| Urine exosomal CP, observed to increase prior to proteinuria, makes it a potential urinary biomarker to diagnose early kidney disease. | Urine exosomal ceruloplasmin: a potential early biomarker of underlying kidney disease.
Gudehithlu KP, Hart P, Joshi A, Garcia-Gomez I, Cimbaluk DJ, Dunea G, Arruda JAL, Singh AK. | 02/1/2020 |
| This study found that CP was expressed on neurons and astrocytes in both cortex and basal ganglia after Intracerebral Hemorrhage. | Brain Ceruloplasmin Expression After Experimental Intracerebral Hemorrhage and Protection Against Iron-Induced Brain Injury.
Liu H, Hua Y, Keep RF, Xi G., Free PMC Article | 04/20/2019 |
| Data suggest beta-glucuronidase and bilitranslocase in vascular endothelium are involved in changes in endothelium-independent vaso-relaxation induced by dietary antioxidants; here, using in vitro studies with thoracic aorta rings in oxidative stress, glucuronides of dietary supplement antioxidant hydroxytyrosol (HT) are deconjugated by beta-glucuronidase before HT is taken up by vascular endothelium via bilitranslocase. | Involvement of bilitranslocase and beta-glucuronidase in the vascular protection by hydroxytyrosol and its glucuronide metabolites in oxidative stress conditions.
Peyrol J, Meyer G, Obert P, Dangles O, Pechère L, Amiot MJ, Riva C. | 05/12/2018 |
| these results suggest that genetically determined Cp levels can alter susceptibility to Crescentic glomerulonephritis through macrophage function and propose a new role for Cp in early macrophage activation. | Identification of Ceruloplasmin as a Gene that Affects Susceptibility to Glomerulonephritis Through Macrophage Function.
Chen TD, Rotival M, Chiu LY, Bagnati M, Ko JH, Srivastava PK, Petretto E, Pusey CD, Lai PC, Aitman TJ, Cook HT, Behmoaras J., Free PMC Article | 07/15/2017 |
| Ferroportin 1 and CP colocalize in the rat brain. | Ceruloplasmin is Involved in the Nigral Iron Accumulation of 6-OHDA-Lesioned Rats.
Wang J, Bi M, Xie J. | 04/2/2016 |
| Cerebral ischemia inhibited ceruloplasmin expression in the cortex and hippocampus of rats. The decrease of Cp might be involved in iron deposition in neurons. | An inhibition of ceruloplasmin expression induced by cerebral ischemia in the cortex and hippocampus of rats.
Li YW, Li L, Zhao JY., Free PMC Article | 12/20/2014 |
| Data show there was no significant difference detected in hepatic and hippocampus iron levels in response to increased serum ceruloplasmin between control and copper-intoxicated rats. | Hepatic and hippocampus iron status is not altered in response to increased serum ceruloplasmin and serum "free" copper in Wistar rat model for non-Wilsonian brain copper toxicosis.
Pal A, Vasishta Rk, Prasad R. | 03/15/2014 |
| FOX activity was present in rat cytosol, and was partly inhibited by anti-Heph antibody. | Immunoreactive hephaestin and ferroxidase activity are present in the cytosolic fraction of rat enterocytes.
Ranganathan PN, Lu Y, Fuqua BK, Collins JF., Free PMC Article | 10/27/2012 |
| Liver copper loading increases metallation of the Cp protein, leading to increased production of the holo enzyme. | Serum ceruloplasmin protein expression and activity increases in iron-deficient rats and is further enhanced by higher dietary copper intake.
Ranganathan PN, Lu Y, Jiang L, Kim C, Collins JF., Free PMC Article | 11/26/2011 |
| Insulin downregulat CP mRNA levels and attenuates CP secretion in rat liver cells. | Ceruloplasmin expression in rat liver cells is attenuated by insulin: role of FoxO transcription factors.
Leyendecker M, Korsten P, Reinehr R, Speckmann B, Schmoll D, Scherbaum WA, Bornstein SR, Barthel A, Klotz LO. | 07/16/2011 |
| Reduction in ceruloplasmin is a sensitive biomarker for copper deficiency in rodents. | Levels of plasma ceruloplasmin protein are markedly lower following dietary copper deficiency in rodents.
