| Experience-dependent grooming microstructure alterations and gastrointestinal dysfunction in the SAPAP3 knockout mouse model of compulsive behaviour. | Experience-dependent grooming microstructure alterations and gastrointestinal dysfunction in the SAPAP3 knockout mouse model of compulsive behaviour.
Wilson C, Gattuso JJ, Kuznetsova M, Li S, Connell S, Choo JM, Rogers GB, Gubert C, Hannan AJ, Renoir T. | 08/26/2024 |
| Pathway-specific alterations in striatal excitability and cholinergic modulation in a SAPAP3 mouse model of compulsive motor behavior. | Pathway-specific alterations in striatal excitability and cholinergic modulation in a SAPAP3 mouse model of compulsive motor behavior.
Malgady JM, Baez A, Hobel ZB, Jimenez K, Goldfried J, Prager EM, Wilking JA, Zhang Q, Feng G, Plotkin JL., Free PMC Article | 12/5/2023 |
| Valence processing alterations in SAPAP3 knockout mice and human OCD. | Valence processing alterations in SAPAP3 knockout mice and human OCD.
Kajs BL, van Roessel PJ, Davis GL, Williams LM, Rodriguez CI, Gunaydin LA. | 07/2/2022 |
| SAPAP3 regulates epileptic seizures involving GluN2A in post-synaptic densities. | SAPAP3 regulates epileptic seizures involving GluN2A in post-synaptic densities.
Zhang Y, Wu J, Yan Y, Gu Y, Ma Y, Wang M, Zhang H, Tao K, Lü Y, Yu W, Jing W, Wang X, Tian X., Free PMC Article | 05/14/2022 |
| Optogenetic inhibition of indirect pathway neurons in the dorsomedial striatum reduces excessive grooming in Sapap3-knockout mice. | Optogenetic inhibition of indirect pathway neurons in the dorsomedial striatum reduces excessive grooming in Sapap3-knockout mice.
Ramírez-Armenta KI, Alatriste-León H, Verma-Rodríguez AK, Llanos-Moreno A, Ramírez-Jarquín JO, Tecuapetla F., Free PMC Article | 03/5/2022 |
| Association of SAPAP3 allelic variants with symptom dimensions and pharmacological treatment response in obsessive-compulsive disorder. | Association of SAPAP3 allelic variants with symptom dimensions and pharmacological treatment response in obsessive-compulsive disorder.
Naaz S, Balachander S, Srinivasa Murthy N, Ms B, Sud R, Saha P, Narayanaswamy JC, Reddy Yc J, Jain S, Purushottam M, Viswanath B. | 01/29/2022 |
| Ketamine increases activity of a fronto-striatal projection that regulates compulsive behavior in SAPAP3 knockout mice. | Ketamine increases activity of a fronto-striatal projection that regulates compulsive behavior in SAPAP3 knockout mice.
Davis GL, Minerva AR, Lario A, Simmler LD, Rodriguez CI, Gunaydin LA., Free PMC Article | 11/13/2021 |
| Disruption of prepulse inhibition is associated with compulsive behavior severity and nucleus accumbens dopamine receptor changes in Sapap3 knockout mice. | Disruption of prepulse inhibition is associated with compulsive behavior severity and nucleus accumbens dopamine receptor changes in Sapap3 knockout mice.
Manning EE, Wang AY, Saikali LM, Winner AS, Ahmari SE., Free PMC Article | 10/23/2021 |
| Progression of obsessive compulsive disorder-like grooming in Sapap3 knockout mice: A longitudinal [(11)C]ABP688 PET study. | Progression of obsessive compulsive disorder-like grooming in Sapap3 knockout mice: A longitudinal [(11)C]ABP688 PET study.
Glorie D, Verhaeghe J, Miranda A, Kertesz I, Wyffels L, Stroobants S, Staelens S. | 08/14/2021 |
| Evidence for Distinct Forms of Compulsivity in the SAPAP3 Mutant-Mouse Model for Obsessive-Compulsive Disorder. | Evidence for Distinct Forms of Compulsivity in the SAPAP3 Mutant-Mouse Model for Obsessive-Compulsive Disorder.
