| Triiodo-L-thyronine (T3) downregulates Npr1 gene (coding for natriuretic peptide receptor-A) transcription in H9c2 cells: involvement of beta-AR-ROS signaling. | Triiodo-L-thyronine (T3) downregulates Npr1 gene (coding for natriuretic peptide receptor-A) transcription in H9c2 cells: involvement of β-AR-ROS signaling.
Nagaraj G, Vellaichamy E. | 08/12/2024 |
| Endothelial Natriuretic Peptide Receptor 1 Play Crucial Role for Acute and Chronic Blood Pressure Regulation by Atrial Natriuretic Peptide. | Endothelial Natriuretic Peptide Receptor 1 Play Crucial Role for Acute and Chronic Blood Pressure Regulation by Atrial Natriuretic Peptide.
Tokudome T, Otani K, Mao Y, Jensen LJ, Arai Y, Miyazaki T, Sonobe T, Pearson JT, Osaki T, Minamino N, Ishida J, Fukamizu A, Kawakami H, Onozuka D, Nishimura K, Miyazato M, Nishimura H. | 06/18/2022 |
| Atenolol treatment normalized the altered expression of Npr1 and Npr2 genes. | Differential expression and regulation of anti-hypertrophic genes Npr1 and Npr2 during β-adrenergic receptor activation-induced hypertrophic growth in rats.
Manivasagam S, Subramanian V, Tumala A, Vellaichamy E. | 11/4/2017 |
| Suppression of Npr1, not Npr2 gene function induces hypertrophic growth in cardiomyocytes in vitro. | Suppression of Npr1, not Npr2 gene function induces hypertrophic growth in H9c2 cells in vitro.
Manivasagam S, Vellaichamy E. | 08/26/2017 |
| The results suggest that an antagonistic cascade exists between the TGF-beta1/Smad/deltaEF1 pathways and Npr1 expression and receptor signaling that is relevant to renal and vascular remodeling, and may be critical in the regulation of blood pressure and cardiovascular homeostasis. | Transforming growth factor β1 antagonizes the transcription, expression and vascular signaling of guanylyl cyclase/natriuretic peptide receptor A - role of δEF1.
Sen A, Kumar P, Garg R, Lindsey SH, Katakam PV, Bloodworth M, Pandey KN., Free PMC Article | 06/24/2017 |
| augmentation of inhibitory effect on basal motility by ANP in experimental colitis may be due an increased expression of colonic natriuretic peptide receptor-A mRNA | Modulation in Natriuretic Peptides System in Experimental Colitis in Rats.
Lee CH, Ha GW, Kim JH, Kim SH. | 08/6/2016 |
| Provide direct evidence for the presence and synthesis of ANP and its receptors in both neuronal and non-neuronal cells within the cochlear spiral ganglion. | Expression patterns of atrial natriuretic peptide and its receptors within the cochlear spiral ganglion of the postnatal rat.
Sun F, Zhou K, Wang SJ, Liang PF, Zhu MZ, Qiu JH. | 10/4/2014 |
| Angiotensin-II down-regulates cardiac natriuretic peptide receptor-A mediated anti-hypertrophic signaling in experimental rat hearts | Angiotensin-II down-regulates cardiac natriuretic peptide receptor-A mediated anti-hypertrophic signaling in experimental rat hearts.
Gopi V, Parthasarathy A, Umadevi S, Vellaichamy E. | 03/23/2013 |
| BNP and NPR-A are expressed in the dorsal horn ganglion, and expressions are elevated in rats with chronic nonbacterial prostatitis. | [Expressions of BNP and NPR-A in rat models of chronic nonbacterial prostatitis and their significance].
Xie WJ, Sun T, Yang XR, Ma M. | 01/26/2013 |
| knockdown of NPR-A up-regulates the expression of NPR-C, Gialpha proteins, and NPR-C-linked adenylyl cyclase signalling and suggests a cross-talk between NPR-A and NPR-C. | Knockdown of natriuretic peptide receptor-A enhances receptor C expression and signalling in vascular smooth muscle cells.
Li Y, Madiraju P, Anand-Srivastava MB. | 05/26/2012 |
| speculate that, in NPRA, the ANP-induced rotation of the juxtamembrane domains, transmitted across the transmembrane helices, may induce a similar rotation in each of the dimerized GC catalytic domains, leading to the stimulation of GC catalytic activity | Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase.
Misono KS, Philo JS, Arakawa T, Ogata CM, Qiu Y, Ogawa H, Young HS., Free PMC Article | 07/23/2011 |
| activation of hypothalamic natriuretic peptide receptor-A in rat has a role in inhibition of dehydration-induced water intake by glucocorticoids | Inhibition of dehydration-induced water intake by glucocorticoids is associated with activation of hypothalamic natriuretic peptide receptor-A in rat.
