Ramon HE, Benoit SE, Ryan MS, Keegan SP, Guay H, Douhan J, Collins M, Dunussi-Joannopoulos K, Medley QG. | 08/18/2012 |
| B cell expression of GITRL induced Treg proliferation, maintaining their numbers above a threshold required for the prevention of autoimmunity. | A novel IL-10-independent regulatory role for B cells in suppressing autoimmunity by maintenance of regulatory T cells via GITR ligand.
Ray A, Basu S, Williams CB, Salzman NH, Dittel BN., Free PMC Article | 06/9/2012 |
| Findings suggest GITRL could enhance the immune stimulation of DC and might facilitate the potential development of DCs-based anti-tumor therapies. | Dendritic cells engineered to express GITRL enhance therapeutic immunity in murine Lewis lung carcinoma.
Ma J, Wang S, Ma B, Mao C, Tong J, Yang M, Wu C, Jiao Z, Lu L, Xu H. | 03/5/2011 |
| GITRL-dependent expansion of Treg within the cornea is one mechanism underlying immune privilege in corneal allografts. | GITR ligand-mediated local expansion of regulatory T cells and immune privilege of corneal allografts.
Hori J, Taniguchi H, Wang M, Oshima M, Azuma M. | 01/15/2011 |
| GITR and GITRL are functionally expressed on brain microglia and that the stimulation of GITRL can induce inflammatory activation of microglia. The GITR/GITRL system may play an important role in neuroinflammation. | Stimulation of glucocorticoid-induced tumor necrosis factor receptor family-related protein ligand (GITRL) induces inflammatory activation of microglia in culture.
Hwang H, Lee S, Lee WH, Lee HJ, Suk K. | 10/30/2010 |
| TRAIL- and GITRL-activated pathways synergise in the development of SCI-related inflammatory damage. | Neutralization of tumor necrosis factor-related apoptosis-inducing ligand reduces spinal cord injury damage in mice.
Cantarella G, Di Benedetto G, Scollo M, Paterniti I, Cuzzocrea S, Bosco P, Nocentini G, Riccardi C, Bernardini R., Free PMC Article | 07/19/2010 |
| GITROL ligation of the costimulatory molecule GITR on Tregs inhibits their ability to promote graft survival. Blocking GITRL with a soluble GITR fusion protein prolongs graft survival. | Blockade of GITR-GITRL interaction maintains Treg function to prolong allograft survival.
Kim JI, Sonawane SB, Lee MK, Lee SH, Duff PE, Moore DJ, O'Connor MR, Lian MM, Deng S, Choi Y, Yeh H, Caton AJ, Markmann JF., Free PMC Article | 06/28/2010 |
| the GITR/GITRLigand pathway has a key role in the development of murine autoimmune diabetes | Key role of the GITR/GITRLigand pathway in the development of murine autoimmune diabetes: a potential therapeutic target.
You S, Poulton L, Cobbold S, Liu CP, Rosenzweig M, Ringler D, Lee WH, Segovia B, Bach JF, Waldmann H, Chatenoud L., Free PMC Article | 05/3/2010 |
| keratinocytes express GITRL, and that through this important co-stimulatory molecule, they have the potential to influence T-cell numbers in the skin through chemokine production and through a direct cell-cell effect on T-cell proliferation | Identification of glucocorticoid-induced TNF receptor-related protein ligand on keratinocytes: ligation by GITR induces keratinocyte chemokine production and augments T-cell proliferation.
Byrne AM, Goleva E, Leung DY., Free PMC Article | 01/21/2010 |
| GITRL requires trimer stabilization for activation | Trimer stabilization, oligomerization, and antibody-mediated cell surface immobilization improve the activity of soluble trimers of CD27L, CD40L, 41BBL, and glucocorticoid-induced TNF receptor ligand.
Wyzgol A, Müller N, Fick A, Munkel S, Grigoleit GU, Pfizenmaier K, Wajant H. | 01/21/2010 |
| The S2 cell-expressed murine GITRL adopts an identical ;strand-exchanged' dimeric structure to that observed for the E. coli-expressed protein, thus conclusively demonstrating the novel quaternary structure assembly behavior of murine GITRL. | 1.8 A structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells.
Chattopadhyay K, Ramagopal UA, Nathenson SG, Almo SC., Free PMC Article | 01/21/2010 |