| S100A4 modulates cell proliferation, apoptosis and fibrosis in the hyperplastic prostate. | S100A4 modulates cell proliferation, apoptosis and fibrosis in the hyperplastic prostate.
Yang L, Liu J, Yin J, Li Y, Liu J, Liu D, Wang Z, DiSanto ME, Zhang W, Zhang X. | 03/26/2024 |
| Upregulation of hypothalamic TRPV4 via S100a4/AMPKalpha signaling pathway promotes the development of diet-induced obesity. | Upregulation of hypothalamic TRPV4 via S100a4/AMPKα signaling pathway promotes the development of diet-induced obesity.
Xi P, Zhu W, Zhang Y, Wang M, Liang H, Wang H, Tian D. | 11/16/2023 |
| These data suggest that the S100-ErbB axis may be an important mechanism regulating neuronal survival and plasticity. | The S100A4 Protein Signals through the ErbB4 Receptor to Promote Neuronal Survival.
Pankratova S, Klingelhofer J, Dmytriyeva O, Owczarek S, Renziehausen A, Syed N, Porter AE, Dexter DT, Kiryushko D., Free PMC Article | 08/31/2019 |
| Data indicate that microRNA miR-124 targets S100 calcium-binding protein A4 (S100A4) 3' UTR and regulates vascular smooth muscle cell proliferation. | The microRNA miR-124 inhibits vascular smooth muscle cell proliferation by targeting S100 calcium-binding protein A4 (S100A4).
Choe N, Kwon DH, Shin S, Kim YS, Kim YK, Kim J, Ahn Y, Eom GH, Kook H. | 06/3/2017 |
| S100A4 is upregulated in the experimental rat periodontitis. | S100A4 upregulation suppresses tissue ossification and enhances matrix degradation in experimental periodontitis models.
Zhou M, Li ZQ, Wang ZL., Free PMC Article | 08/20/2016 |
| Results show S100A4 expression increasing during fibrotic stage and declining during resolution suggesting it as a good marker for liver fibrogenesis. | Involvement of fibroblast-specific protein 1 (S100A4) and matrix metalloproteinase-13 (MMP-13) in CCl4-induced reversible liver fibrosis.
Louka ML, Ramzy MM. | 05/28/2016 |
| found a significant increase in the expression of S100A4 in vitreous samples of rats with diabetic retinopathy | S100A4 is upregulated in proliferative diabetic retinopathy and correlates with markers of angiogenesis and fibrogenesis.
Abu El-Asrar AM, Nawaz MI, De Hertogh G, Alam K, Siddiquei MM, Van den Eynde K, Mousa A, Mohammad G, Geboes K, Opdenakker G., Free PMC Article | 12/12/2015 |
| TG2 regulates S100A4-mediated mammary tumor cell migration. | The role of TG2 in regulating S100A4-mediated mammary tumour cell migration.
Wang Z, Griffin M., Free PMC Article | 08/31/2013 |
| S100A4 modulates p53 function in fibroblasts and thereby mediates myocardial interstitial fibrosis through two distinct mechanisms; cell proliferation and collagen expression. | Metastasis-associated protein, S100A4 mediates cardiac fibrosis potentially through the modulation of p53 in cardiac fibroblasts.
Tamaki Y, Iwanaga Y, Niizuma S, Kawashima T, Kato T, Inuzuka Y, Horie T, Morooka H, Takase T, Akahashi Y, Kobuke K, Ono K, Shioi T, Sheikh SP, Ambartsumian N, Lukanidin E, Koshimizu TA, Miyazaki S, Kimura T. | 08/31/2013 |
| The concentration gradient of S100A4 induces direction guidance for neurons and astrocytes. | Tunneling-nanotube direction determination in neurons and astrocytes.
Sun X, Wang Y, Zhang J, Tu J, Wang XJ, Su XD, Wang L, Zhang Y., Free PMC Article | 06/1/2013 |
| Data show that S100A4 is predominantly expressed in hypoxic rhomboid smooth muscle cells, and regulated by the activation of JAK2-STAT3 signal pathway, which is dependent on hypoxia-induced HIF-1alpha expression. | Regulation of S100A4 expression via the JAK2-STAT3 pathway in rhomboid-phenotype pulmonary arterial smooth muscle cells exposure to hypoxia.
Liu T, Li Y, Lin K, Yin H, He B, Zheng M, Wang G. | 10/27/2012 |
| S100A4 downregulates filopodia formation through increased dynamic instability | S100A4 downregulates filopodia formation through increased dynamic instability.
Goh Then Sin C, Hersch N, Rudland PS, Barraclough R, Hoffmann B, Gross SR., Free PMC Article | 01/28/2012 |
| S100A4 has a stabilizing function in reactive white matter astrocytes | Role of intracellular S100A4 for migration of rat astrocytes.
Takenaga K, Kozlova EN. | 01/21/2010 |
| The presence of S100A4 in sensory neurons, including their processes in the central nervous system, suggests that S100A4 is involved in propagation of sensory impulses in specific fiber types. | Metastasis-associated S100A4 (Mts1) protein is expressed in subpopulations of sensory and autonomic neurons and in Schwann cells of the adult rat.
Sandelin M, Zabihi S, Liu L, Wicher G, Kozlova EN. | 01/21/2010 |
| results indicated that S100A4 may play a role as a possible target molecule for TCR gamma delta T cell-mediated lysis although how S100A4 is involved in TCR gamma delta T cell-mediated lysis remains to be determined | A calcium binding protein, S100A4, mediates T cell dependent cytotoxicity as a transformation-associated antigen.
Kondo N, Ichimiya S, Tamura Y, Tonooka A, Koshiba S, Torigoe T, Kamiguchi K, Takenaga K, Sato N. | 01/21/2010 |
| high-grade glioblastomas express higher amount of S100A4/Mts1 than low-grade astrocytic tumors | Modified expression of Mts1/S100A4 protein in C6 glioma cells or surrounding astrocytes affects migration of tumor cells in vitro and in vivo.
Takenaga K, Nygren J, Zelenina M, Ohira M, Iuchi T, Lukanidin E, Sjöquist M, Kozlova EN. | 01/21/2010 |
| the ability to interact with protein target(s) is important in S100A4-induced metastasis | The C-terminal region of S100A4 is important for its metastasis-inducing properties.
Zhang S, Wang G, Liu D, Bao Z, Fernig DG, Rudland PS, Barraclough R. | 01/21/2010 |