| IL-27/Blimp-1 axis regulates the differentiation and function of Tim-3+ Tregs during early pregnancy. | IL-27/Blimp-1 axis regulates the differentiation and function of Tim-3+ Tregs during early pregnancy.
Zhao SJ, Hu XH, Lin XX, Zhang YJ, Wang J, Wang H, Gong GS, Mor G, Liao AH., Free PMC Article | 10/28/2024 |
| Interleukin-27 signaling resists obesity by promoting the accumulation of Treg cells in visceral adipose tissue. | Interleukin-27 signaling resists obesity by promoting the accumulation of Treg cells in visceral adipose tissue.
Jiang T, Zou A, Song W, Zheng J, Lai L, Wang Q, Cui B. | 10/16/2024 |
| IL-27 Alleviates Airway Inflammation and Airway Hyperresponsiveness in Asthmatic Mice by Targeting the CD39/ATP Axis of Dendritic Cells. | IL-27 Alleviates Airway Inflammation and Airway Hyperresponsiveness in Asthmatic Mice by Targeting the CD39/ATP Axis of Dendritic Cells.
Chen Y, Zhu M, Hu J, He S, Li S, Liu B, Yang J., Free PMC Article | 05/9/2024 |
| Endogenous IL-27 during toxoplasmosis limits early monocyte responses and their inflammatory activation by pathological T cells. | Endogenous IL-27 during toxoplasmosis limits early monocyte responses and their inflammatory activation by pathological T cells.
Aldridge DL, Moodley D, Park J, Phan AT, Rausch M, White KF, Ren Y, Golin K, Radaelli E, Kedl R, Holland PM, Hill J, Hunter CA., Free PMC Article | 03/15/2024 |
| IL-27 alters inflammatory cytokine expression and limits protective immunity against Mycobacterium tuberculosis in a neonatal BCG vaccination model. | IL-27 alters inflammatory cytokine expression and limits protective immunity against Mycobacterium tuberculosis in a neonatal BCG vaccination model.
Bradford SD, Ryan KJ, Divens AM, Povroznik JM, Bonigala S, Robinson CM., Free PMC Article | 02/28/2024 |
| Deletion of IL-27p28 induces CD8 T cell immunity against colorectal tumorigenesis. | Deletion of IL-27p28 induces CD8 T cell immunity against colorectal tumorigenesis.
Li P, Pu S, Yi J, Li X, Wu Q, Yang C, Kang M, Peng F, Zhou Z. | 02/13/2024 |
| IL-27p28 specifically regulates MHC II expression in macrophages through CIITA. | IL-27p28 specifically regulates MHC II expression in macrophages through CIITA.
Han Y, Zhang X, Wang Q, Cui X, Wang H, Zhang X, Wang Q, Ji J, Wang Y, Wang S, Zhang X, Xu H, Qiao M, Wu Z. | 01/10/2024 |
| IL-27 produced during acute malaria infection regulates Plasmodium-specific memory CD4[+] T cells. | IL-27 produced during acute malaria infection regulates Plasmodium-specific memory CD4(+) T cells.
Macalinao ML, Inoue SI, Tsogtsaikhan S, Matsumoto H, Bayarsaikhan G, Jian JY, Kimura K, Yasumizu Y, Inoue T, Yoshida H, Hafalla J, Kimura D, Yui K., Free PMC Article | 12/18/2023 |
| Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of TH17 cell immunity. | Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of T(H)17 cell immunity.
Lin CH, Wu CJ, Cho S, Patkar R, Huth WJ, Lin LL, Chen MC, Israelsson E, Betts J, Niedzielska M, Patel SA, Duong HG, Gerner RR, Hsu CY, Catley M, Maciewicz RA, Chu H, Raffatellu M, Chang JT, Lu LF., Free PMC Article | 11/30/2023 |
| IL-27 regulates NLRP3 inflammasome activation of MDSCs in experimental Sjogren's syndrome. | IL-27 regulates NLRP3 inflammasome activation of MDSCs in experimental Sjögren's syndrome.
Xia X, Long Q, Zha J, Jiang T, Guo J, Jiang B, Li X, Yao G. | 11/16/2023 |
| IL-27 increases energy storage in white adipocytes by enhancing glucose uptake and fatty acid esterification. | IL-27 increases energy storage in white adipocytes by enhancing glucose uptake and fatty acid esterification.
Scaffidi C, Srdic A, Konrad D, Wueest S., Free PMC Article | 11/15/2023 |
| Interleukin-27 potentiates CD8+ T-cell-mediated antitumor immunity in chronic lymphocytic leukemia. | Interleukin-27 potentiates CD8+ T-cell-mediated antitumor immunity in chronic lymphocytic leukemia.
Pagano G, Botana IF, Wierz M, Roessner PM, Ioannou N, Zhou X, Al-Hity G, Borne C, Gargiulo E, Gonder S, Qu B, Stamatopoulos B, Ramsay AG, Seiffert M, Largeot A, Moussay E, Paggetti J., Free PMC Article | 11/7/2023 |
| IL-27p28 knockout aggravates Doxorubicin-induced cardiotoxicity by regulating Macrophage polarization. | IL-27p28 knockout aggravates Doxorubicin-induced cardiotoxicity by regulating Macrophage polarization.
