| mOrange2, a Genetically Encoded, pH Sensitive Fluorescent Protein, is an Alternative to BCECF-AM to Measure Intracellular pH to Determine NHE3 and DRA Activity. | mOrange2, a Genetically Encoded, pH Sensitive Fluorescent Protein, is an Alternative to BCECF-AM to Measure Intracellular pH to Determine NHE3 and DRA Activity.
Sarker R, Tse CM, Lin R, McNamara G, Singh V, Donowitz M., Free PMC Article | 02/12/2022 |
| Computational model of the renal circadian clock predicting effect of circadian clock modulation of NHE3 on proximal tubule cell on sodium transport. | Predicted effect of circadian clock modulation of NHE3 of a proximal tubule cell on sodium transport.
Wei N, Gumz ML, Layton AT., Free PMC Article | 07/13/2019 |
| In spontaneously hypertensive rats, a high plasma level of ANG-(1-7) inhibited NHE3 in the proximal tubule, which mitigated the hypertension caused by the high plasma level of ANG II. | The effects of angiotensin-(1-7) on the exchanger NHE3 and on [Ca(2+)](i) in the proximal tubules of spontaneously hypertensive rats.
Castelo-Branco RC, Leite-Dellova DCA, Fernandes FB, Malnic G, de Mello-Aires M. | 09/23/2017 |
| Results show that renal afferents leads to activation of catecholaminergic and non-catecholaminergic neurons in the medulla oblongata. When renorenal reflex is induced, NHE3 exchanger activity appears to be decreased, resulting in decreased sodium and water reabsorption in the contralateral kidney. | Stimulation of renal afferent fibers leads to activation of catecholaminergic and non-catecholaminergic neurons in the medulla oblongata.
Nishi EE, Martins BS, Milanez MI, Lopes NR, de Melo JF Jr, Pontes RB, Girardi AC, Campos RR, Bergamaschi CT. | 08/26/2017 |
| Reduction of intestinal sodium absorption by selective NHE3 inhibition in the gut lowered high blood pressure and reduced LV remodeling without deteriorating renal functional and structural parameters in obese spontaneously hypertensive rats. | Inhibition of NHE3-mediated Sodium Absorption in the Gut Reduced Cardiac End-organ Damage Without Deteriorating Renal Function in Obese Spontaneously Hypertensive Rats.
Linz B, Hohl M, Reil JC, Böhm M, Linz D. | 12/17/2016 |
| Increased pendrin in pregnant rats may compensate for the decreased NCC and aid in the renal sodium chloride reabsorption of pregnancy. | The chloride-bicarbonate exchanger pendrin is increased in the kidney of the pregnant rat.
West CA, Verlander JW, Wall SM, Baylis C., Free PMC Article | 08/6/2016 |
| a potential link between NHE3 and Na(+) /K(+) -ATPase in the pathophysiological changes in renal protein handling observed in obesity | Diet induced obesity in rats reduces NHE3 and Na(+) /K(+) -ATPase expression in the kidney.
Briffa JF, Grinfeld E, Jenkin KA, Mathai ML, Poronnik P, McAinch AJ, Hryciw DH. | 06/28/2016 |
| These findings indicate that biased signaling of the beta-arrestin pathway through the AT1 receptor inhibits NHE3 activity in the proximal tubule at least in part due to changes in NHE3 subcellular localization. | Proximal tubule NHE3 activity is inhibited by beta-arrestin-biased angiotensin II type 1 receptor signaling.
Carneiro de Morais CP, Polidoro JZ, Ralph DL, Pessoa TD, Oliveira-Souza M, Barauna VG, Rebouças NA, Malnic G, McDonough AA, Girardi AC., Free PMC Article | 01/30/2016 |
| In hypertensive rats, the plasma and tissue renin angiotensin systems are activated, increased Ang II stimulates the expression of NHE3 and SGK1. | Novel mechanism of intra‑renal angiotensin II-induced sodium/proton exchanger 3 expression by losartan in spontaneously hypertensive rats.
Fan X, Liu K, Cui W, Huang J, Wang W, Gao Y. | 06/20/2015 |
| NHE3-mediated proximal tubular sodium reabsorption induced by renal nerve stimulation occurs via intrarenal renin angiotensin system activation and triggering of the AT1 receptor/inhibitory G-protein signaling pathway. | Renal nerve stimulation leads to the activation of the Na+/H+ exchanger isoform 3 via angiotensin II type I receptor.
Pontes RB, Crajoinas RO, Nishi EE, Oliveira-Sales EB, Girardi AC, Campos RR, Bergamaschi CT. | 06/20/2015 |
| local changes in pH reduce NHE3 activity, which may explain the pressure natriuresis response to NHE3 redistribution | Local pH domains regulate NHE3-mediated Na⁺ reabsorption in the renal proximal tubule.
Brasen JC, Burford JL, McDonough AA, Holstein-Rathlou NH, Peti-Peterdi J., Free PMC Article | 01/24/2015 |
| these results support the idea that the lower NHE3 transport activity and higher phosphorylation occurring after the development of hypertension are due, at least in part, to reduced PP1-mediated dephosphorylation of NHE3 at serine 552. | Changes in the activity and expression of protein phosphatase-1 accompany the differential regulation of NHE3 before and after the onset of hypertension in spontaneously hypertensive rats.
