| ERalphaDelta4, an ERalpha splice variant missing exon4, interacts with caveolin-3 and mGluR2/3. | ERαΔ4, an ERα splice variant missing exon4, interacts with caveolin-3 and mGluR2/3.
Wong AM, Scott AK, Johnson CS, Mohr MA, Mittelman-Smith M, Micevych PE., Free PMC Article | 08/15/2020 |
| significant decrease in mGluR5 mRNA expression with a resultant increased expression of mGluR3 mRNA expression and hypermethylation of mGluR1 gene across both generations of rats, is reported. | Transgenerational deep sequencing revealed hypermethylation of hippocampal mGluR1 gene with altered mRNA expression of mGluR5 and mGluR3 associated with behavioral changes in Sprague Dawley rats with history of prolonged febrile seizure.
Alese OO, Mabandla MV., Free PMC Article | 03/21/2020 |
| studies illustrate the significant contribution of mGluR2 to the antipsychotic-like, sleep and EEG effects of drugs acting on group II mGluRs; however, we also provide evidence of a role for mGluR3 activity in the control of sleep and wake cortical theta and gamma oscillations | Investigating the role of mGluR2 versus mGluR3 in antipsychotic-like effects, sleep-wake architecture and network oscillatory activity using novel Han Wistar rats lacking mGluR2 expression.
Wood CM, Wafford KA, McCarthy AP, Hewes N, Shanks E, Lodge D, Robinson ESJ., Free PMC Article | 02/23/2019 |
| Results indicate a double function for glial mGlu3R activation against Abeta neurotoxicity: (i) it increases the release of protective neurotrophins such as sAPPalpha and BDNF, and (ii) it induces amyloid removal from extracellular space by glia-mediated phagocytosis. | Amyloid-beta neurotoxicity and clearance are both regulated by glial group II metabotropic glutamate receptors.
Durand D, Carniglia L, Turati J, Ramírez D, Saba J, Caruso C, Lasaga M. | 04/21/2018 |
| Findings suggest a time dependent evolving pattern of mGluR2/3 density during the pathogenesis of mesial temporal lobe epilepsy and provide insights for utilizing this data for in vivo imaging to predict the specific time points and responsiveness to the therapy targeting mGluR2/3. | Metabotropic glutamate receptor 2/3 density and its relation to the hippocampal neuropathology in a model of temporal lobe epilepsy in rats.
Ali I, Boets S, Janssens P, Van Eetveldt A, Amhaoul H, Langlois X, Dedeurwaerdere S. | 01/6/2018 |
| Study aimed at further characterizing the effects of prenatal immune activation on 5-HT2A and mGlu2/3 receptor function in male and female rat offspring | Maternal lipopolysaccharide treatment differentially affects 5-HT(2A) and mGlu2/3 receptor function in the adult male and female rat offspring.
Wischhof L, Irrsack E, Dietz F, Koch M. | 05/28/2016 |
| This study demonstrated that the Male prenatal chronic mild stress rats expressed significantly higher mGluR2/3 in the prefrontal cortex but lower in female amygalda. | Prenatal chronic mild stress induces depression-like behavior and sex-specific changes in regional glutamate receptor expression patterns in adult rats.
Wang Y, Ma Y, Hu J, Cheng W, Jiang H, Zhang X, Li M, Ren J, Li X. | 04/23/2016 |
| The results of these studies implicate mGlu3 as a major regulator of PFC function and cognition. | Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction.
Walker AG, Wenthur CJ, Xiang Z, Rook JM, Emmitte KA, Niswender CM, Lindsley CW, Conn PJ., Free PMC Article | 04/25/2015 |
| report we describe a novel neuroprotective function of mGlu3 receptors related to their ability to promote the non-amyloidogenic pathway of APP cleavage in astrocytes, thus enhancing sAPPalpha production | Astroglial mGlu3 receptors promote alpha-secretase-mediated amyloid precursor protein cleavage.
Durand D, Carniglia L, Beauquis J, Caruso C, Saravia F, Lasaga M. | 12/6/2014 |
| Following activation of mGluR3 receptors in prefrontal cortex, sensory motor gating deficits were reversed. | Activation of mGluR2/3 receptors in the ventro-rostral prefrontal cortex reverses sensorimotor gating deficits induced by systemic NMDA receptor antagonists.
Valsamis B, Chang M, Typlt M, Schmid S. | 08/30/2014 |
| activation of either the mGlu3 or mGlu2 receptor subtype alone can be sufficient to induce an LTD of synaptic transmission in the cortical input to the lateral amygdala. | Selective activation of either mGlu2 or mGlu3 receptors can induce LTD in the amygdala.
Lucas SJ, Bortolotto ZA, Collingridge GL, Lodge D. | 07/6/2013 |
| Data show that glutamatergic transmission at CA1-subiculum (SUB) synapses is depressed by group II mGluRs in a cell-type specific manner. | Group II metabotropic glutamate receptors depress synaptic transmission onto subicular burst firing neurons.
