| Differential expression of RET and GDNF family receptor, GFR-alpha1, between striatum and substantia nigra following nigrostriatal lesion: A case for diminished GDNF-signaling. | Differential expression of RET and GDNF family receptor, GFR-α1, between striatum and substantia nigra following nigrostriatal lesion: A case for diminished GDNF-signaling.
Kasanga EA, Han Y, Navarrete W, McManus R, Shifflet MK, Parry C, Barahona A, Manfredsson FP, Nejtek VA, Richardson JR, Salvatore MF. | 06/13/2023 |
| GDNF requires HIF-1alpha and RET activation for suppression of programmed cell death of enteric neurons by metabolic challenge. | GDNF requires HIF-1α and RET activation for suppression of programmed cell death of enteric neurons by metabolic challenge.
Kearon JE, Kocherry SC, Zoumboulakis D, Rivera D, Lourenssen SR, Blennerhassett MG. | 01/22/2022 |
| The findings demonstrate that elevated GDNF levels can reduce the retinal injury, whereby down-regulated miR-216a aggravates the YAG laser-induced retinal injury by targeting the GDNF level through the GDNF/GFRa1/RET signaling pathway. | Down-regulation of microRNA-216a confers protection against yttrium aluminium garnet laser-induced retinal injury via the GDNF-mediated GDNF/GFRα1/RET signalling pathway.
Hu XB, Fu SH, Luo QI, He JZ, Qiu YF, Lai W, Zhong M. | 02/2/2019 |
| the inverse relationship between GFRalpha1 and C-Ret, as knocking down C-Ret led to increases in GFRalpha1 expression. | Vitamin D regulation of GDNF/Ret signaling in dopaminergic neurons.
Pertile RAN, Cui X, Hammond L, Eyles DW. | 10/27/2018 |
| activation of the MAPK and PI3K-AKT pathways primarily regulated Ser-727 phosphorylation, whereas a physical interaction between RET/PTC3 and STAT1, followed by a direct tyrosine phosphorylation event, was necessary for STAT1 Tyr-701 phosphorylation. These data provide the first evidence of a direct link between IDO1 expression and the oncogenic activation of RET in thyroid carcinoma | Signal Transducer and Activator of Transcription 1 Plays a Pivotal Role in RET/PTC3 Oncogene-induced Expression of Indoleamine 2,3-Dioxygenase 1.
Moretti S, Menicali E, Nucci N, Voce P, Colella R, Melillo RM, Liotti F, Morelli S, Fallarino F, Macchiarulo A, Santoro M, Avenia N, Puxeddu E., Free PMC Article | 06/3/2017 |
| These data provide the first evidence for a physiologic role of these isoforms in RET pathway function. | Exon Skipping in the RET Gene Encodes Novel Isoforms That Differentially Regulate RET Protein Signal Transduction.
Gabreski NA, Vaghasia JK, Novakova SS, McDonald NQ, Pierchala BA., Free PMC Article | 05/13/2017 |
| STAT3 phosphorylation by neurturin was found to be mediated specifically by GFRalpha2c and RET9 isoforms. | GDNF family ligand dependent STAT3 activation is mediated by specific alternatively spliced isoforms of GFRα2 and RET.
Zhou L, Too HP. | 03/1/2014 |
| Ret receptor is one of the IB4-reactive glycoconjugate accounting for the IB4 stain in microglia under physiological and ischemic conditions. | The isolectin IB4 binds RET receptor tyrosine kinase in microglia.
Boscia F, Esposito CL, Casamassa A, de Franciscis V, Annunziato L, Cerchia L. | 10/26/2013 |
| Identification of a key motif that determines the differential surface levels of RET and TrkB tyrosine kinase receptors and controls depolarization enhanced RET surface insertion. | Identification of a key motif that determines the differential surface levels of RET and TrkB tyrosine kinase receptors and controls depolarization enhanced RET surface insertion.
Li XZ, Yan J, Huang SH, Zhao L, Wang J, Chen ZY., Free PMC Article | 03/10/2012 |
| Tyr981 in the intracellular domain of RET was crucial for the interaction with Rap1GAP. | Rap1GAP interacts with RET and suppresses GDNF-induced neurite outgrowth.
Jiao L, Zhang Y, Hu C, Wang YG, Huang A, He C., Free PMC Article | 05/21/2011 |
| Single nucleotide polymorphisms may function as modifiers of the RET proto-oncogene, resulting in the expression of medullary thyroid carcinoma and papillary thyroid carcinoma. | Single nucleotide polymorphisms act as modifiers and correlate with the development of medullary and simultaneous medullary/papillary thyroid carcinomas in 2 large, non-related families with the RET V804M proto-oncogene mutation.
