| mGluR1/IP3/ERK signaling pathway regulates vestibular compensation in ON UBCs of the cerebellar flocculus. | mGluR1/IP3/ERK signaling pathway regulates vestibular compensation in ON UBCs of the cerebellar flocculus.
Liu D, Wang J, Tian E, Chen J, Kong W, Lu Y, Zhang S., Free PMC Article | 03/4/2024 |
| Activation of adenosine A1 receptor potentiates metabotropic glutamate receptor 1-mediated Ca[2+] mobilization in the rat hippocampal marginal zone. | Activation of adenosine A(1) receptor potentiates metabotropic glutamate receptor 1-mediated Ca(2+) mobilization in the rat hippocampal marginal zone.
Taketo M. | 11/14/2023 |
| [Activation of metabotropic glutamate receptor 1 inhibits chronic intermittent hypoxia-induced carotid body plasticity in rats]. | [Activation of metabotropic glutamate receptor 1 inhibits chronic intermittent hypoxia-induced carotid body plasticity in rats].
Li CH, Zhao CL, Liu YZ. | 11/3/2023 |
| Amygdala Metabotropic Glutamate Receptor 1 Influences Synaptic Transmission to Participate in Fentanyl-Induced Hyperalgesia in Rats. | Amygdala Metabotropic Glutamate Receptor 1 Influences Synaptic Transmission to Participate in Fentanyl-Induced Hyperalgesia in Rats.
Bai T, Chen H, Hu W, Liu J, Lin X, Chen S, Luo F, Yang X, Chen J, Li C. | 03/17/2023 |
| Stabilization of Spine Synaptopodin by mGluR1 Is Required for mGluR-LTD. | Stabilization of Spine Synaptopodin by mGluR1 Is Required for mGluR-LTD.
Speranza L, Inglebert Y, De Sanctis C, Wu PY, Kalinowska M, McKinney RA, Francesconi A., Free PMC Article | 05/7/2022 |
| Upregulation of Striatal Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Rats with Excessive Glutamate Release Induced by N-Acetylcysteine. | Upregulation of Striatal Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Rats with Excessive Glutamate Release Induced by N-Acetylcysteine.
Yamasaki T, Okada M, Hiraishi A, Mori W, Zhang Y, Fujinaga M, Wakizaka H, Kurihara Y, Nengaki N, Zhang MR. | 04/23/2022 |
| Group I metabotropic glutamate receptor-mediated long term depression is disrupted in the hippocampus of WAG/Rij rats modelling absence epilepsy. | Group I metabotropic glutamate receptor-mediated long term depression is disrupted in the hippocampus of WAG/Rij rats modelling absence epilepsy.
Di Cicco G, Marzano E, Iacovelli L, Celli R, van Luijtelaar G, Nicoletti F, Ngomba RT, Wall MJ. | 02/5/2022 |
| Reciprocal regulation of spontaneous synaptic vesicle fusion by Fragile X mental retardation protein and group I metabotropic glutamate receptors. | Reciprocal regulation of spontaneous synaptic vesicle fusion by Fragile X mental retardation protein and group I metabotropic glutamate receptors.
Subrahmanyam R, Dwivedi D, Rashid Z, Bonnycastle K, Cousin MA, Chattarji S. | 11/22/2021 |
| Arc silence aggravates traumatic neuronal injury via mGluR1-mediated ER stress and necroptosis. | Arc silence aggravates traumatic neuronal injury via mGluR1-mediated ER stress and necroptosis.
Chen T, Zhu J, Wang YH, Hang CH., Free PMC Article | 01/16/2021 |
| Neuroprotective effects of mGluR5 activation through the PI3K/Akt pathway and the molecular switch of AMPA receptors. | Neuroprotective effects of mGluR5 activation through the PI3K/Akt pathway and the molecular switch of AMPA receptors.
Cavallo D, Landucci E, Gerace E, Lana D, Ugolini F, Henley JM, Giovannini MG, Pellegrini-Giampietro DE. | 01/9/2021 |
| mGlu1 tonically regulates levels of calcium-permeable AMPA receptors in cultured nucleus accumbens neurons through retinoic acid signaling and protein translation. | mGlu1 tonically regulates levels of calcium-permeable AMPA receptors in cultured nucleus accumbens neurons through retinoic acid signaling and protein translation.
Loweth JA, Reimers JM, Caccamise A, Stefanik MT, Woo KKY, Chauhan NM, Werner CT, Wolf ME., Free PMC Article | 08/13/2020 |
| The protein levels of mGluR1 in cortical neurons were significantly increased by lysophosphatidic acid at 12 and 24h after treatment. LPA treatment induced ER stress and apoptosis in cortical neurons, and its neurotoxicity was partially mediated by Ca(2+) release from the ER via the Homer1/mGluR1 pathway. | Homer1/mGluR1-mediated ER stress contributes to lysophosphatidic acid-induced neurotoxicity in cortical neurons.
Zhu L, Zhu J, Guo SW. | 05/16/2020 |
| Findings suggest a common role for increased GluA1 translation, but not decreased mGlu1 function, in the incubation of methamphetamine and cocaine craving. We speculate that increased GluA1 translation near synapses may drive formation and synaptic insertion of homomeric GluA1 receptors in the absence of detectable changes in GluA1 protein levels. | AMPA receptor and metabotropic glutamate receptor 1 adaptations in the nucleus accumbens core during incubation of methamphetamine craving.
Murray CH, Loweth JA, Milovanovic M, Stefanik MT, Caccamise AJ, Dolubizno H, Funke JR, Foster Olive M, Wolf ME., Free PMC Article | 03/21/2020 |
| significant decrease in mGluR5 mRNA expression with a resultant increased expression of mGluR3 mRNA expression and hypermethylation of mGluR1 gene across both generations of rats, is reported. | Transgenerational deep sequencing revealed hypermethylation of hippocampal mGluR1 gene with altered mRNA expression of mGluR5 and mGluR3 associated with behavioral changes in Sprague Dawley rats with history of prolonged febrile seizure.
