| Erythropoietin alleviates lung ischemia-reperfusion injury by activating the FGF23/FGFR4/ERK signaling pathway. | Erythropoietin alleviates lung ischemia-reperfusion injury by activating the FGF23/FGFR4/ERK signaling pathway.
Jin X, Jin W, Li G, Zheng J, Xu X., Free PMC Article | 04/4/2024 |
| Erythropoietin alleviates astrocyte pyroptosis by targeting the miR-325-3p/Gsdmd axis in rat spinal cord injury. | Erythropoietin alleviates astrocyte pyroptosis by targeting the miR-325-3p/Gsdmd axis in rat spinal cord injury.
Shan W, Wang J, Cheng R, Xuan Y, Yin Z. | 03/5/2024 |
| Pulpal expression of erythropoietin and erythropoietin receptor after direct pulp capping in rat. | Pulpal expression of erythropoietin and erythropoietin receptor after direct pulp capping in rat.
Papic M, Zivanovic S, Vucicevic T, Papic MV, Zdravkovic D, Milivojevic N, Virijevic K, Zivanovic M, Mircic A, Ljujic B, Lukic ML, Popovic M. | 10/8/2022 |
| Carbamylated Erythropoietin Alleviates Kidney Damage in Diabetic Rats by Suppressing Oxidative Stress. | Carbamylated Erythropoietin Alleviates Kidney Damage in Diabetic Rats by Suppressing Oxidative Stress.
Dang JZ, Tu YF, Wang J, Yang YJ. | 12/25/2021 |
| Gamma-Aminobutyric Acid Increases Erythropoietin by Activation of Citrate Cycle and Stimulation of Hypoxia-Inducible Factors Expression in Rats. | Gamma-Aminobutyric Acid Increases Erythropoietin by Activation of Citrate Cycle and Stimulation of Hypoxia-Inducible Factors Expression in Rats.
Park KT, Han JK, Kim SJ, Lim YH., Free PMC Article | 04/13/2021 |
| Erythropoietin attenuates vascular calcification by inhibiting endoplasmic reticulum stress in rats with chronic kidney disease. | Erythropoietin attenuates vascular calcification by inhibiting endoplasmic reticulum stress in rats with chronic kidney disease.
Chang JR, Sun N, Liu Y, Wei M, Zhao Y, Gan L, Zhu JX, Su XL. | 12/12/2020 |
| HIF1alpha attenuates neuronal apoptosis by upregulating EPO expression following cerebral ischemiareperfusion injury in a rat MCAO model. | HIF‑1α attenuates neuronal apoptosis by upregulating EPO expression following cerebral ischemia‑reperfusion injury in a rat MCAO model.
Li J, Tao T, Xu J, Liu Z, Zou Z, Jin M., Free PMC Article | 12/5/2020 |
| Erythropoietin Alleviates Burn-induced Muscle Wasting. | Erythropoietin Alleviates Burn-induced Muscle Wasting.
Wu SH, Lu IC, Tai MH, Chai CY, Kwan AL, Huang SH., Free PMC Article | 10/10/2020 |
| Fludrocortisone stimulated erythropoietin mRNA and protein expressions in the distal nephrons, particularly in the intercalated cells of the collecting ducts. | Fludrocortisone stimulates erythropoietin production in the intercalated cells of the collecting ducts.
Yasuoka Y, Izumi Y, Nagai T, Fukuyama T, Nakayama Y, Inoue H, Horikawa K, Kimura M, Nanami M, Yanagita K, Oshima T, Yamazaki T, Uematsu T, Yamamura R, Kobayashi N, Shimada Y, Nagaba Y, Nakanishi T, Yamashita T, Mukoyama M, Sato Y, Kawahara K, Nonoguchi H. | 01/19/2019 |
| Suggest that EPO is produced in response to hypoxia in rostral ventrolateral medulla neurons and causes a high BP via the stimulation of those neurons. | Erythropoietin, a putative neurotransmitter during hypoxia, is produced in RVLM neurons and activates them in neonatal Wistar rats.
Oshima N, Onimaru H, Yamagata A, Itoh S, Matsubara H, Imakiire T, Nishida Y, Kumagai H., Free PMC Article | 01/12/2019 |
| Increases in plasma erythropoietin and erythropoietin receptor activation are mechanisms implicated in the increase of plasma FGF23 in acute kidney injury. | Erythropoietin induces bone marrow and plasma fibroblast growth factor 23 during acute kidney injury.
Toro L, Barrientos V, León P, Rojas M, Gonzalez M, González-Ibáñez A, Illanes S, Sugikawa K, Abarzúa N, Bascuñán C, Arcos K, Fuentealba C, Tong AM, Elorza AA, Pinto ME, Alzamora R, Romero C, Michea L. | 12/22/2018 |
| Epo and Epo-Receptor are expressed in the spiral ganglion neurons (SGNs) of the inner ear of the rat, and Epo adenovirus vector (AdEpo) can decrease the spontaneous apoptosis of SGNs, which may provide a basis for the prevention or alleviation of sensorineural hearing loss. | Protective effect of adenovirus-mediated erythropoietin expression on the spiral ganglion neurons in the rat inner ear.
Zhong C, Jiang Z, Guo Q, Zhang X., Free PMC Article | 09/1/2018 |
| EPO administration increased TMPRSS6 content in the plasma membrane-enriched fraction of liver homogenate; in iron-pretreated rats, this increase was abolished. The results confirm that iron pretreatment prevents the EPO-induced decrease in liver Hamp expression. | Erythropoietin administration increases splenic erythroferrone protein content and liver TMPRSS6 protein content in rats.
