| In the Rat Hippocampus, Pilocarpine-Induced Status Epilepticus Is Associated with Reactive Glia and Concomitant Increased Expression of CD31, PDGFRbeta, and Collagen IV in Endothelial Cells and Pericytes of the Blood-Brain Barrier. | In the Rat Hippocampus, Pilocarpine-Induced Status Epilepticus Is Associated with Reactive Glia and Concomitant Increased Expression of CD31, PDGFRβ, and Collagen IV in Endothelial Cells and Pericytes of the Blood-Brain Barrier.
Kyriatzis G, Bernard A, Bôle A, Khrestchatisky M, Ferhat L., Free PMC Article | 02/23/2024 |
| PDGFRB upregulation contributes to retinal damages in the rat model of retinal ischemia-reperfusion. | PDGFRB upregulation contributes to retinal damages in the rat model of retinal ischemia-reperfusion.
Li J, Chen C, Zhang L, Ren Y, Li H. | 05/23/2023 |
| PDGF-beta and IL-18 Expressions on Carcinoma Cervical by Rhodomyrtus tomentosa. | PDGF-β and IL-18 Expressions on Carcinoma Cervical by Rhodomyrtus tomentosa.
Simanullang RH, Situmorang PC, Ginting L, Tarigan ER, Syahputra RA, Chairunisa C, Maliki MF. | 01/11/2023 |
| Methylation-mediated silencing of PTPRD induces pulmonary hypertension by promoting pulmonary arterial smooth muscle cell migration via the PDGFRB/PLCgamma1 axis. | Methylation-mediated silencing of PTPRD induces pulmonary hypertension by promoting pulmonary arterial smooth muscle cell migration via the PDGFRB/PLCγ1 axis.
Xu J, Zhong Y, Yin H, Linneman J, Luo Y, Xia S, Xia Q, Yang L, Huang X, Kang K, Wang J, Niu Y, Li L, Gou D., Free PMC Article | 08/27/2022 |
| Cardiac microvascular functions improved by MSC-derived exosomes attenuate cardiac fibrosis after ischemia-reperfusion via PDGFR-beta modulation. | Cardiac microvascular functions improved by MSC-derived exosomes attenuate cardiac fibrosis after ischemia-reperfusion via PDGFR-β modulation.
Wang X, Bai L, Liu X, Shen W, Tian H, Liu W, Yu B. | 11/27/2021 |
| Activation of spinal PDGFRbeta in microglia promotes neuronal autophagy via p38 MAPK pathway in morphine-tolerant rats. | Activation of spinal PDGFRβ in microglia promotes neuronal autophagy via p38 MAPK pathway in morphine-tolerant rats.
Jia X, Zhang A, Li Z, Peng X, Tian X, Gao F. | 11/13/2021 |
| Low-activity programming of the PDGFRbeta/FAK pathway mediates H-type vessel dysplasia and high susceptibility to osteoporosis in female offspring rats after prenatal dexamethasone exposure. | Low-activity programming of the PDGFRβ/FAK pathway mediates H-type vessel dysplasia and high susceptibility to osteoporosis in female offspring rats after prenatal dexamethasone exposure.
Shangguan Y, Wu Z, Xie X, Zhou S, He H, Xiao H, Liu L, Zhu J, Chen H, Han H, Wang H, Chen L. | 07/3/2021 |
| Tensile force-induced PDGF-BB/PDGFRbeta signals in periodontal ligament fibroblasts activate JAK2/STAT3 for orthodontic tooth movement. | Tensile force-induced PDGF-BB/PDGFRβ signals in periodontal ligament fibroblasts activate JAK2/STAT3 for orthodontic tooth movement.
Jin Y, Ding L, Ding Z, Fu Y, Song Y, Jing Y, Li Q, Zhang J, Ni Y, Hu Q., Free PMC Article | 02/2/2021 |
| study shows that Platelet-derived growth factor receptor-beta/interferon regulatory factor 9/sirtuin 1/NF-kappaB signaling played a role in the vascular smooth muscle cell phenotypic transformation after subarachnoid hemorrhage | PDGFR-β modulates vascular smooth muscle cell phenotype via IRF-9/SIRT-1/NF-κB pathway in subarachnoid hemorrhage rats.