Alese OO, Mabandla MV., Free PMC Article | 03/21/2020 |
| synaptic activation of mGluR1 reduced synaptic SEP-GluA2. | The Probability of Neurotransmitter Release Governs AMPA Receptor Trafficking via Activity-Dependent Regulation of mGluR1 Surface Expression.
Sanderson TM, Bradley CA, Georgiou J, Hong YH, Ng AN, Lee Y, Kim HD, Kim D, Amici M, Son GH, Zhuo M, Kim K, Kaang BK, Kim SJ, Collingridge GL., Free PMC Article | 12/7/2019 |
| Longitudinal positron emission tomography using N-[4-[6-(isopropylamino)-pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methyl-4-[(11)C]methylbenzamide ([(11)C]ITDM) could successfully visualize hippocampal and thalamic declines of mGluR1 related to neuroinflammation. | In Vivo Monitoring for Regional Changes of Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Pilocarpine-Induced Epileptic Rat Brain by Small-Animal PET.
Yamasaki T, Fujinaga M, Mori W, Zhang Y, Wakizaka H, Nengaki N, Xie L, Hatori A, Zhang MR., Free PMC Article | 07/20/2019 |
| Study showed that amphetamine-induced conditioned place preference and changes in mGlu1/5 receptor expression and signaling in the rat medial prefrontal cortex. | Amphetamine-induced Conditioned Place Preference and Changes in mGlu1/5 Receptor Expression and Signaling in the Rat Medial Prefrontal Cortex.
Mao LM, Wang JQ., Free PMC Article | 06/22/2019 |
| Transient switching between NMDA-dependent Long-Term Synaptic Potentiation (LTP) and mGluR1-dependent LTP could play a role in the pathogenesis of acquired epilepsy. | Transient Switching of NMDA-Dependent Long-Term Synaptic Potentiation in CA3-CA1 Hippocampal Synapses to mGluR(1)-Dependent Potentiation After Pentylenetetrazole-Induced Acute Seizures in Young Rats.
Postnikova TY, Trofimova AM, Ergina JL, Zubareva OE, Kalemenev SV, Zaitsev AV. | 05/4/2019 |
| ERK that interacts with and phosphorylates mGluR1a is involved in the regulation of the trafficking and signaling of mGluR1. | Synaptic ERK2 Phosphorylates and Regulates Metabotropic Glutamate Receptor 1 In Vitro and in Neurons.
Yang JH, Mao LM, Choe ES, Wang JQ., Free PMC Article | 12/22/2018 |
| Fyn binds to mGluR1a at a consensus binding motif located in the intracellular C-terminus (CT) of mGluR1a in vitro. Active Fyn phosphorylates mGluR1a at a conserved tyrosine residue in the CT region. In cerebellar neurons and transfected HEK293T cells, Fyn-mediated tyrosine phosphorylation of mGluR1a is constitutively active and facilitates surface expression of mGluR1a and potentiates mGluR1a postreceptor signaling. | An Essential Role of Fyn in the Modulation of Metabotropic Glutamate Receptor 1 in Neurons.
Jin DZ, Mao LM, Wang JQ., Free PMC Article | 09/22/2018 |
| Under control conditions, mGluR1alpha dimer expression increased between juvenile and adolescence (209-328%), while monomeric levels remained consistent. Dimeric mGluR5 was steadily expressed across all time points; monomeric mGluR5 was present in juveniles, dramatically declining at adolescence and adulthood (-97-99%). | Neurodevelopmental Expression Profile of Dimeric and Monomeric Group 1 mGluRs: Relevance to Schizophrenia Pathogenesis and Treatment.
Lum JS, Fernandez F, Matosin N, Andrews JL, Huang XF, Ooi L, Newell KA., Free PMC Article | 06/16/2018 |
| GABACR and mGluR1 have roles in contrast response functions of Sprague-Dawley and P23H rat retinal ganglion cells | Effects of GABACR and mGluR1 antagonists on contrast response functions of Sprague-Dawley and P23H rat retinal ganglion cells.
Jensen R., Free PMC Article | 01/13/2018 |
| The goal of this experiment was to determine the effects of mGluR1, as well as mGluR5, antagonism on these parameters. Results show that mGluR1 is an important mediator of impulsive choice, and they provide further evidence that delay order presentation is an important variable that influences drug effects in delay discounting. | Effects of Group I metabotropic glutamate receptor antagonists on sensitivity to reinforcer magnitude and delayed reinforcement in a delay-discounting task in rats: Contribution of delay presentation order.
Yates JR, Rogers KK, Gunkel BT, Prior NA, Hughes MN, Sharpe SM, Campbell HL, Johnson AB, Keller MG, Breitenstein KA, Shults HN., Free PMC Article | 12/2/2017 |
| Transient activation of mGluRs decreased the GIRK current evoked by GABAB and D2 receptors, although less efficaciously for D2. | Calcium Release from Stores Inhibits GIRK.
Kramer PF, Williams JT., Free PMC Article | 11/25/2017 |
| Results suggest that activation of group I metabotropic glutamate receptor regulates the excitability of rat retinal ganglion cells by inhibiting inwardly rectifying potassium channels and hyperpolarization-activated cation channels. | Activation of group I metabotropic glutamate receptors regulates the excitability of rat retinal ganglion cells by suppressing Kir and I (h).
Li Q, Cui P, Miao Y, Gao F, Li XY, Qian WJ, Jiang SX, Wu N, Sun XH, Wang Z. | 10/21/2017 |