| These results indicate that stress conditions most probably altered the cell redox equilibrium, thus influencing the antioxidant response in brain cortex. | Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress.
Pejic S, Stojikjkovic V, Todorovic A, Gavrilovic L, Pavlovic I, Popovic N, Pajovic SB. | 06/30/2018 |
| fenofibrate almost completely abolished GM-induced reactive oxygen species generation, which seemed to be mediated at least in part by the restoration of the expression of PPARalphadependent antioxidant enzymes, including catalase and superoxide dismutase (SOD)-1. | Fenofibrate exerts protective effects against gentamicin-induced toxicity in cochlear hair cells by activating antioxidant enzymes.
Park C, Ji HM, Kim SJ, Kil SH, Lee JN, Kwak S, Choe SK, Park R., Free PMC Article | 04/29/2017 |
| These results indicate that CAT expression is significantly decreased in the hippocampi of aged animals and decreased CAT expression may be closely associated with aging. | Comparison of catalase immunoreactivity in the hippocampus between young, adult and aged mice and rats.
Ahn JH, Chen BH, Shin BN, Lee TK, Cho JH, Kim IH, Park JH, Lee JC, Tae HJ, Lee CH, Won MH, Lee YL, Choi SY, Hong S., Free PMC Article | 04/8/2017 |
| Catalase promoter region (-185 to +52) that contains binding sites for C/EBP-beta showed an augmentation in the methylation level along with a change in methylation pattern of CpG islands in response to PTU treatment | Neonatal Persistent Exposure to 6-Propyl-2-thiouracil, a Thyroid-Disrupting Chemical, Differentially Modulates Expression of Hepatic Catalase and C/EBP-β in Adult Rats.
Bunker SK, Dandapat J, Sahoo SK, Roy A, Chainy GB. | 11/12/2016 |
| Data show that nuclear factor erythroid 2-related factor (Nrf2), superoxide dismutase Sod1 and catalase antioxidant systems are downregulated in isolated arteries and vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats (SHRSP). | Downregulation of Nuclear Factor Erythroid 2-Related Factor and Associated Antioxidant Genes Contributes to Redox-Sensitive Vascular Dysfunction in Hypertension.
Lopes RA, Neves KB, Tostes RC, Montezano AC, Touyz RM. | 04/9/2016 |
| mitochondria-targeted antioxidant SkQ1 (50 nmol/kg during 5 days) significantly increased the mRNA levels of Nrf2 transcription factor and Nrf2-induced genes encoding antioxidant enzymes SOD1, SOD2, CAT, and GPx4 in rat peripheral blood leukocytes. | Influence of SkQ1 on Expression of Nrf2 Transcription Factor Gene, ARE-Controlled Genes of Antioxidant Enzymes and Their Activity in Rat Blood Leukocytes.
Vnukov VV, Gutsenko OI, Milutina NP, Ananyan AA, Danilenko AO, Panina SB, Kornienko IV. | 03/12/2016 |
| Targeted mass spectrometry for the analysis of nutritive modulation of catalase and heme oxygenase-1 expression. | Targeted mass spectrometry for the analysis of nutritive modulation of catalase and heme oxygenase-1 expression.
Zaenglein N, Tucher J, Pischetsrieder M. | 11/21/2015 |
| Decrease in Sirtuin1 (SIRT1) and nuclear factor erythroid 2-related factor (Nrf2) and increase in nuclear factor kappa B (NFkappaB) gene expression in diabetes were associated with a decrease in CAT and GPx mRNA expression. | Redox regulation of antioxidant enzymes: post-translational modulation of catalase and glutathione peroxidase activity by resveratrol in diabetic rat liver.
Sadi G, Bozan D, Yildiz HB. | 02/14/2015 |
| Coronary resistance regulation seems to be more dependent on the hydrogen peroxide that is maintained at low levels by increased catalase activity. | Catalase influence in the regulation of coronary resistance by estrogen: joint action of nitric oxide and hydrogen peroxide.
Schenkel PC, Fernandes RO, Viegas VU, Campos C, Fernandes TR, Araujo AS, Belló-Klein A., Free PMC Article | 11/29/2014 |
| Catalase was found to participate in lead-induced alcohol intake and is elevated in blood following lead exposure. | Participation of catalase in voluntary ethanol consumption in perinatally low-level lead-exposed rats.
Mattalloni MS, De Giovanni LN, Molina JC, Cancela LM, Virgolini MB. | 05/17/2014 |
| The marked increased in alcohol intake that follows an alcohol deprivation period is mediated by acetaldehyde generated in the brain by the action of catalase. | The alcohol deprivation effect: marked inhibition by anticatalase gene administration into the ventral tegmental area in rats.
Tampier L, Quintanilla ME, Karahanian E, Rivera-Meza M, Herrera-Marschitz M, Israel Y. | 01/25/2014 |
| Results suggest that the effects of estrogen on the cell-mediated immune responses are mediated through specific estrogen receptors alpha and beta and antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). | Estrogen modulates in vitro T cell responses in a concentration- and receptor-dependent manner: effects on intracellular molecular targets and antioxidant enzymes.