Wan W, Ding Y, Xie Z, Li Q, Yan F, Budbazar E, Pearce WJ, Hartman R, Obenaus A, Zhang JH, Jiang Y, Tang J., Free PMC Article | 05/9/2020 |
| Developmental 2,3,7,8-tetrachlorodibenzo-p-dioxin and high fat diet exposure induced changes in body growth and feeding behaviors that may be mediated by brain Pdgfrb level changes: Pdgfrb levels in the hippocampus and striatum were inversely correlated with increases in body length, while changes in Pdgfrb in the amygdala and nucleus accumbens were significantly correlated to body weight gain or body mass index. | Effects of high fat diet and perinatal dioxin exposure on development of body size and expression of platelet-derived growth factor receptor β in the rat brain.
Bor A, Nishijo M, Nishimaru H, Nakamura T, Tran NN, Van Le Q, Takamura Y, Matsumoto J, Nishino Y, Nishijo H. | 05/12/2018 |
| Our data provide the first evidence for a critical sequential role for mTOR-Notch3-PDGF-beta receptor signaling in the pathogenesis of chronic neonatal pulmonary hypertension. | mTOR-Notch3 signaling mediates pulmonary hypertension in hypoxia-exposed neonatal rats independent of changes in autophagy.
Ivanovska J, Shah S, Wong MJ, Kantores C, Jain A, Post M, Yeganeh B, Jankov RP. | 04/21/2018 |
| Data indicate transforming growth factor beta (TGFbeta) involvement in early activation of platelet-derived growth factor receptor beta (PDGFRbeta)+ pericytes in aristolochic acid induced acute kidney injury. | Blocking TGF-β Signaling Pathway Preserves Mitochondrial Proteostasis and Reduces Early Activation of PDGFRβ+ Pericytes in Aristolochic Acid Induced Acute Kidney Injury in Wistar Male Rats.
Pozdzik AA, Giordano L, Li G, Antoine MH, Quellard N, Godet J, De Prez E, Husson C, Declèves AE, Arlt VM, Goujon JM, Brochériou-Spelle I, Ledbetter SR, Caron N, Nortier JL., Free PMC Article | 08/5/2017 |
| Results demonstrated that uric acid can stimulate p38 MAPK, p44/42 MAPK and PDGFRbeta phosphorylation in a time- and concentration-dependent manner. Furthermore, treatment of VSMCs with the angiotensin II type I receptor (AT1R) inhibitor losartan suppressed p38 MAPK and p44/42 MAPK induction by uric acid. | Uric acid stimulates proliferative pathways in vascular smooth muscle cells through the activation of p38 MAPK, p44/42 MAPK and PDGFRβ.
Kırça M, Oğuz N, Çetin A, Uzuner F, Yeşilkaya A. | 05/20/2017 |
| These data suggest that miR182 may be a novel smooth muscle cell phenotypic marker and a modulator that may be used to prevent smooth muscle cell dedifferentiation via FGF9/PDGFRbeta signaling. | MicroRNA-182 prevents vascular smooth muscle cell dedifferentiation via FGF9/PDGFRβ signaling.
Dong N, Wang W, Tian J, Xie Z, Lv B, Dai J, Jiang R, Huang D, Fang S, Tian J, Li H, Yu B., Free PMC Article | 04/29/2017 |
| Data suggest that expression of microRNA-9 (Mir9) in cardiac fibroblasts is involved in regulation of expression of Pdgfr-beta (platelet-derived growth factor beta receptor) and in prevention of cardiac fibrosis; here, overexpression of Mir9 inhibits cardiac fibrosis in primary cardiac fibroblasts by targeting Pdgfr-beta. | MicroRNA-9 regulates cardiac fibrosis by targeting PDGFR-β in rats.
Wang L, Ma L, Fan H, Yang Z, Li L, Wang H. | 03/11/2017 |
| dihydroartemisinin protects the liver from injury and fibrogenesis via disruption of the PDGF-betaR/ERK pathway | Dihydroartemisinin alleviates bile duct ligation-induced liver fibrosis and hepatic stellate cell activation by interfering with the PDGF-βR/ERK signaling pathway.
