| Beneficial impact of epigallocatechingallate on LDL-C through PCSK9/LDLR pathway by blocking HNF1alpha and activating FoxO3a. | Beneficial impact of epigallocatechingallate on LDL-C through PCSK9/LDLR pathway by blocking HNF1α and activating FoxO3a.
Cui CJ, Jin JL, Guo LN, Sun J, Wu NQ, Guo YL, Liu G, Dong Q, Li JJ., Free PMC Article | 06/12/2021 |
| HMGB1 Inhibits HNF1A to Modulate Liver Fibrogenesis via p65/miR-146b Signaling. | HMGB1 Inhibits HNF1A to Modulate Liver Fibrogenesis via p65/miR-146b Signaling.
Ge S, Wu X, Xiong Y, Xie J, Liu F, Zhang W, Yang L, Zhang S, Lai L, Huang J, Li M, Yu YQ. | 10/3/2020 |
| coordinated upregulation of genes encoding CRP, interleukin-6 (IL-6), HNF1alpha, and HNF4alpha in the livers and white adipose tissue (WAT) of chronic renal failure rats, as compared to the pair-fed and control animals. | Hepatocyte nuclear factors as possible C-reactive protein transcriptional inducer in the liver and white adipose tissue of rats with experimental chronic renal failure.
Sucajtys-Szulc E, Debska-Slizien A, Rutkowski B, Milczarek R, Pelikant-Malecka I, Sledzinski T, Swierczynski J, Szolkiewicz M., Free PMC Article | 11/3/2018 |
| Hnf1alpha gene expression is upregulated in the liver of rats with experimentally induced chronic renal failure, showing an association between circulating PCSK9 and TAGs | Up-regulation of Hnf1α gene expression in the liver of rats with experimentally induced chronic renal failure - A possible link between circulating PCSK9 and triacylglycerol concentrations.
Sucajtys-Szulc E, Szolkiewicz M, Swierczynski J, Rutkowski B. | 03/11/2017 |
| HNF-1alpha, HNF-4alpha and FOXA2 transcriptional factors are involved in diabetes-induced overexpression of Slc2a2 gene in the liver and kidney. | Hepatocyte nuclear factors 1α/4α and forkhead box A2 regulate the solute carrier 2A2 (Slc2a2) gene expression in the liver and kidney of diabetic rats.
David-Silva A, Freitas HS, Okamoto MM, Sabino-Silva R, Schaan BD, Machado UF. | 12/28/2013 |
| De novo synthesis of HNF-1alpha was seen in rat brain, and an increased interaction of HNF-1alpha with p300 and albumin promoter seems to be responsible for overexpression of albumin in ischemic condition. | Hepatocyte nuclear factor-1alpha mediated upregulation of albumin expression in focal ischemic rat brain.
Prajapati KD, Sharma SS, Roy N. | 04/14/2012 |
| Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress. | Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress.
Kirkpatrick CL, Wiederkehr A, Baquié M, Akhmedov D, Wang H, Gauthier BR, Akerman I, Ishihara H, Ferrer J, Wollheim CB., Free PMC Article | 11/26/2011 |
| a critical link between HNF1A-MODY-induced alterations in Bmp-3 expression and insulin gene levels | Bone morphogenetic protein 3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes of the young mutation.
Bonner C, Farrelly AM, Concannon CG, Dussmann H, Baquié M, Virard I, Wobser H, Kögel D, Wollheim CB, Rupnik M, Byrne MM, König HG, Prehn JH., Free PMC Article | 09/17/2011 |
| Studies suggest that overexpression of DN-HNF1A induces bioenergetic stress and activation of AMPK, and this in turn mediates the transcriptional activation of BMF, coupling prolonged energy stress to apoptosis activation. | AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF.
Kilbride SM, Farrelly AM, Bonner C, Ward MW, Nyhan KC, Concannon CG, Wollheim CB, Byrne MM, Prehn JH., Free PMC Article | 02/26/2011 |
| analysis of isoform-specific expression of the human, mouse and rat HNF1A, HNF1B and HNF4A genes | Species-specific differences in the expression of the HNF1A, HNF1B and HNF4A genes.
Harries LW, Brown JE, Gloyn AL., Free PMC Article | 05/3/2010 |
| Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells | Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells.
