| RyR2/IRBIT regulates insulin gene transcript, insulin content, and secretion in the insulinoma cell line INS-1. | RyR2/IRBIT regulates insulin gene transcript, insulin content, and secretion in the insulinoma cell line INS-1.
Harvey KE, LaVigne EK, Dar MS, Salyer AE, Pratt EPS, Sample PA, Aryal UK, Gowher H, Hockerman GH., Free PMC Article | 05/21/2022 |
| Exogenous Ghrelin Increases Plasma Insulin Level in Diabetic Rats. | Exogenous Ghrelin Increases Plasma Insulin Level in Diabetic Rats.
Elabadlah H, Hameed R, D'Souza C, Mohsin S, Adeghate EA., Free PMC Article | 04/3/2021 |
| Disruption of insulin receptor substrate-2 impairs growth but not insulin function in rats. | Disruption of insulin receptor substrate-2 impairs growth but not insulin function in rats.
Toyoshima Y, Nakamura K, Tokita R, Teramoto N, Sugihara H, Kato H, Yamanouchi K, Minami S., Free PMC Article | 01/23/2021 |
| These results suggest that CPG16 plays a role in the suppression of insulin gene expression in pancreatic beta-cells under glucotoxic conditions. | Candidate plasticity gene 16 mediates suppression of insulin gene expression in rat insulinoma INS-1 cells under glucotoxic conditions.
Nakane T, Ido A, Higuchi T, Todaka H, Morisawa K, Nagamine T, Fukunaga K, Sakamoto S, Murao K, Sugiyama Y. | 02/8/2020 |
| NPB and NPBW1 mRNA was expressed in INS1E cells and rat pancreatic islets. In INS1E cells, NPB enhanced insulin 1 mRNA expression via an ERK1/2dependent mechanism | Neuropeptide B stimulates insulin secretion and expression but not proliferation in rat insulin‑producing INS‑1E cells.
Billert M, Sassek M, Wojciechowicz T, Jasaszwili M, Strowski MZ, Nowak KW, Skrzypski M. | 12/28/2019 |
| BHLHE40 is required for insulin induction of SREBP-1c mRNA in rodent liver. | BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver.
Tian J, Wu J, Chen X, Guo T, Chen ZJ, Goldstein JL, Brown MS., Free PMC Article | 03/23/2019 |
| Nociceptin co-localized only with insulin in pancreatic beta cells. | Effect of nociceptin on insulin release in normal and diabetic rat pancreas.
Adeghate E, Saeed Z, D'Souza C, Tariq S, Kalász H, Tekes K, Adeghate EA. | 01/19/2019 |
| characterized the phosphoproteome that is regulated by insulin as well as its key downstream kinases including Akt, mTORC1, and S6K. | Global Phosphoproteomic Analysis of Insulin/Akt/mTORC1/S6K Signaling in Rat Hepatocytes.
Zhang Y, Zhang Y, Yu Y., Free PMC Article | 05/19/2018 |
| In conclusion, TRPV4 differently regulates insulin mRNA expression in INS-1E cells via ERK1/2 and NO-dependent mechanisms. | TRPV4 regulates insulin mRNA expression and INS-1E cell death via ERK1/2 and NO-dependent mechanisms.
Billert M, Skrzypski M, Sassek M, Szczepankiewicz D, Wojciechowicz T, Mergler S, Strowski MZ, Nowak KW. | 02/24/2018 |
| CART is important for maintaining the beta-cell phenotype. | Endogenous beta-cell CART regulates insulin secretion and transcription of beta-cell genes.
Shcherbina L, Edlund A, Esguerra JL, Abels M, Zhou Y, Ottosson-Laakso E, Wollheim CB, Hansson O, Eliasson L, Wierup N. | 11/25/2017 |
| Expression of ghrelin and ghrelin receptor and glucose stimulated insulin secretion (GSIS) of pancreatic islets. | Ghrelin doesn't limit insulin release in pregnant rats fed low protein diet.
Gao H, Ho E, Yallampalli C. | 09/2/2017 |
| glucagon plus insulin increases FGF21 transcription by stimulating ATF4 expression | Glucagon and Insulin Cooperatively Stimulate Fibroblast Growth Factor 21 Gene Transcription by Increasing the Expression of Activating Transcription Factor 4.
Alonge KM, Meares GP, Hillgartner FB., Free PMC Article | 06/24/2017 |
| Under insulin stimulation, and in spite of the less activated mTOR function in high altitude rats, low altitude rats had higher glycogen content and reduced levels of gluconeogenic enzymes with a more enhanced insulin signaling, mainly due to higher levels of phosphorylated IRS1. | Enhanced hepatic insulin signaling in the livers of high altitude native rats under basal conditions and in the livers of low altitude native rats under insulin stimulation: a mechanistic study.
Al Dera H, Eleawa SM, Al-Hashem FH, Mahzari MM, Hoja I, Al Khateeb M. | 06/3/2017 |
| Reduced sortilin levels associate with lower VLDL apo B secretion. Sortilin facilitates VLDL-B100 secretion by insulin sensitive McArdle RH7777 cells. | Sortilin facilitates VLDL-B100 secretion by insulin sensitive McArdle RH7777 cells.
