| Inhibition of CYP1A1 expression enhances diabetic wound healing by modulating inflammation and oxidative stress in a rat model. | Inhibition of CYP1A1 expression enhances diabetic wound healing by modulating inflammation and oxidative stress in a rat model.
Chen JC, He MQ. | 10/10/2024 |
| Hypoxia caused by unilateral nasal obstruction decreases mandibular density in rats through inhibition of Cyp1a1 expression. | Hypoxia caused by unilateral nasal obstruction decreases mandibular density in rats through inhibition of Cyp1a1 expression.
Xu Y, Wang Y, Xiao H, Li Y. | 09/6/2023 |
| Involvement of the CYP1A1 inhibition-mediated activation of aryl hydrocarbon receptor in drug-induced hepatotoxicity. | Involvement of the CYP1A1 inhibition-mediated activation of aryl hydrocarbon receptor in drug-induced hepatotoxicity.
Yoda T, Tochitani T, Usui T, Kouchi M, Inada H, Hosaka T, Kanno Y, Miyawaki I, Yoshinari K. | 09/10/2022 |
| Aryl Hydrocarbon Receptor is Involved in the Proinflammatory Cytokine Response to Cadmium. | Aryl Hydrocarbon Receptor is Involved in the Proinflammatory Cytokine Response to Cadmium.
Kulas J, Tucovic D, Zeljkovic M, Popovic D, Popov Aleksandrov A, Kataranovski M, Mirkov I. | 04/13/2021 |
| Prediction of regioselectivity and preferred order of CYP1A1-mediated metabolism: Solving the interaction of human and rat CYP1A1 forms with ligands on the template system. | Prediction of regioselectivity and preferred order of CYP1A1-mediated metabolism: Solving the interaction of human and rat CYP1A1 forms with ligands on the template system.
Yamazoe Y, Yoshinari K. | 10/3/2020 |
| Assessment of the pulmonary CYP1A1 metabolism of mavoglurant (AFQ056) in rat. | Assessment of the pulmonary CYP1A1 metabolism of mavoglurant (AFQ056) in rat.
Yilmaz Y, Umehara K, Williams G, Faller T, Schiller H, Walles M, Kraehenbuehl S, Camenisch G, Manevski N. | 10/6/2018 |
| CYP1A1 and CYP1B1 mRNA expression levels were significantly reduced from day 7 and 10, respectively. These results suggested that CpG island hypermethylation of the CYP1A1 and CYP1B1 promoters regulate the low expression of genes involved in the occurrence of isoniazidinduced liver injury | Cytochrome P450 1A1 and 1B1 promoter CpG island methylation regulates rat liver injury induced by isoniazid.
Li Y, Li Y, Zheng G, Zhu L, Wang J, Mu S, Ren Q, Feng F., Free PMC Article | 07/21/2018 |
| We showed that the enhanced activity of the CYP1A1 mutant towards TCDD was due to more efficient binding of the substrate in the active site even though the mutated site was over 2.5nm away from the catalytic center | Molecular insights into the role of a distal F240A mutation that alters CYP1A1 activity towards persistent organic pollutants.
Navrátilová V, Paloncýová M, Berka K, Mise S, Haga Y, Matsumura C, Sakaki T, Inui H, Otyepka M. | 02/10/2018 |
| Data suggest that two inhibitors from grapefruit juice (naringenin and 6',7'-dihydroxybergamottin) block oxidation of 7-ethoxyresorufin via competitive binding to the active site of both human and rat CYP1A1. | Inhibition of human and rat CYP1A1 enzyme by grapefruit juice compounds.
Santes-Palacios R, Romo-Mancillas A, Camacho-Carranza R, Espinosa-Aguirre JJ. | 02/18/2017 |
| Hexachloronaphthalene was found to be a strong inducer of maternal and fetal CYP1A1 in liver and placenta. | Developmental toxicity of hexachloronaphthalene in Wistar rats. A role of CYP1A1 expression.
Kilanowicz A, Czekaj P, Sapota A, Skrzypinska-Gawrysiak M, Bruchajzer E, Darago A, Czech E, Plewka D, Wiaderkiewicz A, Sitarek K. | 10/1/2016 |
| drugs acting as D2-dopamine receptor antagonists can modify several hormone systems that regulate the expression of CYP1A1, CYP1A2 and CYP1B1, and may affect the toxicity and carcinogenicity outcome of numerous toxicants and pre-carcinogenic substances | Dopamine D2-Receptor Antagonists Down-Regulate CYP1A1/2 and CYP1B1 in the Rat Liver.
Harkitis P, Daskalopoulos EP, Malliou F, Lang MA, Marselos M, Fotopoulos A, Albucharali G, Konstandi M., Free PMC Article | 06/11/2016 |
| Incense smoke exposure significantly induced the expression of CYP1A1, CYP1A2, and CYP1B1 mRNAs in both lung and liver tissues. | Induction of CYP1A1, CYP1A2, CYP1B1, increased oxidative stress and inflammation in the lung and liver tissues of rats exposed to incense smoke.
Hussain T, Al-Attas OS, Al-Daghri NM, Mohammed AA, De Rosas E, Ibrahim S, Vinodson B, Ansari MG, El-Din KI. | 11/28/2015 |
| Differential expression of CYP1A1 and CYP1A2 genes in H4IIE rat hepatoma cells exposed to TCDD and PAHs | Differential expression of CYP1A1 and CYP1A2 genes in H4IIE rat hepatoma cells exposed to TCDD and PAHs.
