| RyR2/IRBIT regulates insulin gene transcript, insulin content, and secretion in the insulinoma cell line INS-1. | RyR2/IRBIT regulates insulin gene transcript, insulin content, and secretion in the insulinoma cell line INS-1.
Harvey KE, LaVigne EK, Dar MS, Salyer AE, Pratt EPS, Sample PA, Aryal UK, Gowher H, Hockerman GH., Free PMC Article | 05/21/2022 |
| Disruption of insulin receptor substrate-2 impairs growth but not insulin function in rats. | Disruption of insulin receptor substrate-2 impairs growth but not insulin function in rats.
Toyoshima Y, Nakamura K, Tokita R, Teramoto N, Sugihara H, Kato H, Yamanouchi K, Minami S., Free PMC Article | 01/23/2021 |
| Deletion of the insulin promoter region revealed that nucleotide positions - 238 to - 144 (relative to the transcriptional start site) were needed for ER repression of the rat insulin II gene. | Repression of insulin gene transcription by indirect genomic signaling via the estrogen receptor in pancreatic beta cells.
Sekido T, Nishio SI, Ohkubo Y, Sekido K, Kitahara J, Miyamoto T, Komatsu M., Free PMC Article | 07/20/2019 |
| Expression of ghrelin and ghrelin receptor and glucose stimulated insulin secretion (GSIS) of pancreatic islets. | Ghrelin doesn't limit insulin release in pregnant rats fed low protein diet.
Gao H, Ho E, Yallampalli C. | 09/2/2017 |
| Data show that quercetin acutely stimulates insulin release, inhibits cell proliferation and induces apoptosis of INS-1 beta cells. | Quercetin Stimulates Insulin Secretion and Reduces the Viability of Rat INS-1 Beta-Cells.
Kittl M, Beyreis M, Tumurkhuu M, Fürst J, Helm K, Pitschmann A, Gaisberger M, Glasl S, Ritter M, Jakab M. | 02/18/2017 |
| C-peptide has the potential to act, conditionally, as an antilipolytic hormone by activating phosphodiesterase-3B. | Proinsulin C-peptide inhibits lipolysis in diabetic rat adipose tissue through phosphodiestrase-3B enzyme.
Ghorbani A, Omrani GR, Hadjzadeh MA, Varedi M. | 10/24/2016 |
| Data suggest that rosuvastatin has the potential to increase basal insulin secretion and reduce glucose-induced insulin secretion. | Rosuvastatin Treatment Affects Both Basal and Glucose-Induced Insulin Secretion in INS-1 832/13 Cells.
Salunkhe VA, Elvstam O, Eliasson L, Wendt A., Free PMC Article | 08/6/2016 |
| Data indicate that miR-183 was decreased and Foxo1 was upregulated during conversion of dental pulp cells (DPCs) to insulin-producing cells. | Regulation of miRNA during direct reprogramming of dental pulp cells to insulin-producing cells.
Nozaki T, Ohura K. | 05/3/2014 |
| Beta-cell proliferation increased in animals on tacrolimus while Ins2 gene expression remained unaltered. | The higher diabetogenic risk of tacrolimus depends on pre-existing insulin resistance. A study in obese and lean Zucker rats.
Rodriguez-Rodriguez AE, Triñanes J, Velazquez-Garcia S, Porrini E, Vega Prieto MJ, Diez Fuentes ML, Arevalo M, Salido Ruiz E, Torres A. | 11/2/2013 |
| Testosterone promoted glucose-stimulated insulin secretion and enhance PDX1 and glut2 mRNA expression. | [Positive and negative feedback regulation in the production and secretion of insulin from INS-1 cells by testosterone. ].
Cui Y, Ma J, Shi Y, Huan Q, Guo H, Zhao Y, Chen ZJ. | 06/9/2012 |
| although ATF6 binds directly to the A5/Core of the rat insulin II gene promoter, this direct binding does not appear to contribute to its repressive activity. | Binding of activating transcription factor 6 to the A5/Core of the rat insulin II gene promoter does not mediate its transcriptional repression.
Amyot J, Benterki I, Fontés G, Hagman DK, Ferdaoussi M, Teodoro T, Volchuk A, Joly É, Poitout V., Free PMC Article | 02/18/2012 |
| NAD(P)H oxidase is an important source of superoxide in pancreatic islets and the activity of NAD(P)H oxidase is involved in the control of insulin secretion by palmitate. | NAD(P)H oxidase participates in the palmitate-induced superoxide production and insulin secretion by rat pancreatic islets.
Graciano MF, Santos LR, Curi R, Carpinelli AR. | 12/16/2011 |
| Insulin increased plasma membrane GLUT4 and GLUT1 content 30 and 40 min after treatment and CD36 content in plasma membrane fraction. | Interaction between insulin and estradiol in regulation of cardiac glucose and free fatty acid transporters.
Tepavcevic S, Koricanac G, Zakula Z, Milosavljevic T, Stojiljkovic M, Isenovic ER. | 12/16/2011 |
| Insulin (Ins) release is altered by anesthetics. | Anesthesia's effects on plasma glucose and insulin and cardiac hexokinase at similar hemodynamics and without major surgical stress in fed rats.
Zuurbier CJ, Keijzers PJ, Koeman A, Van Wezel HB, Hollmann MW. | 12/12/2011 |
| insulin stimulates cell proliferation and c-Myc expression in colon cancer cell lines HT29 and Caco-2, intestinal non-cancer cell line IEC-6, and primary fetal rat intestinal cell (FRIC) cultures. | Both Wnt and mTOR signaling pathways are involved in insulin-stimulated proto-oncogene expression in intestinal cells.
Sun J, Jin T. | 12/8/2011 |
| the stimulation of glucose uptake in response to insulin or metabolic stress is dependent in cardiomyocytes on the presence of intact microtubules. | Nuclear receptor agonists improve insulin responsiveness in cultured cardiomyocytes through enhanced signaling and preserved cytoskeletal architecture.
Montessuit C, Papageorgiou I, Lerch R. | 12/7/2011 |