| Pharmacological Inhibition of the VCP/Proteasome Axis Rescues Photoreceptor Degeneration in RHO(P23H) Rat Retinal Explants. | Pharmacological Inhibition of the VCP/Proteasome Axis Rescues Photoreceptor Degeneration in RHO(P23H) Rat Retinal Explants.
Sen M, Kutsyr O, Cao B, Bolz S, Arango-Gonzalez B, Ueffing M., Free PMC Article | 01/22/2022 |
| these results suggest that retinoid metabolism in the eye is impaired in type 1 diabetes, which leads to deficient generation of visual pigments and neural retinal dysfunction in early diabetes. | Impaired Rhodopsin Generation in the Rat Model of Diabetic Retinopathy.
Malechka VV, Moiseyev G, Takahashi Y, Shin Y, Ma JX., Free PMC Article | 10/7/2017 |
| EGF induces Ca(2+) sensitization in vascular smooth muscle by Rho-kinase-dependent inactivation of MLCP mediated by the EGF receptor/MEK/Erk1/2 pathway | Epidermal growth factor induces Ca(2+) sensitization through Rho-kinase-dependent phosphorylation of myosin phosphatase target subunit 1 in vascular smooth muscle.
Sasahara T, Okamoto H, Ohkura N, Kobe A, Yayama K. | 05/21/2016 |
| Allele-specific ASO-mediated knockdown of mutant P23H rhodopsin expression slowed the rate of photoreceptor degeneration and preserved the function of photoreceptor cells in eyes of the P23H rhodopsin transgenic rat. | Allele-Specific Inhibition of Rhodopsin With an Antisense Oligonucleotide Slows Photoreceptor Cell Degeneration.
Murray SF, Jazayeri A, Matthes MT, Yasumura D, Yang H, Peralta R, Watt A, Freier S, Hung G, Adamson PS, Guo S, Monia BP, LaVail MM, McCaleb ML., Free PMC Article | 01/16/2016 |
| Phosphorylation of the Rho/ROCK signaling target cofilin. | Adiponectin stimulates Rho-mediated actin cytoskeleton remodeling and glucose uptake via APPL1 in primary cardiomyocytes.
Palanivel R, Ganguly R, Turdi S, Xu A, Sweeney G. | 11/22/2014 |
| During development, some rhodopsin-expressing cells are displaced to the inner retinal layers. | Immunocytochemical analysis of misplaced rhodopsin-positive cells in the developing rodent retina.
Szabó K, Szabó A, Enzsöly A, Szél A, Lukáts A. | 11/22/2014 |
| We examine and compare the contribution of endoplasmic reticulum stress to retinal degeneration in several vertebrate models of retinitis pigementosa generated through expression of mutant rhodopsins. | Endoplasmic reticulum stress in vertebrate mutant rhodopsin models of retinal degeneration.
Kroeger H, LaVail MM, Lin JH., Free PMC Article | 07/26/2014 |
| Rho kinase is involved in endothelial dysfunction in type 1 diabetes. | Targeting of Rho kinase ameliorates impairment of diabetic endothelial function in intrarenal artery.
Yin H, Ru H, Yu L, Kang Y, Lin G, Liu C, Sun L, Shi L, Sun Q, Liu C., Free PMC Article | 04/26/2014 |
| The aim of this study was to examine the onset of Unfolded Protein Response (UPR) gene expression in S334ter Rho retinas to determine if UPR is activated in autosomal dominant retinitis pigmentosa animal models. | ER stress in retinal degeneration in S334ter Rho rats.
Shinde VM, Sizova OS, Lin JH, LaVail MM, Gorbatyuk MS., Free PMC Article | 07/14/2012 |
| Strong activation of calpain and poly(ADP-ribose) polymerase (PARP) was found in rhodopsin mutants. | Calpain and PARP activation during photoreceptor cell death in P23H and S334ter rhodopsin mutant rats.
Kaur J, Mencl S, Sahaboglu A, Farinelli P, van Veen T, Zrenner E, Ekström P, Paquet-Durand F, Arango-Gonzalez B., Free PMC Article | 11/12/2011 |
| Experiments with dissociated hippocampal cells show that the main factor limiting the spatial resolution is Rhodopsin current density rather than scattering of the excitation light. | Optimizing the spatial resolution of Channelrhodopsin-2 activation.
Schoenenberger P, Grunditz A, Rose T, Oertner TG. | 01/21/2010 |
| iNOS is involved in the increased expression of RhoA in diabetic hearts and that one of the mechanisms by which iNOS inhibition improves cardiac function is by preventing the upregulation of RhoA and its availability for activation. | Role of inducible nitric oxide synthase in induction of RhoA expression in hearts from diabetic rats.
Soliman H, Craig GP, Nagareddy P, Yuen VG, Lin G, Kumar U, McNeill JH, Macleod KM. | 01/21/2010 |
| rats homozygous for P23H rhodopsin mutations have severe loss of rod function already seen by postnatal day 21 | Enhanced cone dysfunction in rats homozygous for the P23H rhodopsin mutation.
Pinilla I, Lund RD, Sauvé Y. | 01/21/2010 |
| Phosphorylation of rhodopsin during dark adaptation in an animal model of retinitis pigmentosa. | Prolonged survival of the phosphorylated form of rhodopsin during dark adaptation of Royal College Surgeons rat.
Ohguro H, Ohguro I, Mamiya K, Maeda T, Nakazawa M. | 01/21/2010 |
| Insulin receptor phosphorylation in rod photoreceptors is signaled through the G-protein-coupled receptor rhodopsin. | G-protein-coupled receptor rhodopsin regulates the phosphorylation of retinal insulin receptor.
Rajala A, Anderson RE, Ma JX, Lem J, Al-Ubaidi MR, Rajala RVS. | 01/21/2010 |
| Rho and Rho kinase are an important component of PTH signaling in osteoblastic cells | Rho and Rho kinase are involved in parathyroid hormone-stimulated protein kinase C alpha translocation and IL-6 promoter activity in osteoblastic cells.
Radeff JM, Nagy Z, Stern PH. | 01/21/2010 |