Feng Y, Ji Q, Ye D, Pan H, Lu X, Gan L, Wang M, Liu J, Xu Y, Zhang J, Zhao M, Xu S, Yin Z, Pan W, Wei C, Liu M, Wan J, Ye J. | 10/26/2023 |
| Externalized histones fuel pulmonary fibrosis via a platelet-macrophage circuit of TGFbeta1 and IL-27. | Externalized histones fuel pulmonary fibrosis via a platelet-macrophage circuit of TGFβ1 and IL-27.
Riehl DR, Sharma A, Roewe J, Murke F, Ruppert C, Eming SA, Bopp T, Kleinert H, Radsak MP, Colucci G, Subramaniam S, Reinhardt C, Giebel B, Prinz I, Guenther A, Strand D, Gunzer M, Waisman A, Ward PA, Ruf W, Schäfer K, Bosmann M., Free PMC Article | 09/29/2023 |
| IL-27 induces an IFN-like signature in murine macrophages which in turn modulate colonic epithelium. | IL-27 induces an IFN-like signature in murine macrophages which in turn modulate colonic epithelium.
Andrews C, McLean MH, Hixon JA, Pontejo SM, Starr T, Malo C, Cam M, Ridnour L, Hickman H, Steele-Mortimer O, Wink DA, Young HA, McVicar DW, Li W, Durum SK., Free PMC Article | 05/12/2023 |
| Interleukin-27-dependent transcriptome signatures during neonatal sepsis. | Interleukin-27-dependent transcriptome signatures during neonatal sepsis.
Povroznik JM, Akhter H, Vance JK, Annamanedi M, Dziadowicz SA, Wang L, Divens AM, Hu G, Robinson CM., Free PMC Article | 03/27/2023 |
| Inactivation of interleukin-30 in colon cancer stem cells via CRISPR/Cas9 genome editing inhibits their oncogenicity and improves host survival. | Inactivation of interleukin-30 in colon cancer stem cells via CRISPR/Cas9 genome editing inhibits their oncogenicity and improves host survival.
D'Antonio L, Fieni C, Ciummo SL, Vespa S, Lotti L, Sorrentino C, Di Carlo E., Free PMC Article | 03/20/2023 |
| IL-27 induces autophagy through regulation of the DNMT1/lncRNA MEG3/ERK/p38 axis to reduce pulmonary fibrosis. | IL-27 induces autophagy through regulation of the DNMT1/lncRNA MEG3/ERK/p38 axis to reduce pulmonary fibrosis.
Ting L, Feng Y, Zhou Y, Tong Z, Dong Z., Free PMC Article | 03/8/2023 |
| IL-27 deficiency inhibits proliferation and invasion of trophoblasts via the SFRP2/Wnt/beta-catenin pathway in fetal growth restriction. | IL-27 deficiency inhibits proliferation and invasion of trophoblasts via the SFRP2/Wnt/β-catenin pathway in fetal growth restriction.
Zhang XY, Qin XY, Shen HH, Liu KT, Wang CJ, Peng T, Wu JN, Zhao SM, Li MQ., Free PMC Article | 03/3/2023 |
| Cell type specific IL-27p28 (IL-30) deletion in mice uncovers an unexpected regulatory function of IL-30 in autoimmune inflammation. | Cell type specific IL-27p28 (IL-30) deletion in mice uncovers an unexpected regulatory function of IL-30 in autoimmune inflammation.
Kim D, Kim S, Kang MS, Yin Z, Min B., Free PMC Article | 02/11/2023 |
| cDC1-derived IL-27 regulates small intestinal CD4+ T cell homeostasis in mice. | cDC1-derived IL-27 regulates small intestinal CD4+ T cell homeostasis in mice.
Ahmadi F, Junghus F, Ashworth C, Lappalainen A, Mörbe U, Kotarsky K, Agace WW., Free PMC Article | 12/24/2022 |
| Interleukin-27 Ameliorates Atherosclerosis in ApoE[-/-] Mice through Regulatory T Cell Augmentation and Dendritic Cell Tolerance. | Interleukin-27 Ameliorates Atherosclerosis in ApoE(-/-) Mice through Regulatory T Cell Augmentation and Dendritic Cell Tolerance.
Xu W, Zhu R, Zhu Z, Yu K, Wang Y, Ding Y, Yu J, Tang H, Zeng Q, Zhong Y., Free PMC Article | 12/3/2022 |
| IL-27 overexpression alleviates inflammatory response in allergic asthma by inhibiting Th9 differentiation and regulating Th1/Th2 balance. | IL-27 overexpression alleviates inflammatory response in allergic asthma by inhibiting Th9 differentiation and regulating Th1/Th2 balance.
Xiong P, Liu T, Huang H, Yuan Y, Zhang W, Fu L, Chen Y. | 10/8/2022 |
| Dendritic cell-derived IL-27 p28 regulates T cell program in pathogenicity and alleviates acute graft-versus-host disease. | Dendritic cell-derived IL-27 p28 regulates T cell program in pathogenicity and alleviates acute graft-versus-host disease.
Gong H, Ma S, Chen J, Yang B, Liu S, Liu X, Han J, Wu X, Lei L, Yin Z, Sun H, Yu D, Liu H, Xu Y, Wu D., Free PMC Article | 10/1/2022 |
| IL-27 Promotes Intestinal Barrier Integrity following Ethanol Intoxication and Burn Injury. | IL-27 Promotes Intestinal Barrier Integrity following Ethanol Intoxication and Burn Injury.
Luck ME, Li X, Herrnreiter CJ, Cannon AR, Choudhry MA. | 08/27/2022 |