| Eukaryotic translation initiation factor 6-mediated ribosome biogenesis promotes synovial aggression and inflammation by increasing the translation of SP1 in rheumatoid arthritis. | Eukaryotic translation initiation factor 6-mediated ribosome biogenesis promotes synovial aggression and inflammation by increasing the translation of SP1 in rheumatoid arthritis.
Shen C, Peng C, Zhang S, Li R, Liu S, Kuang Y, Su F, Liu Y, Liang L, Xiao Y, Xu H. | 10/22/2024 |
| MicroRNA-124-3p targets Sp1 transcription factor to regulate glioma progression in rats. | MicroRNA-124-3p targets Sp1 transcription factor to regulate glioma progression in rats.
Vaghf A, Sadegh M, Khansarinejad B, Mondanizadeh M. | 09/12/2024 |
| Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification. | Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification.
Li Y, Cheng M, Jin J, Zhang D, Zhang S, Bai Y, Xu J., Free PMC Article | 02/23/2024 |
| SP1-stimulated miR-208a-5p aggravates sepsis-induced myocardial injury via targeting XIAP. | SP1-stimulated miR-208a-5p aggravates sepsis-induced myocardial injury via targeting XIAP.
Xu LJ, Yang Y, Yuan LF, Liu H, Xu NP, Yang Y, Huang L. | 02/2/2024 |
| Sp1 mediated the inhibitory effect of glutamate on pulmonary surfactant synthesis. | Sp1 mediated the inhibitory effect of glutamate on pulmonary surfactant synthesis.
Li XH, Fu JJ, Shi XJ, Zhang YN, Shao M, Yue SJ, Li C, Luo ZQ., Free PMC Article | 08/11/2023 |
| Regulation of peroxiredoxin-3 gene expression under basal and hyperglycemic conditions: Key roles for transcription factors Sp1, CREB and NF-kappaB. | Regulation of peroxiredoxin-3 gene expression under basal and hyperglycemic conditions: Key roles for transcription factors Sp1, CREB and NF-κB.
Arkat S, Poovitha S, Vijayakumar A, Dhat R, Sitasawad SL, Mahapatra NR. | 05/13/2023 |
| Sp1 Inhibits PGC-1alpha via HDAC2-Catalyzed Histone Deacetylation in Chronic Constriction Injury-Induced Neuropathic Pain. | Sp1 Inhibits PGC-1α via HDAC2-Catalyzed Histone Deacetylation in Chronic Constriction Injury-Induced Neuropathic Pain.
Miao J, Chen Z, Wu Y, Hu Q, Ji T. | 12/24/2022 |
| Silencing of specificity protein 1 protects H9c2 cells against lipopolysaccharide-induced injury via binding to the promoter of chemokine CXC receptor 4 and suppressing NF-kappaB signaling. | Silencing of specificity protein 1 protects H9c2 cells against lipopolysaccharide-induced injury via binding to the promoter of chemokine CXC receptor 4 and suppressing NF-κB signaling.
Zhu Z, Zhang G, Li D, Yin X, Wang T., Free PMC Article | 02/26/2022 |
| Sp1-induced LncRNA CTBP1-AS2 is a novel regulator in cardiomyocyte hypertrophy by interacting with FUS to stabilize TLR4. | Sp1-induced LncRNA CTBP1-AS2 is a novel regulator in cardiomyocyte hypertrophy by interacting with FUS to stabilize TLR4.
Luo X, He S, Hu Y, Liu J, Chen X. | 01/4/2020 |
| In vascular calcification, elevated Sp1 exerts a pro-apoptotic effect, promoting BMP2 transcription and disease progression. | Sp1 Plays an Important Role in Vascular Calcification Both In Vivo and In Vitro.
Zhang X, Li R, Qin X, Wang L, Xiao J, Song Y, Sheng X, Guo M, Ji X., Free PMC Article | 12/14/2019 |
| Extracellular vesicles from human-induced pluripotent stem cell-derived mesenchymal stromal cells protect against renal ischemia/reperfusion injury via delivering SP1 and transcriptionally activating sphingosine kinase 1 and inhibiting necroptosis. | Extracellular vesicles from human-induced pluripotent stem cell-derived mesenchymal stromal cells (hiPSC-MSCs) protect against renal ischemia/reperfusion injury via delivering specificity protein (SP1) and transcriptional activating of sphingosine kinase 1 and inhibiting necroptosis.
Yuan X, Li D, Chen X, Han C, Xu L, Huang T, Dong Z, Zhang M., Free PMC Article | 07/28/2018 |
| Prdx6 upregulation by Cur treatment attenuates ischemic oxidative damage through SP1 induction in rats after stroke. This represents a novel mechanism of Cur-induced neuroprotection against cerebral ischemia. | Prdx6 Upregulation by Curcumin Attenuates Ischemic Oxidative Damage via SP1 in Rats after Stroke.
Jia G, Tan B, Ma J, Zhang L, Jin X, Li C., Free PMC Article | 03/10/2018 |
| These novel findings suggest that miR-375 acts as a potent negative mediator in regulating the synthesis and secretion of CATs in the adrenal medulla during the maintenance of homeostasis under stress. | miR-375 negatively regulates the synthesis and secretion of catecholamines by targeting Sp1 in rat adrenal medulla.
