| Inhibition of GluN2D-Containing NMDA Receptors Protects Dopaminergic Neurons against 6-OHDA-Induced Neurotoxicity via Activating ERK/NRF2/HO-1 Signaling. | Inhibition of GluN2D-Containing NMDA Receptors Protects Dopaminergic Neurons against 6-OHDA-Induced Neurotoxicity via Activating ERK/NRF2/HO-1 Signaling.
Zhang JB, Wang F, Tang YT, Pang MZ, Li D, Liu CF. | 02/14/2024 |
| UBP791 ((2S*,3R*)-1-(7-(2-carboxyethyl)phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic acid) inhibits GluN2C/2D with 40-fold selectivity over GluN2A-containing receptors, and that a methionine and a lysine residue in the ligand binding pocket are the critical molecular elements for the subtype-specific binding. | Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors.
Wang JX, Irvine MW, Burnell ES, Sapkota K, Thatcher RJ, Li M, Simorowski N, Volianskis A, Collingridge GL, Monaghan DT, Jane DE, Furukawa H., Free PMC Article | 04/18/2020 |
| Study supports a role for GluN2D-NMDARs in L-DOPA-induced dyskinesia (LID), and they confirm that cell-type and subunit specific modifications of NMDARs underlie the pathophysiology of LID. | NMDA receptor GluN2D subunit participates to levodopa-induced dyskinesia pathophysiology.
Mellone M, Zianni E, Stanic J, Campanelli F, Marino G, Ghiglieri V, Longhi A, Thiolat ML, Li Q, Calabresi P, Bezard E, Picconi B, Di Luca M, Gardoni F. | 11/23/2019 |
| Data indicate that tetrahydroisoquinolines showed subunit-selective potentiation of NMDA receptors containing the GluN2C or GluN2D subunits. | Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors.
Santangelo Freel RM, Ogden KK, Strong KL, Khatri A, Chepiga KM, Jensen HS, Traynelis SF, Liotta DC., Free PMC Article | 03/15/2014 |
| Data from molecular modeling suggest that GluN2D-containing NMDA receptors can enter a conformation or mode that allows the pore to gate with high probability of burst of activity. | Modal gating of GluN1/GluN2D NMDA receptors.
Vance KM, Hansen KB, Traynelis SF., Free PMC Article | 01/11/2014 |
| NR2D expression falls significantly from postnatal day P2 to P3, then levels off until P12, and declines again until P21. | Postnatal development of N-methyl-D-aspartate receptor subunits 2A, 2B, 2C, 2D, and 3B immunoreactivity in brain stem respiratory nuclei of the rat.
Liu Q, Wong-Riley MT., Free PMC Article | 11/5/2011 |
| NR1, NR2B, and NR2D were robustly expressed in the supraoptic nucleus of adult rats. | NMDA receptor subunit expression in the supraoptic nucleus of adult rats: dominance of NR2B and NR2D.
Doherty FC, Sladek CD., Free PMC Article | 08/13/2011 |
| The deactivation time of GluN1/GluN2D receptors is influenced by the conformational variability of the ligand-binding domain and the structure of the ligand. | Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors.
Vance KM, Simorowski N, Traynelis SF, Furukawa H., Free PMC Article | 08/13/2011 |
| Expression of NR2D mRNAs in the thalamus was increased by mustard oil application to molar tooth pulp. This was prevented by lidocaine & reversed by MK-801. Naloxone antagonized this reversal. | The role of N-methyl-D-aspartate receptor subunits in the rat thalamic mediodorsal nucleus during central sensitization.
Kaneko M, Kaneko T, Kaneko R, Chokechanachaisakul U, Kawamura J, Sunakawa M, Okiji T, Suda H. | 06/18/2011 |
| At 24 hours after pulp exposure, the expression levels of NR2D mRNA were up-regulated in the contralateral thalamus. | Artificial dental pulp exposure injury up-regulates antigen-presenting cell-related molecules in rat central nervous system.
Kaneko T, Kaneko M, Chokechanachaisakul U, Kawamura J, Kaneko R, Sunakawa M, Okiji T, Suda H. | 07/19/2010 |
| NMDAR-2D subunit is well poised anatomically to modulate pain neurotransmission, but the expression pattern for this subunit is not altered in rats demonstrating the presence of neuropathic-like pain behavior | Anatomical localization and expression pattern for the NMDA-2D receptor subunit in a rat model of neuropathic pain.
