| A SOX9-B7x axis safeguards dedifferentiated tumor cells from immune surveillance to drive breast cancer progression. | A SOX9-B7x axis safeguards dedifferentiated tumor cells from immune surveillance to drive breast cancer progression.
Liu Y, John P, Nishitani K, Cui J, Nishimura CD, Christin JR, Couturier N, Ren X, Wei Y, Pulanco MC, Galbo PM Jr, Zhang X, Fu W, Cui W, Bartholdy BA, Zheng D, Lauvau G, Fineberg SA, Oktay MH, Zang X, Guo W., Free PMC Article | 12/15/2023 |
| Effect of B7-H4 downregulation induced by Toxoplasma gondii infection on dysfunction of decidual macrophages contributes to adverse pregnancy outcomes. | Effect of B7-H4 downregulation induced by Toxoplasma gondii infection on dysfunction of decidual macrophages contributes to adverse pregnancy outcomes.
Cui L, Wang Y, Ren L, Li Z, Jiang Y, Wang C, Liu X, Ren Y, Hu X., Free PMC Article | 12/17/2022 |
| B7-H4 reduction induced by Toxoplasma gondii infection results in dysfunction of decidual dendritic cells by regulating the JAK2/STAT3 pathway. | B7-H4 reduction induced by Toxoplasma gondii infection results in dysfunction of decidual dendritic cells by regulating the JAK2/STAT3 pathway.
Sun X, Xie H, Zhang H, Li Z, Qi H, Yang C, Liu X, Ren L, Jiang Y, Hu X., Free PMC Article | 05/21/2022 |
| Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer. | Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer.
Peuker K, Strigli A, Tauriello DVF, Hendricks A, von Schönfels W, Burmeister G, Brosch M, Herrmann A, Krüger S, Nitsche J, Južnić L, Geissler MM, Hiergeist A, Gessner A, Wirbel J, Ponnudurai RP, Tunger A, Wehner R, Stange DE, Weitz J, Aust DE, Baretton GB, Schmitz M, Röcken C, Hampe J, Hinz S, Zeller G, Chavakis T, Schafmayer C, Batlle E, Zeissig S. | 04/30/2022 |
| The B7-H4 gene induces immune escape partly via upregulating the PD-1/Stat3 pathway in non-small cell lung cancer. | The B7-H4 gene induces immune escape partly via upregulating the PD-1/Stat3 pathway in non-small cell lung cancer.
Yuan L, Ye J, Fan D. | 02/2/2021 |
| Donor and host B7-H4 expression negatively regulates acute graft-versus-host disease lethality. | Donor and host B7-H4 expression negatively regulates acute graft-versus-host disease lethality.
Saha A, Taylor PA, Lees CJ, Panoskaltsis-Mortari A, Osborn MJ, Feser CJ, Thangavelu G, Melchinger W, Refaeli Y, Hill GR, Munn DH, Murphy WJ, Serody JS, Maillard I, Kreymborg K, van den Brink M, Dong C, Huang S, Zang X, Allison JP, Zeiser R, Blazar BR., Free PMC Article | 10/24/2020 |
| study presents first evidence that B7-H4 acts as a tumor suppressor through PTEN/AKT/HIF-1alpha/RCOR2/RUNX1 pathways to promote the differentiation of leukemia-initiating cells but does not impair the normal functions of hematopoietic stem cells | B7-H4 enhances the differentiation of murine leukemia-initiating cells via the PTEN/AKT/RCOR2/RUNX1 pathways.
Xia F, Zhang Y, Xie L, Jiang H, Zeng H, Chen C, Liu L, He X, Hao X, Fang X, Liu X, Zhang F, Gu H, Wan J, Cheng Y, Zhang CC, Chen GQ, Lu Y, Yu Z, Zheng J., Free PMC Article | 09/7/2019 |
| B7S1 initiates dysfunction of tumor-infiltrating CD8+ T cells and may be targeted for cancer immunotherapy. | Co-inhibitory Molecule B7 Superfamily Member 1 Expressed by Tumor-Infiltrating Myeloid Cells Induces Dysfunction of Anti-tumor CD8(+) T Cells.
Li J, Lee Y, Li Y, Jiang Y, Lu H, Zang W, Zhao X, Liu L, Chen Y, Tan H, Yang Z, Zhang MQ, Mak TW, Ni L, Dong C. | 01/12/2019 |
| this study shows that B7-H4 knockout hosts mount greater tumor-associated anti-tumor T cell responses and display reduced tumors | Synergistic effects of host B7-H4 deficiency and gemcitabine treatment on tumor regression and anti-tumor T cell immunity in a mouse model.
Leung J, St-Onge P, Stagg J, Suh WK., Free PMC Article | 09/16/2017 |
| Results highlight an importance of VTCN1 stabilization on cell surfaces for the restoration of altered balance of immune control during T1D. | Loss of Peripheral Protection in Pancreatic Islets by Proteolysis-Driven Impairment of VTCN1 (B7-H4) Presentation Is Associated with the Development of Autoimmune Diabetes.
Radichev IA, Maneva-Radicheva LV, Amatya C, Salehi M, Parker C, Ellefson J, Burn P, Savinov AY., Free PMC Article | 06/28/2016 |
| Ablation of B7-H3 but Not B7-H4 Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer | Ablation of B7-H3 but Not B7-H4 Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer.
Kreymborg K, Haak S, Murali R, Wei J, Waitz R, Gasteiger G, Savage PA, van den Brink MR, Allison JP., Free PMC Article | 05/7/2016 |
| B7-H4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity. | B7-H4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity.