Crajoinas RO, Pessoa TD, Rodrigues MV, Malnic G, Girardi AC. | 01/10/2015 |
| Immunofluorescence experiments showed that NHE3 colocalizes with SGLT2 but not SGLT1 in the renal proximal tubule. Glucose exerts a bimodal effect on NHE3. | Functional role of glucose metabolism, osmotic stress, and sodium-glucose cotransporter isoform-mediated transport on Na+/H+ exchanger isoform 3 activity in the renal proximal tubule.
Pessoa TD, Campos LC, Carraro-Lacroix L, Girardi AC, Malnic G., Free PMC Article | 11/22/2014 |
| noradrenaline released from renal sympathetic nerve endings activates alpha1-adrenoceptors expressed on proximal tubular epithelial cells, increasing the abundance of NHE3 in the apical brush border membranes to enhance sodium and water reabsorption. | The adrenergic regulation of proximal tubular Na⁺/H⁺ exchanger 3 in the rat.
Healy V, Thompson C, Johns EJ. | 10/25/2014 |
| results indicate that central NHE3 might be a molecular target for sleep apnea treatment, whose inhibitors may be potential therapeutic drugs for sleep apnea. | Inhibition of central Na(+)/H(+) exchanger type 3 can alleviate sleep apnea in Sprague-Dawley rats.
Wang Q, Zhou R, Zhang C, Dong H, Ma J, Wang G. | 06/28/2014 |
| There was a significant decrease in the levels of NHE-3 and NHERF-1 proteins, and sodium pump activity, but an increase in the cyclic GMP kinase II levels in spontaneously hypertensive rats. | A role of intestine in hypertension: mechanism of suppression of intestinal Na-H exchanger isoform-3 in spontaneously hypertensive rats.
Abu-Ghefreh A, Khan I. | 06/7/2014 |
| NHERF2 domain was functionally significant in NHE3 regulation, being necessary for stimulation by lysophosphatidic acid of activity and increased mobility of NHE3 | NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells.
Yang J, Singh V, Cha B, Chen TE, Sarker R, Murtazina R, Jin S, Zachos NC, Patterson GH, Tse CM, Kovbasnjuk O, Li X, Donowitz M., Free PMC Article | 08/31/2013 |
| transferable factor(s) mediate the ischemia-reperfusion injury-induced decrease in NHE3 of the kidney. | The reduction of Na/H exchanger-3 protein and transcript expression in acute ischemia-reperfusion injury is mediated by extractable tissue factor(s).
Di Sole F, Hu MC, Zhang J, Babich V, Bobulescu IA, Shi M, McLeroy P, Rogers TE, Moe OW., Free PMC Article | 02/4/2012 |
| Report NHE3 up-regulation in the solitary kidney in response to partial ureteral obstruction in neonatal rats. | Regulation of aquaporins and sodium transporter proteins in the solitary kidney in response to partial ureteral obstruction in neonatal rats.
Topcu SO, Nørregaard R, Pedersen M, Wang G, Jørgensen TM, Frøkiær J. | 12/17/2011 |
| The regulatory interaction whereby NHE1 enhances the activity of NHE3 in the medullary thick ascending limb plays a role in the chronic regulation of HCO(3)(-) absorption. | High sodium intake increases HCO(3)- absorption in medullary thick ascending limb through adaptations in basolateral and apical Na+/H+ exchangers.
Good DW, George T, Watts BA 3rd., Free PMC Article | 10/8/2011 |
| ANG II stimulates NHE3 via AT1R-PLC-CaM pathway and inhibits NHE3 by AT1R-PKG activation. | Angiotensin II-mediated biphasic regulation of proximal tubular Na+/H+ exchanger 3 is impaired during oxidative stress.
Banday AA, Lokhandwala MF. | 10/8/2011 |
| Inhibition of NHE3 expression regulates the expression and function of SGLT1 in the brush border membrane of intestinal epithelial cells. | Reciprocal regulation of the primary sodium absorptive pathways in rat intestinal epithelial cells.
Coon S, Kekuda R, Saha P, Sundaram U., Free PMC Article | 04/23/2011 |
| sgk2 may play a previously unrecognized role in the control of transtubular Na(+) transport through NHE3 in the proximal tubule. | Expression and role of serum and glucocorticoid-regulated kinase 2 in the regulation of Na+/H+ exchanger 3 in the mammalian kidney.
Pao AC, Bhargava A, Di Sole F, Quigley R, Shao X, Wang J, Thomas S, Zhang J, Shi M, Funder JW, Moe OW, Pearce D., Free PMC Article | 01/15/2011 |
| IRBIT is critically involved in mediating activation of NHE3 by ANG II via a Ca(2+)/calmodulin-dependent protein kinases II-dependent pathway. | Activation of Na+/H+ exchanger NHE3 by angiotensin II is mediated by inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3 (IRBIT) and Ca2+/calmodulin-dependent protein kinase II.
He P, Klein J, Yun CC., Free PMC Article | 10/23/2010 |
| Data demonstrate that a calyculin A-sensitive phosphatase, most likely PP1, is involved in the regulation and dephosphorylation of NHE3 at known and novel sites. | NHE3 function and phosphorylation are regulated by a calyculin A-sensitive phosphatase.
Dynia DW, Steinmetz AG, Kocinsky HS., Free PMC Article | 03/22/2010 |