Sparks RP, Guida WC, Sowden MP, Jenkins JL, Starr ML, Fratti RA, Sparks CE, Sparks JD., Free PMC Article | 05/27/2017 |
| Data show that quercetin acutely stimulates insulin release, inhibits cell proliferation and induces apoptosis of INS-1 beta cells. | Quercetin Stimulates Insulin Secretion and Reduces the Viability of Rat INS-1 Beta-Cells.
Kittl M, Beyreis M, Tumurkhuu M, Fürst J, Helm K, Pitschmann A, Gaisberger M, Glasl S, Ritter M, Jakab M. | 02/18/2017 |
| Insulin deficiency increases the expression of IGF-1 and IGF-1R in renal mesangial cells and the kidney of diabetic rats, which contributes to the development of diabetic nephropathy. | Insulin deficiency induces rat renal mesangial cell dysfunction via activation of IGF-1/IGF-1R pathway.
Kong YL, Shen Y, Ni J, Shao DC, Miao NJ, Xu JL, Zhou L, Xue H, Zhang W, Wang XX, Lu LM., Free PMC Article | 01/14/2017 |
| Data suggest that rosuvastatin has the potential to increase basal insulin secretion and reduce glucose-induced insulin secretion. | Rosuvastatin Treatment Affects Both Basal and Glucose-Induced Insulin Secretion in INS-1 832/13 Cells.
Salunkhe VA, Elvstam O, Eliasson L, Wendt A., Free PMC Article | 08/6/2016 |
| These results identify a novel role for Jagn1 in regulating proinsulin biosynthesis. | Jagn1 Is Induced in Response to ER Stress and Regulates Proinsulin Biosynthesis.
Nosak C, Silva PN, Sollazzo P, Moon KM, Odisho T, Foster LJ, Rocheleau JV, Volchuk A., Free PMC Article | 07/30/2016 |
| Data suggest glucose-induced insulin secretion is first up-regulated (acute infection), then down-regulated (chronic infection) in beta cells infected with S. aureus; Pla2g4a is up-regulated in acute infection; Pla2g6 is up-regulated in chronic infection. | Role of cytosolic and calcium independent phospholipases A(2) in insulin secretion impairment of INS-1E cells infected by S. aureus.
Caporarello N, Salmeri M, Scalia M, Motta C, Parrino C, Frittitta L, Olivieri M, Toscano MA, Anfuso CD, Lupo G. | 05/14/2016 |
| These observations support the hypothesis that glucagon acts via adenylate cyclase to decrease hepatic GSH levels and induce insulin resistance. | Acute glucagon induces postprandial peripheral insulin resistance.
Patarrão RS, Lautt WW, Macedo MP., Free PMC Article | 04/16/2016 |
| Insulin reduces ischemia-induced cardiomyocyte necrosis through an Akt/NF-kappaB dependent mechanism. | Insulin/NFκB protects against ischemia-induced necrotic cardiomyocyte death.
Díaz A, Humeres C, González V, Gómez MT, Montt N, Sanchez G, Chiong M, García L. | 02/6/2016 |
| Gamma conglutin and glibenclamide increased Ins-1 gene expression in diabetic rats. | Administration of Lupinus albus gamma conglutin (Cγ) to n5 STZ rats augmented Ins-1 gene expression and pancreatic insulin content.
Vargas-Guerrero B, García-López PM, Martínez-Ayala AL, Domínguez-Rosales JA, Gurrola-Díaz CM. | 11/21/2015 |
| Data suggest neural mechanism of allostatic insulin secretion in male rats fed liquid diet as meals; allostasis leads to postprandial insulin secretion by pancreatic islets suggestive of neural/neurosecretory regulation to prevent hyperglycemia. | Meal feeding improves oral glucose tolerance in male rats and causes adaptations in postprandial islet hormone secretion that are independent of plasma incretins or glycemia.
Vahl TP, Aulinger BA, Smith EP, Drazen DL, Ulrich-Lai Y, Seeley RJ, Woods SC, D'Alessio DA., Free PMC Article | 02/28/2015 |
| Compared to the rats in the control group, the rats in the HF group had the expression levels of 12 genes with significant changes, Agrp, Ghrl, and Nr3c1, Apoa4, Cntf, Ghr, IL-1beta, Ins1, Lepr,Sort, Adcyap1r1 and Adrb1. | Green tea polyphenols reduce body weight in rats by modulating obesity-related genes.
Lu C, Zhu W, Shen CL, Gao W., Free PMC Article | 02/14/2015 |
| Maximal upregulation of many unfolded protein response genes in response to mutant proinsulin production required IRE1. | IRE1 inhibition perturbs the unfolded protein response in a pancreatic β-cell line expressing mutant proinsulin, but does not sensitize the cells to apoptosis.
Zhang L, Nosak C, Sollazzo P, Odisho T, Volchuk A., Free PMC Article | 01/24/2015 |