Kaisarevic S, Dakic V, Hrubik J, Glisic B, Lübcke-von Varel U, Pogrmic-Majkic K, Fa S, Teodorovic I, Brack W, Kovacevic R. | 11/7/2015 |
| BP-lowering effect of sEH inhibition in I3C-induced Cyp1a1-Ren-2 transgenic rats. | Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: studies in Cyp1a1-Ren-2 transgenic rats.
Sporková A, Jíchová S, Husková Z, Kopkan L, Nishiyama A, Hwang SH, Hammock BD, Imig JD, Kompanowska-Jezierska E, Sadowski J, Kramer HJ, Cervenka L., Free PMC Article | 08/22/2015 |
| The influence of dietary lipids on the ontogeny of XMEs was also evaluated. mRNA and protein levels of phase I (CYP1A1, CYP1A2, and CYP1B1) and phase II (NAD(P)H:quinone acceptor oxidoreductase 1 and GSTP1) enzymes were analyzed. | Ontogeny of the major xenobiotic-metabolizing enzymes expression and the dietary lipids modulatory effect in the rat dimethylbenz(a)anthracene-induced breast cancer model.
Manzanares MÁ, Solanas M, Moral R, Escrich R, Vela E, Escrich E. | 07/25/2015 |
| Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats. | Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats.
Holland PR, Pannozzo MA, Bastin ME, McNeilly AD, Ferguson KJ, Caughey S, Jansen MA, Merrifield GD, Marshall I, Mullins JJ, Wardlaw JM, Sutherland C, Horsburgh K., Free PMC Article | 04/11/2015 |
| 5-fold reducing of vitamin content in rat diet lead to significant changes in activity and inducibility of cytochrome P450 of CYP1A and 3A family, which play a key role in the detoxification and metabolism of drugs. | [Effects of vitamins deficiency on the cytochrome P450 inducibility in rats].
Trusov NV, Guseva GV, Beketova NA, Aksenov IV, Avrent'eva LI, Kravchenko LV. | 11/22/2014 |
| High-altitude hypoxia decreases the activity and expression of CYP1A1 and NAT2, but increases that of CYP2D6. | Effect of exposure to acute and chronic high-altitude hypoxia on the activity and expression of CYP1A2, CYP2D6, CYP2C9, CYP2C19 and NAT2 in rats.
Li X, Wang X, Li Y, Yuan M, Zhu J, Su X, Yao X, Fan X, Duan Y. | 11/8/2014 |
| This study aimed to assess cerebrovascular alterations in response to different durations (4 or 6 months) of controlled hypertension in an inducible transgenic rat model of hypertension (Cyp1a1-Ren2) as compared with normotensive litter mate controls. | Controlled hypertension induces cerebrovascular and gene alterations in Cyp1a1-Ren2 transgenic rats.
Pannozzo MA, Holland PR, Scullion G, Talbot R, Mullins JJ, Horsburgh K. | 09/6/2014 |
| Increase of CYP1A1 mRNA level may not only reduce the carcinogenicity of foreign compounds, but may also activate some cardinogens.In case of transporters, an increase of their expression in the body may lead to increased fetoprotection. | The influence of soybean extract on the expression level of selected drug transporters, transcription factors and cytochrome P450 genes encoding phase I drug-metabolizing enzymes.
Bogacz A, Bartkowiak-Wieczorek J, Mikołajczak PŁ, Rakowska-Mrozikiewicz B, Grześkowiak E, Wolski H, Czerny B, Mrozikiewicz PM. | 08/30/2014 |
| CYP1A1 expression in liver and ovaries is increased following chemical induction, along with microRNAs. | Expression of microRNAs, CYP1A1 and CYP2B1 in the livers and ovaries of female rats treated with DDT and PAHs.
Chanyshev MD, Kosorotikov NI, Titov SE, Kolesnikov NN, Gulyaeva LF. | 06/21/2014 |
| A metabolite, derived from the action of CYP1A1 and a nitroreduction-reaction process, has a key role in the bioactivation of niclosamide. | CYP1A1 and Cnr nitroreductase bioactivated niclosamide in vitro.
Beristain-Castillo E, Martínez-Vázquez M, Camacho-Carranza R, Espinosa-Aguirre JJ., Free PMC Article | 05/31/2014 |
| The results suggest that biotin does not influence the CYP1A-mediated metabolism of xenobiotics. | Modulation of the rat hepatic cytochrome P4501A subfamily using biotin supplementation.
Ronquillo-Sánchez MD, Camacho-Carranza R, Fernandez-Mejia C, Hernández-Ojeda S, Elinos-Baez M, Espinosa-Aguirre JJ., Free PMC Article | 03/22/2014 |
| role of bilirubin, tocopherol and corticosterone as mediators of cold induction of CYP1A in the liver was evaluated; results indicate that these compounds can be involved in cold induction of CYP1A, but none of them is the only mediator in this process | Cold-induced activities of cytochromes P450 1A1 and 1A2 in rat liver: putative role of endogenous compounds in induction mechanism.
Perepechaeva ML, Grishanova AY. | 02/22/2014 |
| Severe liver cirrhosis markedly reduces AhR-mediated induction of CYP1A1 in rats by decreasing the transcription of target genes. | Severe liver cirrhosis markedly reduces AhR-mediated induction of cytochrome P450 in rats by decreasing the transcription of target genes.
Floreani M, De Martin S, Gabbia D, Barbierato M, Nassi A, Mescoli C, Orlando R, Bova S, Angeli P, Gola E, Sticca A, Palatini P., Free PMC Article | 11/30/2013 |