Rahbar R, Lin A, Ghazarian M, Yau HL, Paramathas S, Lang PA, Schildknecht A, Elford AR, Garcia-Batres C, Martin B, Berman HK, Leong WL, McCready DR, Reedijk M, Done SJ, Miller N, Youngson B, Suh WK, Mak TW, Ohashi PS. | 11/28/2015 |
| that B7x can modulate kidney damage in autoimmune diseases including lupus nephritis and anti-glomerular basement membrane disease | B7x/B7-H4 modulates the adaptive immune response and ameliorates renal injury in antibody-mediated nephritis.
Pawar RD, Goilav B, Xia Y, Herlitz L, Doerner J, Chalmers S, Ghosh K, Zang X, Putterman C., Free PMC Article | 03/21/2015 |
| B7-H4 can inhibit both antitumor T cells and protumor myeloid-derived suppressor cells ( | Host B7-H4 regulates antitumor T cell responses through inhibition of myeloid-derived suppressor cells in a 4T1 tumor transplantation model.
Leung J, Suh WK. | 08/31/2013 |
| The endogenous expression of B7-H4 in donor beta cells from transgenic mice prolongs islet allograft survival, confirming the negative role of B7-H4 in regulating alloreactive T-cell responses. | Endogenous expression of B7-H4 improves long-term murine islet allograft survival.
Wang X, Hao J, Metzger DL, Mui A, Lee IF, Akhoundsadegh N, Ao Z, Chen L, Ou D, Verchere CB, Warnock GL. | 04/6/2013 |
| Local overexpression of B7x on pancreatic beta cells is sufficient to abolish CD8 T cell-induced diabetes. | B7x in the periphery abrogates pancreas-specific damage mediated by self-reactive CD8 T cells.
Lee JS, Scandiuzzi L, Ray A, Wei J, Hofmeyer KA, Abadi YM, Loke P, Lin J, Yuan J, Serreze DV, Allison JP, Zang X., Free PMC Article | 12/22/2012 |
| An enhanced T cell response contributes to reduced lethality in a pulmonary infection model with Streptococcus pneumoniae. | Tissue-expressed B7x affects the immune response to and outcome of lethal pulmonary infection.
Hofmeyer KA, Scandiuzzi L, Ghosh K, Pirofski LA, Zang X., Free PMC Article | 12/8/2012 |
| B7-H4 expression may influence the outcome of T-cell tumor cell interactions. Tumor-associated macrophage induced membrane-bound B7-H4 on lung cancer cell represents a novel mechanism by which lung cancer cells evade immune recognition and destruction. | Induced expression of B7-H4 on the surface of lung cancer cell by the tumor-associated macrophages: a potential mechanism of immune escape.
Chen C, Qu QX, Shen Y, Mu CY, Zhu YB, Zhang XG, Huang JA. | 03/17/2012 |
| Overexpression of B7-H4 was shown in tumor infiltrated dendritic cells. | Overexpression of B7-H4 in tumor infiltrated dendritic cells.
Cheng C, Qu QX, Shen Y, Lv YT, Zhu YB, Zhang XG, Huang JA. | 10/29/2011 |
| Tissue-specific expression of B7x protects from CD4 T cell-mediated autoimmunity. | Tissue-specific expression of B7x protects from CD4 T cell-mediated autoimmunity.
Wei J, Loke P, Zang X, Allison JP., Free PMC Article | 10/22/2011 |
| intact recipient, but not donor, B7-H4 is essential for prolongation of allograft survival by blocking CD28/CTLA4:B7 pathway using CTLA4-Ig. | In vivo function of immune inhibitory molecule B7-H4 in alloimmune responses.
Yamaura K, Watanabe T, Boenisch O, Yeung M, Yang S, Magee CN, Padera R, Datta S, Schatton T, Kamimura Y, Azuma M, Najafian N. | 04/2/2011 |
| studies reveal a novel role for activated hepatic stellate cells in the attenuation of intrahepatic T cell responses by way of expression of the coinhibitory molecule B7-H4. | B7-H4 mediates inhibition of T cell responses by activated murine hepatic stellate cells.
Chinnadurai R, Grakoui A., Free PMC Article | 01/15/2011 |
| these results suggest a different action of B7-H4 in T cell-mediated inflammatory responses and the possible involvement of soluble B7-H4 in inflammatory immune responses. | Possible involvement of soluble B7-H4 in T cell-mediated inflammatory immune responses.
Kamimura Y, Kobori H, Piao J, Hashiguchi M, Matsumoto K, Hirose S, Azuma M. | 01/21/2010 |
| Local expression of B7-H4 prolongs islet allograft survival in vivo, suggesting translational potential for beta-cell replacement with reduced immune injury. | Local expression of B7-H4 by recombinant adenovirus transduction in mouse islets prolongs allograft survival.
Wang X, Hao J, Metzger DL, Mui A, Ao Z, Verchere CB, Chen L, Ou D, Warnock GL. | 01/21/2010 |
| B7-H4 is a negative regulator of the neutrophil response to infection | B7-H4-deficient mice display augmented neutrophil-mediated innate immunity.
Zhu G, Augustine MM, Azuma T, Luo L, Yao S, Anand S, Rietz AC, Huang J, Xu H, Flies AS, Flies SJ, Tamada K, Colonna M, van Deursen JM, Chen L., Free PMC Article | 01/21/2010 |