Liu C, Guan J, Kang Y, Xiu H, Chen Y, Deng B, Liu K., Free PMC Article | 07/9/2011 |
| Seven sites of phosphorylation were identified in rat GC-A (S497, T500, S502, S506, S510, T513, and S487), and all of these sites except S510 and T513 were observed in human GC-A. | Mass spectrometric identification of phosphorylation sites in guanylyl cyclase A and B.
Yoder AR, Stone MD, Griffin TJ, Potter LR., Free PMC Article | 01/1/2011 |
| The two natriuretic peptide receptors, guanylyl cyclase-A (GC-A) and GC-B are subject to pronounced size alterations in the rat brain between postnatal day 1 and adult. | The membrane receptors guanylyl cyclase-A and -B undergo distinctive changes in post-translational modification during brain development.
Müller D, Hildebrand M, Lübberstedt J, Kuhn M, Middendorff R. | 11/27/2010 |
| results demonstrate that NPRs are clearly expressed in the cells located in the ganglion cell layer including the three major subtypes of retinal ganglion cells and the expression is mainly on the membrane of somata | Natriuretic peptide receptors are expressed in rat retinal ganglion cells.
Xu GZ, Tian J, Zhong YM, Yang XL. | 10/23/2010 |
| A new molecular model is proposed for NPRA's active conformation in which the juxtamembrane and transmembrane regions are taken into account before and after receptor activation. | Role of juxtamembrane and transmembrane domains in the mechanism of natriuretic peptide receptor A activation.
Parat M, Blanchet J, De Léan A. | 08/16/2010 |
| These findings support roles for NPR-A, the common receptor of atrial (ANP) and B-type (BNP) natriuretic peptide in mature neurons and provide evidence for pronounced changes in neuronal submembrane cGMP signalling during neuronal differentiation. | Neuronal differentiation of NG108-15 cells has impact on nitric oxide- and membrane (natriuretic peptide receptor-A) cyclic GMP-generating proteins.
Müller D, Greenland KJ, Speth RC, Middendorff R. | 06/14/2010 |
| Study revealed that GC-B predominates in the developing and GC-A in the adult brain, with regional differences each between cerebral cortex, cerebellum, and brain stem. | Expression of guanylyl cyclase (GC)-A and GC-B during brain development: evidence for a role of GC-B in perinatal neurogenesis.
Müller D, Hida B, Guidone G, Speth RC, Michurina TV, Enikolopov G, Middendorff R. | 01/25/2010 |
| BNP was capable of inhibiting VSMCs proliferation by NPRA/cGMP pathway | NPRA-mediated suppression of AngII-induced ROS production contribute to the antiproliferative effects of B-type natriuretic peptide in VSMC.
Gao P, Qian DH, Li W, Huang L. | 01/21/2010 |
| our results suggest the existence of a local and complex peptidergic system in the rat testis, involving ANP and its receptors that could importantly modulate the androgen biosynthesis. | Regulation of steroidogenesis by atrial natriuretic peptide (ANP) in the rat testis: differential involvement of GC-A and C receptors.
Pereira VM, Costa AP, Rosa-E-Silva AA, Vieira MA, Reis AM. | 01/21/2010 |
| Increase in natriuretic peptide receptor-A expression may account for some of the reported beneficial effect of 1,25(OH)(2)D3 on the cardiovascular system and kidney. | Vitamin D activates type A natriuretic peptide receptor gene transcription in inner medullary collecting duct cells.
Chen S, Olsen K, Grigsby C, Gardner DG. | 01/21/2010 |
| activation of NPRA in relation to eNOS expression in renal medulla cells | Osmoregulation of endothelial nitric-oxide synthase gene expression in inner medullary collecting duct cells. Role in activation of the type A natriuretic peptide receptor.
Chen S, Cao L, Intengan HD, Humphreys M, Gardner DG. | 01/21/2010 |
| there are altered NPR-A receptors in rat spontaneously hypertensive kidney, which might act as a negative feedback in response to hypertension | A-type natriuretic peptide receptor in the spontaneously hypertensive rat kidney.
Woodard GE, Zhao J, Rosado JA, Brown J. | 01/21/2010 |
| seminiferous tubules rather than Leydig cells are the predominant GC-A expression sites in the rat testis and functional activity was proved by ANP- induced cGMP accumulation in isolated seminiferous tubules. | Spatiotemporal regulation of the two atrial natriuretic peptide receptors in testis.
Müller D, Mukhopadhyay AK, Speth RC, Guidone G, Potthast R, Potter LR, Middendorff R. | 01/21/2010 |
| NPRA-PKG association may have a role in compartmentation of cGMP-mediated signaling and regulation of receptor sensitivity | Atrial natriuretic peptide induces natriuretic peptide receptor-cGMP-dependent protein kinase interaction.
Airhart N, Yang YF, Roberts CT Jr, Silberbach M. | 01/21/2010 |