| Self-limiting bidirectional positive feedback between P53 and P21 is involved in cardiac hypertrophy. | Self-limiting bidirectional positive feedback between P53 and P21 is involved in cardiac hypertrophy.
Hong JH, Ding YY, Li JM, Pan XC, Liu Y, Zhang HG. | 10/1/2022 |
| Selective Endothelial Hyperactivation of Oncogenic KRAS Induces Brain Arteriovenous Malformations in Mice. | Selective Endothelial Hyperactivation of Oncogenic KRAS Induces Brain Arteriovenous Malformations in Mice.
Park ES, Kim S, Huang S, Yoo JY, Körbelin J, Lee TJ, Kaur B, Dash PK, Chen PR, Kim E. | 05/29/2021 |
| teolin, and in particular its metabolized product, may represent another natural product-derived therapeutic agent that acts against bladder cancer by upregulating p21 and inhibiting mTOR signaling | Luteolin suppresses bladder cancer growth via regulation of mechanistic target of rapamycin pathway.
Iida K, Naiki T, Naiki-Ito A, Suzuki S, Kato H, Nozaki S, Nagai T, Etani T, Nagayasu Y, Ando R, Kawai N, Yasui T, Takahashi S., Free PMC Article | 04/25/2020 |
| Kras protein mutation is responsible for the development of mucinous adenocarcinoma of the lung in patient born with congenital pulmonary malformation. | Pulmonary Kirsten Rat Sarcoma Virus Mutation Positive Mucinous Adenocarcinoma Arising in a Congenital Pulmonary Airway Malformation, Mixed Type 1 and 2.
Singh G, Coffey A, Neely R, Lambert D, Sonett J, Borczuk AC, Gorenstein L. | 04/15/2017 |
| Taken together, these results reveal the key role of histone H3Kme in TGF-beta1 mediated p21 gene expression in RMC, partly through HMT SET7/9 occupancy, suggesting H3Kme and SET7/9 may be potential renoprotective agents in managing chronic renal diseases. | Histone Lysine Methylation in TGF-β1 Mediated p21 Gene Expression in Rat Mesangial Cells.
Guo Q, Li X, Han H, Li C, Liu S, Gao W, Sun G., Free PMC Article | 02/4/2017 |
| VEGF/VEGFR/K-ras signaling pathway might promote the occurrence and development of hepatocellular carcinoma cells through regulating expression of miRNA21, which has potential clinical value for the development of therapies for hepatocellular carcinoma | Effects of VEGF/VEGFR/K-ras signaling pathways on miRNA21 levels in hepatocellular carcinoma tissues in rats.
Gao JZ, Wang YL, Li J, Wei LX. | 02/6/2016 |
| Ras, ERK, and Akt are key effectors in the glucocorticoid-induced differentiation of growth hormone-secreting cells. | Role of Ras, ERK, and Akt in glucocorticoid-induced differentiation of embryonic rat somatotropes in vitro.
Lv WM, Zhao Y, Yang G, Dong SY, Zhang GH, Zhang Y, Li GZ, Cheng Y. | 11/28/2015 |
| Findings demonstrated that oncogenic K-Ras activates the signaling cascade p38/PDPK1/PKCdelta/p47(phox)/NOX1 for ROS generation and consequent malignant cellular transformation. | Novel signaling axis for ROS generation during K-Ras-induced cellular transformation.
Park MT, Kim MJ, Suh Y, Kim RK, Kim H, Lim EJ, Yoo KC, Lee GH, Kim YH, Hwang SG, Yi JM, Lee SJ., Free PMC Article | 04/25/2015 |
| Piper betle may act as a potential chemopreventive agent in the early stage of colon carcinogenesis by suppressing the expressions of beta-catenin and KRAS. | Inhibition of beta-catenin and KRAS expressions by Piper betle in azoxymethane-induced colon cancer of male Fischer 344 rats.
Esa F, Ngah WZ, Jamal AR, Mohd Yusof YA. | 04/5/2014 |
| beta-cell apoptosis can be triggered by p21 during stress and is thus a potential target to inhibit for protection of functional beta-cell mass. | Upregulation of p21 activates the intrinsic apoptotic pathway in β-cells.
Hernandez AM, Colvin ES, Chen YC, Geiss SL, Eller LE, Fueger PT., Free PMC Article | 11/30/2013 |
| Oncogenic K-Ras modulates expression and localization of catenin and HDAC proteins in Rat2 cells. | Identification of HDAC4 as a target of γ-catenin that regulates the oncogenic K-Ras-mediated malignant phenotype of Rat2 cells.
Yim JH, Baek JH, Lee CW, Kim MJ, Yun HS, Hong EH, Lee SJ, Park JK, Um HD, Hwang SG. | 09/14/2013 |
| Data indicate that Ras-Raf-ERK-Sp1 signaling pathway is responsibe for FGF-2-induced nestin expression. | Fibroblast growth factor-2 up-regulates the expression of nestin through the Ras-Raf-ERK-Sp1 signaling axis in C6 glioma cells.
Chang KW, Huang YL, Wong ZR, Su PH, Huang BM, Ju TK, Yang HY. | 08/31/2013 |
| mitochondrial functional loss may be mediated by oncogenic K-Ras-induced mitophagy during early tumorigenesis even in the absence of hypoxia | Involvement of mitophagy in oncogenic K-Ras-induced transformation: overcoming a cellular energy deficit from glucose deficiency.