Ehmer I, Crown L, van Leeuwen W, Feenstra M, Willuhn I, Denys D., Free PMC Article | 07/31/2021 |
| Projection-specific deficits in synaptic transmission in adult Sapap3-knockout mice. | Projection-specific deficits in synaptic transmission in adult Sapap3-knockout mice.
Hadjas LC, Schartner MM, Cand J, Creed MC, Pascoli V, Lüscher C, Simmler LD., Free PMC Article | 06/26/2021 |
| Instrumental learning in a mouse model for obsessive-compulsive disorder: Impaired habit formation in Sapap3 mutants. | Instrumental learning in a mouse model for obsessive-compulsive disorder: Impaired habit formation in Sapap3 mutants.
Ehmer I, Feenstra M, Willuhn I, Denys D. | 01/16/2021 |
| studies are among the first to describe cognitive impairments in a transgenic Obsessive Compulsive Disorder -relevant model, and demonstrate pronounced heterogeneity among Sapap3-Knockouts. These findings suggest that increased neural activity in m Prefrontal Cortex is associated with impaired reversal learning in Sapap3-KOs, providing a likely neural basis for this observed heterogeneity. | Impaired instrumental reversal learning is associated with increased medial prefrontal cortex activity in Sapap3 knockout mouse model of compulsive behavior.
Manning EE, Dombrovski AY, Torregrossa MM, Ahmari SE., Free PMC Article | 04/4/2020 |
| SAPAP3 mutation in the mouse model of obsessive-compulsive disorder impairs Pavlovian reversal learning. | Behavioral flexibility in a mouse model for obsessive-compulsive disorder: Impaired Pavlovian reversal learning in SAPAP3 mutants.
van den Boom BJG, Mooij AH, Misevičiūtė I, Denys D, Willuhn I., Free PMC Article | 08/31/2019 |
| Recorded ultrasonic vocalizations (USVs) from 5-day-old sapap3 and sapap3 mice, and also monitored developmental reflexes in these mice during the early postnatal period. Sapap3 mice display an increase in the number and duration of USV calls relative to sapap3 littermates, despite otherwise similar developmental profiles. | Altered ultrasonic vocalization in neonatal SAPAP3-deficient mice.
Tesdahl NS, King DK, McDaniel LN, Pieper AA. | 06/23/2018 |
| Both constitutive and induced genetic deletion of the melanocortin 4 receptor gene(MC4R) normalizes compulsive grooming and striatal electrophysiologic impairments in SAPAP3-null mice | Double deletion of melanocortin 4 receptors and SAPAP3 corrects compulsive behavior and obesity in mice.
Xu P, Grueter BA, Britt JK, McDaniel L, Huntington PJ, Hodge R, Tran S, Mason BL, Lee C, Vong L, Lowell BB, Malenka RC, Lutter M, Pieper AA., Free PMC Article | 09/7/2013 |
| The results of this study provide the first evidence for the mechanism by which the SAPAP family of scaffold proteins regulates AMPAR synaptic activity. | Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses.
Wan Y, Feng G, Calakos N., Free PMC Article | 01/14/2012 |
| These results identify a role for SAPAP3 in the regulation of postsynaptic metabotropic glutamate receptors and endocannabinoid-mediated synaptic plasticity. | Sapap3 deletion anomalously activates short-term endocannabinoid-mediated synaptic plasticity.
Chen M, Wan Y, Ade K, Ting J, Feng G, Calakos N., Free PMC Article | 09/17/2011 |
| Semi-quantitative analysis of RNA levels in FMRP immunoprecipitates showed that in the mouse brain mRNAs encoding PSD components, such as Shank1, SAPAP1-3, PSD-95, and the glutamate receptor subunits NR1 and NR2B, are associated with FMRP. | Fragile X mental retardation protein regulates the levels of scaffold proteins and glutamate receptors in postsynaptic densities.
Schütt J, Falley K, Richter D, Kreienkamp HJ, Kindler S., Free PMC Article | 01/21/2010 |