Chen Q, Chen L, Kong D, Shao J, Wu L, Zheng S. | 12/31/2016 |
| IL-1beta-induced MMP-9 expression is mediated through a c-Src-mediated transactivation of PDGFR/PI3K/Akt cascade linking to p47(phox)/NADPH oxidase 2 (Nox2)/reactive oxygen species signaling pathway. | IL-1β Induces MMP-9-Dependent Brain Astrocytic Migration via Transactivation of PDGF Receptor/NADPH Oxidase 2-Derived Reactive Oxygen Species Signals.
Yang CM, Hsieh HL, Yu PH, Lin CC, Liu SW. | 05/7/2016 |
| The mRNA and protein expression levels of PDGFRbeta were upregulated in vascular smooth muscle cells after a 24- and 48-h incubation with Deoxycholic acid, respectively. | Deoxycholic acid is involved in the proliferation and migration of vascular smooth muscle cells.
Shimizu H, Hagio M, Iwaya H, Tsuneki I, Lee JY, Fukiya S, Yokota A, Miyazaki H, Hara H, Ishizuka S. | 03/26/2016 |
| miR-30c regulates PDGFRB expression by its direct binding the 3'UTR of PDGFRB mRNA. | MicroRNA-30c contributes to the development of hypoxia pulmonary hypertension by inhibiting platelet-derived growth factor receptor β expression.
Xing Y, Zheng X, Li G, Liao L, Cao W, Xing H, Shen T, Sun L, Yang B, Zhu D. | 03/12/2016 |
| expression altered in experimental Necrotizing enterocolitis | Alterations in platelet-derived growth factor expression in the pathophysiology of necrotizing enterocolitis.
Shepherd JA, Stamper E, Matheson PJ, Galganski L, Garrison RN, Madden K, Downard CD. | 12/5/2015 |
| Pro-inflammatory cytokines both initiate and maintain a growth response in colonic smooth muscle cells via PDGF-Rbeta. | Inflammatory cytokines promote growth of intestinal smooth muscle cells by induced expression of PDGF-Rβ.
Nair DG, Miller KG, Lourenssen SR, Blennerhassett MG., Free PMC Article | 04/4/2015 |
| These results suggest that gonocyte and F9 cell differentiation is regulated via cross talk between retinoic acid and PDGFRs using different downstream pathways. | Role of retinoic acid and platelet-derived growth factor receptor cross talk in the regulation of neonatal gonocyte and embryonal carcinoma cell differentiation.
Manku G, Wang Y, Merkbaoui V, Boisvert A, Ye X, Blonder J, Culty M., Free PMC Article | 03/21/2015 |
| PPARgamma inhibited angiogenic signal transduction through transrepression of PDGF-beta receptor leading to reduced hepatic stellate cell motility. | Peroxisome proliferator-activated receptor-γ interrupts angiogenic signal transduction by transrepression of platelet-derived growth factor-β receptor in hepatic stellate cells.
Zhang F, Kong D, Chen L, Zhang X, Lian N, Zhu X, Lu Y, Zheng S. | 10/18/2014 |
| During myocardial fibrosis of desoxycorticosterone induced salt-sensitive hypertensive rats, PDGFRalpha acts at early stage, but PDGFRbeta functions in the whole process | Role of PDGFs/PDGFRs signaling pathway in myocardial fibrosis of DOCA/salt hypertensive rats.
Fan B, Ma L, Li Q, Wang L, Zhou J, Wu J., Free PMC Article | 09/6/2014 |
| Data indicate that mechanical stretch induces MMP-2 production in vascular smooth muscle cells (VSMC) via activation of Akt pathway, that is mediated by activation of PDGFR-beta signaling pathways. | Mechanical stretch increases MMP-2 production in vascular smooth muscle cells via activation of PDGFR-β/Akt signaling pathway.
Seo KW, Lee SJ, Kim YH, Bae JU, Park SY, Bae SS, Kim CD., Free PMC Article | 08/23/2014 |