Kim JH, Kim HY, Lee YK, Yoon YS, Xu WG, Yoon JK, Choi SE, Ko YG, Kim MJ, Lee SJ, Wang HJ, Yoon G., Free PMC Article | 03/31/2012 |
| It appears that p21Ras induces asthmatic ASMCs to a proliferative/secretory phenotype, but its inhibitor FTP III, can significantly reverse this phenotype. | Effect of p21Ras in vitro intervention on the phenotype of airway smooth muscle cells from asthmatic rats.
Qiu C, Li N, Chen DD, Li FR. | 08/6/2011 |
| Vascular smooth muscle cell proliferation is influenced by let-7d microRNA and its interaction with KRAS. | Vascular smooth muscle cell proliferation is influenced by let-7d microRNA and its interaction with KRAS.
Yu ML, Wang JF, Wang GK, You XH, Zhao XX, Jing Q, Qin YW. | 07/9/2011 |
| limited clinical usefulness of gene mutation as a selection marker for epidermal growth factor receptor tyrosine-kinase inhibitors sensitivity in non-small cell lung cancer | KRAS mutations and resistance to EGFR-TKIs treatment in patients with non-small cell lung cancer: a meta-analysis of 22 studies.
Mao C, Qiu LX, Liao RY, Du FB, Ding H, Yang WC, Li J, Chen Q. | 03/12/2011 |
| The proto-oncogenic k-Ras is directly involved in the promotion of muscle differentiation via PI3K and its downstream signaling pathways. | Proto-oncogenic H-Ras, K-Ras, and N-Ras are involved in muscle differentiation via phosphatidylinositol 3-kinase.
Lee J, Choi KJ, Lim MJ, Hong F, Choi TG, Tak E, Lee S, Kim YJ, Chang SG, Cho JM, Ha J, Kim SS. | 11/6/2010 |
| Reactive oxygen species, Ki-Ras, and mitochondrial superoxide dismutase cooperate in nerve growth factor-induced differentiation of PC12 cells | Reactive oxygen species, Ki-Ras, and mitochondrial superoxide dismutase cooperate in nerve growth factor-induced differentiation of PC12 cells.
Cassano S, Agnese S, D'Amato V, Papale M, Garbi C, Castagnola P, Ruocco MR, Castellano I, De Vendittis E, Santillo M, Amente S, Porcellini A, Avvedimento EV., Free PMC Article | 09/20/2010 |
| Genome-wide gene expression analysis identifies K-ras as a regulator of alcohol intake. The data implicate K-ras-regulated pathways in the regulation of excessive alcohol drinking after a history of dependence | Genome-wide gene expression analysis identifies K-ras as a regulator of alcohol intake.
Repunte-Canonigo V, van der Stap LD, Chen J, Sabino V, Wagner U, Zorrilla EP, Schumann G, Roberts AJ, Sanna PP., Free PMC Article | 09/6/2010 |
| N-nitroso-N-methylurea disrupted and dietary methylselenocysteine significantly increased the expression of p21 in mammary glands of Fischer 344 rats | Methylselenocysteine resets the rhythmic expression of circadian and growth-regulatory genes disrupted by nitrosomethylurea in vivo.
Fang MZ, Zhang X, Zarbl H., Free PMC Article | 08/2/2010 |
| study shows social isolation decreases content of Bcl-2-associated K-Ras in hippocampal mitochondria but amount of H-Ras is increased in the microsomal fraction; redistribution of Ras isoforms was accompanied by acceleration in mitochondrial hexokinase | Social isolation in rats inhibits oxidative metabolism, decreases the content of mitochondrial K-Ras and activates mitochondrial hexokinase.
Zhuravliova E, Barbakadze T, Zaalishvili E, Chipashvili M, Koshoridze N, Mikeladze D. | 02/8/2010 |
| (18)F-FDG uptake in the thyroid carcinoma cell line ML-1 is no longer regulated by TSH or cAMP or mediated by GLUT-1. | Regulation of uptake of 18F-FDG by a follicular human thyroid cancer cell line with mutation-activated K-ras.
Prante O, Maschauer S, Fremont V, Reinfelder J, Stoehr R, Szkudlinski M, Weintraub B, Hartmann A, Kuwert T. | 01/21/2010 |
| Epithelial cells expressing oncogenic K-Ras showed increased proliferation mediated through COX-2-dependent activation of beta-catenin signaling and inhibition of apoptosis. | Oncogenic K-Ras regulates proliferation and cell junctions in lung epithelial cells through induction of cyclooxygenase-2 and activation of metalloproteinase-9.
Wang XQ, Li H, Van Putten V, Winn RA, Heasley LE, Nemenoff RA., Free PMC Article | 01/21/2010 |
| Differential interference of chlorpromazine with the membrane interactions of oncogenic K-Ras and its effects on cell growth. | Differential interference of chlorpromazine with the membrane interactions of oncogenic K-Ras and its effects on cell growth.
Eisenberg S, Giehl K, Henis YI, Ehrlich M. | 01/21/2010 |
| Transformation by oncogenic Ras expands the early genomic response to transforming growth factor beta in intestinal epithelial cells. | Transformation by oncogenic Ras expands the early genomic response to transforming growth factor beta in intestinal epithelial cells.
Allen CE, Du J, Jiang B, Huang Q, Yakovich AJ, Barnard JA., Free PMC Article | 01/21/2010 |