| Soluble glycoprotein VI predicts abdominal aortic aneurysm growth rate and is a novel therapeutic target. | Soluble glycoprotein VI predicts abdominal aortic aneurysm growth rate and is a novel therapeutic target.
Benson TW, Pike MM, Spuzzillo A, Hicks SM, Ali S, Pham M, Mix DS, Brunner SI, Wadding-Lee C, Conrad KA, Russell HM, Jennings C, Coughlin TM, Aggarwal A, Lyden S, Mani K, Björck M, Wanhainen A, Bhandari R, Lipworth-Elliot L, Robinson-Cohen C, Caputo FJ, Shim S, Quesada O, Tourdot B, Edwards TL, Tranter M, Gardiner EE, Mackman N, Cameron SJ, Owens AP 3rd., | 10/25/2024 |
| Platelets modulate cardiac remodeling via the collagen receptor GPVI after acute myocardial infarction. | Platelets modulate cardiac remodeling via the collagen receptor GPVI after acute myocardial infarction.
Reusswig F, Dille M, Krüger E, Ortscheid J, Feige T, Gorressen S, Fischer JW, Elvers M., Free PMC Article | 02/7/2024 |
| A key role for platelet GPVI in neutrophil recruitment, migration, and NETosis in the early stages of acute lung injury. | A key role for platelet GPVI in neutrophil recruitment, migration, and NETosis in the early stages of acute lung injury.
Burkard P, Schonhart C, Vögtle T, Köhler D, Tang L, Johnson D, Hemmen K, Heinze KG, Zarbock A, Hermanns HM, Rosenberger P, Nieswandt B. | 10/28/2023 |
| Protease-activated receptors and glycoprotein VI cooperatively drive the platelet component in thromboelastography. | Protease-activated receptors and glycoprotein VI cooperatively drive the platelet component in thromboelastography.
Rudran T, Antoniak S, Flick MJ, Ginsberg MH, Wolberg AS, Bergmeier W, Lee RH., Free PMC Article | 09/12/2023 |
| Differential Role of Glycoprotein VI in Mouse and Human Thrombus Progression and Stability. | Differential Role of Glycoprotein VI in Mouse and Human Thrombus Progression and Stability.
Janus-Bell E, Ahmed MU, Receveur N, Mouriaux C, Nieswandt B, Gardiner EE, Gachet C, Jandrot-Perrus M, Mangin PH. | 01/8/2022 |
| The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of beta-amyloid. | The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of β-amyloid.
Donner L, Toska LM, Krüger I, Gröniger S, Barroso R, Burleigh A, Mezzano D, Pfeiler S, Kelm M, Gerdes N, Watson SP, Sun Y, Elvers M. | 11/6/2021 |
| Platelet glycoprotein VI-dependent thrombus stabilization is essential for the intraportal engraftment of pancreatic islets. | Platelet glycoprotein VI-dependent thrombus stabilization is essential for the intraportal engraftment of pancreatic islets.
Chen C, Rawat D, Samikannu B, Bender M, Preissner KT, Linn T. | 07/3/2021 |
| Platelet glycoprotein VI promotes metastasis through interaction with cancer cell-derived galectin-3. | Platelet glycoprotein VI promotes metastasis through interaction with cancer cell-derived galectin-3.
Mammadova-Bach E, Gil-Pulido J, Sarukhanyan E, Burkard P, Shityakov S, Schonhart C, Stegner D, Remer K, Nurden P, Nurden AT, Dandekar T, Nehez L, Dank M, Braun A, Mezzano D, Abrams SI, Nieswandt B. | 11/21/2020 |
| Our results show that, contrary to defects in coagulation, bleeding following a loss of vascular integrity caused by platelet CLEC-2 and GPVI deficiency facilitates wound repair by increasing fibrin(ogen) deposition, reducing inflammation, and promoting angiogenesis. | Platelet glycoprotein VI and C-type lectin-like receptor 2 deficiency accelerates wound healing by impairing vascular integrity in mice.
Wichaiyo S, Lax S, Montague SJ, Li Z, Grygielska B, Pike JA, Haining EJ, Brill A, Watson SP, Rayes J., Free PMC Article | 06/20/2020 |
| the truncated CD45 isoform regulates GPVI-mediated signaling and platelet functional responses by regulating SFK activation | Impaired Glycoprotein VI-Mediated Signaling and Platelet Functional Responses in CD45 Knockout Mice.
Inamdar VV, Kostyak JC, Badolia R, Dangelmaier CA, Manne BK, Patel A, Kim S, Kunapuli SP., Free PMC Article | 03/14/2020 |
| GPVI and alpha2beta1 have no influence on the localization of megakaryocytes within the bone marrow, their association to the sinusoids or their maturation | Impact of Itga2-Gp6-double collagen receptor deficient mice for bone marrow megakaryocytes and platelets.
Semeniak D, Faber K, Öftering P, Manukjan G, Schulze H., Free PMC Article | 02/29/2020 |
| our findings identify platelet GPVI as a key regulator of vascular integrity specifically in growing tumors | Inhibition of platelet GPVI induces intratumor hemorrhage and increases efficacy of chemotherapy in mice.