Hummel M, Strassle B, Miller S, Kaftan E, Whiteside G. | 01/21/2010 |
| NR1/NR2B/NR2D triheteromers form a significant fraction of synaptic NMDA receptors during postnatal development in dopaminergic neurones of the substantia nigra pars compacta. | NR2B- and NR2D-containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones.
Brothwell SL, Barber JL, Monaghan DT, Jane DE, Gibb AJ, Jones S., Free PMC Article | 01/21/2010 |
| study provides evidence that ligand-binding domaine of NR2A/2D subunits influences two characteristic properties of NMDARs, namely coagonist binding/potency and voltage-dependent Mg2+ block | Mg2+ and memantine block of rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes.
Wrighton DC, Baker EJ, Chen PE, Wyllie DJ., Free PMC Article | 01/21/2010 |
| NMDA2C and NMDA2D subunits are in the rat striatum | Cholinergic neurons of the adult rat striatum are immunoreactive for glutamatergic N-methyl-d-aspartate 2D but not N-methyl-d-aspartate 2C receptor subunits.
Bloomfield C, O'Donnell P, French SJ, Totterdell S., Free PMC Article | 01/21/2010 |
| N-methyl-D-aspartate receptor NR2B and NR2D subunits were found in the colon with NR1 splice variants | Expression of the N-methyl-D-aspartate receptor NR1 splice variants and NR2 subunit subtypes in the rat colon.
Del Valle-Pinero AY, Suckow SK, Zhou Q, Perez FM, Verne GN, Caudle RM., Free PMC Article | 01/21/2010 |
| Differential alterations in NMDA receptor subunit expression were seen after chronic ethanol treatment in cultured rat cortical & hippocampal neurons. This may play a role in the neuronal adaptation to ethanol & the development of alcohol dependence. | Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones.
Nagy J, Kolok S, Dezso P, Boros A, Szombathelyi Z. | 01/21/2010 |
| conserved threonine residue plays a crucial role in ligand binding to NMDA NR2 receptor subunits | Influence of a threonine residue in the S2 ligand binding domain in determining agonist potency and deactivation rate of recombinant NR1a/NR2D NMDA receptors.
Chen PE, Johnston AR, Mok MH, Schoepfer R, Wyllie DJ., Free PMC Article | 01/21/2010 |
| NR2B and NR2D subunit mRNAs were found in parasympathetic preganglionic neurons at P7. Expression levels decreased thereafter, reaching the minimal level in adults. | Transient neonatal expression of NR2B/2D subunit mRNAs of the N-methyl-D-aspartate receptor in the parasympathetic preganglionic neurons in the rat spinal cord.
Shibata T, Watanabe M, Ichikawa R, Ameda K, Koyanagi T. | 01/21/2010 |
| released glutamate makes EPSC decay much longer by activating more extrasynaptic NR2B- and NR2D-subunit-containing receptors | Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape 'superslow' afterburst EPSC in rat hippocampus.
Lozovaya NA, Grebenyuk SE, Tsintsadze TSh, Feng B, Monaghan DT, Krishtal OA., Free PMC Article | 01/21/2010 |
| Results demonstrate differential expression levels of NMDA receptor subunits 2C and D and NOS isoforms in the rostral ventrolateral medulla of spontaneously hypertensive rats when compared to Wistar Kyoto rats. | Unique levels of expression of N-methyl-D-aspartate receptor subunits and neuronal nitric oxide synthase in the rostral ventrolateral medulla of the spontaneously hypertensive rat.
Edwards MA, Loxley RA, Powers-Martin K, Lipski J, McKitrick DJ, Arnolda LF, Phillips JK. | 01/21/2010 |
| Taken together, these findings indicate that NR2D and NR2B subunits form functional NMDA receptor channels in SNc dopaminergic neurones. | Functional NR2B- and NR2D-containing NMDA receptor channels in rat substantia nigra dopaminergic neurones.
Jones S, Gibb AJ., Free PMC Article | 01/21/2010 |
| only ERalpha, not ERbeta, could upregulate transcription from the ERE which is in the 3' untranslated region of the NR2D gene. | Isoform specificity for oestrogen receptor and thyroid hormone receptor genes and their interactions on the NR2D gene promoter.
Vasudevan N, Kia HK, Inoue S, Muramatsu M, Pfaff D. | 01/21/2010 |