Kintscher M, Breustedt J, Miceli S, Schmitz D, Wozny C., Free PMC Article | 03/9/2013 |
| An inflammatory environment triggers an opposite gene expression regulation of two predominant subtypes, mGluR3 and mGlur5, found in glial cells. | Opposite regulation of metabotropic glutamate receptor 3 and metabotropic glutamate receptor 5 by inflammatory stimuli in cultured microglia and astrocytes.
Berger JV, Dumont AO, Focant MC, Vergouts M, Sternotte A, Calas AG, Goursaud S, Hermans E. | 11/24/2012 |
| New evidence for the antiparkinsonian efficiency of group III mGlu receptor agonism points to the regulation of the overactive subthalamo-nigral connection as a main site of action in an early stage of Parkinson's disease. | Antiparkinsonian action of a selective group III mGlu receptor agonist is associated with reversal of subthalamonigral overactivity.
Lopez S, Jouve L, Turle-Lorenzo N, Kerkerian-Legoff L, Salin P, Amalric M. | 11/24/2012 |
| analysis of extinction-dependent alterations in corticostriatal mGluR2/3 and mGluR7 receptors following chronic methamphetamine self-administration in rats | Extinction-dependent alterations in corticostriatal mGluR2/3 and mGluR7 receptors following chronic methamphetamine self-administration in rats.
Schwendt M, Reichel CM, See RE., Free PMC Article | 11/17/2012 |
| Data suggest that ezrin is required for the structural plasticity of PAPs and mGluRs can stimulate PAP plasticity. | Structural plasticity of perisynaptic astrocyte processes involves ezrin and metabotropic glutamate receptors.
Lavialle M, Aumann G, Anlauf E, Pröls F, Arpin M, Derouiche A., Free PMC Article | 10/29/2011 |
| Data show that microinjection of the mglu2/3 antagonist LY341495 at sites throughout the medial shell of the nucleus accumbens suppressed appetitive motivation to eat and drink. | Metabotropic glutamate receptor blockade in nucleus accumbens shell shifts affective valence towards fear and disgust.
Richard JM, Berridge KC., Free PMC Article | 06/4/2011 |
| data suggest that spinal mGluR2/3 contributes to the generation of mechanical allodynia induced by peripheral inflammation | Antinociceptive synergistic effect of spinal mGluR2/3 antagonist and glial cells inhibitor on peripheral inflammation-induced mechanical hypersensitivity.
Zhang T, Zhang J, Shi J, Feng Y, Sun ZS, Li H. | 01/21/2010 |
| The present study aimed to examine the role of mGluR3/mGluR7 in lead-induced neurotoxicity. | Effects of lead exposure on hippocampal metabotropic glutamate receptor subtype 3 and 7 in developmental rats.
Xu J, Yan HC, Yang B, Tong LS, Zou YX, Tian Y., Free PMC Article | 01/21/2010 |
| The expression, purification, crystallization and preliminary X-ray crystallographic analysis of mGluR3 extracellular domain, is reported. | Site-specific unglycosylation to improve crystallization of the metabotropic glutamate receptor 3 extracellular domain.
Muto T, Tsuchiya D, Morikawa K, Jingami H., Free PMC Article | 01/21/2010 |
| These data indicate a long-lasting impairment of mGlu2/3 expression that may contribute to abnormal presynaptic plasticity, exaggerate glutamate release and hyperexcitability in temporal lobe epilepsy | Impaired expression and function of group II metabotropic glutamate receptors in pilocarpine-treated chronically epileptic rats.
Garrido-Sanabria ER, Otalora LF, Arshadmansab MF, Herrera B, Francisco S, Ermolinsky BS., Free PMC Article | 01/21/2010 |
| These data confirm that activation of group III mGlu receptors inhibits GABA release in the globus pallidus, thereby supporting their hetero-receptor role in vivo. | Group III metabotropic glutamate receptors act as hetero-receptors modulating evoked GABA release in the globus pallidus in vivo.
Macinnes N, Duty S. | 01/21/2010 |
| Posttraumatic secondary brain insults exacerbate neuronal injury by altering expression of metabotropic glutamate receptors. | Posttraumatic secondary brain insults exacerbates neuronal injury by altering metabotropic glutamate receptors.
Fei Z, Zhang X, Bai HM, Jiang XF, Li X, Zhang W, Hu W., Free PMC Article | 01/21/2010 |
| We suggest that the concurrent depression of action potential-evoked, and enhancement of action potential-independent glutamate release operate through discrete second messenger/effector systems at excitatory entorhinal terminals in rat brain. | Differential control of two forms of glutamate release by group III metabotropic glutamate receptors at rat entorhinal synapses.
Woodhall GL, Ayman G, Jones RS., Free PMC Article | 01/21/2010 |
| These results indicate that mGluR2 and mGluR3 are coupled to Galphai subunits and play roles in glutamate-mediated signaling in taste transductions. | Expression of group II metabotropic glutamate receptors in rat gustatory papillae.
Toyono T, Kataoka S, Seta Y, Shigemoto R, Toyoshima K. | 01/21/2010 |