| Interspecies Variation Affects Islet Amyloid Polypeptide Membrane Binding. | Interspecies Variation Affects Islet Amyloid Polypeptide Membrane Binding.
Sanders HM, Chalyavi F, Fields CR, Kostelic MM, Li MH, Raleigh DP, Zanni MT, Marty MT., Free PMC Article | 06/13/2023 |
| Site-Specific Alkylation of the Islet Amyloid Polypeptide Accelerates Self-Assembly and Potentiates Perturbation of Lipid Membranes. | Site-Specific Alkylation of the Islet Amyloid Polypeptide Accelerates Self-Assembly and Potentiates Perturbation of Lipid Membranes.
Babych M, Nguyen PT, Côté-Cyr M, Kihal N, Quittot N, Golizeh M, Sleno L, Bourgault S. | 11/22/2021 |
| Involvement of amylin B-H2S-connexin 43 signaling pathway in vascular dysfunction and enhanced ischemia-reperfusion-induced myocardial injury in diabetic rats. | Involvement of amylin B-H2S-connexin 43 signaling pathway in vascular dysfunction and enhanced ischemia-reperfusion-induced myocardial injury in diabetic rats.
Liu X, Yang R, Bai W, Xu X, Bi F, Hao Y, Yang Q, Li H., Free PMC Article | 04/3/2021 |
| Amylin and beta amyloid proteins interact to form amorphous heterocomplexes with enhanced toxicity in neuronal cells. | Amylin and beta amyloid proteins interact to form amorphous heterocomplexes with enhanced toxicity in neuronal cells.
Bharadwaj P, Solomon T, Sahoo BR, Ignasiak K, Gaskin S, Rowles J, Verdile G, Howard MJ, Bond CS, Ramamoorthy A, Martins RN, Newsholme P., Free PMC Article | 12/26/2020 |
| The study presents the characterization of the structure ensemble of human IAPP, as well as the differences between human IAPP and its non-amyloidogenic homologous such as rat IAPP and illuminates the amyloidosis mechanism of IAPP. | All-atom structure ensembles of islet amyloid polypeptides determined by enhanced sampling and experiment data restraints.
Su X, Wang K, Liu N, Chen J, Li Y, Duan M. | 04/18/2020 |
| These results are the first to demonstrate the role of rIAPP amyloid oligomers in the development of streptozotocin-induced diabetes in rats. The IAPP amyloid oligomers are biomarkers of the onset and progression of diabetes. | Novel insight into streptozotocin-induced diabetic rats from the protein misfolding perspective.
Leyva-García E, Lara-Martínez R, Morán-Zanabria L, Revilla-Monsalve C, Jiménez-García LF, Oviedo N, Murata C, Garrido-Magaña E, Altamirano-Bustamante NF, Altamirano-Bustamante MM., Free PMC Article | 06/29/2019 |
| IAPP role in the pancreatic islet cell damage in the Type 2 diabetes mellitus. | Lipid accelerating the fibril of islet amyloid polypeptide aggravated the pancreatic islet injury in vitro and in vivo.
Mo XD, Gao LP, Wang QJ, Yin J, Jing YH., Free PMC Article | 09/15/2018 |
| this study reinforces the notion that IAPP amyloidogenesis is governed by precise intermolecular interactions involving specific Asn side chains. | Role of Site-Specific Asparagine Deamidation in Islet Amyloid Polypeptide Amyloidogenesis: Key Contributions of Residues 14 and 21.
Nguyen PT, Zottig X, Sebastiao M, Bourgault S. | 07/29/2017 |
| C4BP protects beta-cells from IAPP cytotoxicity by modulating IAPP fibril formation extracellularly and also, after uptake by the cells, by enhancing cholesterol synthesis. | C4b-binding Protein Protects β-Cells from Islet Amyloid Polypeptide-induced Cytotoxicity.
Sjölander J, Byman E, Kulak K, Nilsson SC, Zhang E, Krus U, Westermark GT, Storm P, King BC, Renström E, Blom AM., Free PMC Article | 05/20/2017 |
| ventromedial hypothalamus amylin signaling is required for full leptin signaling and protection from high fat diet induced obesity | Endogenous VMH amylin signaling is required for full leptin signaling and protection from diet-induced obesity.
Dunn-Meynell AA, Le Foll C, Johnson MD, Lutz TA, Hayes MR, Levin BE., Free PMC Article | 07/2/2016 |
| Secondary Structure of Rat and Human Amylin | Secondary Structure of Rat and Human Amylin across Force Fields.
Hoffmann KQ, McGovern M, Chiu CC, de Pablo JJ., Free PMC Article | 05/14/2016 |
| cross-seeding assemblies between hIAPP and rIAPP oligomers | Interfacial interaction and lateral association of cross-seeding assemblies between hIAPP and rIAPP oligomers.
Zhang M, Hu R, Chen H, Chang Y, Gong X, Liu F, Zheng J. | 04/16/2016 |
| Inhibition of IAPP aggregation by insulin depends on the insulin oligomeric state regulated by zinc ion concentration | Inhibition of IAPP aggregation by insulin depends on the insulin oligomeric state regulated by zinc ion concentration.