Volz J, Mammadova-Bach E, Gil-Pulido J, Nandigama R, Remer K, Sorokin L, Zernecke A, Abrams SI, Ergün S, Henke E, Nieswandt B. | 01/11/2020 |
| these results indicate that the GPVI-ITAM signaling machinery in NFYPs after antibody-mediated thrombocytopenia only becomes fully functional in the blood circulation. | GPVI signaling is compromised in newly formed platelets after acute thrombocytopenia in mice.
Gupta S, Cherpokova D, Spindler M, Morowski M, Bender M, Nieswandt B., Free PMC Article | 03/23/2019 |
| Loss of GPVI expression is associated with pneumonia-derived sepsis. | Platelet glycoprotein VI aids in local immunity during pneumonia-derived sepsis caused by gram-negative bacteria.
Claushuis TAM, de Vos AF, Nieswandt B, Boon L, Roelofs JJTH, de Boer OJ, van 't Veer C, van der Poll T. | 02/2/2019 |
| Platelet-specific deletion of GPVI does not lead to enhanced systemic inflammation and accelerated organ injury in two mouse models of sepsis | The podoplanin-CLEC-2 axis inhibits inflammation in sepsis.
Rayes J, Lax S, Wichaiyo S, Watson SK, Di Y, Lombard S, Grygielska B, Smith SW, Skordilis K, Watson SP., Free PMC Article | 11/10/2018 |
| Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation. | Tetraspanin Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation.
Haining EJ, Matthews AL, Noy PJ, Romanska HM, Harris HJ, Pike J, Morowski M, Gavin RL, Yang J, Milhiet PE, Berditchevski F, Nieswandt B, Poulter NS, Watson SP, Tomlinson MG., Free PMC Article | 07/28/2018 |
| In conclusion, the present study unraveled ceramidase as a crucial player in sphingosine-induced platelet activation following GPVI-dependent signaling. | Ceramidase critically affects GPVI-dependent platelet activation and thrombus formation.
Münzer P, Mittelstädt S, Geue S, Manke MC, Walker-Allgaier B, Lang F, Gawaz M, Borst O. | 02/24/2018 |
| These results reveal a novel and unexpected function of hepatic Fc-gamma-RIIB in the targeted downregulation of GPVI in vivo. | FcγRIIB on liver sinusoidal endothelial cells is essential for antibody-induced GPVI ectodomain shedding in mice.
Stegner D, Popp M, Lorenz V, Wax JK, Gessner JE, Nieswandt B. | 08/5/2017 |
| collagen-I-mediated inhibition of proplatelet formation is specifically controlled by GPVI. | Proplatelet formation is selectively inhibited by collagen type I through Syk-independent GPVI signaling.
Semeniak D, Kulawig R, Stegner D, Meyer I, Schwiebert S, Bösing H, Eckes B, Nieswandt B, Schulze H. | 08/5/2017 |
| platelet GP6 and thromboxane A2 receptor have a role in promoting inflammatory macrophage phenotype in skin inflammation | GPVI and Thromboxane Receptor on Platelets Promote Proinflammatory Macrophage Phenotypes during Cutaneous Inflammation.
Pierre S, Linke B, Suo J, Tarighi N, Del Turco D, Thomas D, Ferreiros N, Stegner D, Frölich S, Sisignano M, Meyer Dos Santos S, deBruin N, Nüsing RM, Deller T, Nieswandt B, Geisslinger G, Scholich K. | 07/29/2017 |
| Novel antithrombotic peptides derived from trowaglerix that acts through GPVI antagonism with greater safety-no severe bleeding. | Trowaglerix Venom Polypeptides As a Novel Antithrombotic Agent by Targeting Immunoglobulin-Like Domains of Glycoprotein VI in Platelet.
Chang CH, Chung CH, Tu YS, Tsai CC, Hsu CC, Peng HC, Tseng YJ, Huang TF. | 07/15/2017 |
| TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk. | TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk.
Reppschläger K, Gosselin J, Dangelmaier CA, Thomas DH, Carpino N, McKenzie SE, Kunapuli SP, Tsygankov AY., Free PMC Article | 05/27/2017 |
| Inhibition of platelet activation by an anti-GPVI antibody significantly reduces infarct size. | Inhibition of Platelet GPVI Protects Against Myocardial Ischemia-Reperfusion Injury.
Pachel C, Mathes D, Arias-Loza AP, Heitzmann W, Nordbeck P, Deppermann C, Lorenz V, Hofmann U, Nieswandt B, Frantz S. | 08/13/2016 |
| These results demonstrate that GPVI is a receptor for fibrin and provide evidence that this interaction contributes to thrombus growth and stability. | Fibrin activates GPVI in human and mouse platelets.
Alshehri OM, Hughes CE, Montague S, Watson SK, Frampton J, Bender M, Watson SP., Free PMC Article | 12/26/2015 |
| data suggest a novel role for FAK in GPVI-dependent ROS formation and platelet activation and elucidate a proximal signaling role for FAK within the GPVI pathway. | Role of focal adhesion tyrosine kinases in GPVI-dependent platelet activation and reactive oxygen species formation.
Carrim N, Walsh TG, Consonni A, Torti M, Berndt MC, Metharom P., Free PMC Article | 12/19/2015 |