Gai Y, Zhang J, Wei C, Cao W, Cui Y, Cui S. | 08/26/2017 |
| SP1 and TFAP2A regulate Gjb2 promoter activity during epididymal differentiation in rat. | Role of Specificity Protein-1 and Activating Protein-2 Transcription Factors in the Regulation of the Gap Junction Protein Beta-2 Gene in the Epididymis of the Rat.
Adam C, Cyr DG., Free PMC Article | 07/8/2017 |
| Hypoxia significantly increased CpG methylation at the cAMP-response elements and Sp1 binding sites and decreased Sp1 binding to GR exon 1 promoter, accounting for the repression of the GR gene in the developing heart. | Antenatal hypoxia induces epigenetic repression of glucocorticoid receptor and promotes ischemic-sensitive phenotype in the developing heart.
Xiong F, Lin T, Song M, Ma Q, Martinez SR, Lv J, MataGreenwood E, Xiao D, Xu Z, Zhang L., Free PMC Article | 11/12/2016 |
| Reduced binding of SP1 to the promoter region of folate transporters may be a part of the regulatory mechanism resulting in decreased expression of folate transporters on ethanol exposure. | Reduced SP1-mediated transcriptional activation decreases expression of intestinal folate transporters in response to ethanol exposure.
Thakur S, Rahat B, More D, Kaur J. | 07/30/2016 |
| Carbon monoxide-releasing molecule-2-enhanced HO-1 promoter activity was inhibited by co-transfection with small interfering RNA (siRNA) of c-Jun, specificity protein 1 (Sp1), or nuclear factor-erythroid 2-related factor 2 (Nrf2). | CO Induces Nrf2-Dependent Heme Oxygenase-1 Transcription by Cooperating with Sp1 and c-Jun in Rat Brain Astrocytes.
Chi PL, Lin CC, Chen YW, Hsiao LD, Yang CM. | 05/7/2016 |
| miR-7a/b has an anti-fibrotic role in ANG II-treated CFs that is mediated by Sp1 mechanism involving the TGF-beta and MAPKs pathways. | Sp1 Mediates a Therapeutic Role of MiR-7a/b in Angiotensin II-Induced Cardiac Fibrosis via Mechanism Involving the TGF-β and MAPKs Pathways in Cardiac Fibroblasts.
Li R, Xiao J, Qing X, Xing J, Xia Y, Qi J, Liu X, Zhang S, Sheng X, Zhang X, Ji X., Free PMC Article | 04/16/2016 |
| There is competitive interaction between redox-sensitive transcription factors Egr1 and Sp1 in the early phases of gastric ulcer development. | REDOX-SENSITIVE TRANSCRIPTION FACTORS EGR-1 AND SP1 IN THE PATHOGENESIS OF EXPERIMENTAL GASTRIC ULCER.
Beregovyi SM, Chervinska TM, Dranitsina AS, Szabo S, Tolstanova GM. | 11/28/2015 |
| These results suggest that XT-1 expression is refractory to the disease process and to inhibition by inflammatory cytokines and that signaling through AP-1, Sp1, and Sp3 is important in the maintenance of XT-1 levels in NP cells. | Xylosyltransferase-1 expression is refractory to inhibition by the inflammatory cytokines tumor necrosis factor α and IL-1β in nucleus pulposus cells: novel regulation by AP-1, Sp1, and Sp3.
Ye W, Zhou J, Markova DZ, Tian Y, Li J, Anderson DG, Shapiro IM, Risbud MV., Free PMC Article | 09/26/2015 |
| Melatonin reduced Erk phosphorylation and Sp1 expression | Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling.
Shin IS, Shin NR, Park JW, Jeon CM, Hong JM, Kwon OK, Kim JS, Lee IC, Kim JC, Oh SR, Ahn KS. | 08/29/2015 |
| Manganese treatment induced robust Sp1 phosphorylation and increased its DNA binding activity. Overexpression of mutant Sp1 lacking phosphorylation sites attenuated Sp1's ability to stimulate manganese-induced caspase-3 promoter activity. | Manganese regulates caspase-3 gene promoter activity by inducing Sp1 phosphorylation in PC12 cells.
Uchida A, Oh-hashi K, Kiuchi K, Hirata Y. | 03/29/2014 |
| results indicate that recruitment of Sp1 by CpG hypomethylation leads to upregulation of Na-K-2Cl cotransporter 1 in hypertensive rats | Recruitment of specificity protein 1 by CpG hypomethylation upregulates Na⁺-K⁺-2Cl⁻ cotransporter 1 in hypertensive rats.
Cho HM, Lee HA, Kim HY, Lee DY, Kim IK. | 02/15/2014 |
| Data suggest that miR-711-SP1-collagen-I pathway may be strategies for miRNA-based anti-fibrotic drug research. | MiRNA-711-SP1-collagen-I pathway is involved in the anti-fibrotic effect of pioglitazone in myocardial infarction.
Zhao N, Yu H, Yu H, Sun M, Zhang Y, Xu M, Gao W. | 12/14/2013 |
| This investigation has thus revealed a novel aspect of Atp7a gene regulation in which Sp1 may be necessary for the HIF-mediated induction of gene transcription during iron deficiency/hypoxia. | Transcription factors Sp1 and Hif2α mediate induction of the copper-transporting ATPase (Atp7a) gene in intestinal epithelial cells during hypoxia.
Xie L, Collins JF., Free PMC Article | 11/30/2013 |