Priyanka HP, Krishnan HC, Singh RV, Hima L, Thyagarajan S. | 12/21/2013 |
| The content of catalase protein in mitochondrial extract increased with aging. | Catalase, a target of glycation damage in rat liver mitochondria with aging.
Bakala H, Hamelin M, Mary J, Borot-Laloi C, Friguet B. | 01/26/2013 |
| Ornithine alpha-ketoglutarate modulates the levels of antioxidants glutathione peroxidase, superoxide dismutase and catalase, as well as lipid peroxidation products in ammonium acetate treated rats | Ornithine alpha-ketoglutarate modulates the levels of antioxidants and lipid peroxidation products in ammonium acetate treated rats.
Dakshayani KB, Velvizhi S, Subramanian P. | 09/22/2012 |
| The increased expression of antioxidant catalase, specifically in hippocampal neurons, will provide protection from age-related cognitive decline. | Influence of viral vector-mediated delivery of superoxide dismutase and catalase to the hippocampus on spatial learning and memory during aging.
Lee WH, Kumar A, Rani A, Herrera J, Xu J, Someya S, Foster TC., Free PMC Article | 09/15/2012 |
| Ang II induces ERK1/2 activation, contributing to the downregulation of CAT as well as promoting oxidative stress and adventitial fibroblast phenotypic differentiation in an AT1R-mediated manner. | Angiotensin II downregulates catalase expression and activity in vascular adventitial fibroblasts through an AT1R/ERK1/2-dependent pathway.
Yang W, Zhang J, Wang H, Gao P, Singh M, Shen K, Fang N. | 02/25/2012 |
| Ang II inhibited catalase (CAT) and peroxisome proliferator-activated receptor gamma (PPAR gamma) protein and mRNA expressions. | Peroxisome proliferator-activated receptor γ regulates angiotensin II-induced catalase downregulation in adventitial fibroblasts of rats.
Yang W, Zhang J, Wang H, Shen W, Gao P, Singh M, Fang N. | 05/7/2011 |
| Chronic psychosocial isolation attenuated peroxide-metabolizing enzymes, CAT and GPx, and decreased GLR activity. | Chronic social isolation compromises the activity of both glutathione peroxidase and catalase in hippocampus of male wistar rats.
Djordjevic J, Djordjevic A, Adzic M, Radojcic MB. | 09/20/2010 |
| catalase activities in liver and kidney of diabetic male or female rats were significantly lower than in non-diabetic rats but the reduction was more pronounced in diabetic female rats. | Catalase activity, lipid peroxidation, cholesterol and triglyceride levels in alloxan--induced diabetes mellitus in female and male rats.
Ebuehi OA, Ajuluchukwu AE, Afolabi OT, Ebuehi OM, Akinwande AI. | 09/20/2010 |
| This protein has been found differentially expressed in the lumbar spinal cord from rats submitted to peripheral lesion during neonatal period. | Proteome analysis of lumbar spinal cord from rats submitted to peripheral lesion during neonatal period.
Castro-Dias E, Vieira AS, Werneck CC, Langone F, Novello JC, Martins-de-Souza D. | 04/21/2010 |
| endogenous PGC-1 alpha is a negative regulator of vascular hypertrophy by up-regulating catalase expression and thus reducing reactive oxygen species levels | PGC-1 alpha serine 570 phosphorylation and GCN5-mediated acetylation by angiotensin II drive catalase down-regulation and vascular hypertrophy.
Xiong S, Salazar G, San Martin A, Ahmad M, Patrushev N, Hilenski L, Nazarewicz RR, Ma M, Ushio-Fukai M, Alexander RW., Free PMC Article | 03/1/2010 |
| No significant differences in superoxide dismutase and catalase activities, but MDA was decreased by ghrelin on day 10. Evidence for antioxidant properties of ghrelin in rat testis. | Antioxidant enzyme activity and MDA level in the rat testis following chronic administration of ghrelin.
Kheradmand A, Alirezaei M, Asadian P, Rafiei Alavi E, Joorabi S. | 01/25/2010 |
| Reduced availability of reactive oxygen species by catalase is a key component of neuroprotection against various toxic stimuli | Neuroprotective effect of adenoviral catalase gene transfer in cortical neuronal cultures.
Gáspár T, Domoki F, Lenti L, Institoris A, Snipes JA, Bari F, Busija DW., Free PMC Article | 01/21/2010 |
| Elevated catalase levels in hearts of long-term type 1 diabetic rats signals improved recovery of postischemic cardiac function and reduced reperfusion arrhythmia. | Elevated catalase and heme oxygenase-1 may contribute to improved postischaemic cardiac function in long-term type 1 diabetes.
Shen WL, Zhong MF, Ding WL, Wang J, Zheng L, Zhu P, Wang BS, Higashino H, Chen H. | 01/21/2010 |
| Results describe the activity of superoxide dismutase and catalase at different ages following methylphenidate treatment in young rats. | Antioxidant enzyme activities following acute or chronic methylphenidate treatment in young rats.
Gomes KM, Petronilho FC, Mantovani M, Garbelotto T, Boeck CR, Dal-Pizzol F, Quevedo J. | 01/21/2010 |