Gurieva I, Frýdlová J, Rychtarčíková Z, Vokurka M, Truksa J, Krijt J. | 08/18/2018 |
| protective effects of EPO may be mediated by nitric oxide and the expression of different NOS enzymes, especially iNOS isoform | Erythropoietin attenuates experimental haemorrhagic shock-induced renal damage through an iNOS- dependent mechanism in male Wistar rats.
Ranjbaran M, Kadkhodaee M, Seifi B, Adelipour M, Azarian B. | 02/3/2018 |
| EPO receptor ligand dimeric peptides AF41676 and AF43136 administered before reperfusion are able to reduce infarct size in a rat model of AMI. | Novel, selective EPO receptor ligands lacking erythropoietic activity reduce infarct size in acute myocardial infarction in rats.
Kiss K, Csonka C, Pálóczi J, Pipis J, Görbe A, Kocsis GF, Murlasits Z, Sárközy M, Szűcs G, Holmes CP, Pan Y, Bhandari A, Csont T, Shamloo M, Woodburn KW, Ferdinandy P, Bencsik P. | 12/23/2017 |
| The present study aimed to determine the expression of erythropoietin (EPO) and the EPO receptor (EPOR) in spiral ganglion neurons (SGNs) in the inner ear of rats of various ages, and the associated neuronal apoptosis and hearing alterations. | Age-associated expression of erythropoietin and its receptor in rat spiral ganglion neurons and its association with neuronal apoptosis and hearing alterations.
Zhong C, Zhang X., Free PMC Article | 04/8/2017 |
| Study shows that erythropoietin reduced chemokine CCL3 mRNA expression in rat cerebellar neuron-enriched preparations during neuroinflammation. | Erythropoietin and CCL3 antagonise their functional properties during neuroinflammation.
Hattermann K, Knerlich-Lukoschus F, Lucius R, Mehdorn M, Held-Feindt J. | 06/28/2016 |
| Taken together, our results reveal that EPO and cEPO mediate MEF2 target gene expression via the regulation of HDAC5 phosphorylation at Ser259/498, and suggest that HDAC5 could be a mechanism contributing to the therapeutic actions of EPO and cEPO. | Erythropoietin and carbamylated erythropoietin promote histone deacetylase 5 phosphorylation and nuclear export in rat hippocampal neurons.
Jo HR, Kim YS, Son H. | 06/11/2016 |
| this study is the first to elucidate the detailed mechanism by which AhR plays an indispensable role in the suppression of HIF activation by IS. | Activation of aryl hydrocarbon receptor mediates suppression of hypoxia-inducible factor-dependent erythropoietin expression by indoxyl sulfate.
Asai H, Hirata J, Hirano A, Hirai K, Seki S, Watanabe-Akanuma M. | 05/21/2016 |
| the hypercapnic hypoxia causes maximum activation of the synthesis and accumulation of erythropoietin HIF-1alpha, and permissive hypercapnia enhances their content more than hypoxic exposure. | [Hypercapnia--alternative hypoxia signal incentives to increase HIF-1α and erythropoietin in the brain].
Kulikov VP, Tregub PP, Kovzelev PD, Dorokhov EA, Belousov AA. | 02/27/2016 |
| Results of the present study demonstrate the neuroprotective, anti-inflammatory and antioxidant effects of EPO in a rotenone-induced neurodegenerative animal model. | The neuroprotective effect of erythropoietin on experimental Parkinson model in rats.
Erbaş O, Çınar BP, Solmaz V, Çavuşoğlu T, Ateş U. | 12/5/2015 |
| Vitamin A deficiency leads to ineffective erythropoiesis by the down-regulation of renal erythropoietin expression in the kidney, resulting in erythrocyte malformation and the consequent accumulation of the heme group in the spleen. | Vitamin A deficiency modulates iron metabolism via ineffective erythropoiesis.
da Cunha MS, Siqueira EM, Trindade LS, Arruda SF. | 11/14/2015 |
| EPO partially rescued insulin-stimulated AKT activation, reduced oxidative stress, and restored heat-shock protein 72 expression in soleus muscles. | Chronic erythropoietin treatment improves diet-induced glucose intolerance in rats.
Caillaud C, Mechta M, Ainge H, Madsen AN, Ruell P, Mas E, Bisbal C, Mercier J, Twigg S, Mori TA, Simar D, Barrès R. | 08/15/2015 |
| Results showed that the inhibitory effects of TNFa on the hypoxia-induced upregulation of erythropoietin expression are mediated primarily by HIF-2a rather than HIF-1a | Inflammatory cytokine tumor necrosis factor α suppresses neuroprotective endogenous erythropoietin from astrocytes mediated by hypoxia-inducible factor-2α.
Nagaya Y, Aoyama M, Tamura T, Kakita H, Kato S, Hida H, Saitoh S, Asai K. | 08/1/2015 |
| Data suggest a potential positive effect of erythropoietin (EPO) on hepatocytes (HCs) proliferation during liver regeneration after a partial hepatectomy. | Expression profiles uncover the relationship between erythropoietin and cell proliferation in rat hepatocytes after a partial hepatectomy.
Zhang J, Yang Y, He T, Liu Y, Zhou Y, Chen Y, Xu C., Free PMC Article | 06/27/2015 |