Broderius M, Mostad E, Wendroth K, Prohaska JR., Free PMC Article | 06/14/2010 |
| down-regulation of ceruloplasmin may be a biomarker for oxidative stress in Gst-p positive lesions in liver tumors | Induction of GST-P-positive proliferative lesions facilitating lipid peroxidation with possible involvement of transferrin receptor up-regulation and ceruloplasmin down-regulation from the early stage of liver tumor promotion in rats.
Mizukami S, Ichimura R, Kemmochi S, Taniai E, Shimamoto K, Ohishi T, Takahashi M, Mitsumori K, Shibutani M. | 04/12/2010 |
| The ceruloplasmin/transferrin ratio tended to be higher in (jugular vein) plasma of nerve-injured rats as compared to controls. | The oxidative response in the chronic constriction injury model of neuropathic pain.
Tan EC, Bahrami S, Kozlov AV, Kurvers HA, Ter Laak HJ, Nohl H, Redl H, Goris RJ. | 01/21/2010 |
| Dominant mutants of ceruloplasmin impair the copper loading machinery in aceruloplasminemia. | Dominant mutants of ceruloplasmin impair the copper loading machinery in aceruloplasminemia.
di Patti MC, Maio N, Rizzo G, De Francesco G, Persichini T, Colasanti M, Polticelli F, Musci G. | 01/21/2010 |
| the role of ceruloplasmin in iron transport in C6 rat glioma cells | Ceruloplasmin expression and its role in iron transport in C6 cells.
Chang YZ, Qian ZM, Du JR, Zhu L, Xu Y, Li LZ, Wang CY, Wang Q, Ge XH, Ho KP, Niu L, Ke Y. | 01/21/2010 |
| iron status is not an important factor in the expression of plasma ceruloplasmin made by the liver | Dietary iron status has little effect on expression of ceruloplasmin but alters that of ferritin in rats.
Tran T, Ashraf M, Jones L, Westbrook T, Hazegh-Azam M, Linder MC. | 01/21/2010 |
| It is suggested that Cp expression at this site may be part of the repertoire of the glomerular parietal epithelial cell to protect the glomerular podocytes. | Antioxidant ceruloplasmin is expressed by glomerular parietal epithelial cells and secreted into urine in association with glomerular aging and high-calorie diet.
Wiggins JE, Goyal M, Wharram BL, Wiggins RC. | 01/21/2010 |
| Ceruloplasmin gene expression is up-regulated by treatment with the pro-inflammatory cytokine IL-1beta in rat C6 cells, taken as a glial cellular model. | Interleukin-1beta up-regulates iron efflux in rat C6 glioma cells through modulation of ceruloplasmin and ferroportin-1 synthesis.
di Patti MC, Persichini T, Mazzone V, Polticelli F, Colasanti M, Musci G. | 01/21/2010 |
| Ceruloplasmin might have a role in heart iron homeostasis. | Expression of ferroportin1, hephaestin and ceruloplasmin in rat heart.
Qian ZM, Chang YZ, Leung G, Du JR, Zhu L, Wang Q, Niu L, Xu YJ, Yang L, Ho KP, Ke Y. | 01/21/2010 |
| Rat leptomeningeal cells covering the surface of the brain express ceruplasmin; its expression on these cells increases with postnatal development and is regulated by cell density, time in culture, and extracellular matrix molecules. | Expression of a membrane-bound form of the ferroxidase ceruloplasmin by leptomeningeal cells.
Mittal B, Doroudchi MM, Jeong SY, Patel BN, David S. | 01/21/2010 |
| ceruloplasmin has a role in the copper/zinc-nitric oxide-dependent degradation of glypican-1 heparan sulfate in rat C6 glioma cells | Involvement of glycosylphosphatidylinositol-linked ceruloplasmin in the copper/zinc-nitric oxide-dependent degradation of glypican-1 heparan sulfate in rat C6 glioma cells.
Mani K, Cheng F, Havsmark B, David S, Fransson LA. | 01/21/2010 |
| Ceruloplasmin carries the anionic glycan oligo/poly alpha2,8 deaminoneuraminic acid | Ceruloplasmin carries the anionic glycan oligo/poly alpha2,8 deaminoneuraminic acid.
Ziak M, Meier M, Novak-Hofer I, Roth J. | 01/21/2010 |