Shifrin AL, Ogilvie JB, Stang MT, Fay AM, Kuo YH, Matulewicz T, Xenachis CZ, Vernick JJ. | 01/15/2011 |
| Protein-tyrosine phosphatase SHP2 contributes to GDNF neurotrophic activity through direct binding to phospho-Tyr687 in the RET receptor tyrosine kinase. | Protein-tyrosine phosphatase SHP2 contributes to GDNF neurotrophic activity through direct binding to phospho-Tyr687 in the RET receptor tyrosine kinase.
Perrinjaquet M, Vilar M, Ibáñez CF., Free PMC Article | 11/6/2010 |
| Expression of RET in adult rat substantia nigra is regulated by Nurr1 and implies that RET is a transcriptional target of this nuclear receptor. | Nurr1 regulates RET expression in dopamine neurons of adult rat midbrain.
Galleguillos D, Fuentealba JA, Gómez LM, Saver M, Gómez A, Nash K, Burger C, Gysling K, Andrés ME. | 10/23/2010 |
| local degradation of Ret in axons dictates whether GDNF family ligands act as retrograde survival factors | The differential axonal degradation of Ret accounts for cell-type-specific function of glial cell line-derived neurotrophic factor as a retrograde survival factor.
Tsui CC, Pierchala BA., Free PMC Article | 05/31/2010 |
| RET was upregulated in cultures of normal rat chromaffin cells and PC12 rat pheochromocytoma cells. | RET expression and neuron-like differentiation of pheochromocytoma and normal chromaffin cells.
Powers JF, Picard KL, Tischler AS. | 01/21/2010 |
| Ret may promote maturation of DA neurons by up-regulating DAT expression through its ligand | Role of Nurr1 and Ret in inducing rat embryonic neural precursors to dopaminergic neurons.
Li L, Su Y, Zhao C, Xu Q. | 01/21/2010 |
| In the rat, GFRalpha3- and RET-like staining were found in the same non-neural cell type only in kidney. | Distribution of GDNF family receptor alpha3 and RET in rat and human non-neural tissues.
Yang C, Hutto D, Sah DW. | 01/21/2010 |
| analysis of how GDNF.GFR alpha 1 can mediate cell adhesion and how heparin might inhibit GDNF signaling through RET | The structure of the glial cell line-derived neurotrophic factor-coreceptor complex: insights into RET signaling and heparin binding.
Parkash V, Leppänen VM, Virtanen H, Jurvansuu JM, Bespalov MM, Sidorova YA, Runeberg-Roos P, Saarma M, Goldman A., Free PMC Article | 01/21/2010 |
| GDNF-RET interaction plays important roles in physiological processes of nigrostriatal neuronal circuits of mammals | Nigrostriatal projecting neurons express GDNF receptor subunit RET in adult rats.
He SM, Zhao ZW, Zhao L, Wang XL, Jia D, Hou F, Gao GD. | 01/21/2010 |
| The dependence receptor Ret induces apoptosis in somatotrophs through a Pit-1/p53 pathway, preventing tumor growth. | The dependence receptor Ret induces apoptosis in somatotrophs through a Pit-1/p53 pathway, preventing tumor growth.
Cañibano C, Rodriguez NL, Saez C, Tovar S, Garcia-Lavandeira M, Borrello MG, Vidal A, Costantini F, Japon M, Dieguez C, Alvarez CV., Free PMC Article | 01/21/2010 |
| c-Ret mRNA expression levels show a significant decrease at 4 h post unilateral labyrinthectomy (UL) followed by another significant decrease 1 week post UL. | Unilateral labyrinthectomy induced changes on GDNF receptor complex proteins in the rat medial vestibular nuclei.
Lozada A, Karlstedt K, Panula P, Aarnisalo AA. | 01/21/2010 |
| Expression and regulation patterns of RET in the spinal cord are in line with its involvement in regenerative processes following nerve injury. The presence of RET in dorsal horn neurons suggests it also has a role in signal transduction. | Distribution of RET immunoreactivity in the rodent spinal cord and changes after nerve injury.
Jongen JL, Jaarsma D, Hossaini M, Natarajan D, Haasdijk ED, Holstege JC. | 01/21/2010 |
| Morphological evidence showed that SH2-Bbeta and RET colocalized in mesencephalic neurons. Morphological evidence showed that SH2-Bbeta and RET colocalized in mesencephalic neurons. | Interaction of SH2-Bbeta with RET is involved in signaling of GDNF-induced neurite outgrowth.
Zhang Y, Zhu W, Wang YG, Liu XJ, Jiao L, Liu X, Zhang ZH, Lu CL, He C. | 01/21/2010 |
| necessary for neural crest stem cell migration in the gut | Hirschsprung disease is linked to defects in neural crest stem cell function.
Iwashita T, Kruger GM, Pardal R, Kiel MJ, Morrison SJ., Free PMC Article | 01/21/2010 |
| GDNF and ret form a novel ligand-receptor complex critical for survival response during podocyte injury | Glial cell line-derived neurotrophic factor and its receptor ret is a novel ligand-receptor complex critical for survival response during podocyte injury.
Tsui CC, Shankland SJ, Pierchala BA. | 01/21/2010 |