Nedumpully-Govindan P, Ding F., Free PMC Article | 11/28/2015 |
| The data indicate minimal membrane disruption by both human and rat-IAPP20-29 when compared to the full-length IAPP peptide. | Membrane disordering is not sufficient for membrane permeabilization by islet amyloid polypeptide: studies of IAPP(20-29) fragments.
Brender JR, Heyl DL, Samisetti S, Kotler SA, Osborne JM, Pesaru RR, Ramamoorthy A., Free PMC Article | 12/14/2013 |
| Amylin receptors are located mostly on presynaptic glutamatergic terminals connecting to area postrema neurons not displaying hyperpolarization-activated cation current. Amylin concentrations can increase glutamate release enough to cause cell firing. | Electrophysiologically identified presynaptic mechanisms underlying amylinergic modulation of area postrema neuronal excitability in rat brain slices.
Fukuda T, Hirai Y, Maezawa H, Kitagawa Y, Funahashi M. | 07/6/2013 |
| C4BP binds to IAPP thereby limiting complement activation and may be enhancing formation of IAPP fibrils from cytotoxic oligomers | Islet amyloid polypeptide triggers limited complement activation and binds complement inhibitor C4b-binding protein, which enhances fibril formation.
Sjölander J, Westermark GT, Renström E, Blom AM., Free PMC Article | 09/22/2012 |
| co-expression of calcitonin receptor(a) with rRAMP1 or 3 produces functional AMY receptor subtypes in rats, which display equivalent potency for rAmy and raCGRP | Pharmacological characterization of rat amylin receptors: implications for the identification of amylin receptor subtypes.
Bailey RJ, Walker CS, Ferner AH, Loomes KM, Prijic G, Halim A, Whiting L, Phillips AR, Hay DL., Free PMC Article | 08/11/2012 |
| at 8 h after mixing, rat amylin blocks the N-terminal beta-sheet of fibrils. At 24 h after mixing, rat amylin blocks neither beta-sheet and forms its own beta-sheet | Two-dimensional infrared spectroscopy reveals the complex behaviour of an amyloid fibril inhibitor.
Middleton CT, Marek P, Cao P, Chiu CC, Singh S, Woys AM, de Pablo JJ, Raleigh DP, Zanni MT., Free PMC Article | 07/28/2012 |
| Data show that the multiplicity in islet amyloid polypeptide (rIAPP) assembly structures indicates the polydispersity of the rIAPP(8-37) beta-like motifs. | Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies.
Mao XB, Wang CX, Wu XK, Ma XJ, Liu L, Zhang L, Niu L, Guo YY, Li DH, Yang YL, Wang C., Free PMC Article | 04/14/2012 |
| The results implicate amylin in the control of maternal adaptations, possibly exerting its actions on maternal behaviors via amylin receptors present in brain regions to which preoptic neurons project. | Amylin is a novel neuropeptide with potential maternal functions in the rat.
Szabó ER, Cservenák M, Dobolyi A. | 03/3/2012 |
| hIAPP overexpression inhibits insulin and IAPP secretion in response to glucose affecting the activity of K(ATP) channels | Involvement of ATP-sensitive potassium (K(ATP)) channels in the loss of beta-cell function induced by human islet amyloid polypeptide.
Soty M, Visa M, Soriano S, Carmona Mdel C, Nadal Á, Novials A., Free PMC Article | 01/21/2012 |
| an actin-mediated and cholesterol-dependent mechanism for selective uptake and clearance of amylin oligomers, impairment of which greatly potentiates amylin toxicity. | Clustering and internalization of toxic amylin oligomers in pancreatic cells require plasma membrane cholesterol.
Trikha S, Jeremic AM., Free PMC Article | 12/17/2011 |
| The study is comparing the structural properties of human and rat islet amyloid polypeptide by MD computer simulations at 310 and 330 K and shows the effect of the disulfide bridge on the conformation of Iapp. | Comparing the structural properties of human and rat islet amyloid polypeptide by MD computer simulations.
Andrews MN, Winter R. | 09/17/2011 |
| Data show that IAPP oligomeric species that arise through stochastic nucleation on membranes and result in disruption of the lipid bilayer. | Islet amyloid polypeptide demonstrates a persistent capacity to disrupt membrane integrity.
Last NB, Rhoades E, Miranker AD., Free PMC Article | 08/27/2011 |
| Ca2+ entry via L-type Ca2+ channels, activation of PKC and Ca2+ release from sarcoplasmic reticulum through ryanodine-sensitive Ca2+ channels may be involved in amylin's positive inotropic effect. | Positive inotropic, positive chronotropic and coronary vasodilatory effects of rat amylin: mechanisms of amylin-induced positive inotropy.
Kaygisiz Z, Ozden H, Erkasap N, Koken T, Gunduz T, Ikizler M, Kural T. | 03/19/2011 |