Flozak AS, Lam AP, Russell S, Jain M, Peled ON, Sheppard KA, Beri R, Mutlu GM, Budinger GR, Gottardi CJ., Free PMC Article | 03/1/2010 |
| in addition to reduced glycolytic flux, uncoupling of mitochondrial oxidative phosphorylation contributes to impaired nutrient-stimulated insulin secretion with either mutations or loss of HNF-1alpha | Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets.
Pongratz RL, Kibbey RG, Kirkpatrick CL, Zhao X, Pontoglio M, Yaniv M, Wollheim CB, Shulman GI, Cline GW., Free PMC Article | 01/21/2010 |
| The overexpression of the SLC2A2 gene in the kidney of diabetic rats is associated with the transcriptional activity of HNF-1alpha and HNF-3beta. | SLC2A2 gene expression in kidney of diabetic rats is regulated by HNF-1alpha and HNF-3beta.
Freitas HS, Schaan BD, David-Silva A, Sabino-Silva R, Okamoto MM, Alves-Wagner AB, Mori RC, Machado UF. | 01/21/2010 |
| signalling through mTORC1 is highly sensitive to suppression of HNF1A function, and may contribute to disturbance of cell-size regulation and cell-cycle progression in HNF1A-maturity onset diabetes. | Early loss of mammalian target of rapamycin complex 1 (mTORC1) signalling and reduction in cell size during dominant-negative suppression of hepatic nuclear factor 1-alpha (HNF1A) function in INS-1 insulinoma cells.
Farrelly AM, Wobser H, Bonner C, Anguissola S, Rehm M, Concannon CG, Prehn JH, Byrne MM. | 01/21/2010 |
| Renal transcription factors HNF1alpha, HNF1beta, and HIF-1 might be the central mediators of drug-induced kidney injury and adaptive response pathways. | Integrated pathway analysis of rat urine metabolic profiles and kidney transcriptomic profiles to elucidate the systems toxicology of model nephrotoxicants.
Xu EY, Perlina A, Vu H, Troth SP, Brennan RJ, Aslamkhan AG, Xu Q. | 01/21/2010 |
| major change in transcriptional control by HNF1 that affects redox and other genes and precedes emergence of hypertensive renal injury | Hepatocyte nuclear factor 1 and hypertensive nephropathy.
Dmitrieva RI, Hinojos CA, Boerwinkle E, Braun MC, Fornage M, Doris PA., Free PMC Article | 01/21/2010 |
| HNF-1alpha, as a modulator of SGLT2 expression, may be involved in diabetic kidney disease | Na(+) -glucose transporter-2 messenger ribonucleic acid expression in kidney of diabetic rats correlates with glycemic levels: involvement of hepatocyte nuclear factor-1alpha expression and activity.
Freitas HS, Anhê GF, Melo KF, Okamoto MM, Oliveira-Souza M, Bordin S, Machado UF. | 01/21/2010 |
| CBP and p300 cooperatively enhance HNF-1alpha-mediated expression of the albumin gene in hepatocytes | Transcriptional coactivators CBP and p300 cooperatively enhance HNF-1alpha-mediated expression of the albumin gene in hepatocytes.
Dohda T, Kaneoka H, Inayoshi Y, Kamihira M, Miyake K, Iijima S. | 01/21/2010 |
| cooperative interaction between NF1 family members and HNF1alpha plays an important role in hepatic L-PK transcription | Nuclear factor 1 family members interact with hepatocyte nuclear factor 1alpha to synergistically activate L-type pyruvate kinase gene transcription.
Satoh S, Noaki T, Ishigure T, Osada S, Imagawa M, Miura N, Yamada K, Noguchi T. | 01/21/2010 |
| HNF4alpha, CREM, HNF1alpha, and C/EBPalpha have roles in transcriptional regulation of the glucose-6-phosphatase gene by cAMP/vasoactive intestinal peptide in the intestine | Transcriptional regulation of the glucose-6-phosphatase gene by cAMP/vasoactive intestinal peptide in the intestine. Role of HNF4alpha, CREM, HNF1alpha, and C/EBPalpha.
Gautier-Stein A, Zitoun C, Lalli E, Mithieux G, Rajas F. | 01/21/2010 |
| Inheritance eis assoiated with type 2 diabetes of the young, polycystic thyroid and urogenital malformations. | Digenic inheritance of hepatocyte nuclear factor-1alpha and -1beta with maturity-onset diabetes of the young, polycystic thyroid, and urogenital malformations.
Karges B, Bergmann C, Scholl K, Heinze E, Rasche FM, Zerres K, Debatin KM, Wabitsch M, Karges W. | 01/21/2010 |